@prefix bemo: . @prefix bfo: . @prefix dcterms: . @prefix iao: . @prefix obo: . @prefix oboInOwl: . @prefix owl: . @prefix prov: . @prefix rdfs: . @prefix skos: . @prefix xsd: . bemo:BEMO_0000002 a owl:Class ; rdfs:label "metric pillar"@en ; iao:0000115 "A high-level organizational class grouping biomedical evidence metrics by scientific function."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000002" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000003 a owl:Class ; rdfs:label "metric category"@en ; iao:0000115 "A source-preserving organizational class grouping biomedical evidence metrics within a metric pillar."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000003" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000101 a owl:Class ; rdfs:label "metric input specification"@en ; iao:0000115 "An information content entity specifying a required or optional input role for a metric computation."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000101" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000102 a owl:Class ; rdfs:label "metric output specification"@en ; iao:0000115 "An information content entity specifying the datatype, scale, unit, range, and interpretation of a metric output."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000102" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000103 a owl:Class ; rdfs:label "metric applicability profile"@en ; iao:0000115 "An information content entity specifying evidence levels, study types, domains, and contexts to which a metric applies."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000103" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000104 a owl:Class ; rdfs:label "metric validation record"@en ; iao:0000115 "An information content entity documenting validation design, benchmark, results, scope, and status for a metric or computation profile."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000104" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000105 a owl:Class ; rdfs:label "metric governance record"@en ; iao:0000115 "An information content entity documenting ownership, review, approval, lifecycle, version, and change history."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000105" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000106 a owl:Class ; rdfs:label "uncertainty specification"@en ; iao:0000115 "An information content entity specifying how uncertainty is estimated, propagated, calibrated, and reported."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000106" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000202 a owl:Class ; rdfs:label "scientific claim"@en ; iao:0000115 "An information content entity asserting a biomedical proposition that may be evaluated using evidence metrics."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000202" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000203 a owl:Class ; rdfs:label "body of evidence"@en ; iao:0000115 "A defined collection of evidence records assembled to evaluate one or more biomedical claims."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000203" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000300 a owl:Class ; rdfs:label "metric computation process"@en ; iao:0000115 "A process that applies a metric computation specification to validated inputs and produces a metric assessment."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000300" ; rdfs:subClassOf bfo:0000015 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_3000002 a owl:ObjectProperty ; rdfs:label "uses metric"@en ; iao:0000115 "Connects a metric assessment to the metric used."@en ; oboInOwl:id "BEMO:3000002" ; rdfs:domain bemo:BEMO_0000200 ; rdfs:range bemo:BEMO_0000001 . bemo:BEMO_3000003 a owl:ObjectProperty ; rdfs:label "assesses evidence object"@en ; iao:0000115 "Connects a metric assessment to the evidence object assessed."@en ; oboInOwl:id "BEMO:3000003" ; rdfs:domain bemo:BEMO_0000200 ; rdfs:range bemo:BEMO_0000201 . bemo:BEMO_3000004 a owl:ObjectProperty ; rdfs:label "has required input specification"@en ; iao:0000115 "Connects a computation specification to a required input specification."@en ; oboInOwl:id "BEMO:3000004" . bemo:BEMO_3000005 a owl:ObjectProperty ; rdfs:label "has optional input specification"@en ; iao:0000115 "Connects a computation specification to an optional input specification."@en ; oboInOwl:id "BEMO:3000005" . bemo:BEMO_3000006 a owl:ObjectProperty ; rdfs:label "has output specification"@en ; iao:0000115 "Connects a computation specification to its output specification."@en ; oboInOwl:id "BEMO:3000006" . bemo:BEMO_3000007 a owl:ObjectProperty ; rdfs:label "has scale type"@en ; iao:0000115 "Connects a computation specification to a controlled scale type."@en ; oboInOwl:id "BEMO:3000007" . bemo:BEMO_3000008 a owl:ObjectProperty ; rdfs:label "has computation mode"@en ; iao:0000115 "Connects a computation specification to a computation-mode category."@en ; oboInOwl:id "BEMO:3000008" . bemo:BEMO_3000009 a owl:ObjectProperty ; rdfs:label "has computation readiness status"@en ; iao:0000115 "Connects a computation specification to its readiness status."@en ; oboInOwl:id "BEMO:3000009" . bemo:BEMO_3000010 a owl:ObjectProperty ; rdfs:label "has formula status"@en ; iao:0000115 "Connects a computation specification to formula availability status."@en ; oboInOwl:id "BEMO:3000010" . bemo:BEMO_3000011 a owl:ObjectProperty ; rdfs:label "has directionality"@en ; iao:0000115 "Connects a computation specification to interpretation directionality."@en ; oboInOwl:id "BEMO:3000011" . bemo:BEMO_3000012 a owl:ObjectProperty ; rdfs:label "has uncertainty specification"@en ; iao:0000115 "Connects a computation specification or assessment to an uncertainty specification."@en ; oboInOwl:id "BEMO:3000012" . bemo:BEMO_3000013 a owl:ObjectProperty ; rdfs:label "has applicability profile"@en ; iao:0000115 "Connects a metric to an applicability profile."@en ; oboInOwl:id "BEMO:3000013" . bemo:BEMO_3000014 a owl:ObjectProperty ; rdfs:label "has validation record"@en ; iao:0000115 "Connects a metric or computation profile to a validation record."@en ; oboInOwl:id "BEMO:3000014" . bemo:BEMO_3000015 a owl:ObjectProperty ; rdfs:label "has governance record"@en ; iao:0000115 "Connects an ontology entity to its governance record."@en ; oboInOwl:id "BEMO:3000015" . bemo:BEMO_3000016 a owl:ObjectProperty ; rdfs:label "depends on metric"@en ; iao:0000115 "Represents a curated computational dependency between metrics."@en ; oboInOwl:id "BEMO:3000016" . bemo:BEMO_3000017 a owl:ObjectProperty ; rdfs:label "derived from metric"@en ; iao:0000115 "Represents a curated derivation relation between metrics."@en ; oboInOwl:id "BEMO:3000017" . bemo:BEMO_3000018 a owl:ObjectProperty ; rdfs:label "composite of metric"@en ; iao:0000115 "Connects a composite metric to a component metric."@en ; oboInOwl:id "BEMO:3000018" . bemo:BEMO_3000019 a owl:ObjectProperty ; rdfs:label "validated against"@en ; iao:0000115 "Connects a metric profile or assessment to a benchmark or reference standard."@en ; oboInOwl:id "BEMO:3000019" . bemo:BEMO_3000020 a owl:ObjectProperty ; rdfs:label "generated by computation process"@en ; iao:0000115 "Connects a metric assessment to the process that generated it."@en ; oboInOwl:id "BEMO:3000020" ; owl:equivalentProperty prov:wasGeneratedBy ; skos:closeMatch . bemo:BEMO_3100001 a owl:DatatypeProperty ; rdfs:label "metric identifier"@en ; iao:0000115 "Stable OBO-style CURIE assigned to a metric."@en ; oboInOwl:id "BEMO:3100001" ; rdfs:range xsd:string . bemo:BEMO_3100002 a owl:DatatypeProperty ; rdfs:label "profile version"@en ; iao:0000115 "Version of a computation profile."@en ; oboInOwl:id "BEMO:3100002" . bemo:BEMO_3100003 a owl:DatatypeProperty ; rdfs:label "human-readable formula"@en ; iao:0000115 "Human-readable formula or protocol requirement."@en ; oboInOwl:id "BEMO:3100003" . bemo:BEMO_3100004 a owl:DatatypeProperty ; rdfs:label "machine formula language"@en ; iao:0000115 "Language used for a machine-readable formula."@en ; oboInOwl:id "BEMO:3100004" . bemo:BEMO_3100005 a owl:DatatypeProperty ; rdfs:label "machine formula expression"@en ; iao:0000115 "Serialized machine-readable computation expression."@en ; oboInOwl:id "BEMO:3100005" . bemo:BEMO_3100006 a owl:DatatypeProperty ; rdfs:label "required inputs text"@en ; iao:0000115 "Semicolon-delimited required input roles."@en ; oboInOwl:id "BEMO:3100006" . bemo:BEMO_3100007 a owl:DatatypeProperty ; rdfs:label "optional inputs text"@en ; iao:0000115 "Semicolon-delimited optional input roles."@en ; oboInOwl:id "BEMO:3100007" . bemo:BEMO_3100008 a owl:DatatypeProperty ; rdfs:label "output datatype"@en ; iao:0000115 "Expected output datatype."@en ; oboInOwl:id "BEMO:3100008" . bemo:BEMO_3100009 a owl:DatatypeProperty ; rdfs:label "unit text"@en ; iao:0000115 "Human-readable unit or scale."@en ; oboInOwl:id "BEMO:3100009" . bemo:BEMO_3100010 a owl:DatatypeProperty ; rdfs:label "minimum value"@en ; iao:0000115 "Minimum allowed or expected numeric value."@en ; oboInOwl:id "BEMO:3100010" . bemo:BEMO_3100011 a owl:DatatypeProperty ; rdfs:label "maximum value"@en ; iao:0000115 "Maximum allowed or expected numeric value."@en ; oboInOwl:id "BEMO:3100011" . bemo:BEMO_3100012 a owl:DatatypeProperty ; rdfs:label "null value"@en ; iao:0000115 "Scientifically meaningful null value."@en ; oboInOwl:id "BEMO:3100012" . bemo:BEMO_3100013 a owl:DatatypeProperty ; rdfs:label "aggregation rule"@en ; iao:0000115 "Aggregation rule for multi-input or composite computations."@en ; oboInOwl:id "BEMO:3100013" . bemo:BEMO_3100014 a owl:DatatypeProperty ; rdfs:label "normalization method"@en ; iao:0000115 "Normalization method and version."@en ; oboInOwl:id "BEMO:3100014" . bemo:BEMO_3100015 a owl:DatatypeProperty ; rdfs:label "missing data policy"@en ; iao:0000115 "Required missing-data handling policy."@en ; oboInOwl:id "BEMO:3100015" . bemo:BEMO_3100016 a owl:DatatypeProperty ; rdfs:label "uncertainty required"@en ; iao:0000115 "Whether uncertainty reporting is mandatory."@en ; oboInOwl:id "BEMO:3100016" ; rdfs:range xsd:boolean . bemo:BEMO_3100017 a owl:DatatypeProperty ; rdfs:label "uncertainty method"@en ; iao:0000115 "Acceptable uncertainty estimation method."@en ; oboInOwl:id "BEMO:3100017" . bemo:BEMO_3100018 a owl:DatatypeProperty ; rdfs:label "confidence interval required"@en ; iao:0000115 "Whether interval estimation is required."@en ; oboInOwl:id "BEMO:3100018" ; rdfs:range xsd:boolean . bemo:BEMO_3100019 a owl:DatatypeProperty ; rdfs:label "threshold policy"@en ; iao:0000115 "Policy governing thresholds."@en ; oboInOwl:id "BEMO:3100019" . bemo:BEMO_3100020 a owl:DatatypeProperty ; rdfs:label "quality control requirements"@en ; iao:0000115 "Quality-control requirements for computation."@en ; oboInOwl:id "BEMO:3100020" . bemo:BEMO_3100021 a owl:DatatypeProperty ; rdfs:label "calibration requirement"@en ; iao:0000115 "Calibration requirement for the output."@en ; oboInOwl:id "BEMO:3100021" . bemo:BEMO_3100022 a owl:DatatypeProperty ; rdfs:label "source row"@en ; iao:0000115 "One-based row number in the source worksheet."@en ; oboInOwl:id "BEMO:3100022" ; rdfs:range xsd:integer . bemo:BEMO_3100023 a owl:DatatypeProperty ; rdfs:label "source record hash"@en ; iao:0000115 "SHA-256 hash of the canonical source record."@en ; oboInOwl:id "BEMO:3100023" ; rdfs:range xsd:string . bemo:BEMO_3100024 a owl:DatatypeProperty ; rdfs:label "scientific importance score"@en ; iao:0000115 "Source-provided scientific importance score."@en ; oboInOwl:id "BEMO:3100024" . bemo:BEMO_3100025 a owl:DatatypeProperty ; rdfs:label "metric value lexical form"@en ; iao:0000115 "Lexical representation of a metric assessment value."@en ; oboInOwl:id "BEMO:3100025" . bemo:BEMO_3100026 a owl:DatatypeProperty ; rdfs:label "numeric metric value"@en ; iao:0000115 "Numeric metric assessment value."@en ; oboInOwl:id "BEMO:3100026" . bemo:BEMO_3100027 a owl:DatatypeProperty ; rdfs:label "assessment timestamp"@en ; iao:0000115 "Time at which an assessment was generated."@en ; oboInOwl:id "BEMO:3100027" . bemo:BEMO_3100028 a owl:DatatypeProperty ; rdfs:label "computation protocol version"@en ; iao:0000115 "Version of the executed protocol."@en ; oboInOwl:id "BEMO:3100028" . bemo:BEMO_3100029 a owl:DatatypeProperty ; rdfs:label "evidence snapshot identifier"@en ; iao:0000115 "Identifier of the immutable evidence snapshot."@en ; oboInOwl:id "BEMO:3100029" . bemo:BEMO_3100030 a owl:DatatypeProperty ; rdfs:label "validation status text"@en ; iao:0000115 "Human-readable validation status."@en ; oboInOwl:id "BEMO:3100030" . bemo:BEMO_3200001 a owl:AnnotationProperty ; rdfs:label "source scientific definition"@en ; iao:0000115 "Preserves the exact scientific definition from the source catalog."@en ; oboInOwl:id "BEMO:3200001" . bemo:BEMO_3200002 a owl:AnnotationProperty ; rdfs:label "what it measures"@en ; iao:0000115 "Preserves the source explanation of what a metric measures."@en ; oboInOwl:id "BEMO:3200002" . bemo:BEMO_3200003 a owl:AnnotationProperty ; rdfs:label "why it matters"@en ; iao:0000115 "Preserves the source rationale."@en ; oboInOwl:id "BEMO:3200003" . bemo:BEMO_3200004 a owl:AnnotationProperty ; rdfs:label "measurement criteria"@en ; iao:0000115 "Preserves the source measurement criteria."@en ; oboInOwl:id "BEMO:3200004" . bemo:BEMO_3200005 a owl:AnnotationProperty ; rdfs:label "methods of assessment"@en ; iao:0000115 "Preserves the source methods of assessment."@en ; oboInOwl:id "BEMO:3200005" . bemo:BEMO_3200006 a owl:AnnotationProperty ; rdfs:label "common misinterpretations"@en ; iao:0000115 "Preserves the source warnings about misinterpretation."@en ; oboInOwl:id "BEMO:3200006" . bemo:BEMO_3200007 a owl:AnnotationProperty ; rdfs:label "limitations"@en ; iao:0000115 "Preserves the source limitations."@en ; oboInOwl:id "BEMO:3200007" . bemo:BEMO_3200008 a owl:AnnotationProperty ; rdfs:label "source evidence level"@en ; iao:0000115 "Preserves the source evidence-level scope."@en ; oboInOwl:id "BEMO:3200008" . bemo:BEMO_3200009 a owl:AnnotationProperty ; rdfs:label "source study types"@en ; iao:0000115 "Preserves the source applicable study types."@en ; oboInOwl:id "BEMO:3200009" . bemo:BEMO_3200010 a owl:AnnotationProperty ; rdfs:label "source frameworks"@en ; iao:0000115 "Preserves the source related frameworks."@en ; oboInOwl:id "BEMO:3200010" . bemo:BEMO_3200011 a owl:AnnotationProperty ; rdfs:label "source references"@en ; iao:0000115 "Preserves the source reference list."@en ; oboInOwl:id "BEMO:3200011" . bemo:BEMO_3200012 a owl:AnnotationProperty ; rdfs:label "computation profile IRI"@en ; iao:0000115 "Links a metric class to its profile using an annotation-safe IRI."@en ; oboInOwl:id "BEMO:3200012" . bemo:BEMO_3200013 a owl:AnnotationProperty ; rdfs:label "closely related metric"@en ; iao:0000115 "Source-declared closely related metric."@en ; oboInOwl:id "BEMO:3200013" . bemo:BEMO_3200014 a owl:AnnotationProperty ; rdfs:label "source workbook"@en ; iao:0000115 "Name of the source workbook."@en ; oboInOwl:id "BEMO:3200014" . bemo:BEMO_3200015 a owl:AnnotationProperty ; rdfs:label "source sheet"@en ; iao:0000115 "Name of the source worksheet."@en ; oboInOwl:id "BEMO:3200015" . bemo:BEMO_3200016 a owl:AnnotationProperty ; rdfs:label "lifecycle status"@en ; iao:0000115 "Term lifecycle status."@en ; oboInOwl:id "BEMO:3200016" . bemo:BEMO_3200017 a owl:AnnotationProperty ; rdfs:label "license status"@en ; iao:0000115 "License status of the record or ontology."@en ; oboInOwl:id "BEMO:3200017" . bemo:BEMO_3200018 a owl:AnnotationProperty ; rdfs:label "editor note"@en ; iao:0000115 "Ontology-editor note."@en ; oboInOwl:id "BEMO:3200018" . bemo:BEMO_3200019 a owl:AnnotationProperty ; rdfs:label "frequency of use"@en ; iao:0000115 "Source-provided frequency-of-use classification."@en ; oboInOwl:id "BEMO:3200019" . bemo:BEMO_3200020 a owl:AnnotationProperty ; rdfs:label "maturity of metric"@en ; iao:0000115 "Source-provided maturity classification."@en ; oboInOwl:id "BEMO:3200020" . bemo:BEMO_4000023 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Candidate"@en ; iao:0000115 "Controlled BEMO LifecycleStatus value: Candidate."@en ; oboInOwl:id "BEMO:4000023" ; skos:notation "Candidate" . bemo:BEMO_4000024 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Stable"@en ; iao:0000115 "Controlled BEMO LifecycleStatus value: Stable."@en ; oboInOwl:id "BEMO:4000024" ; skos:notation "Stable" . bemo:BEMO_4000025 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Deprecated"@en ; iao:0000115 "Controlled BEMO LifecycleStatus value: Deprecated."@en ; oboInOwl:id "BEMO:4000025" ; skos:notation "Deprecated" . bemo:BEMO_4000026 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Obsolete"@en ; iao:0000115 "Controlled BEMO LifecycleStatus value: Obsolete."@en ; oboInOwl:id "BEMO:4000026" ; skos:notation "Obsolete" . bemo:BEMO_4000027 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Draft"@en ; iao:0000115 "Controlled BEMO ApprovalStatus value: Draft."@en ; oboInOwl:id "BEMO:4000027" ; skos:notation "Draft" . bemo:BEMO_4000028 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Under Review"@en ; iao:0000115 "Controlled BEMO ApprovalStatus value: UnderReview."@en ; oboInOwl:id "BEMO:4000028" ; skos:notation "UnderReview" . bemo:BEMO_4000029 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Approved"@en ; iao:0000115 "Controlled BEMO ApprovalStatus value: Approved."@en ; oboInOwl:id "BEMO:4000029" ; skos:notation "Approved" . bemo:BEMO_4000030 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Rejected"@en ; iao:0000115 "Controlled BEMO ApprovalStatus value: Rejected."@en ; oboInOwl:id "BEMO:4000030" ; skos:notation "Rejected" . a prov:Entity ; dcterms:source obo:bfo.owl . a prov:Entity ; dcterms:source obo:eco.owl . a prov:Entity ; dcterms:source obo:obi.owl . a prov:Entity ; dcterms:source . a owl:Ontology ; dcterms:created "2026-08-02"^^xsd:date ; dcterms:creator "BEMO Project" ; dcterms:description "A provisional, computable ontology of pure biomedical evidence research metrics. Each source metric is represented as an OWL class and linked to a versioned computation specification."@en ; dcterms:modified "2026-08-02"^^xsd:date ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; dcterms:title "Biomedical Evidence Metrics Ontology (BEMO)"@en ; rdfs:comment "DRAFT. This namespace is provisional, the ontology has not been reviewed or accepted by the OBO Foundry, and the final open license requires owner approval."@en ; owl:imports obo:bfo.owl, obo:eco.owl, obo:iao.owl, obo:obi.owl, obo:ro.owl, ; owl:versionIRI ; owl:versionInfo "0.1.0" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO Foundry compatibility." . bemo:BEMO_0000201 a owl:Class ; rdfs:label "evidence object"@en ; iao:0000115 "An entity or information artifact evaluated by a biomedical evidence metric, such as a claim, study, dataset, result, hypothesis, assay, or body of evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000201" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000001 a owl:Class ; rdfs:label "Evidence Synthesis and Certainty metric"@en ; iao:0000115 "Metrics assessing the completeness, certainty, consistency, precision, and synthesis of biomedical evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000001" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000008 a owl:Class ; rdfs:label "Pharmacology and Toxicology metric"@en ; iao:0000115 "Metrics assessing pharmacologic activity, exposure, efficacy, selectivity, and toxicologic evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000008" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000200 a owl:Class ; rdfs:label "metric assessment"@en ; iao:0000115 "A measurement datum or structured assessment produced by applying a biomedical evidence metric to a defined evidence object using a specified computation profile."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000200" ; rdfs:subClassOf iao:0000109 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000404 a owl:Class ; rdfs:label "directionality"@en ; iao:0000115 "A controlled concept describing how greater or lower values should be interpreted."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000404" ; rdfs:subClassOf skos:Concept ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000003 a owl:Class ; rdfs:label "Measurement, Assay, and Biospecimen Quality metric"@en ; iao:0000115 "Metrics assessing analytical measurement performance, assay validity, biospecimen handling, and preanalytical quality."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000003" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000004 a owl:Class ; rdfs:label "Reproducibility, Replication, and Research Transparency metric"@en ; iao:0000115 "Metrics assessing reproducibility, independent replication, reporting completeness, and research transparency."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000004" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000006 a owl:Class ; rdfs:label "Biological Mechanism and Experimental Evidence metric"@en ; iao:0000115 "Metrics assessing biological plausibility, mechanistic evidence, experimental biology, and model-system evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000006" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_2000002 a owl:Class ; rdfs:label "Biological Plausibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biological plausibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000002" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000002" ; bemo:BEMO_3100022 9 ; bemo:BEMO_3100023 "6cbc5f525d668cebb0928b8428848a625103a7b6492d0a2a618adb116f200bd3" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses biological plausibility using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biological plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biological plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000012, bemo:BEMO_2000014 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000034 a owl:Class ; rdfs:label "Clinical Validity"@en ; iao:0000115 "The degree to which clinical supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000034" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000034" ; bemo:BEMO_3100022 41 ; bemo:BEMO_3100023 "628005d99d3e18a7b100ce400c64fc5218e46beeaa2cfec80dbac2445270cead" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses clinical validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in clinical validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating clinical validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000028, bemo:BEMO_2000033 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000059 a owl:Class ; rdfs:label "Biospecimen Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biospecimen integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000059" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000059" ; bemo:BEMO_3100022 66 ; bemo:BEMO_3100023 "b89a21b15f8ca110af0a2e2a28ae4ce7939819f7d62769c459c1cd5dc9b712cc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biospecimen integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biospecimen integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biospecimen integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000060, bemo:BEMO_2000064 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000086 a owl:Class ; rdfs:label "Causal Identifiability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of causal identifiability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000086" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000086" ; bemo:BEMO_3100022 93 ; bemo:BEMO_3100023 "a6559bfe5ff78dd7455ed538b35cec6508c7c5507441bc614a71e2140188258e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses causal identifiability using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in causal identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating causal identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000088, bemo:BEMO_2000104 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000116 a owl:Class ; rdfs:label "Diagnostic Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of diagnostic sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000116" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000116" ; bemo:BEMO_3100022 123 ; bemo:BEMO_3100023 "4ea75714eea731a1e4644a00db0476f8628bf028934f92bd9e4029ee31ddf173" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses diagnostic sensitivity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in diagnostic sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating diagnostic sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000117, bemo:BEMO_2000128 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000160 a owl:Class ; rdfs:label "Overall Evidence Certainty"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of overall evidence certainty."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000160" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000160" ; bemo:BEMO_3100022 167 ; bemo:BEMO_3100023 "31b48110148a1ebdd1379016bfff93898087ec61573fac3b850ccada3e1f7ae5" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses overall evidence certainty using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in overall evidence certainty can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating overall evidence certainty as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000151, bemo:BEMO_2000154 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000176 a owl:Class ; rdfs:label "Experimental Unit Validity"@en ; iao:0000115 "The degree to which experimental unit supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000176" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000176" ; bemo:BEMO_3100022 183 ; bemo:BEMO_3100023 "3d08eaaab51eb4d1095b9fb5e884110ba36de86e61615acc1661c581f985a6b1" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses experimental unit validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in experimental unit validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating experimental unit validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000171, bemo:BEMO_2000189 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000197 a owl:Class ; rdfs:label "External Validity"@en ; iao:0000115 "The degree to which external supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000197" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000197" ; bemo:BEMO_3100022 204 ; bemo:BEMO_3100023 "291600cbcf719af0c4e82629e00cccabf1b55b19eff672c1fb6c5c7fe2ec4338" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses external validity using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in external validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating external validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000203, bemo:BEMO_2000205 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000221 a owl:Class ; rdfs:label "Gene–Disease Validity"@en ; iao:0000115 "The degree to which gene–disease supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000221" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000221" ; bemo:BEMO_3100022 228 ; bemo:BEMO_3100023 "4501a0d637c0d3d7b3852d3be8f61115b2b1ac442582dd9a3ec88bd21dad9f7c" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses gene–disease validity using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in gene–disease validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating gene–disease validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000230, bemo:BEMO_2000235 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000257 a owl:Class ; rdfs:label "Sequencing Depth Adequacy"@en ; iao:0000115 "The extent to which sequencing depth is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000257" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000257" ; bemo:BEMO_3100022 264 ; bemo:BEMO_3100023 "719d5f0d3157f75114503dd8e8b0e75aa481929ab009d6c25b68024c7b5f71a0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses sequencing depth adequacy using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sequencing depth adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating sequencing depth adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000246, bemo:BEMO_2000250 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000272 a owl:Class ; rdfs:label "Analytical Validity"@en ; iao:0000115 "The degree to which analytical supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000272" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000272" ; bemo:BEMO_3100022 279 ; bemo:BEMO_3100023 "e4b1deae92fd2c549054f6f19f234dbf0b73ab8ff30ff5741db1c88b5618f6c3" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses analytical validity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in analytical validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating analytical validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000267, bemo:BEMO_2000302 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000304 a owl:Class ; rdfs:label "Cross-Omics Integration Coherence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cross-omics integration coherence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000304" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000304" ; bemo:BEMO_3100022 311 ; bemo:BEMO_3100023 "c10b406fc4ce6db5663280fc4b358cc062cc17f0ce7a593af68a762307815cdc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cross-omics integration coherence using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-omics integration coherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-omics integration coherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000303, bemo:BEMO_2000305 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000348 a owl:Class ; rdfs:label "Pharmacological Target Validity"@en ; iao:0000115 "The degree to which pharmacological target supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000348" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000348" ; bemo:BEMO_3100022 355 ; bemo:BEMO_3100023 "2cff4752043ea892788f37639d922b1a249d83c13dfedf581ad1a4ad12ab95b8" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses pharmacological target validity using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pharmacological target validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pharmacological target validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000337, bemo:BEMO_2000347 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000374 a owl:Class ; rdfs:label "Peptide Identification Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to peptide identification given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000374" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000374" ; bemo:BEMO_3100022 381 ; bemo:BEMO_3100023 "7f78eede8aa05781dde3f12d7ea8111e1c0b552f5b722c402b0de5323e65b0ea" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses peptide identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in peptide identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating peptide identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000363, bemo:BEMO_2000377 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000394 a owl:Class ; rdfs:label "Independent Replication Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting independent replication."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000394" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000394" ; bemo:BEMO_3100022 401 ; bemo:BEMO_3100023 "3837461a84fca58515b90e02475b1cf195c845c2cf4704aa9d0c7c2b412d9406" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses independent replication strength using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in independent replication strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating independent replication strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000389, bemo:BEMO_2000392 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000426 a owl:Class ; rdfs:label "Protocol Availability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protocol availability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000426" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000426" ; bemo:BEMO_3100022 433 ; bemo:BEMO_3100023 "6e6dfc0138818017108063ab02fea9da669c25ffc36ec988048eb058c538f84a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses protocol availability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protocol availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating protocol availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000423, bemo:BEMO_2000425 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000439 a owl:Class ; rdfs:label "Effect Magnitude"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of effect magnitude."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000439" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000439" ; bemo:BEMO_3100022 446 ; bemo:BEMO_3100023 "e21896fd55cc8da1ecb273cc15de195832d87a4d4554d2b68b3a9ce060442d84" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses effect magnitude using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in effect magnitude can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating effect magnitude as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000435, bemo:BEMO_2000441 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000485 a owl:Class ; rdfs:label "Randomization Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of randomization integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000485" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000485" ; bemo:BEMO_3100022 492 ; bemo:BEMO_3100023 "8438f239c984919f366a44747e2e32efd683c0e45e3f7af6c269801f1d6694c8" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses randomization integrity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in randomization integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating randomization integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000464, bemo:BEMO_2000466 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biological Gradient"@en ; dcterms:subject bemo:BEMO_2000001 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biological Plausibility"@en ; dcterms:subject bemo:BEMO_2000002 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cell-Type Specificity"@en ; dcterms:subject bemo:BEMO_2000003 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Species Biological Concordance"@en ; dcterms:subject bemo:BEMO_2000004 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Epistasis Support"@en ; dcterms:subject bemo:BEMO_2000005 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Gain-of-Function Validation"@en ; dcterms:subject bemo:BEMO_2000006 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Homeostatic Compensation Assessment"@en ; dcterms:subject bemo:BEMO_2000007 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Loss-of-Function Validation"@en ; dcterms:subject bemo:BEMO_2000008 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mechanistic Causality Strength"@en ; dcterms:subject bemo:BEMO_2000009 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mechanistic Coherence"@en ; dcterms:subject bemo:BEMO_2000010 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mechanistic Completeness"@en ; dcterms:subject bemo:BEMO_2000011 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mechanistic Coverage"@en ; dcterms:subject bemo:BEMO_2000012 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mechanistic Specificity"@en ; dcterms:subject bemo:BEMO_2000013 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mechanistic Support"@en ; dcterms:subject bemo:BEMO_2000014 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Molecular-Phenotypic Concordance"@en ; dcterms:subject bemo:BEMO_2000015 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Network Context Support"@en ; dcterms:subject bemo:BEMO_2000016 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Off-Target Liability Evidence"@en ; dcterms:subject bemo:BEMO_2000017 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for On-Target Specificity"@en ; dcterms:subject bemo:BEMO_2000018 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pathway-Level Support"@en ; dcterms:subject bemo:BEMO_2000019 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Perturbational Validation"@en ; dcterms:subject bemo:BEMO_2000020 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Phenotypic Concordance"@en ; dcterms:subject bemo:BEMO_2000021 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Rescue Experiment Support"@en ; dcterms:subject bemo:BEMO_2000022 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Spatial Biological Concordance"@en ; dcterms:subject bemo:BEMO_2000023 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Systems-Level Emergence Support"@en ; dcterms:subject bemo:BEMO_2000024 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Target Engagement Evidence"@en ; dcterms:subject bemo:BEMO_2000025 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Temporal Biological Concordance"@en ; dcterms:subject bemo:BEMO_2000026 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Tissue Specificity"@en ; dcterms:subject bemo:BEMO_2000027 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biomarker Clinical Relevance"@en ; dcterms:subject bemo:BEMO_2000028 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biomarker Qualification Strength"@en ; dcterms:subject bemo:BEMO_2000029 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biomarker Reliability"@en ; dcterms:subject bemo:BEMO_2000030 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biomarker Responsiveness"@en ; dcterms:subject bemo:BEMO_2000031 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biomarker Sensitivity to Change"@en ; dcterms:subject bemo:BEMO_2000032 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biomarker-Outcome Association Strength"@en ; dcterms:subject bemo:BEMO_2000033 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Clinical Validity"@en ; dcterms:subject bemo:BEMO_2000034 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Construct Validity"@en ; dcterms:subject bemo:BEMO_2000035 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Content Validity"@en ; dcterms:subject bemo:BEMO_2000036 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Context-of-Use Validity"@en ; dcterms:subject bemo:BEMO_2000037 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Convergent Validity"@en ; dcterms:subject bemo:BEMO_2000038 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Criterion Validity"@en ; dcterms:subject bemo:BEMO_2000039 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Diagnostic Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000040 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Discriminant Validity"@en ; dcterms:subject bemo:BEMO_2000041 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Endpoint Reliability"@en ; dcterms:subject bemo:BEMO_2000042 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Endpoint Responsiveness"@en ; dcterms:subject bemo:BEMO_2000043 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Endpoint Validity"@en ; dcterms:subject bemo:BEMO_2000044 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Individual-Level Surrogacy"@en ; dcterms:subject bemo:BEMO_2000045 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Known-Groups Validity"@en ; dcterms:subject bemo:BEMO_2000046 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Minimal Clinically Important Difference Validity"@en ; dcterms:subject bemo:BEMO_2000047 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Monitoring Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000048 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Outcome Relevance"@en ; dcterms:subject bemo:BEMO_2000049 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pharmacodynamic Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000050 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Predictive Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000051 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prognostic Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000052 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Response Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000053 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Safety Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000054 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Surrogate Endpoint Validity"@en ; dcterms:subject bemo:BEMO_2000055 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Susceptibility/Risk Biomarker Validity"@en ; dcterms:subject bemo:BEMO_2000056 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Trial-Level Surrogacy"@en ; dcterms:subject bemo:BEMO_2000057 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Anatomical Site Fidelity"@en ; dcterms:subject bemo:BEMO_2000058 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biospecimen Integrity"@en ; dcterms:subject bemo:BEMO_2000059 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biospecimen Provenance Completeness"@en ; dcterms:subject bemo:BEMO_2000060 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cellularity Adequacy"@en ; dcterms:subject bemo:BEMO_2000061 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Chain-of-Custody Integrity"@en ; dcterms:subject bemo:BEMO_2000062 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cold Ischemia Control"@en ; dcterms:subject bemo:BEMO_2000063 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Collection Procedure Consistency"@en ; dcterms:subject bemo:BEMO_2000064 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for DNA Integrity"@en ; dcterms:subject bemo:BEMO_2000065 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Fixation Adequacy"@en ; dcterms:subject bemo:BEMO_2000066 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Freeze–Thaw Burden"@en ; dcterms:subject bemo:BEMO_2000067 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Hemolysis Burden"@en ; dcterms:subject bemo:BEMO_2000068 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Icterus Interference"@en ; dcterms:subject bemo:BEMO_2000069 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Lipemia Burden"@en ; dcterms:subject bemo:BEMO_2000070 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Matched-Sample Integrity"@en ; dcterms:subject bemo:BEMO_2000071 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Microbial Contamination"@en ; dcterms:subject bemo:BEMO_2000072 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Necrosis Burden"@en ; dcterms:subject bemo:BEMO_2000073 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pathology Confirmation"@en ; dcterms:subject bemo:BEMO_2000074 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Preservation Adequacy"@en ; dcterms:subject bemo:BEMO_2000075 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Processing Delay Control"@en ; dcterms:subject bemo:BEMO_2000076 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protein Integrity"@en ; dcterms:subject bemo:BEMO_2000077 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for RNA Integrity"@en ; dcterms:subject bemo:BEMO_2000078 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Storage Temperature Control"@en ; dcterms:subject bemo:BEMO_2000079 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Time-to-Fixation Adequacy"@en ; dcterms:subject bemo:BEMO_2000080 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Transport Condition Integrity"@en ; dcterms:subject bemo:BEMO_2000081 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Tumor Purity"@en ; dcterms:subject bemo:BEMO_2000082 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Warm Ischemia Control"@en ; dcterms:subject bemo:BEMO_2000083 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Assumption Sensitivity"@en ; dcterms:subject bemo:BEMO_2000084 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Causal Contrast Clarity"@en ; dcterms:subject bemo:BEMO_2000085 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Causal Identifiability"@en ; dcterms:subject bemo:BEMO_2000086 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Collider Bias Risk"@en ; dcterms:subject bemo:BEMO_2000087 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Confounding Risk"@en ; dcterms:subject bemo:BEMO_2000088 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Consistency Assumption Plausibility"@en ; dcterms:subject bemo:BEMO_2000089 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Correct Temporal Ordering"@en ; dcterms:subject bemo:BEMO_2000090 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dechallenge–Rechallenge Support"@en ; dcterms:subject bemo:BEMO_2000091 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dose–Response Support"@en ; dcterms:subject bemo:BEMO_2000092 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for E-value Strength"@en ; dcterms:subject bemo:BEMO_2000093 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000005 ; bemo:BEMO_3000008 bemo:BEMO_4000009 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator; the null value is typically 1 where scientifically applicable"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator != 0\"],\"null_value\":1}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "confidence_level; stratum" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Ratio scale; null typically 1" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100012 "1" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Not generally required unless converted to a probability or score."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Effect-Modification Credibility"@en ; dcterms:subject bemo:BEMO_2000094 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Exchangeability Plausibility"@en ; dcterms:subject bemo:BEMO_2000095 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Falsification Test Support"@en ; dcterms:subject bemo:BEMO_2000096 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Immortal-Time Bias Risk"@en ; dcterms:subject bemo:BEMO_2000097 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Instrument Validity"@en ; dcterms:subject bemo:BEMO_2000098 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mediation Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000099 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Negative-Control Validation"@en ; dcterms:subject bemo:BEMO_2000100 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for No-Interference Plausibility"@en ; dcterms:subject bemo:BEMO_2000101 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Positivity Adequacy"@en ; dcterms:subject bemo:BEMO_2000102 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Quantitative Bias Analysis Robustness"@en ; dcterms:subject bemo:BEMO_2000103 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Residual Confounding Risk"@en ; dcterms:subject bemo:BEMO_2000104 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reverse-Causation Risk"@en ; dcterms:subject bemo:BEMO_2000105 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Selection-on-Survival Bias Risk"@en ; dcterms:subject bemo:BEMO_2000106 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Target Trial Emulation Fidelity"@en ; dcterms:subject bemo:BEMO_2000107 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Time-Varying Confounding Control"@en ; dcterms:subject bemo:BEMO_2000108 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Unmeasured Confounding Sensitivity"@en ; dcterms:subject bemo:BEMO_2000109 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Area Under the Receiver Operating Characteristic Curve"@en ; dcterms:subject bemo:BEMO_2000110 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Calibration Slope"@en ; dcterms:subject bemo:BEMO_2000111 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Calibration-in-the-Large"@en ; dcterms:subject bemo:BEMO_2000112 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Comparative Test Accuracy"@en ; dcterms:subject bemo:BEMO_2000113 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Competing-Risk Model Validity"@en ; dcterms:subject bemo:BEMO_2000114 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Diagnostic Odds Ratio"@en ; dcterms:subject bemo:BEMO_2000115 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000005 ; bemo:BEMO_3000008 bemo:BEMO_4000009 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator; the null value is typically 1 where scientifically applicable"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator != 0\"],\"null_value\":1}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "confidence_level; stratum" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Ratio scale; null typically 1" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100012 "1" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Not generally required unless converted to a probability or score."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Diagnostic Sensitivity"@en ; dcterms:subject bemo:BEMO_2000116 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Diagnostic Specificity"@en ; dcterms:subject bemo:BEMO_2000117 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Differential Verification Bias Risk"@en ; dcterms:subject bemo:BEMO_2000118 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Incorporation Bias Risk"@en ; dcterms:subject bemo:BEMO_2000119 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Incremental Diagnostic Value"@en ; dcterms:subject bemo:BEMO_2000120 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Index-Test Blinding"@en ; dcterms:subject bemo:BEMO_2000121 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Negative Likelihood Ratio"@en ; dcterms:subject bemo:BEMO_2000122 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000005 ; bemo:BEMO_3000008 bemo:BEMO_4000009 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator; the null value is typically 1 where scientifically applicable"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator != 0\"],\"null_value\":1}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "confidence_level; stratum" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Ratio scale; null typically 1" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100012 "1" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Not generally required unless converted to a probability or score."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Negative Predictive Value"@en ; dcterms:subject bemo:BEMO_2000123 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Observed-to-Expected Ratio"@en ; dcterms:subject bemo:BEMO_2000124 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Partial Area Under the Receiver Operating Characteristic Curve"@en ; dcterms:subject bemo:BEMO_2000125 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Patient Flow Integrity"@en ; dcterms:subject bemo:BEMO_2000126 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Positive Likelihood Ratio"@en ; dcterms:subject bemo:BEMO_2000127 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000005 ; bemo:BEMO_3000008 bemo:BEMO_4000009 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator; the null value is typically 1 where scientifically applicable"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator != 0\"],\"null_value\":1}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "confidence_level; stratum" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Ratio scale; null typically 1" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100012 "1" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Not generally required unless converted to a probability or score."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Positive Predictive Value"@en ; dcterms:subject bemo:BEMO_2000128 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prognostic Added Value"@en ; dcterms:subject bemo:BEMO_2000129 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prognostic Calibration"@en ; dcterms:subject bemo:BEMO_2000130 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prognostic Discrimination"@en ; dcterms:subject bemo:BEMO_2000131 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prognostic Transportability"@en ; dcterms:subject bemo:BEMO_2000132 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reclassification Improvement"@en ; dcterms:subject bemo:BEMO_2000133 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reference Standard Validity"@en ; dcterms:subject bemo:BEMO_2000134 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Test-Timing Appropriateness"@en ; dcterms:subject bemo:BEMO_2000135 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Threshold Validity"@en ; dcterms:subject bemo:BEMO_2000136 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Time-Dependent Discrimination"@en ; dcterms:subject bemo:BEMO_2000137 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Verification Bias Risk"@en ; dcterms:subject bemo:BEMO_2000138 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Between-Study Variance"@en ; dcterms:subject bemo:BEMO_2000139 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Counterevidence Strength"@en ; dcterms:subject bemo:BEMO_2000140 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cumulative Evidence Stability"@en ; dcterms:subject bemo:BEMO_2000141 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Coherence"@en ; dcterms:subject bemo:BEMO_2000142 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Completeness"@en ; dcterms:subject bemo:BEMO_2000143 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Confidence"@en ; dcterms:subject bemo:BEMO_2000144 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Consensus Strength"@en ; dcterms:subject bemo:BEMO_2000145 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Consistency"@en ; dcterms:subject bemo:BEMO_2000146 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Coverage"@en ; dcterms:subject bemo:BEMO_2000147 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Directness"@en ; dcterms:subject bemo:BEMO_2000148 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Freshness"@en ; dcterms:subject bemo:BEMO_2000149 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Precision"@en ; dcterms:subject bemo:BEMO_2000150 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Quality"@en ; dcterms:subject bemo:BEMO_2000151 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Robustness"@en ; dcterms:subject bemo:BEMO_2000152 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Stability"@en ; dcterms:subject bemo:BEMO_2000153 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000154 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Sufficiency"@en ; dcterms:subject bemo:BEMO_2000155 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Evidence Triangulation Strength"@en ; dcterms:subject bemo:BEMO_2000156 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Information Size Adequacy"@en ; dcterms:subject bemo:BEMO_2000157 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Missing Evidence Risk"@en ; dcterms:subject bemo:BEMO_2000158 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Multiplicity-Adjusted Credibility"@en ; dcterms:subject bemo:BEMO_2000159 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Overall Evidence Certainty"@en ; dcterms:subject bemo:BEMO_2000160 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prediction Interval Adequacy"@en ; dcterms:subject bemo:BEMO_2000161 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Publication Bias Risk"@en ; dcterms:subject bemo:BEMO_2000162 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Selective Nonreporting Risk"@en ; dcterms:subject bemo:BEMO_2000163 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Small-Study Effects"@en ; dcterms:subject bemo:BEMO_2000164 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Study Heterogeneity"@en ; dcterms:subject bemo:BEMO_2000165 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Age Appropriateness"@en ; dcterms:subject bemo:BEMO_2000166 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Animal Model Construct Validity"@en ; dcterms:subject bemo:BEMO_2000167 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Animal Model Face Validity"@en ; dcterms:subject bemo:BEMO_2000168 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Animal Model Predictive Validity"@en ; dcterms:subject bemo:BEMO_2000169 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Attrition Accounting in Animal Studies"@en ; dcterms:subject bemo:BEMO_2000170 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Biological Replicate Adequacy"@en ; dcterms:subject bemo:BEMO_2000171 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Blinding in Experimental Assessment"@en ; dcterms:subject bemo:BEMO_2000172 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Environmental Standardization"@en ; dcterms:subject bemo:BEMO_2000173 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Exclusion-Criteria Prespecification"@en ; dcterms:subject bemo:BEMO_2000174 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Experimental Batch Randomization"@en ; dcterms:subject bemo:BEMO_2000175 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Experimental Unit Validity"@en ; dcterms:subject bemo:BEMO_2000176 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Genetic Background Control"@en ; dcterms:subject bemo:BEMO_2000177 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Housing and Husbandry Control"@en ; dcterms:subject bemo:BEMO_2000178 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Humane Endpoint Appropriateness"@en ; dcterms:subject bemo:BEMO_2000179 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Intervention Fidelity in Animal Studies"@en ; dcterms:subject bemo:BEMO_2000180 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Negative-Control Performance"@en ; dcterms:subject bemo:BEMO_2000181 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Orthogonal Validation"@en ; dcterms:subject bemo:BEMO_2000182 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Positive-Control Performance"@en ; dcterms:subject bemo:BEMO_2000183 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Randomization in Experimental Allocation"@en ; dcterms:subject bemo:BEMO_2000184 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sample Size Justification"@en ; dcterms:subject bemo:BEMO_2000185 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sex as a Biological Variable Adequacy"@en ; dcterms:subject bemo:BEMO_2000186 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Species Appropriateness"@en ; dcterms:subject bemo:BEMO_2000187 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Technical Artifact Exclusion"@en ; dcterms:subject bemo:BEMO_2000188 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Technical Replicate Adequacy"@en ; dcterms:subject bemo:BEMO_2000189 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Vehicle-Control Validity"@en ; dcterms:subject bemo:BEMO_2000190 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Care-Pathway Independence"@en ; dcterms:subject bemo:BEMO_2000191 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Comparator Applicability"@en ; dcterms:subject bemo:BEMO_2000192 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Context Sensitivity"@en ; dcterms:subject bemo:BEMO_2000193 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Demographic Generalizability"@en ; dcterms:subject bemo:BEMO_2000194 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Disease-Severity Generalizability"@en ; dcterms:subject bemo:BEMO_2000195 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Ecological Validity"@en ; dcterms:subject bemo:BEMO_2000196 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for External Validity"@en ; dcterms:subject bemo:BEMO_2000197 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Generalizability"@en ; dcterms:subject bemo:BEMO_2000198 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Geographic Consistency"@en ; dcterms:subject bemo:BEMO_2000199 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Intervention Applicability"@en ; dcterms:subject bemo:BEMO_2000200 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Outcome Applicability"@en ; dcterms:subject bemo:BEMO_2000201 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Population Applicability"@en ; dcterms:subject bemo:BEMO_2000202 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Population Representativeness"@en ; dcterms:subject bemo:BEMO_2000203 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Real-World Evidence Alignment"@en ; dcterms:subject bemo:BEMO_2000204 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sampling Frame Adequacy"@en ; dcterms:subject bemo:BEMO_2000205 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Setting Applicability"@en ; dcterms:subject bemo:BEMO_2000206 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Spectrum Representativeness"@en ; dcterms:subject bemo:BEMO_2000207 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Subgroup Consistency"@en ; dcterms:subject bemo:BEMO_2000208 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Temporal Generalizability"@en ; dcterms:subject bemo:BEMO_2000209 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Transportability"@en ; dcterms:subject bemo:BEMO_2000210 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Allelic Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000211 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Case-Control Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000212 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Case-Level Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000213 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Co-segregation Likelihood"@en ; dcterms:subject bemo:BEMO_2000214 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Computational Variant Evidence"@en ; dcterms:subject bemo:BEMO_2000215 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Conflicting Interpretation Burden"@en ; dcterms:subject bemo:BEMO_2000216 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for De Novo Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000217 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Expressivity Consistency"@en ; dcterms:subject bemo:BEMO_2000218 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Founder-Effect Assessment"@en ; dcterms:subject bemo:BEMO_2000219 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Functional Variant Evidence"@en ; dcterms:subject bemo:BEMO_2000220 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Gene–Disease Validity"@en ; dcterms:subject bemo:BEMO_2000221 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Genotype–Phenotype Concordance"@en ; dcterms:subject bemo:BEMO_2000222 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Hotspot/Functional-Domain Evidence"@en ; dcterms:subject bemo:BEMO_2000223 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Locus Heterogeneity Assessment"@en ; dcterms:subject bemo:BEMO_2000224 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Loss-of-Function Mechanism Validity"@en ; dcterms:subject bemo:BEMO_2000225 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Null-Variant Quality"@en ; dcterms:subject bemo:BEMO_2000226 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Penetrance Evidence"@en ; dcterms:subject bemo:BEMO_2000227 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Phenocopy Risk"@en ; dcterms:subject bemo:BEMO_2000228 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Phenotypic Specificity for Variant"@en ; dcterms:subject bemo:BEMO_2000229 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Population Frequency Compatibility"@en ; dcterms:subject bemo:BEMO_2000230 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for RNA Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000231 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Segregation Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000232 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Splicing Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000233 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Variant Classification Stability"@en ; dcterms:subject bemo:BEMO_2000234 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Variant Pathogenicity Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000235 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Variant Phase Evidence"@en ; dcterms:subject bemo:BEMO_2000236 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Allelic Balance"@en ; dcterms:subject bemo:BEMO_2000237 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Alternative Splicing Validation"@en ; dcterms:subject bemo:BEMO_2000238 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Batch-Effect Control"@en ; dcterms:subject bemo:BEMO_2000239 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Call-Rate Completeness"@en ; dcterms:subject bemo:BEMO_2000240 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cell-Type Annotation Confidence"@en ; dcterms:subject bemo:BEMO_2000241 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Contamination Burden"@en ; dcterms:subject bemo:BEMO_2000242 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Platform Genomic Concordance"@en ; dcterms:subject bemo:BEMO_2000243 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Differential Expression Robustness"@en ; dcterms:subject bemo:BEMO_2000244 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Duplicate Read Burden"@en ; dcterms:subject bemo:BEMO_2000245 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Genome Coverage Uniformity"@en ; dcterms:subject bemo:BEMO_2000246 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Genotype Quality"@en ; dcterms:subject bemo:BEMO_2000247 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Hardy–Weinberg Equilibrium Compatibility"@en ; dcterms:subject bemo:BEMO_2000248 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Library Complexity"@en ; dcterms:subject bemo:BEMO_2000249 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mapping Quality"@en ; dcterms:subject bemo:BEMO_2000250 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Normalization Adequacy"@en ; dcterms:subject bemo:BEMO_2000251 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Population Stratification Control"@en ; dcterms:subject bemo:BEMO_2000252 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Read Quality"@en ; dcterms:subject bemo:BEMO_2000253 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reference Bias"@en ; dcterms:subject bemo:BEMO_2000254 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Relatedness Control"@en ; dcterms:subject bemo:BEMO_2000255 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sample Identity Concordance"@en ; dcterms:subject bemo:BEMO_2000256 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sequencing Depth Adequacy"@en ; dcterms:subject bemo:BEMO_2000257 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sex Concordance"@en ; dcterms:subject bemo:BEMO_2000258 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Single-Cell Ambient RNA Burden"@en ; dcterms:subject bemo:BEMO_2000259 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Single-Cell Doublet Burden"@en ; dcterms:subject bemo:BEMO_2000260 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Single-Cell Feature Detection Rate"@en ; dcterms:subject bemo:BEMO_2000261 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Single-Cell Viability"@en ; dcterms:subject bemo:BEMO_2000262 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Spatial Transcriptomic Registration Accuracy"@en ; dcterms:subject bemo:BEMO_2000263 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Strand Bias"@en ; dcterms:subject bemo:BEMO_2000264 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Transcript Quantification Reliability"@en ; dcterms:subject bemo:BEMO_2000265 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Variant Call Quality"@en ; dcterms:subject bemo:BEMO_2000266 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Accuracy"@en ; dcterms:subject bemo:BEMO_2000267 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Analytical Measurement Range"@en ; dcterms:subject bemo:BEMO_2000268 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Analytical Precision"@en ; dcterms:subject bemo:BEMO_2000269 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Analytical Sensitivity"@en ; dcterms:subject bemo:BEMO_2000270 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Analytical Specificity"@en ; dcterms:subject bemo:BEMO_2000271 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Analytical Validity"@en ; dcterms:subject bemo:BEMO_2000272 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Batch-Effect Sensitivity"@en ; dcterms:subject bemo:BEMO_2000273 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Calibration Traceability"@en ; dcterms:subject bemo:BEMO_2000274 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Carryover"@en ; dcterms:subject bemo:BEMO_2000275 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Commutability"@en ; dcterms:subject bemo:BEMO_2000276 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Reactivity"@en ; dcterms:subject bemo:BEMO_2000277 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cutoff Validity"@en ; dcterms:subject bemo:BEMO_2000278 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dilution Integrity"@en ; dcterms:subject bemo:BEMO_2000279 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dynamic Range"@en ; dcterms:subject bemo:BEMO_2000280 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Hook Effect Risk"@en ; dcterms:subject bemo:BEMO_2000281 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Instrument Drift"@en ; dcterms:subject bemo:BEMO_2000282 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Interference Susceptibility"@en ; dcterms:subject bemo:BEMO_2000283 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Intermediate Precision"@en ; dcterms:subject bemo:BEMO_2000284 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Limit of Detection"@en ; dcterms:subject bemo:BEMO_2000285 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Limit of Quantification"@en ; dcterms:subject bemo:BEMO_2000286 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Linearity"@en ; dcterms:subject bemo:BEMO_2000287 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Matrix Effect"@en ; dcterms:subject bemo:BEMO_2000288 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Measurement Uncertainty"@en ; dcterms:subject bemo:BEMO_2000289 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Method Comparison Agreement"@en ; dcterms:subject bemo:BEMO_2000290 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Operator Variability"@en ; dcterms:subject bemo:BEMO_2000291 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Postanalytical Integrity"@en ; dcterms:subject bemo:BEMO_2000292 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Preanalytical Robustness"@en ; dcterms:subject bemo:BEMO_2000293 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reagent Lot Consistency"@en ; dcterms:subject bemo:BEMO_2000294 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Recovery"@en ; dcterms:subject bemo:BEMO_2000295 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reference Interval Validity"@en ; dcterms:subject bemo:BEMO_2000296 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Repeatability"@en ; dcterms:subject bemo:BEMO_2000297 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reportable Range"@en ; dcterms:subject bemo:BEMO_2000298 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reproducibility of Measurement"@en ; dcterms:subject bemo:BEMO_2000299 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sample Stability"@en ; dcterms:subject bemo:BEMO_2000300 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Site-to-Site Assay Portability"@en ; dcterms:subject bemo:BEMO_2000301 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Trueness"@en ; dcterms:subject bemo:BEMO_2000302 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Layer Directional Concordance"@en ; dcterms:subject bemo:BEMO_2000303 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Omics Integration Coherence"@en ; dcterms:subject bemo:BEMO_2000304 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Omics Replication"@en ; dcterms:subject bemo:BEMO_2000305 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dynamical Stability"@en ; dcterms:subject bemo:BEMO_2000306 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Emergent-Property Reproducibility"@en ; dcterms:subject bemo:BEMO_2000307 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Entity Resolution Accuracy"@en ; dcterms:subject bemo:BEMO_2000308 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Flux-Balance Consistency"@en ; dcterms:subject bemo:BEMO_2000309 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Knowledge-Graph Evidence Completeness"@en ; dcterms:subject bemo:BEMO_2000310 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Knowledge-Graph Provenance Quality"@en ; dcterms:subject bemo:BEMO_2000311 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Latent-Factor Stability"@en ; dcterms:subject bemo:BEMO_2000312 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Model–Experiment Concordance"@en ; dcterms:subject bemo:BEMO_2000313 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Module Stability"@en ; dcterms:subject bemo:BEMO_2000314 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Network Edge Confidence"@en ; dcterms:subject bemo:BEMO_2000315 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Network Node Confidence"@en ; dcterms:subject bemo:BEMO_2000316 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Network Reconstruction Robustness"@en ; dcterms:subject bemo:BEMO_2000317 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Ontology Annotation Completeness"@en ; dcterms:subject bemo:BEMO_2000318 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Ontology Evidence-Code Strength"@en ; dcterms:subject bemo:BEMO_2000319 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Parameter Identifiability"@en ; dcterms:subject bemo:BEMO_2000320 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Parameter Sensitivity"@en ; dcterms:subject bemo:BEMO_2000321 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pathway Enrichment Consistency"@en ; dcterms:subject bemo:BEMO_2000322 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pathway Topology Support"@en ; dcterms:subject bemo:BEMO_2000323 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Perturbation Prediction Accuracy"@en ; dcterms:subject bemo:BEMO_2000324 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Practical Identifiability"@en ; dcterms:subject bemo:BEMO_2000325 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Relation Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000326 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Steady-State Validity"@en ; dcterms:subject bemo:BEMO_2000327 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Structural Identifiability"@en ; dcterms:subject bemo:BEMO_2000328 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Adverse Outcome Pathway Support"@en ; dcterms:subject bemo:BEMO_2000329 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Benchmark Dose Reliability"@en ; dcterms:subject bemo:BEMO_2000330 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Bioavailability"@en ; dcterms:subject bemo:BEMO_2000331 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Carcinogenicity Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000332 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Developmental Toxicity Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000333 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dose Proportionality"@en ; dcterms:subject bemo:BEMO_2000334 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Drug–Drug Interaction Evidence"@en ; dcterms:subject bemo:BEMO_2000335 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Efficacy Reproducibility"@en ; dcterms:subject bemo:BEMO_2000336 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Exposure–Response Relationship"@en ; dcterms:subject bemo:BEMO_2000337 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Genotoxicity Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000338 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Human-Relevance of Toxicological Evidence"@en ; dcterms:subject bemo:BEMO_2000339 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Immunotoxicity Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000340 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Lowest-Observed-Adverse-Effect Level Robustness"@en ; dcterms:subject bemo:BEMO_2000341 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Metabolite Coverage"@en ; dcterms:subject bemo:BEMO_2000342 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mixture Interaction Assessment"@en ; dcterms:subject bemo:BEMO_2000343 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for No-Observed-Adverse-Effect Level Robustness"@en ; dcterms:subject bemo:BEMO_2000344 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Organ-Specific Toxicity Evidence"@en ; dcterms:subject bemo:BEMO_2000345 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pharmacodynamic Adequacy"@en ; dcterms:subject bemo:BEMO_2000346 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pharmacokinetic Adequacy"@en ; dcterms:subject bemo:BEMO_2000347 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pharmacological Target Validity"@en ; dcterms:subject bemo:BEMO_2000348 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Potency Reproducibility"@en ; dcterms:subject bemo:BEMO_2000349 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Receptor Occupancy Evidence"@en ; dcterms:subject bemo:BEMO_2000350 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reproductive Toxicity Evidence Strength"@en ; dcterms:subject bemo:BEMO_2000351 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Safety Margin Evidence"@en ; dcterms:subject bemo:BEMO_2000352 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Selectivity Profile"@en ; dcterms:subject bemo:BEMO_2000353 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Species Extrapolation Validity"@en ; dcterms:subject bemo:BEMO_2000354 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Therapeutic Window Evidence"@en ; dcterms:subject bemo:BEMO_2000355 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Time–Concentration Profile Adequacy"@en ; dcterms:subject bemo:BEMO_2000356 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000003 ; bemo:BEMO_3000008 bemo:BEMO_4000012 ; bemo:BEMO_3000009 bemo:BEMO_4000013 ; bemo:BEMO_3000010 bemo:BEMO_4000020 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a validated analyte- and method-specific measurement procedure with calibration and quality control."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"unitRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "specimen_or_material; measurement_procedure; calibration_reference; quality_control_results; unit" ; bemo:BEMO_3100007 "replicate_measurements; environmental_conditions; instrument_version" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Method- and analyte-specific physical units" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Toxicokinetic Concordance"@en ; dcterms:subject bemo:BEMO_2000357 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Toxicological Mode-of-Action Support"@en ; dcterms:subject bemo:BEMO_2000358 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cross-Omics Concordance"@en ; dcterms:subject bemo:BEMO_2000359 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Derivatization Efficiency"@en ; dcterms:subject bemo:BEMO_2000360 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Dynamic Range Coverage"@en ; dcterms:subject bemo:BEMO_2000361 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Extraction Recovery"@en ; dcterms:subject bemo:BEMO_2000362 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for False Discovery Rate Control"@en ; dcterms:subject bemo:BEMO_2000363 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Fragmentation Spectrum Quality"@en ; dcterms:subject bemo:BEMO_2000364 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Internal Standard Performance"@en ; dcterms:subject bemo:BEMO_2000365 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Ion Suppression Assessment"@en ; dcterms:subject bemo:BEMO_2000366 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Isotope Pattern Fidelity"@en ; dcterms:subject bemo:BEMO_2000367 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Mass Accuracy"@en ; dcterms:subject bemo:BEMO_2000368 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Metabolic Feature Reproducibility"@en ; dcterms:subject bemo:BEMO_2000369 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Metabolite Annotation Level"@en ; dcterms:subject bemo:BEMO_2000370 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Metabolite Identification Confidence"@en ; dcterms:subject bemo:BEMO_2000371 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Missing-Value Burden"@en ; dcterms:subject bemo:BEMO_2000372 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Pathway Enrichment Robustness"@en ; dcterms:subject bemo:BEMO_2000373 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Peptide Identification Confidence"@en ; dcterms:subject bemo:BEMO_2000374 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Peptide-Spectrum Match Quality"@en ; dcterms:subject bemo:BEMO_2000375 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Post-Translational Modification Localization Confidence"@en ; dcterms:subject bemo:BEMO_2000376 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protein Identification Confidence"@en ; dcterms:subject bemo:BEMO_2000377 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protein Inference Reliability"@en ; dcterms:subject bemo:BEMO_2000378 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Proteoform Identification Confidence"@en ; dcterms:subject bemo:BEMO_2000379 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Proteome Coverage"@en ; dcterms:subject bemo:BEMO_2000380 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Quantification Accuracy"@en ; dcterms:subject bemo:BEMO_2000381 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Quantification Precision"@en ; dcterms:subject bemo:BEMO_2000382 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Retention-Time Stability"@en ; dcterms:subject bemo:BEMO_2000383 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Sequence Coverage"@en ; dcterms:subject bemo:BEMO_2000384 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Spectral Library Match Quality"@en ; dcterms:subject bemo:BEMO_2000385 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Analytical Reproducibility"@en ; dcterms:subject bemo:BEMO_2000386 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Code Availability"@en ; dcterms:subject bemo:BEMO_2000387 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Computational Reproducibility"@en ; dcterms:subject bemo:BEMO_2000388 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Conceptual Replication Success"@en ; dcterms:subject bemo:BEMO_2000389 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Data Availability"@en ; dcterms:subject bemo:BEMO_2000390 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Data Provenance Completeness"@en ; dcterms:subject bemo:BEMO_2000391 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Direct Replication Success"@en ; dcterms:subject bemo:BEMO_2000392 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Experimental Reproducibility"@en ; dcterms:subject bemo:BEMO_2000393 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Independent Replication Strength"@en ; dcterms:subject bemo:BEMO_2000394 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Inferential Reproducibility"@en ; dcterms:subject bemo:BEMO_2000395 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Interlaboratory Reproducibility"@en ; dcterms:subject bemo:BEMO_2000396 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Intralaboratory Repeatability"@en ; dcterms:subject bemo:BEMO_2000397 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Material Availability"@en ; dcterms:subject bemo:BEMO_2000398 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Method Reproducibility"@en ; dcterms:subject bemo:BEMO_2000399 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Multiverse Analysis Robustness"@en ; dcterms:subject bemo:BEMO_2000400 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protocol Reproducibility"@en ; dcterms:subject bemo:BEMO_2000401 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Random-Seed Stability"@en ; dcterms:subject bemo:BEMO_2000402 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reanalysis Concordance"@en ; dcterms:subject bemo:BEMO_2000403 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Researcher-Degrees-of-Freedom Sensitivity"@en ; dcterms:subject bemo:BEMO_2000404 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Result Reproducibility"@en ; dcterms:subject bemo:BEMO_2000405 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Specification-Curve Robustness"@en ; dcterms:subject bemo:BEMO_2000406 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Developing; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Code-Sharing Transparency"@en ; dcterms:subject bemo:BEMO_2000407 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Comparator Description Completeness"@en ; dcterms:subject bemo:BEMO_2000408 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Conflict-of-Interest Transparency"@en ; dcterms:subject bemo:BEMO_2000409 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Data-Sharing Transparency"@en ; dcterms:subject bemo:BEMO_2000410 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Deviations-from-Protocol Transparency"@en ; dcterms:subject bemo:BEMO_2000411 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Eligibility Criteria Completeness"@en ; dcterms:subject bemo:BEMO_2000412 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Funding-Source Transparency"@en ; dcterms:subject bemo:BEMO_2000413 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Harms Reporting Completeness"@en ; dcterms:subject bemo:BEMO_2000414 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Intervention Description Completeness"@en ; dcterms:subject bemo:BEMO_2000415 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Materials-and-Reagents Reporting Completeness"@en ; dcterms:subject bemo:BEMO_2000416 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Metadata Completeness"@en ; dcterms:subject bemo:BEMO_2000417 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Missing-Data Reporting Completeness"@en ; dcterms:subject bemo:BEMO_2000418 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Negative-Result Reporting"@en ; dcterms:subject bemo:BEMO_2000419 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Null-Result Interpretability"@en ; dcterms:subject bemo:BEMO_2000420 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Outcome Definition Completeness"@en ; dcterms:subject bemo:BEMO_2000421 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Participant Flow Completeness"@en ; dcterms:subject bemo:BEMO_2000422 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prespecified Analysis Adherence"@en ; dcterms:subject bemo:BEMO_2000423 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Processed-Data Availability"@en ; dcterms:subject bemo:BEMO_2000424 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prospective Registration"@en ; dcterms:subject bemo:BEMO_2000425 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protocol Availability"@en ; dcterms:subject bemo:BEMO_2000426 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Quality-Control Reporting Completeness"@en ; dcterms:subject bemo:BEMO_2000427 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Raw-Data Availability"@en ; dcterms:subject bemo:BEMO_2000428 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Recruitment Reporting Completeness"@en ; dcterms:subject bemo:BEMO_2000429 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Reproducibility Information Completeness"@en ; dcterms:subject bemo:BEMO_2000430 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Statistical Methods Reporting Completeness"@en ; dcterms:subject bemo:BEMO_2000431 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Bayes Factor Evidence"@en ; dcterms:subject bemo:BEMO_2000432 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Calibration of Statistical Predictions"@en ; dcterms:subject bemo:BEMO_2000433 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Clinical Relevance of Effect"@en ; dcterms:subject bemo:BEMO_2000434 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Confidence Interval Compatibility"@en ; dcterms:subject bemo:BEMO_2000435 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Decision-Curve Net Benefit"@en ; dcterms:subject bemo:BEMO_2000436 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Discrimination of Statistical Predictions"@en ; dcterms:subject bemo:BEMO_2000437 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Distributional Assumption Adequacy"@en ; dcterms:subject bemo:BEMO_2000438 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Effect Magnitude"@en ; dcterms:subject bemo:BEMO_2000439 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Equivalence Margin Validity"@en ; dcterms:subject bemo:BEMO_2000440 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Estimate Precision"@en ; dcterms:subject bemo:BEMO_2000441 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Fragility Index"@en ; dcterms:subject bemo:BEMO_2000442 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Imputation Validity"@en ; dcterms:subject bemo:BEMO_2000443 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Influential Observation Sensitivity"@en ; dcterms:subject bemo:BEMO_2000444 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Interaction Assessment Adequacy"@en ; dcterms:subject bemo:BEMO_2000445 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Measurement Error Correction"@en ; dcterms:subject bemo:BEMO_2000446 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Missing-Data Mechanism Plausibility"@en ; dcterms:subject bemo:BEMO_2000447 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Missing-Data Sensitivity"@en ; dcterms:subject bemo:BEMO_2000448 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Model Fit"@en ; dcterms:subject bemo:BEMO_2000449 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Model Specification Adequacy"@en ; dcterms:subject bemo:BEMO_2000450 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Multiplicity Control"@en ; dcterms:subject bemo:BEMO_2000451 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Noninferiority Margin Validity"@en ; dcterms:subject bemo:BEMO_2000452 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Nonlinearity Assessment"@en ; dcterms:subject bemo:BEMO_2000453 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Outlier Influence Robustness"@en ; dcterms:subject bemo:BEMO_2000454 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Overadjustment Bias Risk"@en ; dcterms:subject bemo:BEMO_2000455 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Posterior Probability Strength"@en ; dcterms:subject bemo:BEMO_2000456 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Prior Sensitivity"@en ; dcterms:subject bemo:BEMO_2000457 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Residual Diagnostics Adequacy"@en ; dcterms:subject bemo:BEMO_2000458 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Statistical Power"@en ; dcterms:subject bemo:BEMO_2000459 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Type I Error Control"@en ; dcterms:subject bemo:BEMO_2000460 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Type II Error Risk"@en ; dcterms:subject bemo:BEMO_2000461 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Variance Estimation Validity"@en ; dcterms:subject bemo:BEMO_2000462 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Adherence Integrity"@en ; dcterms:subject bemo:BEMO_2000463 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Allocation Concealment"@en ; dcterms:subject bemo:BEMO_2000464 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Attrition Bias Risk"@en ; dcterms:subject bemo:BEMO_2000465 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Baseline Comparability"@en ; dcterms:subject bemo:BEMO_2000466 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Blinding Integrity"@en ; dcterms:subject bemo:BEMO_2000467 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Carryover Effect Risk"@en ; dcterms:subject bemo:BEMO_2000468 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Cluster Recruitment Bias Risk"@en ; dcterms:subject bemo:BEMO_2000469 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Co-intervention Bias Risk"@en ; dcterms:subject bemo:BEMO_2000470 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Comparator Validity"@en ; dcterms:subject bemo:BEMO_2000471 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Contamination Risk"@en ; dcterms:subject bemo:BEMO_2000472 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Control Group Appropriateness"@en ; dcterms:subject bemo:BEMO_2000473 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Detection Bias Risk"@en ; dcterms:subject bemo:BEMO_2000474 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Differential Follow-up Risk"@en ; dcterms:subject bemo:BEMO_2000475 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Early Stopping Bias Risk"@en ; dcterms:subject bemo:BEMO_2000476 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Exposure Classification Validity"@en ; dcterms:subject bemo:BEMO_2000477 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Follow-up Completeness"@en ; dcterms:subject bemo:BEMO_2000478 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000004 ; bemo:BEMO_3000008 bemo:BEMO_4000008 ; bemo:BEMO_3000009 bemo:BEMO_4000017 ; bemo:BEMO_3000010 bemo:BEMO_4000019 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "value = numerator / denominator, with denominator > 0"@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"divide\",\"arguments\":[\"numerator\",\"denominator\"],\"constraints\":[\"denominator > 0\"]}" ; bemo:BEMO_3100006 "numerator; denominator; operational_definition; assessment_context" ; bemo:BEMO_3100007 "weight; stratum; confidence_level" ; bemo:BEMO_3100008 "xsd:decimal" ; bemo:BEMO_3100009 "Proportion or percentage (0–1 or 0–100%)" ; bemo:BEMO_3100010 0.0 ; bemo:BEMO_3100011 1.0 ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; required when interpreted probabilistically."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Intervention Classification Validity"@en ; dcterms:subject bemo:BEMO_2000479 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Outcome Ascertainment Validity"@en ; dcterms:subject bemo:BEMO_2000480 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Performance Bias Risk"@en ; dcterms:subject bemo:BEMO_2000481 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Period Effect Risk"@en ; dcterms:subject bemo:BEMO_2000482 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protocol Deviation Risk"@en ; dcterms:subject bemo:BEMO_2000483 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Protocol Fidelity"@en ; dcterms:subject bemo:BEMO_2000484 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Randomization Integrity"@en ; dcterms:subject bemo:BEMO_2000485 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Mature; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Selective Outcome Reporting Risk"@en ; dcterms:subject bemo:BEMO_2000486 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000006 ; bemo:BEMO_3000008 bemo:BEMO_4000010 ; bemo:BEMO_3000009 bemo:BEMO_4000015 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000022 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned risk rubric or calibrated probability model defined for the metric and context."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_risk_category\",\"probability\",\"percentage\"]}" ; bemo:BEMO_3100006 "risk_factors; assessment_context; rubric_or_model_version; evidence_records" ; bemo:BEMO_3100007 "weights; thresholds; calibration_dataset" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal risk rating or quantitative percentage/probability; lower is generally better" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for probability outputs; rubric reliability required for ordinal outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Study Design Appropriateness"@en ; dcterms:subject bemo:BEMO_2000487 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000002 ; bemo:BEMO_3000008 bemo:BEMO_4000011 ; bemo:BEMO_3000009 bemo:BEMO_4000016 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned, prespecified domain rubric or validated normalized scoring model."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\",\"allowed_outputs\":[\"ordinal_category\",\"normalized_score\"]}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; rubric_version; operational_definition" ; bemo:BEMO_3100007 "weights; thresholds; expert_adjudication" ; bemo:BEMO_3100008 "xsd:string_or_decimal" ; bemo:BEMO_3100009 "Ordinal rubric, domain judgment, or normalized score" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 false ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "Required for normalized scores; inter-rater reliability required for human rubrics."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a bemo:BEMO_0000100 ; rdfs:label "Computation profile for Temporal Precedence"@en ; dcterms:subject bemo:BEMO_2000488 ; prov:wasDerivedFrom ; bemo:BEMO_3000007 bemo:BEMO_4000001 ; bemo:BEMO_3000008 bemo:BEMO_4000007 ; bemo:BEMO_3000009 bemo:BEMO_4000014 ; bemo:BEMO_3000010 bemo:BEMO_4000018 ; bemo:BEMO_3000011 bemo:BEMO_4000021 ; bemo:BEMO_3100002 "0.1.0" ; bemo:BEMO_3100003 "Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods."@en ; bemo:BEMO_3100004 "BEMO-Expression-JSON" ; bemo:BEMO_3100005 "{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}" ; bemo:BEMO_3100006 "evidence_records; assessment_context; operational_definition; computation_protocol_version" ; bemo:BEMO_3100007 "weights; thresholds; reference_standard; expert_adjudication" ; bemo:BEMO_3100008 "xsd:anySimpleType" ; bemo:BEMO_3100009 "Metric-specific continuous, categorical, or ordinal scale" ; bemo:BEMO_3100013 "Not specified in source; must be defined and versioned before composite use."@en ; bemo:BEMO_3100014 "None by default; any normalization must be justified, versioned, and validated."@en ; bemo:BEMO_3100015 "Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material."@en ; bemo:BEMO_3100016 true ; bemo:BEMO_3100017 "Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable."@en ; bemo:BEMO_3100018 true ; bemo:BEMO_3100019 "Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction."@en ; bemo:BEMO_3100020 "Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable."@en ; bemo:BEMO_3100021 "As applicable; mandatory for probabilistic or normalized outputs."@en ; bemo:BEMO_3100030 "Source maturity: Established; BEMO computation profile requires independent validation."@en . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 10" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Pathway-Level Support; Tissue Specificity; Spatial Biological Concordance\", \"Common Misinterpretations\": \"Treating cell-type specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Cell-Type Specificity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cell-type specificity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses cell-type specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cell-type specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 10 ; bemo:BEMO_3100023 "8fcb10135485d0dff26bef51519f2178a09a543c766f354a728ca79b2c39c582" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 100" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Quantitative Bias Analysis Robustness; Assumption Sensitivity; Falsification Test Support\", \"Common Misinterpretations\": \"Treating e-value strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Specialized / infrequent\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"E-value Strength\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting e-value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ratio scale; null typically 1\", \"What It Measures\": \"Assesses e-value strength using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in e-value strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 100 ; bemo:BEMO_3100023 "8587ae49790e995db7d3bf84506f3bebdce4263532f6e5dcbd136229f5da442f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 101" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Mediation Evidence Strength; Collider Bias Risk; Time-Varying Confounding Control\", \"Common Misinterpretations\": \"Treating effect-modification credibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Effect-Modification Credibility\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of effect-modification credibility.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses effect-modification credibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in effect-modification credibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 101 ; bemo:BEMO_3100023 "f66521085db07e7bd17f7b93b07cf74e57b1c85461a2555c1146f672069098b2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 102" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Unmeasured Confounding Sensitivity; Positivity Adequacy; Consistency Assumption Plausibility\", \"Common Misinterpretations\": \"Treating exchangeability plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Exchangeability Plausibility\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of exchangeability plausibility.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses exchangeability plausibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in exchangeability plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 102 ; bemo:BEMO_3100023 "7f4004986e0cd5fd0b8462346aec167d3be6e60fe67bb8a5838de7a005fd58d1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 103" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Assumption Sensitivity\", \"Common Misinterpretations\": \"Treating falsification test support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Falsification Test Support\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting falsification test.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses falsification test support using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in falsification test support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 103 ; bemo:BEMO_3100023 "280760fd65dbda26ef711b182bed36c1b7e3679af41be52e50dfca26f92b3400" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 104" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Time-Varying Confounding Control; Reverse-Causation Risk; Selection-on-Survival Bias Risk\", \"Common Misinterpretations\": \"Treating immortal-time bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Immortal-Time Bias Risk\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The probability or degree that immortal-time bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses immortal-time bias risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in immortal-time bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 104 ; bemo:BEMO_3100023 "21a510319cb99a940f9fc99111522f80932b8a874f1ea984fb332f8f218483c8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 105" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Target Trial Emulation Fidelity; Negative-Control Validation; Dose–Response Support\", \"Common Misinterpretations\": \"Treating instrument validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Instrument Validity\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The degree to which instrument supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses instrument validity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in instrument validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 105 ; bemo:BEMO_3100023 "e7033f91a59f115f9fba748b04cab66664ac151f4c8d653ea61aa823a8c6cce4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 106" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Dechallenge–Rechallenge Support; Effect-Modification Credibility; Collider Bias Risk\", \"Common Misinterpretations\": \"Treating mediation evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mediation Evidence Strength\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting mediation evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses mediation evidence strength using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mediation evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 106 ; bemo:BEMO_3100023 "b7abd5f34cd2addb34f26d923a9c80b402d8914f57510a7f5fe8c4ed41659c58" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 107" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Instrument Validity; Dose–Response Support; Dechallenge–Rechallenge Support\", \"Common Misinterpretations\": \"Treating negative-control validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Negative-Control Validation\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative-control validation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses negative-control validation using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in negative-control validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 107 ; bemo:BEMO_3100023 "63bedc3fc09ef48160a8d522d76618e50e47197d3d502ae109f1015d0fbcb67e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 108" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Consistency Assumption Plausibility; Correct Temporal Ordering; Causal Contrast Clarity\", \"Common Misinterpretations\": \"Treating no-interference plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"No-Interference Plausibility\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of no-interference plausibility.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses no-interference plausibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in no-interference plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 108 ; bemo:BEMO_3100023 "8aa9a1ba76fa5fd8217fff1b4352656d262602a1040dc8618b138b2e37a93d9a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 109" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Exchangeability Plausibility; Consistency Assumption Plausibility; No-Interference Plausibility\", \"Common Misinterpretations\": \"Treating positivity adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Positivity Adequacy\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The extent to which positivity is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses positivity adequacy using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in positivity adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 109 ; bemo:BEMO_3100023 "be2ac5c0345d954f0ccc1ce41f05b792425f3fb9c158083a6db1928102b69608" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 11" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Temporal Biological Concordance; Phenotypic Concordance; Molecular-Phenotypic Concordance\", \"Common Misinterpretations\": \"Treating cross-species biological concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cross-Species Biological Concordance\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The degree of agreement in cross-species biological across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cross-species biological concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-species biological concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 11 ; bemo:BEMO_3100023 "6f883b8ebe7aa3d7407688c8b2390b245a894c21f5c21ffef99fe634674c5fd3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 110" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Selection-on-Survival Bias Risk; E-value Strength; Assumption Sensitivity\", \"Common Misinterpretations\": \"Treating quantitative bias analysis robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Quantitative Bias Analysis Robustness\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of quantitative bias analysis robustness.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses quantitative bias analysis robustness using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in quantitative bias analysis robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 110 ; bemo:BEMO_3100023 "7ee1bd197cfd8211ed7ac785b0e49ec8e73324814e415213789e479477f73c74" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 111" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Confounding Risk; Unmeasured Confounding Sensitivity; Exchangeability Plausibility\", \"Common Misinterpretations\": \"Treating residual confounding risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Residual Confounding Risk\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The probability or degree that residual confounding introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses residual confounding risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in residual confounding risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 111 ; bemo:BEMO_3100023 "fef3c7d8a6ff0d0d4088a08abb2cfe7420127e6170b4998b7b5ce06d44124e81" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 112" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Immortal-Time Bias Risk; Selection-on-Survival Bias Risk; Quantitative Bias Analysis Robustness\", \"Common Misinterpretations\": \"Treating reverse-causation risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Reverse-Causation Risk\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The probability or degree that reverse-causation introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses reverse-causation risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reverse-causation risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 112 ; bemo:BEMO_3100023 "17fc4b74f3434a4ae22f908b09530b9a1be33f82af499c89239235d78d7e1375" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 113" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Reverse-Causation Risk; Quantitative Bias Analysis Robustness; E-value Strength\", \"Common Misinterpretations\": \"Treating selection-on-survival bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Selection-on-Survival Bias Risk\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The probability or degree that selection-on-survival bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses selection-on-survival bias risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in selection-on-survival bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 113 ; bemo:BEMO_3100023 "ba5e2bde29a386ccb9cae3afe1f1c9476a350f65371bc1aebd58a3579e6e702c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 114" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Causal Contrast Clarity; Instrument Validity; Negative-Control Validation\", \"Common Misinterpretations\": \"Treating target trial emulation fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Target Trial Emulation Fidelity\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of target trial emulation fidelity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses target trial emulation fidelity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in target trial emulation fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 114 ; bemo:BEMO_3100023 "7a907a8dc4fe2c40df0aa3c333c85c8e7231c1e33d26321171335bcd3464b6a6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 115" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Collider Bias Risk; Immortal-Time Bias Risk; Reverse-Causation Risk\", \"Common Misinterpretations\": \"Treating time-varying confounding control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Time-Varying Confounding Control\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of time-varying confounding control.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses time-varying confounding control using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in time-varying confounding control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 115 ; bemo:BEMO_3100023 "f46690f0cea7611ea5bb0e9a0e5c1b90d25ecad9c8f28f3083cc2a71b53ce7f0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 116" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Residual Confounding Risk; Exchangeability Plausibility; Positivity Adequacy\", \"Common Misinterpretations\": \"Treating unmeasured confounding sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Unmeasured Confounding Sensitivity\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of unmeasured confounding sensitivity.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses unmeasured confounding sensitivity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in unmeasured confounding sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 116 ; bemo:BEMO_3100023 "50677da95ed69c14f1f1ec5786cb5c4d590d6e339c1a13fdedfd18d811ffc8f4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 117" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Diagnostic Odds Ratio; Partial Area Under the Receiver Operating Characteristic Curve; Threshold Validity\", \"Common Misinterpretations\": \"Treating area under the receiver operating characteristic curve as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Area Under the Receiver Operating Characteristic Curve\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of area under the receiver operating characteristic curve.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses area under the receiver operating characteristic curve using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in area under the receiver operating characteristic curve can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 117 ; bemo:BEMO_3100023 "5c4feaae4c2a565042108ac4cb807678f9be09f3e84e62f596afd3338e3ceec6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 118" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Prognostic Calibration; Calibration-in-the-Large; Observed-to-Expected Ratio\", \"Common Misinterpretations\": \"Treating calibration slope as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Calibration Slope\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration slope.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses calibration slope using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in calibration slope can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 118 ; bemo:BEMO_3100023 "44bfcfec74d2b98de3507998b5e63f6506912c93210fea4df7a678aed4417a75" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 119" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Calibration Slope; Observed-to-Expected Ratio; Prognostic Added Value\", \"Common Misinterpretations\": \"Treating calibration-in-the-large as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Calibration-in-the-Large\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration-in-the-large.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses calibration-in-the-large using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in calibration-in-the-large can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 119 ; bemo:BEMO_3100023 "4a117ceb82993be69cf387d42f6626e25d4ff682e98eb458d01d55a60ca6f29d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 12" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Rescue Experiment Support; Target Engagement Evidence; On-Target Specificity\", \"Common Misinterpretations\": \"Treating epistasis support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Epistasis Support\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting epistasis.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses epistasis support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in epistasis support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 12 ; bemo:BEMO_3100023 "cd57f610728234561644257a8387987f0aa8934688593c5fbd817b3779032054" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 120" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Test-Timing Appropriateness; Incremental Diagnostic Value; Reclassification Improvement\", \"Common Misinterpretations\": \"Treating comparative test accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Comparative Test Accuracy\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The closeness of comparative test to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses comparative test accuracy using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in comparative test accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 120 ; bemo:BEMO_3100023 "01f4b65430acfaca391e550bb1550450d424a1dd47aebe4ed0f6dd9d60fe28ab" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 121" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Time-Dependent Discrimination\", \"Common Misinterpretations\": \"Treating competing-risk model validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Competing-Risk Model Validity\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The probability or degree that competing-risk model validity introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses competing-risk model validity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in competing-risk model validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 121 ; bemo:BEMO_3100023 "6f322698057cc9561b413498181b8f2503720420a935d144d2173ae5298a3b2f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 122" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Negative Likelihood Ratio; Area Under the Receiver Operating Characteristic Curve; Partial Area Under the Receiver Operating Characteristic Curve\", \"Common Misinterpretations\": \"Treating diagnostic odds ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Diagnostic Odds Ratio\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of diagnostic odds ratio.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Ratio scale; null typically 1\", \"What It Measures\": \"Assesses diagnostic odds ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in diagnostic odds ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 122 ; bemo:BEMO_3100023 "a903f03627bce43e756f3c1d10c27c552a53bce0346a40196ea1cd72afe63de0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 123" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Diagnostic Specificity; Positive Predictive Value\", \"Common Misinterpretations\": \"Treating diagnostic sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Diagnostic Sensitivity\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of diagnostic sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses diagnostic sensitivity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in diagnostic sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 123 ; bemo:BEMO_3100023 "4ea75714eea731a1e4644a00db0476f8628bf028934f92bd9e4029ee31ddf173" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 124" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Diagnostic Sensitivity; Positive Predictive Value; Negative Predictive Value\", \"Common Misinterpretations\": \"Treating diagnostic specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Diagnostic Specificity\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of diagnostic specificity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses diagnostic specificity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in diagnostic specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 124 ; bemo:BEMO_3100023 "14be8f0b88f11902e6b1562a38b9cb710840858fc59f748048f96b74c8f6c2b2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 125" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Verification Bias Risk; Incorporation Bias Risk; Patient Flow Integrity\", \"Common Misinterpretations\": \"Treating differential verification bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Differential Verification Bias Risk\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The probability or degree that differential verification bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses differential verification bias risk using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in differential verification bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 125 ; bemo:BEMO_3100023 "2805e0d0838d99254f4675a5517e72c35cb3e1cb875fbc214edb03376568c858" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 126" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Differential Verification Bias Risk; Patient Flow Integrity; Test-Timing Appropriateness\", \"Common Misinterpretations\": \"Treating incorporation bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Incorporation Bias Risk\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The probability or degree that incorporation bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses incorporation bias risk using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in incorporation bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 126 ; bemo:BEMO_3100023 "00ceeb2a9486ba76c68ad0f07ad3fe11fadf573e3b3b3fb37898281142b34a91" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 127" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Comparative Test Accuracy; Reclassification Improvement; Prognostic Discrimination\", \"Common Misinterpretations\": \"Treating incremental diagnostic value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Incremental Diagnostic Value\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of incremental diagnostic value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses incremental diagnostic value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in incremental diagnostic value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 127 ; bemo:BEMO_3100023 "8c0d8dc6983b3100a525f45a2c3c327af7d21cf2d155dc05a19b99e0d7f43578" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 128" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Reference Standard Validity; Verification Bias Risk; Differential Verification Bias Risk\", \"Common Misinterpretations\": \"Treating index-test blinding as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Index-Test Blinding\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of index-test blinding.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses index-test blinding using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in index-test blinding can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 128 ; bemo:BEMO_3100023 "3bc623a30f8cb3956f6d71196888c1021137e72c87604513c9fc1e352f98bb4c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 129" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Positive Likelihood Ratio; Diagnostic Odds Ratio; Area Under the Receiver Operating Characteristic Curve\", \"Common Misinterpretations\": \"Treating negative likelihood ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Negative Likelihood Ratio\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative likelihood ratio.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Ratio scale; null typically 1\", \"What It Measures\": \"Assesses negative likelihood ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in negative likelihood ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 129 ; bemo:BEMO_3100023 "6dc29889e79017542636c8b841aff4c0f5947b19dec51307e00a9c51cdc593cc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 13" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Loss-of-Function Validation; Rescue Experiment Support; Epistasis Support\", \"Common Misinterpretations\": \"Treating gain-of-function validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Gain-of-Function Validation\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of gain-of-function validation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses gain-of-function validation using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in gain-of-function validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 13 ; bemo:BEMO_3100023 "5c02cfac370a9d2c1514479546d6e291e60bffe1758412ceec02bbf8edaab2dc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 130" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Positive Predictive Value; Positive Likelihood Ratio; Negative Likelihood Ratio\", \"Common Misinterpretations\": \"Treating negative predictive value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Negative Predictive Value\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative predictive value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses negative predictive value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in negative predictive value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 130 ; bemo:BEMO_3100023 "9f42e5362ad2e55445a028ec6d3cc9c062886d8c9272f983b0c1acec345502f7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 131" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Calibration-in-the-Large; Prognostic Added Value; Prognostic Transportability\", \"Common Misinterpretations\": \"Treating observed-to-expected ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Observed-to-Expected Ratio\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of observed-to-expected ratio.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses observed-to-expected ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in observed-to-expected ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 131 ; bemo:BEMO_3100023 "cdf33871a90f7426da799fbf8148672bff9e925c7981ff58372c39511bd4050e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 132" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Area Under the Receiver Operating Characteristic Curve; Threshold Validity; Reference Standard Validity\", \"Common Misinterpretations\": \"Treating partial area under the receiver operating characteristic curve as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Partial Area Under the Receiver Operating Characteristic Curve\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of partial area under the receiver operating characteristic curve.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses partial area under the receiver operating characteristic curve using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in partial area under the receiver operating characteristic curve can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 132 ; bemo:BEMO_3100023 "79f6b607e0d7504f46e1d3842fa8966ae929db7058236a6b4ed553277ad444b5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 133" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Incorporation Bias Risk; Test-Timing Appropriateness; Comparative Test Accuracy\", \"Common Misinterpretations\": \"Treating patient flow integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Patient Flow Integrity\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of patient flow integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses patient flow integrity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in patient flow integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 133 ; bemo:BEMO_3100023 "67544e05c38d184f5e9fa9830136b1408e7835e115b1fa9c54147ad65e14b99c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 134" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Negative Predictive Value; Negative Likelihood Ratio; Diagnostic Odds Ratio\", \"Common Misinterpretations\": \"Treating positive likelihood ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Positive Likelihood Ratio\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of positive likelihood ratio.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Ratio scale; null typically 1\", \"What It Measures\": \"Assesses positive likelihood ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in positive likelihood ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 134 ; bemo:BEMO_3100023 "65ab6bc3c7bfa89dbab942e4977888e1ec5d3ea554c360ceffa76f4daab1fd7e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 135" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Diagnostic Specificity; Negative Predictive Value; Positive Likelihood Ratio\", \"Common Misinterpretations\": \"Treating positive predictive value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Positive Predictive Value\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of positive predictive value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses positive predictive value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in positive predictive value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 135 ; bemo:BEMO_3100023 "89034784369de0142956f172eb3ca87ccad9b4cc69ac8a45b8a92adf9cc1731f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 136" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Observed-to-Expected Ratio; Prognostic Transportability; Time-Dependent Discrimination\", \"Common Misinterpretations\": \"Treating prognostic added value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Prognostic Added Value\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic added value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses prognostic added value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prognostic added value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 136 ; bemo:BEMO_3100023 "6a8e54c8d71bbaa2bc8361d6fc19eb1f50b8f4acd2b6d09e2b648f2337fa9298" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 137" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Prognostic Discrimination; Calibration Slope; Calibration-in-the-Large\", \"Common Misinterpretations\": \"Treating prognostic calibration as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Prognostic Calibration\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic calibration.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses prognostic calibration using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prognostic calibration can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 137 ; bemo:BEMO_3100023 "bddeb4ff61529649f6f5d81ae9a9ab5588a6f6aed10ca70d0d400119d6c2e940" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 138" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Reclassification Improvement; Prognostic Calibration; Calibration Slope\", \"Common Misinterpretations\": \"Treating prognostic discrimination as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Prognostic Discrimination\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic discrimination.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses prognostic discrimination using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prognostic discrimination can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 138 ; bemo:BEMO_3100023 "b58deaf6b24f17f45025c2e10bd742dcb00a937cc0410366fbe092bfbfd13882" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 139" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Prognostic Added Value; Time-Dependent Discrimination; Competing-Risk Model Validity\", \"Common Misinterpretations\": \"Treating prognostic transportability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Prognostic Transportability\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic transportability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses prognostic transportability using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prognostic transportability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 139 ; bemo:BEMO_3100023 "c2720768cdf2be8ed6a3b935c205e9cb522ea1c958d036e680eee5e7cba4038e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 14" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Biological Gradient; Network Context Support; Systems-Level Emergence Support\", \"Common Misinterpretations\": \"Treating homeostatic compensation assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Homeostatic Compensation Assessment\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of homeostatic compensation assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses homeostatic compensation assessment using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in homeostatic compensation assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 14 ; bemo:BEMO_3100023 "61aaa3d7ba71760f01fcbbb79304031b61f416940944ef459f48b6d07dc0628d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 140" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Incremental Diagnostic Value; Prognostic Discrimination; Prognostic Calibration\", \"Common Misinterpretations\": \"Treating reclassification improvement as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Reclassification Improvement\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of reclassification improvement.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses reclassification improvement using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reclassification improvement can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 140 ; bemo:BEMO_3100023 "74d83029c18dff3247c8fb9baae1d6aba52c9b7328d218dd0210458cbd5ad7d5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 141" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Threshold Validity; Index-Test Blinding; Verification Bias Risk\", \"Common Misinterpretations\": \"Treating reference standard validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Reference Standard Validity\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The degree to which reference standard supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses reference standard validity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reference standard validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 141 ; bemo:BEMO_3100023 "3bd12b9aed8e6e227ec8b1e5082fc9060b988babbc4204f8a360bb7503e6ad49" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 142" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Patient Flow Integrity; Comparative Test Accuracy; Incremental Diagnostic Value\", \"Common Misinterpretations\": \"Treating test-timing appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Test-Timing Appropriateness\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The extent to which test-timing is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses test-timing appropriateness using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in test-timing appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 142 ; bemo:BEMO_3100023 "ffb2707e3bed89aca5f5c790dc5a9b0312e89c5a1dba27ebac908e4597a355bd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 143" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Partial Area Under the Receiver Operating Characteristic Curve; Reference Standard Validity; Index-Test Blinding\", \"Common Misinterpretations\": \"Treating threshold validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Threshold Validity\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The degree to which threshold supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses threshold validity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in threshold validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 143 ; bemo:BEMO_3100023 "c27bfe6217acf4b748aeb85aa4e9c4176c8256e12b7c61ff84a201b6fd374c82" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 144" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Prognostic Transportability; Competing-Risk Model Validity\", \"Common Misinterpretations\": \"Treating time-dependent discrimination as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Time-Dependent Discrimination\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of time-dependent discrimination.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses time-dependent discrimination using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in time-dependent discrimination can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 144 ; bemo:BEMO_3100023 "5232bfe9f1dc1ddd88662ddb65a550d0d1fc5338bb4a530ed1072ed6078116bf" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 145" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies\", \"Category\": \"Diagnostic and Prognostic Evidence\", \"Closely Related Metrics\": \"Index-Test Blinding; Differential Verification Bias Risk; Incorporation Bias Risk\", \"Common Misinterpretations\": \"Treating verification bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Verification Bias Risk\", \"References or Origin\": \"https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"QUADAS-2; STARD; TRIPOD; REMARK\", \"Scientific Definition\": \"The probability or degree that verification bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses verification bias risk using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in verification bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 145 ; bemo:BEMO_3100023 "2f165758b70b1e482bfb8517e1a69a7d4e05ba84cd41dc36c2f346f991371034" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 146" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Study Heterogeneity; Prediction Interval Adequacy; Cumulative Evidence Stability\", \"Common Misinterpretations\": \"Treating between-study variance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Between-Study Variance\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of between-study variance.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses between-study variance using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in between-study variance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 146 ; bemo:BEMO_3100023 "167d33dabeef5837833710d7e97d42ff17e46ede74b98e0e88db46e921ff811e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 147" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Triangulation Strength; Missing Evidence Risk; Publication Bias Risk\", \"Common Misinterpretations\": \"Treating counterevidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Counterevidence Strength\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting counterevidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses counterevidence strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in counterevidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 147 ; bemo:BEMO_3100023 "d4c1d3bbceb7e86e058c678a7bbc386dd5980f93dcbc9a60ebc6c6d39231fcdb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 148" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Prediction Interval Adequacy; Information Size Adequacy; Multiplicity-Adjusted Credibility\", \"Common Misinterpretations\": \"Treating cumulative evidence stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Cumulative Evidence Stability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cumulative evidence stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cumulative evidence stability using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cumulative evidence stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 148 ; bemo:BEMO_3100023 "e87943e84aae44a1eeb6300f5a52416f0528fe0f3bf76f40f0a2a4486c87ea6a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 149" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Precision; Evidence Consensus Strength; Evidence Sufficiency\", \"Common Misinterpretations\": \"Treating evidence coherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Coherence\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence coherence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses evidence coherence using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence coherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 149 ; bemo:BEMO_3100023 "573628981de9da600edff4f13001018973ec4403d9ad58179a02f6958d0404dd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 15" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Perturbational Validation; Gain-of-Function Validation; Rescue Experiment Support\", \"Common Misinterpretations\": \"Treating loss-of-function validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Loss-of-Function Validation\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of loss-of-function validation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses loss-of-function validation using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in loss-of-function validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 15 ; bemo:BEMO_3100023 "7b09e166eefa32f832c89264de2b3521f93b540fbc674d78fc625fd792779d09" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 150" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Sufficiency; Evidence Coverage; Evidence Freshness\", \"Common Misinterpretations\": \"Treating evidence completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Evidence Completeness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of evidence are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses evidence completeness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 150 ; bemo:BEMO_3100023 "263bd485141b0cc75ee285fb1989c667b83eb378666886a960ed5bd2a610f232" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 151" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Strength; Evidence Stability; Evidence Consistency\", \"Common Misinterpretations\": \"Treating evidence confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Confidence\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The justified degree of certainty assigned to evidence given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses evidence confidence using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 151 ; bemo:BEMO_3100023 "a6abc5b380d07d44d4ec1e48b63cf0e3bf7299ab7264d6edcc898627f3bd0952" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 152" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Coherence; Evidence Sufficiency; Evidence Completeness\", \"Common Misinterpretations\": \"Treating evidence consensus strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Consensus Strength\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting evidence consensus.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses evidence consensus strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence consensus strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 152 ; bemo:BEMO_3100023 "f207ed4da0508b76cb7e86f43fc62efc4861d327760c860608fc73ff3f4a6da8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 153" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Stability; Evidence Directness; Evidence Precision\", \"Common Misinterpretations\": \"Treating evidence consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Consistency\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The degree of agreement in evidence across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence consistency using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 153 ; bemo:BEMO_3100023 "f74a279906eee7e4453803727494ade321b94fc1d6196fb1882daae7f1abcf75" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 154" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Completeness; Evidence Freshness; Evidence Robustness\", \"Common Misinterpretations\": \"Treating evidence coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Coverage\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The proportion and representativeness of the relevant evidence captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses evidence coverage using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 154 ; bemo:BEMO_3100023 "a64cee9a2114ea7d5580ea8d59eaef0691fce1d63dd3e4fd9f3d63e0dac86a3d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 155" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Consistency; Evidence Precision; Evidence Coherence\", \"Common Misinterpretations\": \"Treating evidence directness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Directness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence directness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence directness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence directness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 155 ; bemo:BEMO_3100023 "880de5f192c9dc60c14576e428f1c46fbdcda3180afe950bcde297920e65c6df" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 156" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Coverage; Evidence Robustness; Evidence Triangulation Strength\", \"Common Misinterpretations\": \"Treating evidence freshness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Freshness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence freshness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence freshness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence freshness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 156 ; bemo:BEMO_3100023 "2dc879dd1ad8ed3ebf228b83983e7de95e06b9c72131b584ccaa785f551eea2b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 157" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Directness; Evidence Coherence; Evidence Consensus Strength\", \"Common Misinterpretations\": \"Treating evidence precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Precision\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The closeness of repeated estimates or measurements and the narrowness of uncertainty around evidence.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence precision using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 157 ; bemo:BEMO_3100023 "fed12d9ff25f08fc6db399dc5bed2e8d719fc0db8bcefb33987a3ef3db40f55c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 158" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Overall Evidence Certainty; Evidence Strength; Evidence Confidence\", \"Common Misinterpretations\": \"Treating evidence quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Quality\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence quality using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 158 ; bemo:BEMO_3100023 "f4e08b1965ce7d1832ff4c5191f1e7298781d9bec3cb9a96c09198d6faaa1339" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 159" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Freshness; Evidence Triangulation Strength; Counterevidence Strength\", \"Common Misinterpretations\": \"Treating evidence robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Evidence Robustness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses evidence robustness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 159 ; bemo:BEMO_3100023 "59315ce160586081fc3fd71f96646716829d26fde9e0a21aa0afec923b5083d6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 16" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Specificity; Pathway-Level Support; Cell-Type Specificity\", \"Common Misinterpretations\": \"Treating mechanistic causality strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mechanistic Causality Strength\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting mechanistic causality.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses mechanistic causality strength using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mechanistic causality strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 16 ; bemo:BEMO_3100023 "114851a566f6667271761fd50b701ab810f623c4ee0ecdabe88d5bbacc5941db" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 160" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Confidence; Evidence Consistency; Evidence Directness\", \"Common Misinterpretations\": \"Treating evidence stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Evidence Stability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence stability using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 160 ; bemo:BEMO_3100023 "1f9ca5bc5be56489e2caf9d2f3eaaf37b12ae4271716853fb373d2db6aa8d657" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 161" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Quality; Evidence Confidence; Evidence Stability\", \"Common Misinterpretations\": \"Treating evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Strength\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses evidence strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 161 ; bemo:BEMO_3100023 "d0050ec2d0692a0a792ec941fce4c076cf8613142effd9ef06a03cab99fa82fe" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 162" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Consensus Strength; Evidence Completeness; Evidence Coverage\", \"Common Misinterpretations\": \"Treating evidence sufficiency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Sufficiency\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence sufficiency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses evidence sufficiency using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence sufficiency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 162 ; bemo:BEMO_3100023 "516f7f59fc37d19455d99f12f79cf9f0baf5cd671807c3364f013a016d7ec68a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 163" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Robustness; Counterevidence Strength; Missing Evidence Risk\", \"Common Misinterpretations\": \"Treating evidence triangulation strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Evidence Triangulation Strength\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting evidence triangulation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses evidence triangulation strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in evidence triangulation strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 163 ; bemo:BEMO_3100023 "b9d887ba211f3aea4699afd087a0aa12fb8ca924209ee34ccda2bfd968c02a4a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 164" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Cumulative Evidence Stability; Multiplicity-Adjusted Credibility\", \"Common Misinterpretations\": \"Treating information size adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Information Size Adequacy\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The extent to which information size is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses information size adequacy using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in information size adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 164 ; bemo:BEMO_3100023 "1349313eaf86ad90454f8dbf26aa9cb5389132fc9ac2e44b703024851df5136c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 165" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Counterevidence Strength; Publication Bias Risk; Selective Nonreporting Risk\", \"Common Misinterpretations\": \"Treating missing evidence risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Missing Evidence Risk\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The probability or degree that missing evidence introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses missing evidence risk using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in missing evidence risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 165 ; bemo:BEMO_3100023 "ffec67315125f9639a3601d51e352906c34b1c9847a274942f934888c1188977" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 166" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Information Size Adequacy\", \"Common Misinterpretations\": \"Treating multiplicity-adjusted credibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Multiplicity-Adjusted Credibility\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of multiplicity-adjusted credibility.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses multiplicity-adjusted credibility using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in multiplicity-adjusted credibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 166 ; bemo:BEMO_3100023 "40900cc3965adf1a4a61ca1880158e0ed27ede5d1a6163f63eb4f6d38b99a3b8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 167" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Evidence Quality; Evidence Strength\", \"Common Misinterpretations\": \"Treating overall evidence certainty as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Overall Evidence Certainty\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of overall evidence certainty.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses overall evidence certainty using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in overall evidence certainty can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 167 ; bemo:BEMO_3100023 "31b48110148a1ebdd1379016bfff93898087ec61573fac3b850ccada3e1f7ae5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 168" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Between-Study Variance; Cumulative Evidence Stability; Information Size Adequacy\", \"Common Misinterpretations\": \"Treating prediction interval adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Prediction Interval Adequacy\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The extent to which prediction interval is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses prediction interval adequacy using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prediction interval adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 168 ; bemo:BEMO_3100023 "0acc1464b5d065a6f38744191dff4d933036cf918aeac3f16274b9cdb9dd1059" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 169" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Missing Evidence Risk; Selective Nonreporting Risk; Small-Study Effects\", \"Common Misinterpretations\": \"Treating publication bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Publication Bias Risk\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The probability or degree that publication bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses publication bias risk using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in publication bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 169 ; bemo:BEMO_3100023 "ae14a6a3126f2ecd31144006a017263d5e10df0fcde0e6bd8cc0872e93853a7a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 17" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Completeness; Mechanistic Specificity; Mechanistic Causality Strength\", \"Common Misinterpretations\": \"Treating mechanistic coherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mechanistic Coherence\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mechanistic coherence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses mechanistic coherence using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mechanistic coherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 17 ; bemo:BEMO_3100023 "dc1b3b375698d0aec42693d5a0b2f87405e7e7bf90759105797ad714ab4e9ab2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 170" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Publication Bias Risk; Small-Study Effects; Study Heterogeneity\", \"Common Misinterpretations\": \"Treating selective nonreporting risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Selective Nonreporting Risk\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"The probability or degree that selective nonreporting introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses selective nonreporting risk using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in selective nonreporting risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 170 ; bemo:BEMO_3100023 "8c42609174eeba28064b2f75bd158a40f97b17f9cdaa32aed81219eddf87ef89" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 171" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Selective Nonreporting Risk; Study Heterogeneity; Between-Study Variance\", \"Common Misinterpretations\": \"Treating small-study effects as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Small-Study Effects\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of small-study effects.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses small-study effects using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in small-study effects can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 171 ; bemo:BEMO_3100023 "ec5ee159f748d5035209ae456b71092c6724bc73af9b720bf70afe3ffc41f242" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 172" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Systematic reviews, meta-analyses, evidence profiles, guidelines\", \"Category\": \"Evidence Certainty and Synthesis\", \"Closely Related Metrics\": \"Small-Study Effects; Between-Study Variance; Prediction Interval Adequacy\", \"Common Misinterpretations\": \"Treating study heterogeneity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Study Heterogeneity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/\", \"Related Frameworks\": \"GRADE; PRISMA; AMSTAR 2; RoB\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of study heterogeneity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses study heterogeneity using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in study heterogeneity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 172 ; bemo:BEMO_3100023 "93fce0e52f596e9f5e6b6636a82da697803846e686e6144faa894115a270196a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 173" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Sex as a Biological Variable Adequacy; Genetic Background Control; Housing and Husbandry Control\", \"Common Misinterpretations\": \"Treating age appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Age Appropriateness\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The extent to which age is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses age appropriateness using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in age appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 173 ; bemo:BEMO_3100023 "6f50922de3489bf44a56c621fcc8933973821a524b4c3ba13cb746276b4a9bea" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 174" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Animal Model Face Validity; Animal Model Predictive Validity; Species Appropriateness\", \"Common Misinterpretations\": \"Treating animal model construct validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Animal Model Construct Validity\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The degree to which animal model construct supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses animal model construct validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in animal model construct validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 174 ; bemo:BEMO_3100023 "f8c928bcc279a4856d6377104c402fb4a00d102300c3c3fa14181f174b53f974" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 175" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Blinding in Experimental Assessment; Animal Model Construct Validity; Animal Model Predictive Validity\", \"Common Misinterpretations\": \"Treating animal model face validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Animal Model Face Validity\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The degree to which animal model face supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses animal model face validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in animal model face validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 175 ; bemo:BEMO_3100023 "1bc9d94635678f728d2a96fd7016f3d61e24c78d9e33c5093213c9d715511534" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 176" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Animal Model Construct Validity; Species Appropriateness; Sex as a Biological Variable Adequacy\", \"Common Misinterpretations\": \"Treating animal model predictive validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Animal Model Predictive Validity\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The degree to which animal model predictive supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses animal model predictive validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in animal model predictive validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 176 ; bemo:BEMO_3100023 "ae7f68af5b958c01b88066cf76664c77d333abaff4414b63760b817bf19359d0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 177" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Humane Endpoint Appropriateness; Exclusion-Criteria Prespecification; Experimental Batch Randomization\", \"Common Misinterpretations\": \"Treating attrition accounting in animal studies as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Attrition Accounting in Animal Studies\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of attrition accounting in animal studies.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses attrition accounting in animal studies using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in attrition accounting in animal studies can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 177 ; bemo:BEMO_3100023 "bfb6735bf1e0494f94802ec087edc274ccdaea50558f3ea043f6f21ae9210505" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 178" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Experimental Unit Validity; Technical Replicate Adequacy; Sample Size Justification\", \"Common Misinterpretations\": \"Treating biological replicate adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Biological Replicate Adequacy\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The extent to which biological replicate is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses biological replicate adequacy using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biological replicate adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 178 ; bemo:BEMO_3100023 "74976e4cf57f53c444f4721c04fc26fb7298cad4ac743db45feeb9a0be34587a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 179" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Randomization in Experimental Allocation; Animal Model Face Validity; Animal Model Construct Validity\", \"Common Misinterpretations\": \"Treating blinding in experimental assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Blinding in Experimental Assessment\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of blinding in experimental assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses blinding in experimental assessment using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in blinding in experimental assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 179 ; bemo:BEMO_3100023 "2a7451a420224db55e7f75f4a33818fc20cbc59d2bbc81f21fd652f7ea1a7931" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 18" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Coverage; Mechanistic Coherence; Mechanistic Specificity\", \"Common Misinterpretations\": \"Treating mechanistic completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Mechanistic Completeness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of mechanistic are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses mechanistic completeness using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mechanistic completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 18 ; bemo:BEMO_3100023 "70dc43fe10f07fb6cf3546a825ad424f5db2e21cc1b19a9f92b47d758bf660bd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 180" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Housing and Husbandry Control; Intervention Fidelity in Animal Studies; Humane Endpoint Appropriateness\", \"Common Misinterpretations\": \"Treating environmental standardization as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Environmental Standardization\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of environmental standardization.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses environmental standardization using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in environmental standardization can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 180 ; bemo:BEMO_3100023 "432e96e9d5c02fcda1a353b0ddb2e18d1019ff594f33c248eedfbe337bf31fae" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 181" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Attrition Accounting in Animal Studies; Experimental Batch Randomization; Positive-Control Performance\", \"Common Misinterpretations\": \"Treating exclusion-criteria prespecification as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Exclusion-Criteria Prespecification\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of exclusion-criteria prespecification.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses exclusion-criteria prespecification using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in exclusion-criteria prespecification can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 181 ; bemo:BEMO_3100023 "9718ea523adf00e3cd776b8e22423abc28cf080bd659786c7568ddd524ab9208" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 182" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Exclusion-Criteria Prespecification; Positive-Control Performance; Negative-Control Performance\", \"Common Misinterpretations\": \"Treating experimental batch randomization as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Experimental Batch Randomization\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of experimental batch randomization.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses experimental batch randomization using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in experimental batch randomization can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 182 ; bemo:BEMO_3100023 "1291027c6f53e5902a86a2cf22b3cca02564dbc940590bb8b8bcfd5004b998b7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 183" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Biological Replicate Adequacy; Technical Replicate Adequacy\", \"Common Misinterpretations\": \"Treating experimental unit validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Experimental Unit Validity\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The degree to which experimental unit supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses experimental unit validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in experimental unit validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 183 ; bemo:BEMO_3100023 "3d08eaaab51eb4d1095b9fb5e884110ba36de86e61615acc1661c581f985a6b1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 184" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Age Appropriateness; Housing and Husbandry Control; Environmental Standardization\", \"Common Misinterpretations\": \"Treating genetic background control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Genetic Background Control\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of genetic background control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses genetic background control using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in genetic background control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 184 ; bemo:BEMO_3100023 "3f6791503c2895971802b5fb5573311999fc32cde51839dc771c56e4855ceb83" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 185" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Genetic Background Control; Environmental Standardization; Intervention Fidelity in Animal Studies\", \"Common Misinterpretations\": \"Treating housing and husbandry control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Housing and Husbandry Control\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of housing and husbandry control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses housing and husbandry control using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in housing and husbandry control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 185 ; bemo:BEMO_3100023 "d4c26e56573de7f55de0caafd1e2880580fe66b8b4d599787ebf0b2bb3808344" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 186" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Intervention Fidelity in Animal Studies; Attrition Accounting in Animal Studies; Exclusion-Criteria Prespecification\", \"Common Misinterpretations\": \"Treating humane endpoint appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Humane Endpoint Appropriateness\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The extent to which humane endpoint is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses humane endpoint appropriateness using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in humane endpoint appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 186 ; bemo:BEMO_3100023 "efafe26c06dac15c0d485bfb264933c40fe9cf7ca97c5195ea92c9cfeb3f7a98" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 187" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Environmental Standardization; Humane Endpoint Appropriateness; Attrition Accounting in Animal Studies\", \"Common Misinterpretations\": \"Treating intervention fidelity in animal studies as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Intervention Fidelity in Animal Studies\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of intervention fidelity in animal studies.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses intervention fidelity in animal studies using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in intervention fidelity in animal studies can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 187 ; bemo:BEMO_3100023 "f4ebc6af400b7084f27d64f43d25beed78acdab6caf4a03c3179cab231054034" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 188" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Positive-Control Performance; Vehicle-Control Validity; Orthogonal Validation\", \"Common Misinterpretations\": \"Treating negative-control performance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Negative-Control Performance\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative-control performance.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses negative-control performance using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in negative-control performance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 188 ; bemo:BEMO_3100023 "0095c2122f8f2e2a2aa6070b8c33f6576321db691574400350300c93ce956830" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 189" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Vehicle-Control Validity; Technical Artifact Exclusion\", \"Common Misinterpretations\": \"Treating orthogonal validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Orthogonal Validation\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of orthogonal validation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses orthogonal validation using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in orthogonal validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 189 ; bemo:BEMO_3100023 "86d52a57d493edc61e94352ed7d2d8f4feaaa492b37b0afb047315bb8706c00e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 19" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Support; Mechanistic Completeness; Mechanistic Coherence\", \"Common Misinterpretations\": \"Treating mechanistic coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mechanistic Coverage\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The proportion and representativeness of the relevant mechanistic captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses mechanistic coverage using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mechanistic coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 19 ; bemo:BEMO_3100023 "8582aac321a237f1dd1db68f0893021d3bc987b71b373d1879cc2dfb098adbdb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 190" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Experimental Batch Randomization; Negative-Control Performance; Vehicle-Control Validity\", \"Common Misinterpretations\": \"Treating positive-control performance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Positive-Control Performance\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of positive-control performance.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses positive-control performance using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in positive-control performance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 190 ; bemo:BEMO_3100023 "98f43a472c5bc9ced611ad7ff89ac485c18a5c20ba0a8428164700738b649f75" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 191" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Sample Size Justification; Blinding in Experimental Assessment; Animal Model Face Validity\", \"Common Misinterpretations\": \"Treating randomization in experimental allocation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Randomization in Experimental Allocation\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of randomization in experimental allocation.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses randomization in experimental allocation using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in randomization in experimental allocation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 191 ; bemo:BEMO_3100023 "5cc94b6085b9c596d4f74c18712e9f8177db4335ab703b2218b9c3a63209c113" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 192" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Technical Replicate Adequacy; Randomization in Experimental Allocation; Blinding in Experimental Assessment\", \"Common Misinterpretations\": \"Treating sample size justification as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Sample Size Justification\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of sample size justification.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses sample size justification using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sample size justification can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 192 ; bemo:BEMO_3100023 "9c4289123cb7c0f9d87fa9453151e360a9b6781cd9fbb6f6b26a09f4543b0dab" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 193" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Species Appropriateness; Age Appropriateness; Genetic Background Control\", \"Common Misinterpretations\": \"Treating sex as a biological variable adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Sex as a Biological Variable Adequacy\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The extent to which sex as a biological variable is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses sex as a biological variable adequacy using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sex as a biological variable adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 193 ; bemo:BEMO_3100023 "67d1bc84f2c2d0324ee734ed3d2df1c72cd4820b21290b5a8b136d75863a4866" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 194" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Animal Model Predictive Validity; Sex as a Biological Variable Adequacy; Age Appropriateness\", \"Common Misinterpretations\": \"Treating species appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Species Appropriateness\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The extent to which species is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses species appropriateness using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in species appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 194 ; bemo:BEMO_3100023 "93f7de14ca784e8a47e3c6ab351c1e75c21a4c3e26305cfe63e0d4fef2122575" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 195" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Orthogonal Validation\", \"Common Misinterpretations\": \"Treating technical artifact exclusion as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Technical Artifact Exclusion\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of technical artifact exclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses technical artifact exclusion using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in technical artifact exclusion can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 195 ; bemo:BEMO_3100023 "8d21017136fa388d87b531d9b552fc3f6787a0b2615866e0c0a1ca9ae2fb0bbf" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 196" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Biological Replicate Adequacy; Sample Size Justification; Randomization in Experimental Allocation\", \"Common Misinterpretations\": \"Treating technical replicate adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Technical Replicate Adequacy\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The extent to which technical replicate is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses technical replicate adequacy using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in technical replicate adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 196 ; bemo:BEMO_3100023 "8f5bd5eed372632eafdff28f1c8035067d4634c207012fb089ff55a67d705176" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 197" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"In vitro, ex vivo, organoid, animal, and preclinical experiments\", \"Category\": \"Experimental Biology and Animal Research\", \"Closely Related Metrics\": \"Negative-Control Performance; Orthogonal Validation; Technical Artifact Exclusion\", \"Common Misinterpretations\": \"Treating vehicle-control validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Vehicle-Control Validity\", \"References or Origin\": \"https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"ARRIVE 2.0; SYRCLE; OECD\", \"Scientific Definition\": \"The degree to which vehicle-control supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses vehicle-control validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in vehicle-control validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 197 ; bemo:BEMO_3100023 "b1aee501d417f186bec79f011141586c66408c5b9c272dd6db3a4fa3a34f419d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 198" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Disease-Severity Generalizability; Context Sensitivity; Ecological Validity\", \"Common Misinterpretations\": \"Treating care-pathway independence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Care-Pathway Independence\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of care-pathway independence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses care-pathway independence using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in care-pathway independence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 198 ; bemo:BEMO_3100023 "e39c9004563f895f591d754f0c2c01d5cfe45a0e26d44584ecb91c07d72c494a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 199" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Intervention Applicability; Outcome Applicability; Spectrum Representativeness\", \"Common Misinterpretations\": \"Treating comparator applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Comparator Applicability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of comparator applicability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses comparator applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in comparator applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 199 ; bemo:BEMO_3100023 "607cceee390b7cb8ce577becf5db87c7c9a4643da6c8fbe5bd44948e1b9e3853" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 20" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Coherence; Mechanistic Causality Strength; Pathway-Level Support\", \"Common Misinterpretations\": \"Treating mechanistic specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Mechanistic Specificity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mechanistic specificity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses mechanistic specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mechanistic specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 20 ; bemo:BEMO_3100023 "29074cf2dac765628d0a639b922f2e3313846aa414af9c4ef760ea93c86819ca" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 200" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Care-Pathway Independence; Ecological Validity; Real-World Evidence Alignment\", \"Common Misinterpretations\": \"Treating context sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Context Sensitivity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of context sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses context sensitivity using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in context sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 200 ; bemo:BEMO_3100023 "84e49bfba34c254503c96b181528bf2beab33e58bfa3d6d711b6afaa740ea566" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 201" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Temporal Generalizability; Disease-Severity Generalizability; Care-Pathway Independence\", \"Common Misinterpretations\": \"Treating demographic generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Demographic Generalizability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of demographic generalizability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses demographic generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in demographic generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 201 ; bemo:BEMO_3100023 "e22341c32d6f7aad19740ed4b08e7f5ffc168107f1e04a79ba4ec60f6b92c463" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 202" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Demographic Generalizability; Care-Pathway Independence; Context Sensitivity\", \"Common Misinterpretations\": \"Treating disease-severity generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Disease-Severity Generalizability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of disease-severity generalizability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses disease-severity generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in disease-severity generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 202 ; bemo:BEMO_3100023 "867ff07055e7596b98039def11c9ce9ca056af7a3a11134bb8f46a0bd5adc97a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 203" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Context Sensitivity; Real-World Evidence Alignment\", \"Common Misinterpretations\": \"Treating ecological validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Ecological Validity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"The degree to which ecological supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses ecological validity using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in ecological validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 203 ; bemo:BEMO_3100023 "04e73707dc619457f6718e0be03029ef6e99208f68cbcad30d9f5bb20b2cd94b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 204" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Population Representativeness; Sampling Frame Adequacy\", \"Common Misinterpretations\": \"Treating external validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"External Validity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"The degree to which external supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses external validity using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in external validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 204 ; bemo:BEMO_3100023 "291600cbcf719af0c4e82629e00cccabf1b55b19eff672c1fb6c5c7fe2ec4338" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 205" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Transportability; Setting Applicability; Population Applicability\", \"Common Misinterpretations\": \"Treating generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Generalizability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of generalizability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 205 ; bemo:BEMO_3100023 "27f8a61447192cbdeaaa7e84078183a3604b2e6ac6c0df13be6cfe9e4a09224a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 206" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Subgroup Consistency; Temporal Generalizability; Demographic Generalizability\", \"Common Misinterpretations\": \"Treating geographic consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Geographic Consistency\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"The degree of agreement in geographic across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses geographic consistency using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in geographic consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 206 ; bemo:BEMO_3100023 "22cb03e816656f6f9ad7a2acb4c32a01ffbc6b40d04a48011cef0a52134d504e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 207" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Population Applicability; Comparator Applicability; Outcome Applicability\", \"Common Misinterpretations\": \"Treating intervention applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Intervention Applicability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of intervention applicability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses intervention applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in intervention applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 207 ; bemo:BEMO_3100023 "d1cb3929ecc9b0976fba4823cb5a09ca13a634dd6efaa3ee43969eafe3250a95" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 208" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Comparator Applicability; Spectrum Representativeness; Subgroup Consistency\", \"Common Misinterpretations\": \"Treating outcome applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Outcome Applicability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of outcome applicability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses outcome applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in outcome applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 208 ; bemo:BEMO_3100023 "5c0db0a0257f7b171655d97624fdf4764d1fabad77716300abc92c2debe71f7d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 209" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Setting Applicability; Intervention Applicability; Comparator Applicability\", \"Common Misinterpretations\": \"Treating population applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Population Applicability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population applicability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses population applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in population applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 209 ; bemo:BEMO_3100023 "9073b7f8b73fc788aa084d5c4ac174d69482c2a1439b22f86a39e465503328bc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 21" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Biological Plausibility; Mechanistic Coverage; Mechanistic Completeness\", \"Common Misinterpretations\": \"Treating mechanistic support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mechanistic Support\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting mechanistic.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses mechanistic support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mechanistic support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 21 ; bemo:BEMO_3100023 "d05eb179325de1077bb0eedc4d22a5f8c9cc2049d4ca5a5830b380984606cc90" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 210" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"External Validity; Sampling Frame Adequacy; Transportability\", \"Common Misinterpretations\": \"Treating population representativeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Population Representativeness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population representativeness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses population representativeness using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in population representativeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 210 ; bemo:BEMO_3100023 "efa730876069251ed2dde336a59f381b8c109c4ee429da0b68bf8bae61b0ba48" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 211" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Ecological Validity\", \"Common Misinterpretations\": \"Treating real-world evidence alignment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Real-World Evidence Alignment\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of real-world evidence alignment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses real-world evidence alignment using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in real-world evidence alignment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 211 ; bemo:BEMO_3100023 "2bcc973aa3f12efded260e2aef1541636262ee110856a34255ce0823d91dfb20" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 212" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Population Representativeness; Transportability; Generalizability\", \"Common Misinterpretations\": \"Treating sampling frame adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Sampling Frame Adequacy\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"The extent to which sampling frame is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses sampling frame adequacy using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sampling frame adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 212 ; bemo:BEMO_3100023 "39b818e971de479787fde11a4523a1b0d31f5dcbc88f645b968cff60fa6bf381" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 213" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Generalizability; Population Applicability; Intervention Applicability\", \"Common Misinterpretations\": \"Treating setting applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Setting Applicability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of setting applicability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses setting applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in setting applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 213 ; bemo:BEMO_3100023 "323f595d53815c626b380456c55c73f7ff5e2e10beb1e0ffc44edb8067c37e86" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 214" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Outcome Applicability; Subgroup Consistency; Geographic Consistency\", \"Common Misinterpretations\": \"Treating spectrum representativeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Spectrum Representativeness\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of spectrum representativeness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses spectrum representativeness using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in spectrum representativeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 214 ; bemo:BEMO_3100023 "771c727a328004aa438f83d20410cd3600ce67ac5affa57fc6e9aaee55cb7ed9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 215" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Spectrum Representativeness; Geographic Consistency; Temporal Generalizability\", \"Common Misinterpretations\": \"Treating subgroup consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Subgroup Consistency\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"The degree of agreement in subgroup across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses subgroup consistency using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in subgroup consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 215 ; bemo:BEMO_3100023 "26cabc1a909ce4ef7d5d54dc609f85f9fea3829985a8f8573b3da07a3e225f5b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 216" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Geographic Consistency; Demographic Generalizability; Disease-Severity Generalizability\", \"Common Misinterpretations\": \"Treating temporal generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Temporal Generalizability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of temporal generalizability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses temporal generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in temporal generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 216 ; bemo:BEMO_3100023 "dc35bc0fc74498ddd3acc1a47faf52ec96fba459b80f9800025d1a3d1e674317" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 217" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Clinical, epidemiologic, diagnostic, translational, and population studies\", \"Category\": \"External Validity and Applicability\", \"Closely Related Metrics\": \"Sampling Frame Adequacy; Generalizability; Setting Applicability\", \"Common Misinterpretations\": \"Treating transportability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Body of evidence / synthesis / outcome\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Transportability\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/\", \"Related Frameworks\": \"GRADE; QUADAS-2; CONSORT; STROBE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of transportability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses transportability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in transportability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 217 ; bemo:BEMO_3100023 "ef0b46b07942a1780f9e2e890b09b7edc3579f016762848aa46c4d956da3075d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 218" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"De Novo Evidence Strength; Case-Level Evidence Strength; Case-Control Evidence Strength\", \"Common Misinterpretations\": \"Treating allelic evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Allelic Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting allelic evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses allelic evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in allelic evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 218 ; bemo:BEMO_3100023 "2dd4a685750034c6175101f0128d889784cf621fed0cf93a74098e6b4879332b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 219" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Case-Level Evidence Strength; Functional Variant Evidence; Computational Variant Evidence\", \"Common Misinterpretations\": \"Treating case-control evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Case-Control Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting case-control evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses case-control evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in case-control evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 219 ; bemo:BEMO_3100023 "a2868c878aff5e68e6f9aeb87fd5a98fd776f1ca106d2e9dbad34a8cc81ecfd8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 22" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Phenotypic Concordance; Perturbational Validation; Loss-of-Function Validation\", \"Common Misinterpretations\": \"Treating molecular-phenotypic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Molecular-Phenotypic Concordance\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The degree of agreement in molecular-phenotypic across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses molecular-phenotypic concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in molecular-phenotypic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 22 ; bemo:BEMO_3100023 "81a78e88eaa62f6e2bb0ae947aba28fe819150032abcf9264f9205803cc7dfd1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 220" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Allelic Evidence Strength; Case-Control Evidence Strength; Functional Variant Evidence\", \"Common Misinterpretations\": \"Treating case-level evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Case-Level Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting case-level evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses case-level evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in case-level evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 220 ; bemo:BEMO_3100023 "e9e681d8a3c5b4ca82348a6cd8fe70f3f48bd8351d482c3aa492a6712873c3db" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 221" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"RNA Evidence Strength; Penetrance Evidence; Expressivity Consistency\", \"Common Misinterpretations\": \"Treating co-segregation likelihood as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Co-segregation Likelihood\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of co-segregation likelihood.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses co-segregation likelihood using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in co-segregation likelihood can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 221 ; bemo:BEMO_3100023 "965b0273f9a305e64b50437dcad85ab39818fad51d561d0ac4da1daaf7d204f2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 222" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Functional Variant Evidence; Phenotypic Specificity for Variant; Variant Phase Evidence\", \"Common Misinterpretations\": \"Treating computational variant evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Computational Variant Evidence\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of computational variant evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses computational variant evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in computational variant evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 222 ; bemo:BEMO_3100023 "1f84faa3d8c87f3b1ed44b62077d2c489782ab72b149d6009c127395a0070a10" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 223" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Variant Classification Stability\", \"Common Misinterpretations\": \"Treating conflicting interpretation burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Conflicting Interpretation Burden\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of conflicting interpretation burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses conflicting interpretation burden using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in conflicting interpretation burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 223 ; bemo:BEMO_3100023 "54567aec6ae0bbdadfae015005c07328ab45d161c0cc6d36f9e5198150b2b29e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 224" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Segregation Evidence Strength; Allelic Evidence Strength; Case-Level Evidence Strength\", \"Common Misinterpretations\": \"Treating de novo evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"De Novo Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting de novo evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses de novo evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in de novo evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 224 ; bemo:BEMO_3100023 "e1a17a41d450c91691b405a890d0fa9af7ecd8fed12385f8124d85b912c16860" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 225" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Penetrance Evidence; Founder-Effect Assessment; Phenocopy Risk\", \"Common Misinterpretations\": \"Treating expressivity consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Expressivity Consistency\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The degree of agreement in expressivity across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses expressivity consistency using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in expressivity consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 225 ; bemo:BEMO_3100023 "d100842d4d2c367ecd1122df00784975aa0a773a92bbb5c68a8ff23fbbd4dfc4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 226" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Expressivity Consistency; Phenocopy Risk; Locus Heterogeneity Assessment\", \"Common Misinterpretations\": \"Treating founder-effect assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Founder-Effect Assessment\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of founder-effect assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses founder-effect assessment using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in founder-effect assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 226 ; bemo:BEMO_3100023 "6530e53b02059e4bfd6465ae64ac385198a560d8a80df4ba701894a8c5cb0975" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 227" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Case-Control Evidence Strength; Computational Variant Evidence; Phenotypic Specificity for Variant\", \"Common Misinterpretations\": \"Treating functional variant evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Functional Variant Evidence\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of functional variant evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses functional variant evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in functional variant evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 227 ; bemo:BEMO_3100023 "7a71bec12dfb580d6d32593ad450868d51a755f2a8b35e7eee350ad98d24c73e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 228" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Variant Pathogenicity Evidence Strength; Population Frequency Compatibility\", \"Common Misinterpretations\": \"Treating gene–disease validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Gene–Disease Validity\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The degree to which gene–disease supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses gene–disease validity using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in gene–disease validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 228 ; bemo:BEMO_3100023 "4501a0d637c0d3d7b3852d3be8f61115b2b1ac442582dd9a3ec88bd21dad9f7c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 229" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Locus Heterogeneity Assessment; Variant Classification Stability; Conflicting Interpretation Burden\", \"Common Misinterpretations\": \"Treating genotype–phenotype concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Genotype–Phenotype Concordance\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The degree of agreement in genotype–phenotype across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses genotype–phenotype concordance using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in genotype–phenotype concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 229 ; bemo:BEMO_3100023 "baeee8e900a9ffef8f3ddd054b3a12f2233d89fc626f852fd31efc4b84b81685" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 23" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Homeostatic Compensation Assessment; Systems-Level Emergence Support\", \"Common Misinterpretations\": \"Treating network context support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Network Context Support\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting network context.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses network context support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in network context support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 23 ; bemo:BEMO_3100023 "d14cae7a1ae4e812a18da95395619423ade3837794dc32beea80cb11af0003f0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 230" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Loss-of-Function Mechanism Validity; Null-Variant Quality; Splicing Evidence Strength\", \"Common Misinterpretations\": \"Treating hotspot/functional-domain evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Hotspot/Functional-Domain Evidence\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of hotspot/functional-domain evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses hotspot/functional-domain evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in hotspot/functional-domain evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 230 ; bemo:BEMO_3100023 "d2e72ca269dc077aef430f8efab1ad3e7adf8db5e6aa339468796f69dfaaee12" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 231" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Phenocopy Risk; Genotype–Phenotype Concordance; Variant Classification Stability\", \"Common Misinterpretations\": \"Treating locus heterogeneity assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Locus Heterogeneity Assessment\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of locus heterogeneity assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses locus heterogeneity assessment using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in locus heterogeneity assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 231 ; bemo:BEMO_3100023 "bd3af304ec15826df5f67db7f079c0ba66a1f5f5a3e852d600550186267f50cb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 232" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Variant Phase Evidence; Hotspot/Functional-Domain Evidence; Null-Variant Quality\", \"Common Misinterpretations\": \"Treating loss-of-function mechanism validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Loss-of-Function Mechanism Validity\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The degree to which loss-of-function mechanism supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses loss-of-function mechanism validity using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in loss-of-function mechanism validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 232 ; bemo:BEMO_3100023 "a389d5411c414282451fe5495bf2c1c444f06ae12cd17457edf93df2953dc32e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 233" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Hotspot/Functional-Domain Evidence; Splicing Evidence Strength; RNA Evidence Strength\", \"Common Misinterpretations\": \"Treating null-variant quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Null-Variant Quality\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of null-variant quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses null-variant quality using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in null-variant quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 233 ; bemo:BEMO_3100023 "de2f4749e64a7014070a28c9c8587efaf4dbb9b3583c2ab6e78cd6826c00de34" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 234" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Co-segregation Likelihood; Expressivity Consistency; Founder-Effect Assessment\", \"Common Misinterpretations\": \"Treating penetrance evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Penetrance Evidence\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of penetrance evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses penetrance evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in penetrance evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 234 ; bemo:BEMO_3100023 "83c8ddff797d0831554af5cae66094d559ff9fcf3cefc498edc05f2c18b6ee97" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 235" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Founder-Effect Assessment; Locus Heterogeneity Assessment; Genotype–Phenotype Concordance\", \"Common Misinterpretations\": \"Treating phenocopy risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Phenocopy Risk\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The probability or degree that phenocopy introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses phenocopy risk using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in phenocopy risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 235 ; bemo:BEMO_3100023 "eba377fe2c190b6390cd804f64874ad58540debe287184cfa259e70d97d1fcc8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 236" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Computational Variant Evidence; Variant Phase Evidence; Loss-of-Function Mechanism Validity\", \"Common Misinterpretations\": \"Treating phenotypic specificity for variant as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Phenotypic Specificity for Variant\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of phenotypic specificity for variant.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses phenotypic specificity for variant using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in phenotypic specificity for variant can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 236 ; bemo:BEMO_3100023 "ae0b81578c2487ac58cc25c0925e5e5b5580990b17b1391fc512e266a26a2788" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 237" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Variant Pathogenicity Evidence Strength; Segregation Evidence Strength; De Novo Evidence Strength\", \"Common Misinterpretations\": \"Treating population frequency compatibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Population Frequency Compatibility\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population frequency compatibility.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses population frequency compatibility using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in population frequency compatibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 237 ; bemo:BEMO_3100023 "da2b6bc79f60e4e8121c9a5cd9a562fbe0d255feef3ecb78f1de13bffe50a0f4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 238" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Splicing Evidence Strength; Co-segregation Likelihood; Penetrance Evidence\", \"Common Misinterpretations\": \"Treating rna evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"RNA Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting rna evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses rna evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in rna evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 238 ; bemo:BEMO_3100023 "8e776a34bb92ed3d093c7eb03481f1c61ce724a0995235355586c28e53418e35" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 239" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Population Frequency Compatibility; De Novo Evidence Strength; Allelic Evidence Strength\", \"Common Misinterpretations\": \"Treating segregation evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Segregation Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting segregation evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses segregation evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in segregation evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 239 ; bemo:BEMO_3100023 "4f9bdcfda63260ced3f40796d43228eea03ead68f517bc87939698d4f5d4faf2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 24" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"On-Target Specificity; Biological Gradient; Homeostatic Compensation Assessment\", \"Common Misinterpretations\": \"Treating off-target liability evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Off-Target Liability Evidence\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of off-target liability evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses off-target liability evidence using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in off-target liability evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 24 ; bemo:BEMO_3100023 "688a2bdbd29ad4b59eca6350cf3462f2bc158ee3d70ef4de59f338b6e6c797a6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 240" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Null-Variant Quality; RNA Evidence Strength; Co-segregation Likelihood\", \"Common Misinterpretations\": \"Treating splicing evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Splicing Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting splicing evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses splicing evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in splicing evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 240 ; bemo:BEMO_3100023 "50c6384810a1443b5a98f42466fb8ab2489b57dad29ed2dab35ef7acec1960d2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 241" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Genotype–Phenotype Concordance; Conflicting Interpretation Burden\", \"Common Misinterpretations\": \"Treating variant classification stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Variant Classification Stability\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of variant classification stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses variant classification stability using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in variant classification stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 241 ; bemo:BEMO_3100023 "103d1dc365ad36d3caee0208333084352e814015d8cdbebbb9964106d3315f21" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 242" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Gene–Disease Validity; Population Frequency Compatibility; Segregation Evidence Strength\", \"Common Misinterpretations\": \"Treating variant pathogenicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Variant Pathogenicity Evidence Strength\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting variant pathogenicity evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses variant pathogenicity evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in variant pathogenicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 242 ; bemo:BEMO_3100023 "ce239eedae0622eb1018ab2bfc52cd2d32ef0a5f6a874008c2d8838deb99bd4a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 243" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mendelian disease, cancer genetics, association, segregation, and functional studies\", \"Category\": \"Genetics and Variant Evidence\", \"Closely Related Metrics\": \"Phenotypic Specificity for Variant; Loss-of-Function Mechanism Validity; Hotspot/Functional-Domain Evidence\", \"Common Misinterpretations\": \"Treating variant phase evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Variant Phase Evidence\", \"References or Origin\": \"https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/\", \"Related Frameworks\": \"ClinGen; ACMG AMP; STREGA; Gene Ontology\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of variant phase evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses variant phase evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in variant phase evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 243 ; bemo:BEMO_3100023 "e63350cbc225389693f86f1ceb6c24e47930b1a6b522574479bcaf1390376503" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 244" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Genotype Quality; Strand Bias; Reference Bias\", \"Common Misinterpretations\": \"Treating allelic balance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Allelic Balance\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of allelic balance.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses allelic balance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in allelic balance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 244 ; bemo:BEMO_3100023 "0857b2292263da43e4b892ac8b30335b2a7fd8730d0baae8269f0919f1da549b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 245" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Transcript Quantification Reliability; Single-Cell Doublet Burden; Single-Cell Ambient RNA Burden\", \"Common Misinterpretations\": \"Treating alternative splicing validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Alternative Splicing Validation\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of alternative splicing validation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses alternative splicing validation using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in alternative splicing validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 245 ; bemo:BEMO_3100023 "64b27913521868b5a9491d569eb82729fee0c3cb2133bfc9132e110785fa8847" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 246" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Hardy–Weinberg Equilibrium Compatibility; Population Stratification Control; Relatedness Control\", \"Common Misinterpretations\": \"Treating batch-effect control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Batch-Effect Control\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of batch-effect control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses batch-effect control using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in batch-effect control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 246 ; bemo:BEMO_3100023 "0751d3491af658db1257b3b04a366a751c7fd0fdfb5e615ebbae3dab6970c7c9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 247" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Reference Bias; Hardy–Weinberg Equilibrium Compatibility; Batch-Effect Control\", \"Common Misinterpretations\": \"Treating call-rate completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Call-Rate Completeness\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of call-rate are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses call-rate completeness using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in call-rate completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 247 ; bemo:BEMO_3100023 "c69a25da4615faa5675944ca32d4c5ec30a0c44f5216034581329797d9a32abc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 248" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Single-Cell Feature Detection Rate; Spatial Transcriptomic Registration Accuracy; Cross-Platform Genomic Concordance\", \"Common Misinterpretations\": \"Treating cell-type annotation confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cell-Type Annotation Confidence\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The justified degree of certainty assigned to cell-type annotation given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses cell-type annotation confidence using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cell-type annotation confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 248 ; bemo:BEMO_3100023 "f7aebc612affb172059739df32608fb7c4d69384f1ff8c565432595eea6b9937" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 249" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Library Complexity; Sample Identity Concordance; Sex Concordance\", \"Common Misinterpretations\": \"Treating contamination burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Contamination Burden\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of contamination burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses contamination burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in contamination burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 249 ; bemo:BEMO_3100023 "fc0cd98bc92235d469bf2bc025f0d327d8170dfb4df97b973710a8d887eff3f4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 25" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Target Engagement Evidence; Off-Target Liability Evidence; Biological Gradient\", \"Common Misinterpretations\": \"Treating on-target specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"On-Target Specificity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of on-target specificity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses on-target specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in on-target specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 25 ; bemo:BEMO_3100023 "5b75004715c78ae57eb0dfbf1a6fe3b6212289ca6b06f39e35b36270d16b13e5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 250" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Spatial Transcriptomic Registration Accuracy\", \"Common Misinterpretations\": \"Treating cross-platform genomic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cross-Platform Genomic Concordance\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The degree of agreement in cross-platform genomic across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cross-platform genomic concordance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-platform genomic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 250 ; bemo:BEMO_3100023 "91130249c6d3c5254de370a79251a5dce82ecc1afbe7b1276235f59ee93b7b5a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 251" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Relatedness Control; Normalization Adequacy; Transcript Quantification Reliability\", \"Common Misinterpretations\": \"Treating differential expression robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Differential Expression Robustness\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of differential expression robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses differential expression robustness using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in differential expression robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 251 ; bemo:BEMO_3100023 "e70802b2991914211c0dcd91213c02319dd673fc93963b9e2064b8bca944c528" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 252" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Read Quality; Library Complexity; Contamination Burden\", \"Common Misinterpretations\": \"Treating duplicate read burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Duplicate Read Burden\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of duplicate read burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses duplicate read burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in duplicate read burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 252 ; bemo:BEMO_3100023 "c1d6b63aea87c65750f96b5e3a771c6866843a2e5ba7e8081dd07af03bc0e9c5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 253" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Sequencing Depth Adequacy; Mapping Quality; Read Quality\", \"Common Misinterpretations\": \"Treating genome coverage uniformity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Genome Coverage Uniformity\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The proportion and representativeness of the relevant genome uniformity captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses genome coverage uniformity using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in genome coverage uniformity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 253 ; bemo:BEMO_3100023 "c86e8ba8cbfb79ea4dbc1a9a4cd5da76837e35c7f45f5966b51b9734760bdf1f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 254" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Variant Call Quality; Allelic Balance; Strand Bias\", \"Common Misinterpretations\": \"Treating genotype quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Genotype Quality\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of genotype quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses genotype quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in genotype quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 254 ; bemo:BEMO_3100023 "6b3ff41c46f655393bf02a8730b778b41b8fad3c6f62302d7543aef197484ea3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 255" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Call-Rate Completeness; Batch-Effect Control; Population Stratification Control\", \"Common Misinterpretations\": \"Treating hardy–weinberg equilibrium compatibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Hardy–Weinberg Equilibrium Compatibility\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of hardy–weinberg equilibrium compatibility.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses hardy–weinberg equilibrium compatibility using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in hardy–weinberg equilibrium compatibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 255 ; bemo:BEMO_3100023 "158d6abc0d325612b86f33eeb0aa8e0dbdfd4460dc9c1934f90601f28ed25284" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 256" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Duplicate Read Burden; Contamination Burden; Sample Identity Concordance\", \"Common Misinterpretations\": \"Treating library complexity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Library Complexity\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of library complexity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses library complexity using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in library complexity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 256 ; bemo:BEMO_3100023 "fb650cc4b9fc46d550895b59d1656dada1a7ec625426686e0a708ba75b6fc5f0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 257" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Genome Coverage Uniformity; Read Quality; Duplicate Read Burden\", \"Common Misinterpretations\": \"Treating mapping quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mapping Quality\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mapping quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses mapping quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mapping quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 257 ; bemo:BEMO_3100023 "aef9eeffa971170a3db3642e806206bdf35806d1d8cc427e16ad9106f7e0207c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 258" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Differential Expression Robustness; Transcript Quantification Reliability; Alternative Splicing Validation\", \"Common Misinterpretations\": \"Treating normalization adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Normalization Adequacy\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The extent to which normalization is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses normalization adequacy using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in normalization adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 258 ; bemo:BEMO_3100023 "518f55960ed771c22a0c382ff436c097ae34f4481b35b5a64e7f2cf8493778a4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 259" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Batch-Effect Control; Relatedness Control; Differential Expression Robustness\", \"Common Misinterpretations\": \"Treating population stratification control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Population Stratification Control\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population stratification control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses population stratification control using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in population stratification control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 259 ; bemo:BEMO_3100023 "c82d16c5b00c0127f5b02c510a48d677f57d7580cba4dcb68dce1141e1686c1d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 26" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Causality Strength; Cell-Type Specificity; Tissue Specificity\", \"Common Misinterpretations\": \"Treating pathway-level support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Pathway-Level Support\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting pathway-level.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pathway-level support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pathway-level support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 26 ; bemo:BEMO_3100023 "a1a0e0a377d9f949a45a0ad0a040b0443e29f24bfe701f3b015420b52cd21ab2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 260" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Mapping Quality; Duplicate Read Burden; Library Complexity\", \"Common Misinterpretations\": \"Treating read quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Read Quality\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of read quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses read quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in read quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 260 ; bemo:BEMO_3100023 "e9483af6db486496b6f4b0c18d333bb38a6c500a6b80dd23beefe82c05de4acc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 261" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Strand Bias; Call-Rate Completeness; Hardy–Weinberg Equilibrium Compatibility\", \"Common Misinterpretations\": \"Treating reference bias as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Reference Bias\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of reference bias.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses reference bias using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reference bias can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 261 ; bemo:BEMO_3100023 "7f170b7ac0b632bb15937074f6f54297bd1374274ba7dd6a71c308a1270c144b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 262" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Population Stratification Control; Differential Expression Robustness; Normalization Adequacy\", \"Common Misinterpretations\": \"Treating relatedness control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Relatedness Control\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of relatedness control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses relatedness control using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in relatedness control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 262 ; bemo:BEMO_3100023 "c66c714b8c2b1fb9da08eabc61ab1b346b5733232f7901baf90ed1206b3491ba" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 263" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Contamination Burden; Sex Concordance; Variant Call Quality\", \"Common Misinterpretations\": \"Treating sample identity concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Sample Identity Concordance\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The degree of agreement in sample identity across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses sample identity concordance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sample identity concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 263 ; bemo:BEMO_3100023 "cf22f061ff0a6f0403c89f061c9c86c0fdc0e5186e885958801878829549f2cd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 264" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Genome Coverage Uniformity; Mapping Quality\", \"Common Misinterpretations\": \"Treating sequencing depth adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Sequencing Depth Adequacy\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The extent to which sequencing depth is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses sequencing depth adequacy using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sequencing depth adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 264 ; bemo:BEMO_3100023 "719d5f0d3157f75114503dd8e8b0e75aa481929ab009d6c25b68024c7b5f71a0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 265" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Sample Identity Concordance; Variant Call Quality; Genotype Quality\", \"Common Misinterpretations\": \"Treating sex concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Sex Concordance\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The degree of agreement in sex across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses sex concordance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sex concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 265 ; bemo:BEMO_3100023 "897b2797d8e6449a88906be71f955c7726607e3b28833aef8661c12a890476a4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 266" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Single-Cell Doublet Burden; Single-Cell Viability; Single-Cell Feature Detection Rate\", \"Common Misinterpretations\": \"Treating single-cell ambient rna burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Single-Cell Ambient RNA Burden\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell ambient rna burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses single-cell ambient rna burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in single-cell ambient rna burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 266 ; bemo:BEMO_3100023 "1685a23504d9a42b00cb2ea9bdca0c2daeec5f3be11cc0d479a9acb5349c658a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 267" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Alternative Splicing Validation; Single-Cell Ambient RNA Burden; Single-Cell Viability\", \"Common Misinterpretations\": \"Treating single-cell doublet burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Single-Cell Doublet Burden\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell doublet burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses single-cell doublet burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in single-cell doublet burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 267 ; bemo:BEMO_3100023 "47e6d4bd3f64b35d8abb9925b05e112fbb1356d383dc641a47f78f8e9bbeb676" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 268" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Single-Cell Viability; Cell-Type Annotation Confidence; Spatial Transcriptomic Registration Accuracy\", \"Common Misinterpretations\": \"Treating single-cell feature detection rate as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Single-Cell Feature Detection Rate\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell feature detection rate.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses single-cell feature detection rate using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in single-cell feature detection rate can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 268 ; bemo:BEMO_3100023 "1ce87bfa0e14b3c49cdf26e92f3b39ba4ce32c6192d394a99b4f3b80c80031b2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 269" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Single-Cell Ambient RNA Burden; Single-Cell Feature Detection Rate; Cell-Type Annotation Confidence\", \"Common Misinterpretations\": \"Treating single-cell viability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Single-Cell Viability\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell viability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses single-cell viability using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in single-cell viability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 269 ; bemo:BEMO_3100023 "faf5bedb35b3c8e6f9b571b29c9788bb087192d600f7d5646da266201f76f5dd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 27" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Molecular-Phenotypic Concordance; Loss-of-Function Validation; Gain-of-Function Validation\", \"Common Misinterpretations\": \"Treating perturbational validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Perturbational Validation\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of perturbational validation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses perturbational validation using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in perturbational validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 27 ; bemo:BEMO_3100023 "e56c259480c9a3f5c7efe467a62a9721824469292b9aeb900d1804f2bbfb7983" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 270" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Cell-Type Annotation Confidence; Cross-Platform Genomic Concordance\", \"Common Misinterpretations\": \"Treating spatial transcriptomic registration accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Spatial Transcriptomic Registration Accuracy\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"The closeness of spatial transcriptomic registration to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses spatial transcriptomic registration accuracy using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in spatial transcriptomic registration accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 270 ; bemo:BEMO_3100023 "e61d8e9d42dcb8b644bc33652bdf4f396f77ace1c2d848fb684d0c722e5a1598" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 271" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Allelic Balance; Reference Bias; Call-Rate Completeness\", \"Common Misinterpretations\": \"Treating strand bias as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Strand Bias\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of strand bias.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses strand bias using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in strand bias can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 271 ; bemo:BEMO_3100023 "6ac08afc8cf99d9cd5ee94bc247ff32edf260fc542fd5e27409d9c3b702afd66" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 272" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Normalization Adequacy; Alternative Splicing Validation; Single-Cell Doublet Burden\", \"Common Misinterpretations\": \"Treating transcript quantification reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Transcript Quantification Reliability\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of transcript quantification reliability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses transcript quantification reliability using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in transcript quantification reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 272 ; bemo:BEMO_3100023 "45c762be688f8b3f57f3b563b58fc816d5802e731de9aee9acb732eea429ea1a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 273" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies\", \"Category\": \"Genomics and Transcriptomics\", \"Closely Related Metrics\": \"Sex Concordance; Genotype Quality; Allelic Balance\", \"Common Misinterpretations\": \"Treating variant call quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Variant Call Quality\", \"References or Origin\": \"https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/\", \"Related Frameworks\": \"MIAME; MINSEQE; STROBE-ME; GA4GH; HCA\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of variant call quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses variant call quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in variant call quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 273 ; bemo:BEMO_3100023 "45320c5b96fc37b8148ee2721453c92e6bec79491a4ed2d2f6fedbc2cb99cb01" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 274" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Analytical Validity; Trueness; Analytical Precision\", \"Common Misinterpretations\": \"Treating accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Accuracy\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The closeness of accuracy to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses accuracy using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 274 ; bemo:BEMO_3100023 "35d988975cf78a06cb70788f89a4196551552de36a3cf47e57d2d96fc8cf41fd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 275" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Linearity; Reportable Range; Dynamic Range\", \"Common Misinterpretations\": \"Treating analytical measurement range as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Analytical Measurement Range\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of analytical measurement range.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses analytical measurement range using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in analytical measurement range can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 275 ; bemo:BEMO_3100023 "40562e2bdf0f0c373312aa0a75941fd6a83f056ba5201b300a46242b3f5457df" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 276" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Trueness; Repeatability; Intermediate Precision\", \"Common Misinterpretations\": \"Treating analytical precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Analytical Precision\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The closeness of repeated estimates or measurements and the narrowness of uncertainty around analytical.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses analytical precision using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in analytical precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 276 ; bemo:BEMO_3100023 "7c4987f5f8c3c9cca41bb28896f2392e5c664fc505d3f5db2c63ad7c10e1d04d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 277" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Reproducibility of Measurement; Analytical Specificity; Limit of Detection\", \"Common Misinterpretations\": \"Treating analytical sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Analytical Sensitivity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of analytical sensitivity.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses analytical sensitivity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in analytical sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 277 ; bemo:BEMO_3100023 "193a9fb566dfa18750368d0657f7d1e8c3de7251eea014f0d99b1b3e73df3afa" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 278" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Analytical Sensitivity; Limit of Detection; Limit of Quantification\", \"Common Misinterpretations\": \"Treating analytical specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Analytical Specificity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of analytical specificity.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses analytical specificity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in analytical specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 278 ; bemo:BEMO_3100023 "f6458dae6787eecc6dbfe775e26236c89d02f80c2f92e3575c7f9ddfa0e84b0e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 279" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Accuracy; Trueness\", \"Common Misinterpretations\": \"Treating analytical validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Analytical Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree to which analytical supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses analytical validity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in analytical validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 279 ; bemo:BEMO_3100023 "e4b1deae92fd2c549054f6f19f234dbf0b73ab8ff30ff5741db1c88b5618f6c3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 28" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Cross-Species Biological Concordance; Molecular-Phenotypic Concordance; Perturbational Validation\", \"Common Misinterpretations\": \"Treating phenotypic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Phenotypic Concordance\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The degree of agreement in phenotypic across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses phenotypic concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in phenotypic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 28 ; bemo:BEMO_3100023 "d6b2622e1418a4a4c75dd4e74edee6d3fe7ea5ecac7eb6c453c614421e29173a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 280" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Site-to-Site Assay Portability; Preanalytical Robustness; Postanalytical Integrity\", \"Common Misinterpretations\": \"Treating batch-effect sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Batch-Effect Sensitivity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of batch-effect sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses batch-effect sensitivity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in batch-effect sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 280 ; bemo:BEMO_3100023 "7222c30713cc035f86bae406549aaf0d4751a919d50ae68b917efd9629244d28" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 281" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Hook Effect Risk; Reference Interval Validity; Cutoff Validity\", \"Common Misinterpretations\": \"Treating calibration traceability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Calibration Traceability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration traceability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses calibration traceability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in calibration traceability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 281 ; bemo:BEMO_3100023 "7d6efe540a48fdb6c1d86b381d867ad016fd03d3ba3039e34ba0dd8d59bcbf8d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 282" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Cross-Reactivity; Hook Effect Risk; Calibration Traceability\", \"Common Misinterpretations\": \"Treating carryover as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Carryover\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of carryover.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses carryover using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in carryover can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 282 ; bemo:BEMO_3100023 "0e987b7e93f5f6b586140ce3b08eb3d87acd863bc4cb825ee0d1e4b7b1bb3994" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 283" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Method Comparison Agreement; Sample Stability; Reagent Lot Consistency\", \"Common Misinterpretations\": \"Treating commutability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Commutability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of commutability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses commutability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in commutability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 283 ; bemo:BEMO_3100023 "0d8876821c8ce33e4a6f72fcdd334c759d21fb2784bd7f9f779179758d7849c8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 284" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Interference Susceptibility; Carryover; Hook Effect Risk\", \"Common Misinterpretations\": \"Treating cross-reactivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cross-Reactivity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cross-reactivity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cross-reactivity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-reactivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 284 ; bemo:BEMO_3100023 "1de0ffae2d83059ba1d111ea3bf309f20078d963ac7b7f912a42e8b4e10e5e32" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 285" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Reference Interval Validity; Measurement Uncertainty; Method Comparison Agreement\", \"Common Misinterpretations\": \"Treating cutoff validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Cutoff Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree to which cutoff supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses cutoff validity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cutoff validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 285 ; bemo:BEMO_3100023 "f74e484a95fd67b9bd73e0f0c112bc85ddaf01e7476f82b9c24c9382fe2bfe48" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 286" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Recovery; Matrix Effect; Interference Susceptibility\", \"Common Misinterpretations\": \"Treating dilution integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Dilution Integrity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dilution integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses dilution integrity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dilution integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 286 ; bemo:BEMO_3100023 "a31ef0b724223ebc3d1ad0dbe731b0b7823f6b347840ea43769f01a33866757b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 287" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Reportable Range; Recovery; Dilution Integrity\", \"Common Misinterpretations\": \"Treating dynamic range as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Dynamic Range\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dynamic range.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses dynamic range using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dynamic range can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 287 ; bemo:BEMO_3100023 "41309e5f36c397d08d76621c273137352b099c93484f2a2eca025bcf85ccffdc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 288" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Carryover; Calibration Traceability; Reference Interval Validity\", \"Common Misinterpretations\": \"Treating hook effect risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Hook Effect Risk\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The probability or degree that hook effect introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses hook effect risk using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in hook effect risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 288 ; bemo:BEMO_3100023 "3d6a1547d736b7a958bf1c94a2df8cb5599400f10305a91c657ae1dce184650b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 289" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Reagent Lot Consistency; Operator Variability; Site-to-Site Assay Portability\", \"Common Misinterpretations\": \"Treating instrument drift as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Instrument Drift\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of instrument drift.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses instrument drift using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in instrument drift can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 289 ; bemo:BEMO_3100023 "39eec82dab659b7826d3bea8f3227e8afeb55e0f15214b02955200cb8a59a8ba" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 29" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Gain-of-Function Validation; Epistasis Support; Target Engagement Evidence\", \"Common Misinterpretations\": \"Treating rescue experiment support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Rescue Experiment Support\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting rescue experiment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses rescue experiment support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in rescue experiment support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 29 ; bemo:BEMO_3100023 "9f3de30fb4252544b664477f26ad879c47cffd18e4a902652a07ca5b9fa59ec2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 290" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Matrix Effect; Cross-Reactivity; Carryover\", \"Common Misinterpretations\": \"Treating interference susceptibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Interference Susceptibility\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of interference susceptibility.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses interference susceptibility using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in interference susceptibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 290 ; bemo:BEMO_3100023 "af7341a32f2656e5638dc5bce7ac126974e88c78554d2916a696247ebbe11d2b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 291" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Repeatability; Reproducibility of Measurement; Analytical Sensitivity\", \"Common Misinterpretations\": \"Treating intermediate precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Intermediate Precision\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The closeness of repeated estimates or measurements and the narrowness of uncertainty around intermediate.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses intermediate precision using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in intermediate precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 291 ; bemo:BEMO_3100023 "543dc6e95f52dce066f892ad8d141154500ea9d0cf35d11564c84cc551f70c3b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 292" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Analytical Specificity; Limit of Quantification; Linearity\", \"Common Misinterpretations\": \"Treating limit of detection as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Limit of Detection\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of limit of detection.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses limit of detection using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in limit of detection can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 292 ; bemo:BEMO_3100023 "32751f0c3f93a66c901d3c5cea950ee45482dac2a524a6e4ed0ddc20000649d1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 293" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Limit of Detection; Linearity; Analytical Measurement Range\", \"Common Misinterpretations\": \"Treating limit of quantification as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Limit of Quantification\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of limit of quantification.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses limit of quantification using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in limit of quantification can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 293 ; bemo:BEMO_3100023 "e110a21f976b308d8a01ff42efac55157e3af426e1182c74cf700e2fb4ce3595" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 294" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Limit of Quantification; Analytical Measurement Range; Reportable Range\", \"Common Misinterpretations\": \"Treating linearity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Linearity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of linearity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses linearity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in linearity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 294 ; bemo:BEMO_3100023 "511e3fb111714ad52a916859d22dfd9a9aa36539d615e5b295fdf52500ac32e5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 295" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Dilution Integrity; Interference Susceptibility; Cross-Reactivity\", \"Common Misinterpretations\": \"Treating matrix effect as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Matrix Effect\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of matrix effect.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses matrix effect using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in matrix effect can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 295 ; bemo:BEMO_3100023 "e901d4ca31939164c2ecbe0d0bed735b156c8e09a3c3f28444f5359947798b49" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 296" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Cutoff Validity; Method Comparison Agreement; Commutability\", \"Common Misinterpretations\": \"Treating measurement uncertainty as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Measurement Uncertainty\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of measurement uncertainty.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses measurement uncertainty using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in measurement uncertainty can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 296 ; bemo:BEMO_3100023 "02b8d5d020f47fcd1190b0fa52a15a86a5dd04748bbf2908e8c4e87ccdb4670f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 297" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Measurement Uncertainty; Commutability; Sample Stability\", \"Common Misinterpretations\": \"Treating method comparison agreement as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Method Comparison Agreement\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree of agreement in method comparison across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses method comparison agreement using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in method comparison agreement can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 297 ; bemo:BEMO_3100023 "8f2dfbddd616818e03a89990f48f31b1db69460f1919bb65cc71ee0d68b7b4f6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 298" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Instrument Drift; Site-to-Site Assay Portability; Batch-Effect Sensitivity\", \"Common Misinterpretations\": \"Treating operator variability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Operator Variability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of operator variability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses operator variability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in operator variability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 298 ; bemo:BEMO_3100023 "ae9e50b8f8857543ecb1eb315c23fc88dd3a028cfd40ee4377e1039431544ca0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 299" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Preanalytical Robustness\", \"Common Misinterpretations\": \"Treating postanalytical integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Postanalytical Integrity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of postanalytical integrity.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses postanalytical integrity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in postanalytical integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 299 ; bemo:BEMO_3100023 "b1cf2cbf0a36602510f89d4d570874b9d2148d8bd132ef3b47e7be72655f9ff3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 30" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Tissue Specificity; Temporal Biological Concordance; Cross-Species Biological Concordance\", \"Common Misinterpretations\": \"Treating spatial biological concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Spatial Biological Concordance\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The degree of agreement in spatial biological across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses spatial biological concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in spatial biological concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 30 ; bemo:BEMO_3100023 "6c08ba26b1257f37b62212d7633a9e83166a0f74706ae3ffbb9de90cd98613f7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 300" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Batch-Effect Sensitivity; Postanalytical Integrity\", \"Common Misinterpretations\": \"Treating preanalytical robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Preanalytical Robustness\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of preanalytical robustness.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses preanalytical robustness using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in preanalytical robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 300 ; bemo:BEMO_3100023 "b76350bac6098346689193598ba9a67fbdcf0cc16c9a9abb5e49d8238a97798b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 301" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Sample Stability; Instrument Drift; Operator Variability\", \"Common Misinterpretations\": \"Treating reagent lot consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Reagent Lot Consistency\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree of agreement in reagent lot across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses reagent lot consistency using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reagent lot consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 301 ; bemo:BEMO_3100023 "66143063e8139ffa9de4cc6fb03a0eb1778bd92be05c901387fc7af071b0e433" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 302" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Dynamic Range; Dilution Integrity; Matrix Effect\", \"Common Misinterpretations\": \"Treating recovery as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Recovery\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of recovery.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses recovery using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in recovery can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 302 ; bemo:BEMO_3100023 "5e396bd1803ce209b22910e5705b5bf0dc26bd235bba5ac5c904b2514e3f7ea8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 303" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Calibration Traceability; Cutoff Validity; Measurement Uncertainty\", \"Common Misinterpretations\": \"Treating reference interval validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Reference Interval Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree to which reference interval supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses reference interval validity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reference interval validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 303 ; bemo:BEMO_3100023 "3706e41c2a6c519ccdfb2643facf47ec1d2a45cc4b5b902e54040a5a53624b7e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 304" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Analytical Precision; Intermediate Precision; Reproducibility of Measurement\", \"Common Misinterpretations\": \"Treating repeatability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Repeatability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree to which repeatability yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses repeatability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in repeatability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 304 ; bemo:BEMO_3100023 "289ee6101d32dc64bb4644380815480f0d1de4b3d0512c355bf6d1bb8e30c7f2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 305" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Analytical Measurement Range; Dynamic Range; Recovery\", \"Common Misinterpretations\": \"Treating reportable range as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Reportable Range\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of reportable range.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses reportable range using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reportable range can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 305 ; bemo:BEMO_3100023 "1958a10669f076f26b0e434840fd948f2a615d7e3a768038db89230b0e148857" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 306" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Intermediate Precision; Analytical Sensitivity; Analytical Specificity\", \"Common Misinterpretations\": \"Treating reproducibility of measurement as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Reproducibility of Measurement\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"The degree to which reproducibility of measurement yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses reproducibility of measurement using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reproducibility of measurement can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 306 ; bemo:BEMO_3100023 "83e10528c5f3255388bb807d6bfc99c4e2c93d4f418421fcd184c242521982d5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 307" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Commutability; Reagent Lot Consistency; Instrument Drift\", \"Common Misinterpretations\": \"Treating sample stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Sample Stability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of sample stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses sample stability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sample stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 307 ; bemo:BEMO_3100023 "42f10127b0bb2f21e12bfaaba11ee2a6c8335cd39935669d6733741eadfc7015" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 308" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Operator Variability; Batch-Effect Sensitivity; Preanalytical Robustness\", \"Common Misinterpretations\": \"Treating site-to-site assay portability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Site-to-Site Assay Portability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of site-to-site assay portability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses site-to-site assay portability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in site-to-site assay portability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 308 ; bemo:BEMO_3100023 "c0e7317023f6c1fc290d021e4b38163503a72ee411cc671fe6aae25ee84d1ee5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 309" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies\", \"Category\": \"Measurement and Assay Analytical Validity\", \"Closely Related Metrics\": \"Accuracy; Analytical Precision; Repeatability\", \"Common Misinterpretations\": \"Treating trueness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Trueness\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/\", \"Related Frameworks\": \"FDA Biomarker; CLSI; ISO 15189; MIQE\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of trueness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses trueness using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in trueness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 309 ; bemo:BEMO_3100023 "9094cf98fb975c34384185560acacc946dab62ebd8f1815100dcaac099d9df1b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 31" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Network Context Support\", \"Common Misinterpretations\": \"Treating systems-level emergence support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Systems-Level Emergence Support\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting systems-level emergence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses systems-level emergence support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in systems-level emergence support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 31 ; bemo:BEMO_3100023 "07df8f6070c405006e36806e8ccb515126dc2c7269ea9cf3934662d28e9264c6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 310" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Cross-Omics Replication; Latent-Factor Stability; Network Reconstruction Robustness\", \"Common Misinterpretations\": \"Treating cross-layer directional concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cross-Layer Directional Concordance\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The degree of agreement in cross-layer directional across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cross-layer directional concordance using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-layer directional concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 310 ; bemo:BEMO_3100023 "89f675805a18a02e8214d03853d6a7cdcea2d29079ee839babae7605cea7a581" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 311" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Cross-Omics Replication; Cross-Layer Directional Concordance\", \"Common Misinterpretations\": \"Treating cross-omics integration coherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cross-Omics Integration Coherence\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cross-omics integration coherence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses cross-omics integration coherence using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-omics integration coherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 311 ; bemo:BEMO_3100023 "c10b406fc4ce6db5663280fc4b358cc062cc17f0ce7a593af68a762307815cdc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 312" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Cross-Omics Integration Coherence; Cross-Layer Directional Concordance; Latent-Factor Stability\", \"Common Misinterpretations\": \"Treating cross-omics replication as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Cross-Omics Replication\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cross-omics replication.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cross-omics replication using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-omics replication can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 312 ; bemo:BEMO_3100023 "5b9be25d7af680eef194d1d2e393dbdeaaf607f62c516cb41c75f5dfd1ba50b9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 313" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Practical Identifiability; Steady-State Validity; Flux-Balance Consistency\", \"Common Misinterpretations\": \"Treating dynamical stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Dynamical Stability\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dynamical stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses dynamical stability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dynamical stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 313 ; bemo:BEMO_3100023 "d58852cf510c70b8fcfa12f792791c36728adc16d59c5b9bb4b7a9b129c39f52" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 314" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Perturbation Prediction Accuracy\", \"Common Misinterpretations\": \"Treating emergent-property reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Specialized / infrequent\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Emergent-Property Reproducibility\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The degree to which emergent-property reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses emergent-property reproducibility using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in emergent-property reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 314 ; bemo:BEMO_3100023 "e554ab3ba02f294f767076d372c3967762b850eccc356bf4d7c243480641cd98" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 315" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Knowledge-Graph Provenance Quality; Relation Evidence Strength; Ontology Annotation Completeness\", \"Common Misinterpretations\": \"Treating entity resolution accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Entity Resolution Accuracy\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The closeness of entity resolution to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses entity resolution accuracy using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in entity resolution accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 315 ; bemo:BEMO_3100023 "81ae3d3ac205c8d1258be22f4b5818a5c36df354b19605060eb458cfdfef682e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 316" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Steady-State Validity; Perturbation Prediction Accuracy; Emergent-Property Reproducibility\", \"Common Misinterpretations\": \"Treating flux-balance consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Flux-Balance Consistency\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The degree of agreement in flux-balance across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses flux-balance consistency using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in flux-balance consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 316 ; bemo:BEMO_3100023 "f8d3b19efd68e0150e437c71bac90ab2bb80f33877b4a0e74bc52542a0fd3c26" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 317" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Pathway Topology Support; Knowledge-Graph Provenance Quality; Entity Resolution Accuracy\", \"Common Misinterpretations\": \"Treating knowledge-graph evidence completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Knowledge-Graph Evidence Completeness\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of knowledge-graph evidence are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses knowledge-graph evidence completeness using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in knowledge-graph evidence completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 317 ; bemo:BEMO_3100023 "082de1cac908d5d8b791ddee2974743d0e0eae71997e72080a5d978e931f8b6c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 318" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Knowledge-Graph Evidence Completeness; Entity Resolution Accuracy; Relation Evidence Strength\", \"Common Misinterpretations\": \"Treating knowledge-graph provenance quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Knowledge-Graph Provenance Quality\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of knowledge-graph provenance quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses knowledge-graph provenance quality using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in knowledge-graph provenance quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 318 ; bemo:BEMO_3100023 "50aaf6749314a5ad4694891f48d60c74feaa99da022b5cc91c17f4221f0696a2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 319" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Cross-Layer Directional Concordance; Network Reconstruction Robustness; Network Edge Confidence\", \"Common Misinterpretations\": \"Treating latent-factor stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Latent-Factor Stability\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of latent-factor stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses latent-factor stability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in latent-factor stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 319 ; bemo:BEMO_3100023 "be1e726b2fd3735d5492ec8f375d473b36cbff860abc6d682d2065974c115c50" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 32" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Epistasis Support; On-Target Specificity; Off-Target Liability Evidence\", \"Common Misinterpretations\": \"Treating target engagement evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Target Engagement Evidence\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of target engagement evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses target engagement evidence using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in target engagement evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 32 ; bemo:BEMO_3100023 "a51c69d24f2bf9ef711f1d3b54d2086032245754bf1992c1b5999a88e3ca185f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 320" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Ontology Evidence-Code Strength; Parameter Identifiability; Parameter Sensitivity\", \"Common Misinterpretations\": \"Treating model–experiment concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Model–Experiment Concordance\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The degree of agreement in model–experiment across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses model–experiment concordance using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in model–experiment concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 320 ; bemo:BEMO_3100023 "433f97851837c60d123f8a332258d7d5b3872aa7c5564c19691b4c4c00871a8b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 321" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Network Node Confidence; Pathway Enrichment Consistency; Pathway Topology Support\", \"Common Misinterpretations\": \"Treating module stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Module Stability\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of module stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses module stability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in module stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 321 ; bemo:BEMO_3100023 "191acd0c1abb112365dc2e82b9a1c639642c0798eb52983d078ac92e3f0fbeec" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 322" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Network Reconstruction Robustness; Network Node Confidence; Module Stability\", \"Common Misinterpretations\": \"Treating network edge confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Network Edge Confidence\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The justified degree of certainty assigned to network edge given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses network edge confidence using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in network edge confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 322 ; bemo:BEMO_3100023 "6118b228a2af4e149e82150fb026ef08cdd6d05b9748a0128d6e8c14f147784c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 323" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Network Edge Confidence; Module Stability; Pathway Enrichment Consistency\", \"Common Misinterpretations\": \"Treating network node confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Network Node Confidence\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The justified degree of certainty assigned to network node given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses network node confidence using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in network node confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 323 ; bemo:BEMO_3100023 "79eaf0a8e6c6fc3012d48e379c545c17d89aecf6de033d40ae6399ec89441a3b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 324" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Latent-Factor Stability; Network Edge Confidence; Network Node Confidence\", \"Common Misinterpretations\": \"Treating network reconstruction robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Network Reconstruction Robustness\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of network reconstruction robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses network reconstruction robustness using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in network reconstruction robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 324 ; bemo:BEMO_3100023 "0b4f2bdfa3ccc3b3abdb67b1f3be15b6d8479743942152580ad3f1929db67d5f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 325" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Relation Evidence Strength; Ontology Evidence-Code Strength; Model–Experiment Concordance\", \"Common Misinterpretations\": \"Treating ontology annotation completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Ontology Annotation Completeness\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of ontology annotation are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses ontology annotation completeness using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in ontology annotation completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 325 ; bemo:BEMO_3100023 "b8714924720c209e415f9bf2c9aaf707f6bf0edbbbf6ca8da11d2546f9da563d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 326" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Ontology Annotation Completeness; Model–Experiment Concordance; Parameter Identifiability\", \"Common Misinterpretations\": \"Treating ontology evidence-code strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Ontology Evidence-Code Strength\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting ontology evidence-code.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses ontology evidence-code strength using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in ontology evidence-code strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 326 ; bemo:BEMO_3100023 "98cc3b5d977b0d0bd7a309c477d2653f05eeb7554078021a2d0b2bf21036d891" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 327" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Model–Experiment Concordance; Parameter Sensitivity; Structural Identifiability\", \"Common Misinterpretations\": \"Treating parameter identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Parameter Identifiability\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of parameter identifiability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses parameter identifiability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in parameter identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 327 ; bemo:BEMO_3100023 "e1eaab072c302dca725ea1fb92e565c0aead2c5a6ddd49490dbfa43ad163dd03" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 328" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Parameter Identifiability; Structural Identifiability; Practical Identifiability\", \"Common Misinterpretations\": \"Treating parameter sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Parameter Sensitivity\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of parameter sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses parameter sensitivity using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in parameter sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 328 ; bemo:BEMO_3100023 "9735c06335e80bafcbeea74ccb7b405e18e8684330b82448424f6e83ef3974ba" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 329" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Module Stability; Pathway Topology Support; Knowledge-Graph Evidence Completeness\", \"Common Misinterpretations\": \"Treating pathway enrichment consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Pathway Enrichment Consistency\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The degree of agreement in pathway enrichment across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses pathway enrichment consistency using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pathway enrichment consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 329 ; bemo:BEMO_3100023 "d7e323b8eddcaff29fe662695a2fa9bae2a0f04120cfdf422fa3e2d1cd3b117e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 33" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Spatial Biological Concordance; Cross-Species Biological Concordance; Phenotypic Concordance\", \"Common Misinterpretations\": \"Treating temporal biological concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Temporal Biological Concordance\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"The degree of agreement in temporal biological across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses temporal biological concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in temporal biological concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 33 ; bemo:BEMO_3100023 "57d68c3c49543e85a4a6ee1a26a1705e9e0e05df169673d5a8f0a00632bfa39b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 330" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Pathway Enrichment Consistency; Knowledge-Graph Evidence Completeness; Knowledge-Graph Provenance Quality\", \"Common Misinterpretations\": \"Treating pathway topology support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Pathway Topology Support\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting pathway topology.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pathway topology support using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pathway topology support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 330 ; bemo:BEMO_3100023 "f408d8b817c9e3179698dad395d8e94ea187b92ae192e0ab52e026106d82f40a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 331" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Flux-Balance Consistency; Emergent-Property Reproducibility\", \"Common Misinterpretations\": \"Treating perturbation prediction accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Perturbation Prediction Accuracy\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The closeness of perturbation prediction to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses perturbation prediction accuracy using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in perturbation prediction accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 331 ; bemo:BEMO_3100023 "5cc466b3de703eb697570667c57a9230690c56d69b5cf6ec528e42740ec621e9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 332" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Structural Identifiability; Dynamical Stability; Steady-State Validity\", \"Common Misinterpretations\": \"Treating practical identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Practical Identifiability\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of practical identifiability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses practical identifiability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in practical identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 332 ; bemo:BEMO_3100023 "cb110edeb57b36960477192ea5d1484823905d046fc0f22c33bc8eb340c3c4c3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 333" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Entity Resolution Accuracy; Ontology Annotation Completeness; Ontology Evidence-Code Strength\", \"Common Misinterpretations\": \"Treating relation evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Relation Evidence Strength\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting relation evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses relation evidence strength using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in relation evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 333 ; bemo:BEMO_3100023 "9009911ac3f6266273d49aa664b528314dd25468ab2969a5c3dfb8593502a99c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 334" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Dynamical Stability; Flux-Balance Consistency; Perturbation Prediction Accuracy\", \"Common Misinterpretations\": \"Treating steady-state validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Steady-State Validity\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"The degree to which steady-state supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses steady-state validity using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in steady-state validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 334 ; bemo:BEMO_3100023 "3a349724361b2712b35c94baaaa135ce8e313533d3edafc463242f1cddef411b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 335" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Integrated omics, networks, pathways, mechanistic and dynamic systems models\", \"Category\": \"Multi-omics and Systems Biology\", \"Closely Related Metrics\": \"Parameter Sensitivity; Practical Identifiability; Dynamical Stability\", \"Common Misinterpretations\": \"Treating structural identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Dataset / model / pathway / network / evidence body\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Structural Identifiability\", \"References or Origin\": \"https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/\", \"Related Frameworks\": \"Gene Ontology; Reactome; UniProt; GA4GH\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of structural identifiability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses structural identifiability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in structural identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 335 ; bemo:BEMO_3100023 "36fbdf592582d2c048b53d43d95edfca8afe5d6c7c93d352f32f2a7d7644cfbe" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 336" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Toxicological Mode-of-Action Support; Organ-Specific Toxicity Evidence; Genotoxicity Evidence Strength\", \"Common Misinterpretations\": \"Treating adverse outcome pathway support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Adverse Outcome Pathway Support\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting adverse outcome pathway.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses adverse outcome pathway support using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in adverse outcome pathway support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 336 ; bemo:BEMO_3100023 "8935703e7b30761e4213b86ddafc1aecae0696f4523a201860d9e64493990a74" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 337" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Lowest-Observed-Adverse-Effect Level Robustness; Toxicological Mode-of-Action Support; Adverse Outcome Pathway Support\", \"Common Misinterpretations\": \"Treating benchmark dose reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Benchmark Dose Reliability\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of benchmark dose reliability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses benchmark dose reliability using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in benchmark dose reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 337 ; bemo:BEMO_3100023 "43d4a4ce7127bc52167a879f611c41413072f25e775dbe7c9446cf4028783b10" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 338" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Pharmacodynamic Adequacy; Dose Proportionality; Time–Concentration Profile Adequacy\", \"Common Misinterpretations\": \"Treating bioavailability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Bioavailability\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of bioavailability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses bioavailability using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in bioavailability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 338 ; bemo:BEMO_3100023 "1dbec5a00f53d17cad5a3a88dd4dfde9ceab9bbbe33a898c76c7086698d1a0a2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 339" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Genotoxicity Evidence Strength; Reproductive Toxicity Evidence Strength; Developmental Toxicity Evidence Strength\", \"Common Misinterpretations\": \"Treating carcinogenicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Carcinogenicity Evidence Strength\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting carcinogenicity evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses carcinogenicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in carcinogenicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 339 ; bemo:BEMO_3100023 "a171459b41fd9ad0436588a80669a48227118c77c3d87194654b56ab6dfa6ad7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 34" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Cell-Type Specificity; Spatial Biological Concordance; Temporal Biological Concordance\", \"Common Misinterpretations\": \"Treating tissue specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Tissue Specificity\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of tissue specificity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses tissue specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in tissue specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 34 ; bemo:BEMO_3100023 "e3cc6b49f3bcbfabd500e6222a7c3cc053aca55c824a6afddd04a9b448378651" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 340" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Reproductive Toxicity Evidence Strength; Immunotoxicity Evidence Strength; Toxicokinetic Concordance\", \"Common Misinterpretations\": \"Treating developmental toxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Developmental Toxicity Evidence Strength\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting developmental toxicity evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses developmental toxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in developmental toxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 340 ; bemo:BEMO_3100023 "f5636ed02b8746eb48d98671b027c695a8940399bff60ebeae8ca955d99bae6a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 341" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Bioavailability; Time–Concentration Profile Adequacy; Metabolite Coverage\", \"Common Misinterpretations\": \"Treating dose proportionality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Dose Proportionality\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dose proportionality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses dose proportionality using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dose proportionality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 341 ; bemo:BEMO_3100023 "6d7bafb114f62ee059333139662f0dfa2a0fb0aaab829ac8fcdb03ed2fbd0708" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 342" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Metabolite Coverage; Receptor Occupancy Evidence; Selectivity Profile\", \"Common Misinterpretations\": \"Treating drug–drug interaction evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Drug–Drug Interaction Evidence\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of drug–drug interaction evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses drug–drug interaction evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in drug–drug interaction evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 342 ; bemo:BEMO_3100023 "3a82aa8a1751fa8372cd9735fd975781682a359be68aacfb1d0d78e896d96ce5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 343" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Potency Reproducibility; Therapeutic Window Evidence; Safety Margin Evidence\", \"Common Misinterpretations\": \"Treating efficacy reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Efficacy Reproducibility\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The degree to which efficacy reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses efficacy reproducibility using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in efficacy reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 343 ; bemo:BEMO_3100023 "e3d46320b779b7100a656dae6dcb02f7b9eae6762c1680f48b9313843cb64c84" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 344" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Pharmacological Target Validity; Pharmacokinetic Adequacy; Pharmacodynamic Adequacy\", \"Common Misinterpretations\": \"Treating exposure–response relationship as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Exposure–Response Relationship\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of exposure–response relationship.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses exposure–response relationship using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in exposure–response relationship can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 344 ; bemo:BEMO_3100023 "882d0346f9d5903a7e9b6a2b5ae992e9e24bd2be9c7e249168f2f9e157dc0354" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 345" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Organ-Specific Toxicity Evidence; Carcinogenicity Evidence Strength; Reproductive Toxicity Evidence Strength\", \"Common Misinterpretations\": \"Treating genotoxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Genotoxicity Evidence Strength\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting genotoxicity evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses genotoxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in genotoxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 345 ; bemo:BEMO_3100023 "e40592e267890e51ad35407c7dc2af7775fdac9174afe2f08486d28a5e2901b8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 346" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Species Extrapolation Validity; Mixture Interaction Assessment\", \"Common Misinterpretations\": \"Treating human-relevance of toxicological evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Human-Relevance of Toxicological Evidence\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of human-relevance of toxicological evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses human-relevance of toxicological evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in human-relevance of toxicological evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 346 ; bemo:BEMO_3100023 "32b4aadfeeab004a7a018b1fe09f04f0b2283eb92e7749123f8ac828db8cfce6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 347" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Developmental Toxicity Evidence Strength; Toxicokinetic Concordance; Species Extrapolation Validity\", \"Common Misinterpretations\": \"Treating immunotoxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Immunotoxicity Evidence Strength\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting immunotoxicity evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses immunotoxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in immunotoxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 347 ; bemo:BEMO_3100023 "577a4370c7a1dc270882fc655889fdc7a0b8ee20d5e6f81f1f733233db939fbd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 348" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"No-Observed-Adverse-Effect Level Robustness; Benchmark Dose Reliability; Toxicological Mode-of-Action Support\", \"Common Misinterpretations\": \"Treating lowest-observed-adverse-effect level robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Lowest-Observed-Adverse-Effect Level Robustness\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of lowest-observed-adverse-effect level robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses lowest-observed-adverse-effect level robustness using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in lowest-observed-adverse-effect level robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 348 ; bemo:BEMO_3100023 "cd00c7765086fbbe65040e649de98f22bdf10298c91d8da0f6e7300a18f0ba9f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 349" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Time–Concentration Profile Adequacy; Drug–Drug Interaction Evidence; Receptor Occupancy Evidence\", \"Common Misinterpretations\": \"Treating metabolite coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Metabolite Coverage\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The proportion and representativeness of the relevant metabolite captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses metabolite coverage using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in metabolite coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 349 ; bemo:BEMO_3100023 "4bb05358971c228c81cd2238f505b14da043cabfc3f68e3d2dd07884c7f72bc5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 35" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker-Outcome Association Strength; Context-of-Use Validity; Biomarker Qualification Strength\", \"Common Misinterpretations\": \"Treating biomarker clinical relevance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biomarker Clinical Relevance\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker clinical relevance.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses biomarker clinical relevance using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biomarker clinical relevance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 35 ; bemo:BEMO_3100023 "70bbbca5f05350dbfed193659c18ff0eef66a6552528618a931911c0bbfe7878" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 350" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Human-Relevance of Toxicological Evidence\", \"Common Misinterpretations\": \"Treating mixture interaction assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mixture Interaction Assessment\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mixture interaction assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses mixture interaction assessment using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mixture interaction assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 350 ; bemo:BEMO_3100023 "241ffa4364ee9325fbb3832728344d8484375a1aca172f524b6f871b9dc07687" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 351" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Safety Margin Evidence; Lowest-Observed-Adverse-Effect Level Robustness; Benchmark Dose Reliability\", \"Common Misinterpretations\": \"Treating no-observed-adverse-effect level robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"No-Observed-Adverse-Effect Level Robustness\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of no-observed-adverse-effect level robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses no-observed-adverse-effect level robustness using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in no-observed-adverse-effect level robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 351 ; bemo:BEMO_3100023 "f5f71661574e809d9eb1b7625ffde603665b4c0d25ddbb968f6b8d1a88c38a42" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 352" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Adverse Outcome Pathway Support; Genotoxicity Evidence Strength; Carcinogenicity Evidence Strength\", \"Common Misinterpretations\": \"Treating organ-specific toxicity evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Organ-Specific Toxicity Evidence\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of organ-specific toxicity evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses organ-specific toxicity evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in organ-specific toxicity evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 352 ; bemo:BEMO_3100023 "277a918d22b52db9e79eabf5451f64320f342f326be1cc2382f16c69ec72f0a9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 353" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Pharmacokinetic Adequacy; Bioavailability; Dose Proportionality\", \"Common Misinterpretations\": \"Treating pharmacodynamic adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Pharmacodynamic Adequacy\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The extent to which pharmacodynamic is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pharmacodynamic adequacy using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pharmacodynamic adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 353 ; bemo:BEMO_3100023 "99eef93672d2993b0ec131c09788c14463fd2a5166870e81b6b8d81c3637506b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 354" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Exposure–Response Relationship; Pharmacodynamic Adequacy; Bioavailability\", \"Common Misinterpretations\": \"Treating pharmacokinetic adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Pharmacokinetic Adequacy\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The extent to which pharmacokinetic is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pharmacokinetic adequacy using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pharmacokinetic adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 354 ; bemo:BEMO_3100023 "2b02efdd0f6a774096cee910d90b575b8f28f136a8ee594876642fb213f66330" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 355" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Exposure–Response Relationship; Pharmacokinetic Adequacy\", \"Common Misinterpretations\": \"Treating pharmacological target validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Pharmacological Target Validity\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The degree to which pharmacological target supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pharmacological target validity using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pharmacological target validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 355 ; bemo:BEMO_3100023 "2cff4752043ea892788f37639d922b1a249d83c13dfedf581ad1a4ad12ab95b8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 356" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Selectivity Profile; Efficacy Reproducibility; Therapeutic Window Evidence\", \"Common Misinterpretations\": \"Treating potency reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Potency Reproducibility\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The degree to which potency reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses potency reproducibility using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in potency reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 356 ; bemo:BEMO_3100023 "2199b92ac6c23ce1866fa6fdae782c65a478ec51834e2f0193f79d608ea4c3e7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 357" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Drug–Drug Interaction Evidence; Selectivity Profile; Potency Reproducibility\", \"Common Misinterpretations\": \"Treating receptor occupancy evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Receptor Occupancy Evidence\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of receptor occupancy evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses receptor occupancy evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in receptor occupancy evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 357 ; bemo:BEMO_3100023 "5025e34702ce03c8ed7e7aa3ed95dd9bde6bac1786183651ce608b34ffcc6a28" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 358" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Carcinogenicity Evidence Strength; Developmental Toxicity Evidence Strength; Immunotoxicity Evidence Strength\", \"Common Misinterpretations\": \"Treating reproductive toxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Reproductive Toxicity Evidence Strength\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting reproductive toxicity evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses reproductive toxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reproductive toxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 358 ; bemo:BEMO_3100023 "1725f0845040d88689ff2869cde10ea44454b5cfaa1c303d02071f7ff5ccb751" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 359" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Therapeutic Window Evidence; No-Observed-Adverse-Effect Level Robustness; Lowest-Observed-Adverse-Effect Level Robustness\", \"Common Misinterpretations\": \"Treating safety margin evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Safety Margin Evidence\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of safety margin evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses safety margin evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in safety margin evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 359 ; bemo:BEMO_3100023 "51ce0324d6952becbbadfd71ba2913a1f56afbcc33aa0148093d10994d18697d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 36" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Context-of-Use Validity; Biomarker Reliability; Biomarker Responsiveness\", \"Common Misinterpretations\": \"Treating biomarker qualification strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biomarker Qualification Strength\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting biomarker qualification.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses biomarker qualification strength using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biomarker qualification strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 36 ; bemo:BEMO_3100023 "35003a5d4be2844c7914597bb95d8d44ce388ce934a6b5067c8e498ac9e8de35" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 360" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Receptor Occupancy Evidence; Potency Reproducibility; Efficacy Reproducibility\", \"Common Misinterpretations\": \"Treating selectivity profile as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Selectivity Profile\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of selectivity profile.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses selectivity profile using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in selectivity profile can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 360 ; bemo:BEMO_3100023 "2957579a3d734fc808c8a89eb160fb182b5f5a0f68ba40c4eecc1921dea93153" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 361" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Toxicokinetic Concordance; Human-Relevance of Toxicological Evidence; Mixture Interaction Assessment\", \"Common Misinterpretations\": \"Treating species extrapolation validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Species Extrapolation Validity\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The degree to which species extrapolation supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses species extrapolation validity using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in species extrapolation validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 361 ; bemo:BEMO_3100023 "f3eb077ab3d21773df18d06eb29c8a11272ed7cbfe8f22da0ffedd8a171bc393" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 362" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Efficacy Reproducibility; Safety Margin Evidence; No-Observed-Adverse-Effect Level Robustness\", \"Common Misinterpretations\": \"Treating therapeutic window evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Therapeutic Window Evidence\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of therapeutic window evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses therapeutic window evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in therapeutic window evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 362 ; bemo:BEMO_3100023 "34f5d4730ddbb7e269fc6713d96c49c0fba2d2f738ddbfb47d339a6ed5f8cf6e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 363" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Dose Proportionality; Metabolite Coverage; Drug–Drug Interaction Evidence\", \"Common Misinterpretations\": \"Treating time–concentration profile adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Time–Concentration Profile Adequacy\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The extent to which time–concentration profile is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses time–concentration profile adequacy using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in time–concentration profile adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 363 ; bemo:BEMO_3100023 "8bfcea065494f7118cb14f95a9459e3f35fa404437872877955c4fdff069147a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 364" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Immunotoxicity Evidence Strength; Species Extrapolation Validity; Human-Relevance of Toxicological Evidence\", \"Common Misinterpretations\": \"Treating toxicokinetic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Toxicokinetic Concordance\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The degree of agreement in toxicokinetic across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses toxicokinetic concordance using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in toxicokinetic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 364 ; bemo:BEMO_3100023 "6cda2f6cb167ccc21d05523345b2fef382432ceed6ebbcbe84fa383cddc4562e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 365" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies\", \"Category\": \"Pharmacology and Toxicology\", \"Closely Related Metrics\": \"Benchmark Dose Reliability; Adverse Outcome Pathway Support; Organ-Specific Toxicity Evidence\", \"Common Misinterpretations\": \"Treating toxicological mode-of-action support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Toxicological Mode-of-Action Support\", \"References or Origin\": \"https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline\", \"Related Frameworks\": \"OECD; OHAT; FDA Biomarker; EMA E16\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting toxicological mode-of-action.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses toxicological mode-of-action support using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in toxicological mode-of-action support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 365 ; bemo:BEMO_3100023 "05b74bda1c6ce0d8b99d4d0ffdc239f28a207c0631f25d1605f8d1438c74148a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 366" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Pathway Enrichment Robustness\", \"Common Misinterpretations\": \"Treating cross-omics concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cross-Omics Concordance\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The degree of agreement in cross-omics across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cross-omics concordance using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cross-omics concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 366 ; bemo:BEMO_3100023 "447ad3207c1d5333015f6a5189727d810a3a517e4d6a4351f8dc28acbe93a5f0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 367" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Extraction Recovery; Metabolic Feature Reproducibility; Pathway Enrichment Robustness\", \"Common Misinterpretations\": \"Treating derivatization efficiency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Derivatization Efficiency\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of derivatization efficiency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses derivatization efficiency using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in derivatization efficiency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 367 ; bemo:BEMO_3100023 "d83b78fc8beda508a5c18da8dbb9e284c948a9741d4fb8d070f9f30bc9267827" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 368" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Quantification Accuracy; Missing-Value Burden; Ion Suppression Assessment\", \"Common Misinterpretations\": \"Treating dynamic range coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Dynamic Range Coverage\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The proportion and representativeness of the relevant dynamic range captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses dynamic range coverage using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dynamic range coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 368 ; bemo:BEMO_3100023 "57e4c77ea2a48565f0758aadf8529c7db52bab9beb67f6e9c8366f0f3232e753" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 369" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Internal Standard Performance; Derivatization Efficiency; Metabolic Feature Reproducibility\", \"Common Misinterpretations\": \"Treating extraction recovery as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Extraction Recovery\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of extraction recovery.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses extraction recovery using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in extraction recovery can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 369 ; bemo:BEMO_3100023 "5024c9034e231e8bc296cf1d9092cc063fe94890f4856d8bf70ac077514b55f9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 37" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker Qualification Strength; Biomarker Responsiveness; Biomarker Sensitivity to Change\", \"Common Misinterpretations\": \"Treating biomarker reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biomarker Reliability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker reliability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses biomarker reliability using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biomarker reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 37 ; bemo:BEMO_3100023 "74c0c7f33ecc210cbe2fa1dd5ddc15c31273005f3e5caaa4afc370a3f6c94a4e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 370" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Protein Identification Confidence; Peptide-Spectrum Match Quality; Protein Inference Reliability\", \"Common Misinterpretations\": \"Treating false discovery rate control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"False Discovery Rate Control\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of false discovery rate control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses false discovery rate control using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in false discovery rate control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 370 ; bemo:BEMO_3100023 "4059adb92dbe8fea43e57c309bf3c42531450ae52d814c6f79932af37f2f97a2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 371" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Isotope Pattern Fidelity; Post-Translational Modification Localization Confidence; Proteoform Identification Confidence\", \"Common Misinterpretations\": \"Treating fragmentation spectrum quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Fragmentation Spectrum Quality\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of fragmentation spectrum quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses fragmentation spectrum quality using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in fragmentation spectrum quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 371 ; bemo:BEMO_3100023 "4295f539b87882bc52461f7bd190419d6afdf7864927b9a24efe1e5f65c9fcd7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 372" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Spectral Library Match Quality; Extraction Recovery; Derivatization Efficiency\", \"Common Misinterpretations\": \"Treating internal standard performance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Internal Standard Performance\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of internal standard performance.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses internal standard performance using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in internal standard performance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 372 ; bemo:BEMO_3100023 "904dce77d19fcc637d6eae56d2d92b19b7052fd578de120e2a18bb08d00f2f54" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 373" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Missing-Value Burden; Retention-Time Stability; Mass Accuracy\", \"Common Misinterpretations\": \"Treating ion suppression assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Ion Suppression Assessment\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of ion suppression assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses ion suppression assessment using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in ion suppression assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 373 ; bemo:BEMO_3100023 "c108ebf1ca903ed7e96063f24ecaf39723dd5e925f97d641601f89fd859897b9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 374" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Mass Accuracy; Fragmentation Spectrum Quality; Post-Translational Modification Localization Confidence\", \"Common Misinterpretations\": \"Treating isotope pattern fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Isotope Pattern Fidelity\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of isotope pattern fidelity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses isotope pattern fidelity using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in isotope pattern fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 374 ; bemo:BEMO_3100023 "beec5d62727ea3baba10451d532801205b190af60b03027284c15989d51ba1e4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 375" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Retention-Time Stability; Isotope Pattern Fidelity; Fragmentation Spectrum Quality\", \"Common Misinterpretations\": \"Treating mass accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Mass Accuracy\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The closeness of mass to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses mass accuracy using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in mass accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 375 ; bemo:BEMO_3100023 "ebb0e828e6a056d20bce6788aee10b743cfcc2fc175a82fd693585711880ff73" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 376" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Derivatization Efficiency; Pathway Enrichment Robustness; Cross-Omics Concordance\", \"Common Misinterpretations\": \"Treating metabolic feature reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Metabolic Feature Reproducibility\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The degree to which metabolic feature reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses metabolic feature reproducibility using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in metabolic feature reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 376 ; bemo:BEMO_3100023 "521bf8b7c1bbe892685e95c05cc7d63a05c4e26119e9951d705ff460b3bb99d1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 377" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Metabolite Identification Confidence; Spectral Library Match Quality; Internal Standard Performance\", \"Common Misinterpretations\": \"Treating metabolite annotation level as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Metabolite Annotation Level\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of metabolite annotation level.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses metabolite annotation level using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in metabolite annotation level can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 377 ; bemo:BEMO_3100023 "883e5fdd2ff9e198b3ddcbafc3e6478eed144bbcc7f46c67f19ec93850e8ec4c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 378" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Proteoform Identification Confidence; Metabolite Annotation Level; Spectral Library Match Quality\", \"Common Misinterpretations\": \"Treating metabolite identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Metabolite Identification Confidence\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The justified degree of certainty assigned to metabolite identification given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses metabolite identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in metabolite identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 378 ; bemo:BEMO_3100023 "dd08774f62d4c8036bc0f7c590a94eca58c7ca0613c38dec0e386cab59cc0dbd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 379" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Dynamic Range Coverage; Ion Suppression Assessment; Retention-Time Stability\", \"Common Misinterpretations\": \"Treating missing-value burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Missing-Value Burden\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of missing-value burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses missing-value burden using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in missing-value burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 379 ; bemo:BEMO_3100023 "770bd2fa8c1eedf14831e8e8caca6d53a1ad4a7b7272433891be0eac41a4e30c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 38" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker Reliability; Biomarker Sensitivity to Change; Known-Groups Validity\", \"Common Misinterpretations\": \"Treating biomarker responsiveness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biomarker Responsiveness\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker responsiveness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses biomarker responsiveness using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biomarker responsiveness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 38 ; bemo:BEMO_3100023 "19a54854b5dfb7168eddad304da95ddbab2e1ad34992146fcedfd650dfe09548" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 380" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Metabolic Feature Reproducibility; Cross-Omics Concordance\", \"Common Misinterpretations\": \"Treating pathway enrichment robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Pathway Enrichment Robustness\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of pathway enrichment robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pathway enrichment robustness using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pathway enrichment robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 380 ; bemo:BEMO_3100023 "1a891a794290e0f5eee9ca88b64bc6b46d5840f63c8709e0e546399158fbb914" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 381" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Protein Identification Confidence; False Discovery Rate Control\", \"Common Misinterpretations\": \"Treating peptide identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Peptide Identification Confidence\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The justified degree of certainty assigned to peptide identification given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses peptide identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in peptide identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 381 ; bemo:BEMO_3100023 "7f78eede8aa05781dde3f12d7ea8111e1c0b552f5b722c402b0de5323e65b0ea" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 382" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"False Discovery Rate Control; Protein Inference Reliability; Proteome Coverage\", \"Common Misinterpretations\": \"Treating peptide-spectrum match quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Peptide-Spectrum Match Quality\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of peptide-spectrum match quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses peptide-spectrum match quality using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in peptide-spectrum match quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 382 ; bemo:BEMO_3100023 "69f7898b8265a7daaa45bd90d4d5387c92da6521721d3c4901a5c208a63f0169" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 383" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Fragmentation Spectrum Quality; Proteoform Identification Confidence; Metabolite Identification Confidence\", \"Common Misinterpretations\": \"Treating post-translational modification localization confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Post-Translational Modification Localization Confidence\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The justified degree of certainty assigned to post-translational modification localization given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses post-translational modification localization confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in post-translational modification localization confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 383 ; bemo:BEMO_3100023 "6761ab89a934b85357a2d58a5e53503065037a8cd658104babdb5536291a3653" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 384" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Peptide Identification Confidence; False Discovery Rate Control; Peptide-Spectrum Match Quality\", \"Common Misinterpretations\": \"Treating protein identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Protein Identification Confidence\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The justified degree of certainty assigned to protein identification given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses protein identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protein identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 384 ; bemo:BEMO_3100023 "86cf8ad175ebd274f625e908935f946750c2c41a33f40e7a8dc33224d8db7d28" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 385" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Peptide-Spectrum Match Quality; Proteome Coverage; Sequence Coverage\", \"Common Misinterpretations\": \"Treating protein inference reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Protein Inference Reliability\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protein inference reliability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses protein inference reliability using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protein inference reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 385 ; bemo:BEMO_3100023 "601ad0978c475da6065d2502b00169f5521ae97cb0543ad15ad88f49903cb27e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 386" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Post-Translational Modification Localization Confidence; Metabolite Identification Confidence; Metabolite Annotation Level\", \"Common Misinterpretations\": \"Treating proteoform identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Proteoform Identification Confidence\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The justified degree of certainty assigned to proteoform identification given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses proteoform identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in proteoform identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 386 ; bemo:BEMO_3100023 "8df86e86625f432ba76b927808300a9cfa4a9b6844cae40ca0c6240f4f899eda" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 387" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Protein Inference Reliability; Sequence Coverage; Quantification Precision\", \"Common Misinterpretations\": \"Treating proteome coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Proteome Coverage\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The proportion and representativeness of the relevant proteome captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses proteome coverage using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in proteome coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 387 ; bemo:BEMO_3100023 "5fec1390446b523e8b6072b1babcb11902375d326650ad448b800e258e0a8401" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 388" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Quantification Precision; Dynamic Range Coverage; Missing-Value Burden\", \"Common Misinterpretations\": \"Treating quantification accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Quantification Accuracy\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The closeness of quantification to the accepted reference or true value.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses quantification accuracy using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in quantification accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 388 ; bemo:BEMO_3100023 "5205abd1da59c18e5b7272ce8586c2ec2bee590ad36aa3289ce71f4aa4c17c0b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 389" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Sequence Coverage; Quantification Accuracy; Dynamic Range Coverage\", \"Common Misinterpretations\": \"Treating quantification precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Quantification Precision\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The closeness of repeated estimates or measurements and the narrowness of uncertainty around quantification.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses quantification precision using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in quantification precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 389 ; bemo:BEMO_3100023 "6e5af7c1fffa7603da0abd7518a670fd09cade5fe3e47c8417886f91e6b4e07a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 39" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker Responsiveness; Known-Groups Validity; Convergent Validity\", \"Common Misinterpretations\": \"Treating biomarker sensitivity to change as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Biomarker Sensitivity to Change\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker sensitivity to change.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses biomarker sensitivity to change using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biomarker sensitivity to change can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 39 ; bemo:BEMO_3100023 "80beed232e03f65da1843b394120d8baef7fb4428401374caac926260837e2b2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 390" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Ion Suppression Assessment; Mass Accuracy; Isotope Pattern Fidelity\", \"Common Misinterpretations\": \"Treating retention-time stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Retention-Time Stability\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of retention-time stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses retention-time stability using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in retention-time stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 390 ; bemo:BEMO_3100023 "7ed489b83705dc957b891fd6483e7b54ca4c70547f903f7dfa9e53d0ca59fa58" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 391" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Proteome Coverage; Quantification Precision; Quantification Accuracy\", \"Common Misinterpretations\": \"Treating sequence coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Sequence Coverage\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"The proportion and representativeness of the relevant sequence captured by the evidence or measurement process.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses sequence coverage using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in sequence coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 391 ; bemo:BEMO_3100023 "f98e41911ad517a10150d0d24373bec15a553a9812e119c2e6a10081e9a89aaf" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 392" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies\", \"Category\": \"Proteomics and Metabolomics\", \"Closely Related Metrics\": \"Metabolite Annotation Level; Internal Standard Performance; Extraction Recovery\", \"Common Misinterpretations\": \"Treating spectral library match quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Spectral Library Match Quality\", \"References or Origin\": \"https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/\", \"Related Frameworks\": \"MIAPE; HUPO PSI; Metabolomics Standards\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of spectral library match quality.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses spectral library match quality using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in spectral library match quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 392 ; bemo:BEMO_3100023 "5f1fa5732761f5ddf9eae216997fca90d2ec95264368ca476160849aac179e9a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 393" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Conceptual Replication Success; Computational Reproducibility; Experimental Reproducibility\", \"Common Misinterpretations\": \"Treating analytical reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Analytical Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which analytical reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses analytical reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in analytical reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 393 ; bemo:BEMO_3100023 "8e400bbae5ea25bca3af45f9c956cb2ceeb52ded61247de3b92d5364736bab99" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 394" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Material Availability; Data Availability; Random-Seed Stability\", \"Common Misinterpretations\": \"Treating code availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Code Availability\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of code availability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses code availability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in code availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 394 ; bemo:BEMO_3100023 "196f2dc58cfb1ea70e003d9904020fcfd1f4feec7308ace2e85d573eb71d3b5e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 395" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Analytical Reproducibility; Experimental Reproducibility; Interlaboratory Reproducibility\", \"Common Misinterpretations\": \"Treating computational reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Computational Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which computational reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses computational reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in computational reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 395 ; bemo:BEMO_3100023 "c15f070192e578e50deb91384b3e8099e5c4b1a0c28cc84d1ac6a3163d36cd17" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 396" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Direct Replication Success; Analytical Reproducibility; Computational Reproducibility\", \"Common Misinterpretations\": \"Treating conceptual replication success as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Conceptual Replication Success\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of conceptual replication success.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses conceptual replication success using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in conceptual replication success can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 396 ; bemo:BEMO_3100023 "45fcdc0cd9da1d73796f886d24683b4f40ead7f7a14a06e84d39631b66a910ad" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 397" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Code Availability; Random-Seed Stability; Researcher-Degrees-of-Freedom Sensitivity\", \"Common Misinterpretations\": \"Treating data availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Data Availability\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of data availability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses data availability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in data availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 397 ; bemo:BEMO_3100023 "89d3d59a31fe591c17a3c61f83a55d18326e4b311b8033047e95bfb2a93715fa" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 398" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Reanalysis Concordance; Protocol Reproducibility; Material Availability\", \"Common Misinterpretations\": \"Treating data provenance completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Data Provenance Completeness\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of data provenance are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses data provenance completeness using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in data provenance completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 398 ; bemo:BEMO_3100023 "da25c768c2ee710f0cf6b50b686a1880c8166dd651b4f062c14e952fc1bdf622" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 399" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Independent Replication Strength; Conceptual Replication Success; Analytical Reproducibility\", \"Common Misinterpretations\": \"Treating direct replication success as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Direct Replication Success\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of direct replication success.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses direct replication success using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in direct replication success can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 399 ; bemo:BEMO_3100023 "e6b0ec1b803bb2c7cb8becab175dbb88ab91c9d8ccd3f713a814c836846ea547" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 40" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Clinical Validity; Biomarker Clinical Relevance; Context-of-Use Validity\", \"Common Misinterpretations\": \"Treating biomarker-outcome association strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biomarker-Outcome Association Strength\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting biomarker-outcome association.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses biomarker-outcome association strength using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biomarker-outcome association strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 40 ; bemo:BEMO_3100023 "d54499df144e3534026302c035690746b731c0abf25107f5fccdd8bada0bd79a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 400" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Computational Reproducibility; Interlaboratory Reproducibility; Intralaboratory Repeatability\", \"Common Misinterpretations\": \"Treating experimental reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Experimental Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which experimental reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses experimental reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in experimental reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 400 ; bemo:BEMO_3100023 "6c9d1f649c85d73c0009300283cb79e817b0ca9b1d53444f1a4aa4b5a2e6d8ae" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 401" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Direct Replication Success; Conceptual Replication Success\", \"Common Misinterpretations\": \"Treating independent replication strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Independent Replication Strength\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting independent replication.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses independent replication strength using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in independent replication strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 401 ; bemo:BEMO_3100023 "3837461a84fca58515b90e02475b1cf195c845c2cf4704aa9d0c7c2b412d9406" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 402" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Result Reproducibility; Reanalysis Concordance; Data Provenance Completeness\", \"Common Misinterpretations\": \"Treating inferential reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Inferential Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which inferential reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses inferential reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in inferential reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 402 ; bemo:BEMO_3100023 "b49eb32e7bf118727039f0240b17aee8970c665e4a359a2bcecc87341188ecf1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 403" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Experimental Reproducibility; Intralaboratory Repeatability; Method Reproducibility\", \"Common Misinterpretations\": \"Treating interlaboratory reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Interlaboratory Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which interlaboratory reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses interlaboratory reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in interlaboratory reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 403 ; bemo:BEMO_3100023 "0977ae8d7278730723c8d024585a95d1125aa9fe6da897fe977a079b172ddb48" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 404" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Interlaboratory Reproducibility; Method Reproducibility; Result Reproducibility\", \"Common Misinterpretations\": \"Treating intralaboratory repeatability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Intralaboratory Repeatability\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which intralaboratory repeatability yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses intralaboratory repeatability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in intralaboratory repeatability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 404 ; bemo:BEMO_3100023 "44bfb4ae3b82bb963a97cc8f3dfed3bd610b7903405993c8f3031931f746d1ce" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 405" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Protocol Reproducibility; Code Availability; Data Availability\", \"Common Misinterpretations\": \"Treating material availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Material Availability\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of material availability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses material availability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in material availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 405 ; bemo:BEMO_3100023 "ad24de4b8dd0c9ae8c1a3d7d5fcdd166b9bd923967cbf8032882e26fce35feb2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 406" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Intralaboratory Repeatability; Result Reproducibility; Inferential Reproducibility\", \"Common Misinterpretations\": \"Treating method reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Method Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which method reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses method reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in method reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 406 ; bemo:BEMO_3100023 "b36c4ba0356ae6813b5bb255ebc6934635b0cbf83c44326cfea7019592803c5e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 407" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Researcher-Degrees-of-Freedom Sensitivity; Specification-Curve Robustness\", \"Common Misinterpretations\": \"Treating multiverse analysis robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Specialized / infrequent\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Multiverse Analysis Robustness\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of multiverse analysis robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses multiverse analysis robustness using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in multiverse analysis robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 407 ; bemo:BEMO_3100023 "80472d064c943a6566bee4bd605245ecac370ebde0eb5ae577d7687482d47cc8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 408" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Data Provenance Completeness; Material Availability; Code Availability\", \"Common Misinterpretations\": \"Treating protocol reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Protocol Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which protocol reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses protocol reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protocol reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 408 ; bemo:BEMO_3100023 "caa28491bc96ceb6cd2e1c6685b9eb89f21391a6d4502473143986af13cc088b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 409" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Data Availability; Researcher-Degrees-of-Freedom Sensitivity; Multiverse Analysis Robustness\", \"Common Misinterpretations\": \"Treating random-seed stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Random-Seed Stability\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of random-seed stability.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses random-seed stability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in random-seed stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 409 ; bemo:BEMO_3100023 "c1a5a2e956afa3ff1606fb1893282ee7b8d5d3733fbd04798630fe0746f86074" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 41" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker-Outcome Association Strength; Biomarker Clinical Relevance\", \"Common Misinterpretations\": \"Treating clinical validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Clinical Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which clinical supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses clinical validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in clinical validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 41 ; bemo:BEMO_3100023 "628005d99d3e18a7b100ce400c64fc5218e46beeaa2cfec80dbac2445270cead" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 410" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Inferential Reproducibility; Data Provenance Completeness; Protocol Reproducibility\", \"Common Misinterpretations\": \"Treating reanalysis concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Reanalysis Concordance\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree of agreement in reanalysis across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses reanalysis concordance using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reanalysis concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 410 ; bemo:BEMO_3100023 "07f0b47b85e307e7887d3c938a89cbcad651d37d8bfa888ea4ce710d25410a29" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 411" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Random-Seed Stability; Multiverse Analysis Robustness; Specification-Curve Robustness\", \"Common Misinterpretations\": \"Treating researcher-degrees-of-freedom sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Researcher-Degrees-of-Freedom Sensitivity\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of researcher-degrees-of-freedom sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses researcher-degrees-of-freedom sensitivity using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in researcher-degrees-of-freedom sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 411 ; bemo:BEMO_3100023 "c196ee0e5b3c49cffc78d559a15b400e1dec74f4854200e7fbd341eef60a59c4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 412" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Method Reproducibility; Inferential Reproducibility; Reanalysis Concordance\", \"Common Misinterpretations\": \"Treating result reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Result Reproducibility\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"The degree to which result reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses result reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in result reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 412 ; bemo:BEMO_3100023 "60121a2998efa943018d3ff7dd4130d4332ee279da0e8111b650ea175e9dacce" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 413" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All experimental, computational, clinical, and omics studies\", \"Category\": \"Reproducibility and Replication\", \"Closely Related Metrics\": \"Multiverse Analysis Robustness\", \"Common Misinterpretations\": \"Treating specification-curve robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Specialized / infrequent\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Developing\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Specification-Curve Robustness\", \"References or Origin\": \"https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines\", \"Related Frameworks\": \"PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of specification-curve robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses specification-curve robustness using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in specification-curve robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 413 ; bemo:BEMO_3100023 "290b2551a20c17c23c05ae84270ce7ac2c9d4a43b9817050cdbe8a353ce743ac" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 414" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Data-Sharing Transparency; Materials-and-Reagents Reporting Completeness; Metadata Completeness\", \"Common Misinterpretations\": \"Treating code-sharing transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Code-Sharing Transparency\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of code-sharing transparency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses code-sharing transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in code-sharing transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 414 ; bemo:BEMO_3100023 "d85d4b116984de9e36c9410fc248aae4b536153c50f4651cf7e48c6b558b49eb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 415" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Intervention Description Completeness; Eligibility Criteria Completeness; Recruitment Reporting Completeness\", \"Common Misinterpretations\": \"Treating comparator description completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Comparator Description Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of comparator description are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses comparator description completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in comparator description completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 415 ; bemo:BEMO_3100023 "a4617b71362b91773383e09e14a13eab2a1f342da234aa0f9bf7cc4400a6ff10" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 416" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Funding-Source Transparency; Data-Sharing Transparency; Code-Sharing Transparency\", \"Common Misinterpretations\": \"Treating conflict-of-interest transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Conflict-of-Interest Transparency\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of conflict-of-interest transparency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses conflict-of-interest transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in conflict-of-interest transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 416 ; bemo:BEMO_3100023 "e951e1891736a22e6ef317b85f2f1f3032c69473b10d7ac72b1ed8342656df25" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 417" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Conflict-of-Interest Transparency; Code-Sharing Transparency; Materials-and-Reagents Reporting Completeness\", \"Common Misinterpretations\": \"Treating data-sharing transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Data-Sharing Transparency\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of data-sharing transparency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses data-sharing transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in data-sharing transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 417 ; bemo:BEMO_3100023 "24a8774755f1b71359ef7a35f4a7813a446670f2da0ccc38d22836e1a84f1453" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 418" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Null-Result Interpretability; Reproducibility Information Completeness\", \"Common Misinterpretations\": \"Treating deviations-from-protocol transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Deviations-from-Protocol Transparency\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of deviations-from-protocol transparency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses deviations-from-protocol transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in deviations-from-protocol transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 418 ; bemo:BEMO_3100023 "6d08df9b94938aa4356ba3bbe963ef6fed2e0e499e09e30936b635d55a24d3c8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 419" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Comparator Description Completeness; Recruitment Reporting Completeness; Participant Flow Completeness\", \"Common Misinterpretations\": \"Treating eligibility criteria completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Eligibility Criteria Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of eligibility criteria are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses eligibility criteria completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in eligibility criteria completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 419 ; bemo:BEMO_3100023 "02e23f40dd856c6f19f825d6191af4cb70f9ed2e604c47f5cbd7bf406e4d2381" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 42" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Criterion Validity; Content Validity; Predictive Biomarker Validity\", \"Common Misinterpretations\": \"Treating construct validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Construct Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which construct supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses construct validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in construct validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 42 ; bemo:BEMO_3100023 "5bd558ed006f260bde44545e9ab38951fc6c2e450b4d3cb07f929d1fcb479f4e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 420" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Missing-Data Reporting Completeness; Conflict-of-Interest Transparency; Data-Sharing Transparency\", \"Common Misinterpretations\": \"Treating funding-source transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Funding-Source Transparency\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of funding-source transparency.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses funding-source transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in funding-source transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 420 ; bemo:BEMO_3100023 "35377c10ba740cabcf147ce4b6ab00e3a9c4087ca2ca810c337f7fe08223e6f9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 421" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Participant Flow Completeness; Statistical Methods Reporting Completeness; Missing-Data Reporting Completeness\", \"Common Misinterpretations\": \"Treating harms reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Harms Reporting Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of harms reporting are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses harms reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in harms reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 421 ; bemo:BEMO_3100023 "15ffc51fd66113f5e5c480a7127c592104dbff4a2e6faafcfafb509cd725ea07" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 422" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Outcome Definition Completeness; Comparator Description Completeness; Eligibility Criteria Completeness\", \"Common Misinterpretations\": \"Treating intervention description completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Intervention Description Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of intervention description are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses intervention description completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in intervention description completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 422 ; bemo:BEMO_3100023 "52ff9263e3651129913da102dae69c16126528e71dde3bf30595ca84301723b5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 423" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Code-Sharing Transparency; Metadata Completeness; Raw-Data Availability\", \"Common Misinterpretations\": \"Treating materials-and-reagents reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Materials-and-Reagents Reporting Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of materials-and-reagents reporting are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses materials-and-reagents reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in materials-and-reagents reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 423 ; bemo:BEMO_3100023 "fc72795f141f7cb81bc8cc86190a0c7cf2a5f2f6065d3b22f9bc88dd2e13080e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 424" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Materials-and-Reagents Reporting Completeness; Raw-Data Availability; Processed-Data Availability\", \"Common Misinterpretations\": \"Treating metadata completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Metadata Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of metadata are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses metadata completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in metadata completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 424 ; bemo:BEMO_3100023 "cfce2b3ca58f108e1dc5461ad1ef2f5a84b55171c75536d306bf4e1e2b3bc58d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 425" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Statistical Methods Reporting Completeness; Funding-Source Transparency; Conflict-of-Interest Transparency\", \"Common Misinterpretations\": \"Treating missing-data reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Missing-Data Reporting Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of missing-data reporting are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses missing-data reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in missing-data reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 425 ; bemo:BEMO_3100023 "810e02862dfc4630d6f7a0d7bd830ccd305d847e2d0153cfdb863b68f1c2ece8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 426" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Quality-Control Reporting Completeness; Null-Result Interpretability; Deviations-from-Protocol Transparency\", \"Common Misinterpretations\": \"Treating negative-result reporting as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Negative-Result Reporting\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative-result reporting.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses negative-result reporting using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in negative-result reporting can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 426 ; bemo:BEMO_3100023 "f6803e55dc7d7550d62e5bed1f8773c7da7d0266b37145da5354a96ceaf769c2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 427" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Negative-Result Reporting; Deviations-from-Protocol Transparency; Reproducibility Information Completeness\", \"Common Misinterpretations\": \"Treating null-result interpretability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Null-Result Interpretability\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of null-result interpretability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses null-result interpretability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in null-result interpretability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 427 ; bemo:BEMO_3100023 "0e7be34e4db71c86201d878decffa3c8da8ca62a1c8481dc3779d3c4caa454b1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 428" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Prespecified Analysis Adherence; Intervention Description Completeness; Comparator Description Completeness\", \"Common Misinterpretations\": \"Treating outcome definition completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Outcome Definition Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of outcome definition are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses outcome definition completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in outcome definition completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 428 ; bemo:BEMO_3100023 "129e8fff9350e8d3fb88d0a300e3816f498afcc03cf17b3f6037da094441e4fe" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 429" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Recruitment Reporting Completeness; Harms Reporting Completeness; Statistical Methods Reporting Completeness\", \"Common Misinterpretations\": \"Treating participant flow completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Participant Flow Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of participant flow are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses participant flow completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in participant flow completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 429 ; bemo:BEMO_3100023 "c3caaa14ecea68f7075a25ef235cdae89d1a9b9b86ed2b5a30dab5cb5b8bf20d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 43" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Construct Validity; Predictive Biomarker Validity; Prognostic Biomarker Validity\", \"Common Misinterpretations\": \"Treating content validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Content Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which content supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses content validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in content validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 43 ; bemo:BEMO_3100023 "1ceb580fd3a672a7c14d44163bda2886dd03d14b99ce004f1db40aa485bb3e1b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 430" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Prospective Registration; Outcome Definition Completeness; Intervention Description Completeness\", \"Common Misinterpretations\": \"Treating prespecified analysis adherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Prespecified Analysis Adherence\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prespecified analysis adherence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses prespecified analysis adherence using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prespecified analysis adherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 430 ; bemo:BEMO_3100023 "fe370510831c4feb18d187a9f8348ee0b93ff3174da9ddceea906467255bbd60" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 431" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Raw-Data Availability; Quality-Control Reporting Completeness; Negative-Result Reporting\", \"Common Misinterpretations\": \"Treating processed-data availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Processed-Data Availability\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of processed-data availability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses processed-data availability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in processed-data availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 431 ; bemo:BEMO_3100023 "3d4a65e6d3c66bcaca4ff40b6df33feaedf2f77c58697c32f80c96a00d211e95" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 432" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Protocol Availability; Prespecified Analysis Adherence; Outcome Definition Completeness\", \"Common Misinterpretations\": \"Treating prospective registration as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Prospective Registration\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prospective registration.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses prospective registration using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prospective registration can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 432 ; bemo:BEMO_3100023 "32ae2352b0f17339d30893a08c10c681c7fa3992e6b60a3343dae6e95aa8dda5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 433" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Prospective Registration; Prespecified Analysis Adherence\", \"Common Misinterpretations\": \"Treating protocol availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Protocol Availability\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protocol availability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses protocol availability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protocol availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 433 ; bemo:BEMO_3100023 "6e6dfc0138818017108063ab02fea9da669c25ffc36ec988048eb058c538f84a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 434" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Processed-Data Availability; Negative-Result Reporting; Null-Result Interpretability\", \"Common Misinterpretations\": \"Treating quality-control reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Quality-Control Reporting Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of quality-control reporting are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses quality-control reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in quality-control reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 434 ; bemo:BEMO_3100023 "b53b586f994fd48c27b9acc1c6fff59b966085610e593ec05c03735d90e329b2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 435" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Metadata Completeness; Processed-Data Availability; Quality-Control Reporting Completeness\", \"Common Misinterpretations\": \"Treating raw-data availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Raw-Data Availability\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of raw-data availability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses raw-data availability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in raw-data availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 435 ; bemo:BEMO_3100023 "2fcf4f96e7ca202f61d3de161ead38ea506d30ac8f05b66ac8a84b27f3da645e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 436" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Eligibility Criteria Completeness; Participant Flow Completeness; Harms Reporting Completeness\", \"Common Misinterpretations\": \"Treating recruitment reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Recruitment Reporting Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of recruitment reporting are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses recruitment reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in recruitment reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 436 ; bemo:BEMO_3100023 "d9e587b4cd42324cc1668fb835e848ce02fea72bac0af2f37bcc6e0a40cbc327" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 437" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Deviations-from-Protocol Transparency\", \"Common Misinterpretations\": \"Treating reproducibility information completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Reproducibility Information Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of reproducibility information are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses reproducibility information completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in reproducibility information completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 437 ; bemo:BEMO_3100023 "3aaeec4ac26a2a3b26b615c686a2f19768e2153bd9e1e676bdcd1f2ba2812fc8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 438" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All biomedical study reports and data releases\", \"Category\": \"Research Transparency and Reporting Completeness\", \"Closely Related Metrics\": \"Harms Reporting Completeness; Missing-Data Reporting Completeness; Funding-Source Transparency\", \"Common Misinterpretations\": \"Treating statistical methods reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Study report / dataset / evidence package\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Statistical Methods Reporting Completeness\", \"References or Origin\": \"https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/\", \"Related Frameworks\": \"EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of statistical methods reporting are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses statistical methods reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in statistical methods reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 438 ; bemo:BEMO_3100023 "d8af14618f3e80ecff3b617a35c54caa9b3c73184f234fcea88a9ee83c7090ff" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 439" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Fragility Index; Posterior Probability Strength; Prior Sensitivity\", \"Common Misinterpretations\": \"Treating bayes factor evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Bayes Factor Evidence\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of bayes factor evidence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses bayes factor evidence using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in bayes factor evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 439 ; bemo:BEMO_3100023 "ea8be0499c9c5441e47cac85f3e884bcc28099d593610c01dc6ad24ba5c3d0f3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 44" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker Clinical Relevance; Biomarker Qualification Strength; Biomarker Reliability\", \"Common Misinterpretations\": \"Treating context-of-use validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Context-of-Use Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which context-of-use supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses context-of-use validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in context-of-use validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 44 ; bemo:BEMO_3100023 "170c4bee423f9901b11abd5c6c7203f1253da40dbd46a33c459bac07471058e8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 440" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Measurement Error Correction; Discrimination of Statistical Predictions; Decision-Curve Net Benefit\", \"Common Misinterpretations\": \"Treating calibration of statistical predictions as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Calibration of Statistical Predictions\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration of statistical predictions.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses calibration of statistical predictions using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in calibration of statistical predictions can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 440 ; bemo:BEMO_3100023 "1d5cbda1b0dc5b30aa8339e6219d08168170bd684f74bf0679b26dd4ece9ead4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 441" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Decision-Curve Net Benefit; Fragility Index; Bayes Factor Evidence\", \"Common Misinterpretations\": \"Treating clinical relevance of effect as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Clinical Relevance of Effect\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of clinical relevance of effect.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses clinical relevance of effect using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in clinical relevance of effect can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 441 ; bemo:BEMO_3100023 "7e04bf59de003d9389f3d5e5a39c09dbec7b25b54fdd665e24d339ccf148fb17" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 442" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Estimate Precision; Statistical Power; Type I Error Control\", \"Common Misinterpretations\": \"Treating confidence interval compatibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Confidence Interval Compatibility\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The justified degree of certainty assigned to confidence interval compatibility given the quantity, quality, consistency, and limitations of supporting evidence.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses confidence interval compatibility using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in confidence interval compatibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 442 ; bemo:BEMO_3100023 "4b44e65362db0ef8f1ef0ae6eb87b631fd22642d5790f792ab6c3d6a9a693508" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 443" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Discrimination of Statistical Predictions; Clinical Relevance of Effect; Fragility Index\", \"Common Misinterpretations\": \"Treating decision-curve net benefit as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Decision-Curve Net Benefit\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of decision-curve net benefit.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses decision-curve net benefit using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in decision-curve net benefit can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 443 ; bemo:BEMO_3100023 "7e96f3c494e389efab04f0ca564863ebd840cadeaf424446d3f94ddb483ed76c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 444" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Calibration of Statistical Predictions; Decision-Curve Net Benefit; Clinical Relevance of Effect\", \"Common Misinterpretations\": \"Treating discrimination of statistical predictions as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Discrimination of Statistical Predictions\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of discrimination of statistical predictions.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses discrimination of statistical predictions using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in discrimination of statistical predictions can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 444 ; bemo:BEMO_3100023 "cf100cd63561a5d7a167b9d561a196b9309ca048456a8705766e76a54a524fce" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 445" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Residual Diagnostics Adequacy; Variance Estimation Validity; Missing-Data Mechanism Plausibility\", \"Common Misinterpretations\": \"Treating distributional assumption adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Distributional Assumption Adequacy\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The extent to which distributional assumption is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses distributional assumption adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in distributional assumption adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 445 ; bemo:BEMO_3100023 "79608c041c0babc1613cca804b9e22a2fcbadbeabfda7d7b0bf2336528db7db1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 446" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Estimate Precision; Confidence Interval Compatibility\", \"Common Misinterpretations\": \"Treating effect magnitude as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Effect Magnitude\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of effect magnitude.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses effect magnitude using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in effect magnitude can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 446 ; bemo:BEMO_3100023 "e21896fd55cc8da1ecb273cc15de195832d87a4d4554d2b68b3a9ce060442d84" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 447" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Prior Sensitivity; Noninferiority Margin Validity\", \"Common Misinterpretations\": \"Treating equivalence margin validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Equivalence Margin Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The degree to which equivalence margin supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses equivalence margin validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in equivalence margin validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 447 ; bemo:BEMO_3100023 "226b21fe561d36c12bfde0bcc47bb1ad6cb02760533a4b768747d6a0ab92184b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 448" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Effect Magnitude; Confidence Interval Compatibility; Statistical Power\", \"Common Misinterpretations\": \"Treating estimate precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Estimate Precision\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The closeness of repeated estimates or measurements and the narrowness of uncertainty around estimate.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses estimate precision using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in estimate precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 448 ; bemo:BEMO_3100023 "9458d6e4371d11a80963339d3a9a6c5dcc187a36080cf18d964ecb5827c41820" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 449" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Clinical Relevance of Effect; Bayes Factor Evidence; Posterior Probability Strength\", \"Common Misinterpretations\": \"Treating fragility index as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Fragility Index\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of fragility index.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses fragility index using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in fragility index can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 449 ; bemo:BEMO_3100023 "045c39ed086cc31d598f1fe91547a90170ea8cc0b684f22d5338144e750a0843" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 45" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Known-Groups Validity; Discriminant Validity; Criterion Validity\", \"Common Misinterpretations\": \"Treating convergent validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Convergent Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which convergent supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses convergent validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in convergent validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 45 ; bemo:BEMO_3100023 "4ad4866845885f677cad74042f65b0303f2d26597ea694b76dfed4bc71fedd68" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 450" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Missing-Data Sensitivity; Outlier Influence Robustness; Influential Observation Sensitivity\", \"Common Misinterpretations\": \"Treating imputation validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Imputation Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The degree to which imputation supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses imputation validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in imputation validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 450 ; bemo:BEMO_3100023 "451bb1f13aa8cd7feb728a231f72c948355ace1a73de7f1903381352517ceaf5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 451" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Outlier Influence Robustness; Nonlinearity Assessment; Interaction Assessment Adequacy\", \"Common Misinterpretations\": \"Treating influential observation sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Influential Observation Sensitivity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of influential observation sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses influential observation sensitivity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in influential observation sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 451 ; bemo:BEMO_3100023 "0202d30b443e9ba2dd8ad4597c8e7b9fcc240af0f60b19db4a115b1d2866e858" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 452" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Nonlinearity Assessment; Overadjustment Bias Risk; Measurement Error Correction\", \"Common Misinterpretations\": \"Treating interaction assessment adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Interaction Assessment Adequacy\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The extent to which interaction assessment is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses interaction assessment adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in interaction assessment adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 452 ; bemo:BEMO_3100023 "7942499ba472159741e9410722d92887d17131b3d661f12b98b8ec8f2d490791" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 453" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Overadjustment Bias Risk; Calibration of Statistical Predictions; Discrimination of Statistical Predictions\", \"Common Misinterpretations\": \"Treating measurement error correction as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Measurement Error Correction\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of measurement error correction.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses measurement error correction using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in measurement error correction can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 453 ; bemo:BEMO_3100023 "47dddb5f2dde48130ebfa9464b01b7ed1efb5da34ac2d484caa4259055162e55" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 454" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Variance Estimation Validity; Missing-Data Sensitivity; Imputation Validity\", \"Common Misinterpretations\": \"Treating missing-data mechanism plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Missing-Data Mechanism Plausibility\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of missing-data mechanism plausibility.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses missing-data mechanism plausibility using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in missing-data mechanism plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 454 ; bemo:BEMO_3100023 "399e0c1d410c7ca1c5cc767b5afb9291915d1ee3db3b4d7314b2092c6d4765e1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 455" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Missing-Data Mechanism Plausibility; Imputation Validity; Outlier Influence Robustness\", \"Common Misinterpretations\": \"Treating missing-data sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Missing-Data Sensitivity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of missing-data sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses missing-data sensitivity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in missing-data sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 455 ; bemo:BEMO_3100023 "6708217d617153345c000ff0b34cc96bd34facf9514e5d1a84b3e56623ffb545" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 456" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Model Specification Adequacy; Residual Diagnostics Adequacy; Distributional Assumption Adequacy\", \"Common Misinterpretations\": \"Treating model fit as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Model Fit\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of model fit.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses model fit using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in model fit can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 456 ; bemo:BEMO_3100023 "bf6f70bdb1883a9c1ba70dc7d37eb1885dd46ed70094a2b12bd2cc41e0f53bad" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 457" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Multiplicity Control; Model Fit; Residual Diagnostics Adequacy\", \"Common Misinterpretations\": \"Treating model specification adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Model Specification Adequacy\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The extent to which model specification is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses model specification adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in model specification adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 457 ; bemo:BEMO_3100023 "c5d48404d8de034fc4aa45bb9f64638b1d861e61321423aa5f11d4f63cc6783b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 458" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Type II Error Risk; Model Specification Adequacy; Model Fit\", \"Common Misinterpretations\": \"Treating multiplicity control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Multiplicity Control\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of multiplicity control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses multiplicity control using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in multiplicity control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 458 ; bemo:BEMO_3100023 "282fd29ea793d9f6346d4b34598e7ca30406dad2a72b3f3167d354ca92803ec0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 459" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Equivalence Margin Validity\", \"Common Misinterpretations\": \"Treating noninferiority margin validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Noninferiority Margin Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The degree to which noninferiority margin supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses noninferiority margin validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in noninferiority margin validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 459 ; bemo:BEMO_3100023 "5c494db875d0f3ad6860a3bba83e6ac01d9f571b40aa89617a37a42c1c489cab" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 46" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Discriminant Validity; Construct Validity; Content Validity\", \"Common Misinterpretations\": \"Treating criterion validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Criterion Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which criterion supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses criterion validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in criterion validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 46 ; bemo:BEMO_3100023 "04af58cc2d88f851cf92e0d1960d29a74b3d8a5cf3525dda9579101a813732b2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 460" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Influential Observation Sensitivity; Interaction Assessment Adequacy; Overadjustment Bias Risk\", \"Common Misinterpretations\": \"Treating nonlinearity assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Nonlinearity Assessment\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of nonlinearity assessment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses nonlinearity assessment using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in nonlinearity assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 460 ; bemo:BEMO_3100023 "aec401720de6539460ff9d49f62284a772b28790802eda1b3dc7c5fc2d67af3f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 461" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Imputation Validity; Influential Observation Sensitivity; Nonlinearity Assessment\", \"Common Misinterpretations\": \"Treating outlier influence robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds.\", \"Metric\": \"Outlier Influence Robustness\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of outlier influence robustness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses outlier influence robustness using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in outlier influence robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 461 ; bemo:BEMO_3100023 "3a52b33f3faa79b95100ff084b9c7ca54158523c656fcaf5c298f073960428c9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 462" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Interaction Assessment Adequacy; Measurement Error Correction; Calibration of Statistical Predictions\", \"Common Misinterpretations\": \"Treating overadjustment bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Overadjustment Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The probability or degree that overadjustment bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses overadjustment bias risk using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in overadjustment bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 462 ; bemo:BEMO_3100023 "20f394b3ef37b7c0b5d8426ebcce5fe9f9ef841bbb2622101174fbb411ab7957" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 463" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Bayes Factor Evidence; Prior Sensitivity; Equivalence Margin Validity\", \"Common Misinterpretations\": \"Treating posterior probability strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Posterior Probability Strength\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting posterior probability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses posterior probability strength using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in posterior probability strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 463 ; bemo:BEMO_3100023 "8a96194c8b8e65d04df266b282704e480656791b819df12c8c4924c984b02272" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 464" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Posterior Probability Strength; Equivalence Margin Validity; Noninferiority Margin Validity\", \"Common Misinterpretations\": \"Treating prior sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Prior Sensitivity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prior sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses prior sensitivity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prior sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 464 ; bemo:BEMO_3100023 "ced026349740f092de03ee4146894b4367dab3b43793f3aa048eac1fd782cbda" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 465" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Model Fit; Distributional Assumption Adequacy; Variance Estimation Validity\", \"Common Misinterpretations\": \"Treating residual diagnostics adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Residual Diagnostics Adequacy\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The extent to which residual diagnostics is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses residual diagnostics adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in residual diagnostics adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 465 ; bemo:BEMO_3100023 "1193234e513641f836d7ad506af2e69fb2fcba17a604fff5710f7b53f487ad89" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 466" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Confidence Interval Compatibility; Type I Error Control; Type II Error Risk\", \"Common Misinterpretations\": \"Treating statistical power as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Statistical Power\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of statistical power.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses statistical power using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in statistical power can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 466 ; bemo:BEMO_3100023 "b5866270dc0b1ae7d14dc9e42f0ff6a1d28896f404d73ddeb44c5f7fdaf6b51a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 467" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Statistical Power; Type II Error Risk; Multiplicity Control\", \"Common Misinterpretations\": \"Treating type i error control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Type I Error Control\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of type i error control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses type i error control using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in type i error control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 467 ; bemo:BEMO_3100023 "a3eba05a4613d95dc796e3df689756346c4f78ac2fda1dcb4e8cf4b813a22638" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 468" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Type I Error Control; Multiplicity Control; Model Specification Adequacy\", \"Common Misinterpretations\": \"Treating type ii error risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Type II Error Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The probability or degree that type ii error introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses type ii error risk using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in type ii error risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 468 ; bemo:BEMO_3100023 "de4287424d92a6f5a119531d8abefacf3d79beff40059540425ff1afc5f1021d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 469" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All quantitative biomedical studies\", \"Category\": \"Statistical Validity and Inference\", \"Closely Related Metrics\": \"Distributional Assumption Adequacy; Missing-Data Mechanism Plausibility; Missing-Data Sensitivity\", \"Common Misinterpretations\": \"Treating variance estimation validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Variance Estimation Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"CONSORT; STROBE; TRIPOD; REMARK; ICH E9\", \"Scientific Definition\": \"The degree to which variance estimation supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses variance estimation validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in variance estimation validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 469 ; bemo:BEMO_3100023 "43a84aea1ea6cc79814a3121476a165954a222aece0c751b1ff5414b40efbe28" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 47" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Prognostic Biomarker Validity; Pharmacodynamic Biomarker Validity; Monitoring Biomarker Validity\", \"Common Misinterpretations\": \"Treating diagnostic biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Diagnostic Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which diagnostic biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses diagnostic biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in diagnostic biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 47 ; bemo:BEMO_3100023 "b87f6768315d9d24a6505cd78867a8b0dc9310fbd10aa04b46856994c12562e5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 470" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Early Stopping Bias Risk; Exposure Classification Validity; Intervention Classification Validity\", \"Common Misinterpretations\": \"Treating adherence integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Adherence Integrity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of adherence integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses adherence integrity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in adherence integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 470 ; bemo:BEMO_3100023 "9a20a1494ccbc46d7bc0acd4d260241ebc29edd15b77d8ccc525c9f0dba8e8de" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 471" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Randomization Integrity; Baseline Comparability; Blinding Integrity\", \"Common Misinterpretations\": \"Treating allocation concealment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Allocation Concealment\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of allocation concealment.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses allocation concealment using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in allocation concealment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 471 ; bemo:BEMO_3100023 "3367e7e58461dcb460260b263a504d906f8c26af8608d0cf2767790d3843a2e7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 472" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Detection Bias Risk; Selective Outcome Reporting Risk; Protocol Deviation Risk\", \"Common Misinterpretations\": \"Treating attrition bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Attrition Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that attrition bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses attrition bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in attrition bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 472 ; bemo:BEMO_3100023 "0783cbbb1a7caf7ef448d6830ae564e73010beb87e2e08710ddb494b6b76ccb3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 473" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Allocation Concealment; Blinding Integrity; Performance Bias Risk\", \"Common Misinterpretations\": \"Treating baseline comparability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Baseline Comparability\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of baseline comparability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses baseline comparability using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in baseline comparability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 473 ; bemo:BEMO_3100023 "93fad13257c869638e96dc16ab4687d4b955a0d40d8d10736f49f12cebec65eb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 474" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Baseline Comparability; Performance Bias Risk; Detection Bias Risk\", \"Common Misinterpretations\": \"Treating blinding integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Blinding Integrity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of blinding integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses blinding integrity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in blinding integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 474 ; bemo:BEMO_3100023 "4e84b980ded4e833e93013ba317d5857e2211ad9b612e4b77eb9308cf8244573" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 475" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Co-intervention Bias Risk; Period Effect Risk; Cluster Recruitment Bias Risk\", \"Common Misinterpretations\": \"Treating carryover effect risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Carryover Effect Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that carryover effect introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses carryover effect risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in carryover effect risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 475 ; bemo:BEMO_3100023 "6dbe1d75153c55efcce7da9af8dda3fe869c2f426eaaad651ee6f91b1670d205" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 476" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Period Effect Risk; Early Stopping Bias Risk; Adherence Integrity\", \"Common Misinterpretations\": \"Treating cluster recruitment bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Cluster Recruitment Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that cluster recruitment bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses cluster recruitment bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cluster recruitment bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 476 ; bemo:BEMO_3100023 "a9882065e899d9f8a8f701c6291666b702a9ad5b769971c1d3cb596c9e39b960" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 477" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Contamination Risk; Carryover Effect Risk; Period Effect Risk\", \"Common Misinterpretations\": \"Treating co-intervention bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Co-intervention Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that co-intervention bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses co-intervention bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in co-intervention bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 477 ; bemo:BEMO_3100023 "de36d6b209ddc70bf44fd968006b0ba61482bcc4bbe42db3c2a605301631de5e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 478" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Intervention Classification Validity; Control Group Appropriateness; Temporal Precedence\", \"Common Misinterpretations\": \"Treating comparator validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Comparator Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The degree to which comparator supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses comparator validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in comparator validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 478 ; bemo:BEMO_3100023 "de06a641ed9f64a7c11259e9a1d1346140c2469d57bbd106c6257d947909a5a3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 479" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Protocol Deviation Risk; Co-intervention Bias Risk; Carryover Effect Risk\", \"Common Misinterpretations\": \"Treating contamination risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Contamination Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that contamination introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses contamination risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in contamination risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 479 ; bemo:BEMO_3100023 "eed78db6e72161c41f0a51c8bc55e5d20b0d6675373ef1a7bf65b4c5b0dc75c0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 48" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Convergent Validity; Criterion Validity; Construct Validity\", \"Common Misinterpretations\": \"Treating discriminant validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Discriminant Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which discriminant supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses discriminant validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in discriminant validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 48 ; bemo:BEMO_3100023 "c0e22c7d45b8b17a4c9f1de5c7c7bb4e085d98eb667da8d43e452ea31955900b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 480" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Comparator Validity; Temporal Precedence; Study Design Appropriateness\", \"Common Misinterpretations\": \"Treating control group appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Control Group Appropriateness\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The extent to which control group is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses control group appropriateness using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in control group appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 480 ; bemo:BEMO_3100023 "47dcb7d2162b3c8496d326c0cd9b9dfbef0e0b4032c2c7d93f31f67139c5990f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 481" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Performance Bias Risk; Attrition Bias Risk; Selective Outcome Reporting Risk\", \"Common Misinterpretations\": \"Treating detection bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Detection Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that detection bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses detection bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in detection bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 481 ; bemo:BEMO_3100023 "98c36b49fe475eec66359fae3b2440fc1429c378e2bbe5896e082ec203855535" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 482" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Follow-up Completeness\", \"Common Misinterpretations\": \"Treating differential follow-up risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Differential Follow-up Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that differential follow-up introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses differential follow-up risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in differential follow-up risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 482 ; bemo:BEMO_3100023 "ccfe7e445aeb97f5f6fbabfec00706b7cd315705f68e05e908e47860b40d8ad4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 483" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Cluster Recruitment Bias Risk; Adherence Integrity; Exposure Classification Validity\", \"Common Misinterpretations\": \"Treating early stopping bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Early Stopping Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that early stopping bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses early stopping bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in early stopping bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 483 ; bemo:BEMO_3100023 "8ac86a4a6b6a886dad127939918a466b8c70bd2b6b13b03a987aab048ac4c7c3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 484" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Adherence Integrity; Intervention Classification Validity; Comparator Validity\", \"Common Misinterpretations\": \"Treating exposure classification validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Exposure Classification Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The degree to which exposure classification supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses exposure classification validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in exposure classification validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 484 ; bemo:BEMO_3100023 "6d08552ad6c8b3c6d5a3c8ed35293fcfc624984197116fb158f6c3a04698789f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 485" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Outcome Ascertainment Validity; Differential Follow-up Risk\", \"Common Misinterpretations\": \"Treating follow-up completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Follow-up Completeness\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of follow-up are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses follow-up completeness using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in follow-up completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 485 ; bemo:BEMO_3100023 "a99fe581309ce29c4e888ffbd9a1cba6c99a6948f2a8e99e23714e0f40920b87" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 486" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Exposure Classification Validity; Comparator Validity; Control Group Appropriateness\", \"Common Misinterpretations\": \"Treating intervention classification validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Intervention Classification Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The degree to which intervention classification supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses intervention classification validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in intervention classification validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 486 ; bemo:BEMO_3100023 "283a3544a9dd5cb1a16190c929c82c6db2608db0f4c24860780498cb89bc0ac5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 487" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Protocol Fidelity; Follow-up Completeness; Differential Follow-up Risk\", \"Common Misinterpretations\": \"Treating outcome ascertainment validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Outcome Ascertainment Validity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The degree to which outcome ascertainment supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses outcome ascertainment validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in outcome ascertainment validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 487 ; bemo:BEMO_3100023 "654f73aad6650cd58d63f5a49ae9e034bfcb22952cbf7a018f652c070e1ba6c1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 488" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Blinding Integrity; Detection Bias Risk; Attrition Bias Risk\", \"Common Misinterpretations\": \"Treating performance bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Performance Bias Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that performance bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses performance bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in performance bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 488 ; bemo:BEMO_3100023 "67d1ca80d7087e3cfba7c1c9f64d45d3f4094887ac27aef09ef61bfb6d49d732" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 489" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Carryover Effect Risk; Cluster Recruitment Bias Risk; Early Stopping Bias Risk\", \"Common Misinterpretations\": \"Treating period effect risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Period Effect Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that period effect introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses period effect risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in period effect risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 489 ; bemo:BEMO_3100023 "78e4475c3f570e4a3e966d2bc7b940517b5d7eaa514d888dc22a6ea5b68d38fb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 49" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Outcome Relevance; Endpoint Responsiveness; Minimal Clinically Important Difference Validity\", \"Common Misinterpretations\": \"Treating endpoint reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Endpoint Reliability\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of endpoint reliability.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses endpoint reliability using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in endpoint reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 49 ; bemo:BEMO_3100023 "e147bf4116de09d3c1bd6b5fb8081223589d31f54f697b6e869790830619757d" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 490" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Selective Outcome Reporting Risk; Contamination Risk; Co-intervention Bias Risk\", \"Common Misinterpretations\": \"Treating protocol deviation risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Protocol Deviation Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that protocol deviation introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses protocol deviation risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protocol deviation risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 490 ; bemo:BEMO_3100023 "7632dd2b67a9f407b6c186b3a54ef8714ff7082ed9c885957d4f06c0008e5f26" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 491" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Study Design Appropriateness; Outcome Ascertainment Validity; Follow-up Completeness\", \"Common Misinterpretations\": \"Treating protocol fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Protocol Fidelity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protocol fidelity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses protocol fidelity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protocol fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 491 ; bemo:BEMO_3100023 "ae404e8a9df9a665347ede4db7ae7370bdc6c77c15da3474e23c516ad81dd25e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 492" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Allocation Concealment; Baseline Comparability\", \"Common Misinterpretations\": \"Treating randomization integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Randomization Integrity\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of randomization integrity.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses randomization integrity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in randomization integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 492 ; bemo:BEMO_3100023 "8438f239c984919f366a44747e2e32efd683c0e45e3f7af6c269801f1d6694c8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 493" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Attrition Bias Risk; Protocol Deviation Risk; Contamination Risk\", \"Common Misinterpretations\": \"Treating selective outcome reporting risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Selective Outcome Reporting Risk\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The probability or degree that selective outcome reporting introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses selective outcome reporting risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in selective outcome reporting risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 493 ; bemo:BEMO_3100023 "bcdaa5f06df0a5ab7941c490a740787093ffc20f433c48125d9c2e174850f7fd" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 494" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Temporal Precedence; Protocol Fidelity; Outcome Ascertainment Validity\", \"Common Misinterpretations\": \"Treating study design appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Study Design Appropriateness\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"The extent to which study design is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses study design appropriateness using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in study design appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 494 ; bemo:BEMO_3100023 "7f9fb8e0c1ccb555a18bd7b6b07b3173d661a6707fab17a21ee632e59503b393" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 495" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies\", \"Category\": \"Study Design and Internal Validity\", \"Closely Related Metrics\": \"Control Group Appropriateness; Study Design Appropriateness; Protocol Fidelity\", \"Common Misinterpretations\": \"Treating temporal precedence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Temporal Precedence\", \"References or Origin\": \"https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools\", \"Related Frameworks\": \"CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of temporal precedence.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses temporal precedence using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in temporal precedence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 495 ; bemo:BEMO_3100023 "ec85a4abfc9e480fea03dfff5177f17a293899d488f06a679715de258c8591b9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 50" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Endpoint Reliability; Minimal Clinically Important Difference Validity\", \"Common Misinterpretations\": \"Treating endpoint responsiveness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Endpoint Responsiveness\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of endpoint responsiveness.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses endpoint responsiveness using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in endpoint responsiveness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 50 ; bemo:BEMO_3100023 "3cb1f45a15a5daa5f6b98c2d745a57440f42e5840e757c82a744e9f010f76df0" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 51" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Trial-Level Surrogacy; Outcome Relevance; Endpoint Reliability\", \"Common Misinterpretations\": \"Treating endpoint validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Endpoint Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which endpoint supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses endpoint validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in endpoint validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 51 ; bemo:BEMO_3100023 "f79c486fa1f56b17619593da318c44a3704cbd1294be41ae30a2b38ceb9410d1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 52" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Surrogate Endpoint Validity; Trial-Level Surrogacy; Endpoint Validity\", \"Common Misinterpretations\": \"Treating individual-level surrogacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Individual-Level Surrogacy\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of individual-level surrogacy.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses individual-level surrogacy using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in individual-level surrogacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 52 ; bemo:BEMO_3100023 "4d46697f970727d741077ee1e1f9eeeaed4beee8d6ef96a339ca927181b91ef5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 53" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Biomarker Sensitivity to Change; Convergent Validity; Discriminant Validity\", \"Common Misinterpretations\": \"Treating known-groups validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Known-Groups Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which known-groups supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses known-groups validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in known-groups validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 53 ; bemo:BEMO_3100023 "8e195ef346deba393b7a3adaf4c77bfbd949dbf0f057cd9af26312568cb85421" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 54" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Endpoint Responsiveness\", \"Common Misinterpretations\": \"Treating minimal clinically important difference validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Minimal Clinically Important Difference Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which minimal clinically important difference supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses minimal clinically important difference validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in minimal clinically important difference validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 54 ; bemo:BEMO_3100023 "604e83a95f413c6c8ddc8abe7ad03f24c441ede8e65d506baef0410866c23fa7" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 55" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Pharmacodynamic Biomarker Validity; Safety Biomarker Validity; Susceptibility/Risk Biomarker Validity\", \"Common Misinterpretations\": \"Treating monitoring biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Monitoring Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which monitoring biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses monitoring biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in monitoring biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 55 ; bemo:BEMO_3100023 "cc605972d7119b4dabf5e0bc927d29fa05979e706703654bb3ea93c2ebe95461" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 56" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Endpoint Validity; Endpoint Reliability; Endpoint Responsiveness\", \"Common Misinterpretations\": \"Treating outcome relevance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Outcome Relevance\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of outcome relevance.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses outcome relevance using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in outcome relevance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 56 ; bemo:BEMO_3100023 "1adca583ee04c245cdae3428bd050f3ed8796d29bf4b214b5880769da8977172" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 57" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Diagnostic Biomarker Validity; Monitoring Biomarker Validity; Safety Biomarker Validity\", \"Common Misinterpretations\": \"Treating pharmacodynamic biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Pharmacodynamic Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which pharmacodynamic biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses pharmacodynamic biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pharmacodynamic biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 57 ; bemo:BEMO_3100023 "4eb497c772907b7927e32ee929fba9a804b1c75888594041caa61dfab977440a" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 58" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Content Validity; Prognostic Biomarker Validity; Diagnostic Biomarker Validity\", \"Common Misinterpretations\": \"Treating predictive biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Predictive Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which predictive biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses predictive biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in predictive biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 58 ; bemo:BEMO_3100023 "c5c7cbb5b7738940f61731df207186f05f8ae71ecab7ca3c5588c823af8d00eb" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 59" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Predictive Biomarker Validity; Diagnostic Biomarker Validity; Pharmacodynamic Biomarker Validity\", \"Common Misinterpretations\": \"Treating prognostic biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Prognostic Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which prognostic biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses prognostic biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in prognostic biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 59 ; bemo:BEMO_3100023 "2dd804ff14e01e089d83a5d2d6ef790d24cf90ca54d3426049116e4e7aeb095f" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 60" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Susceptibility/Risk Biomarker Validity; Surrogate Endpoint Validity; Individual-Level Surrogacy\", \"Common Misinterpretations\": \"Treating response biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Response Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which response biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses response biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in response biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 60 ; bemo:BEMO_3100023 "a8e8ef21a701fbb547c028557e4678bc79ebeda610eb6926bf0061b6e9a016c4" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 61" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Monitoring Biomarker Validity; Susceptibility/Risk Biomarker Validity; Response Biomarker Validity\", \"Common Misinterpretations\": \"Treating safety biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Safety Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which safety biomarker supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses safety biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in safety biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 61 ; bemo:BEMO_3100023 "a6b6c6cf8ada87a1112583df9bc78595f4f0975ec0e8bbfc01ca6f00c2c0adf1" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 62" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Response Biomarker Validity; Individual-Level Surrogacy; Trial-Level Surrogacy\", \"Common Misinterpretations\": \"Treating surrogate endpoint validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Surrogate Endpoint Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The degree to which surrogate endpoint supports the intended scientific interpretation without material systematic error.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses surrogate endpoint validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in surrogate endpoint validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 62 ; bemo:BEMO_3100023 "880b1c4a9fa2a25e2876679a2a7e759365591c8d0d0ae431e9a6e89a9d327bd9" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 63" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Safety Biomarker Validity; Response Biomarker Validity; Surrogate Endpoint Validity\", \"Common Misinterpretations\": \"Treating susceptibility/risk biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Susceptibility/Risk Biomarker Validity\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"The probability or degree that susceptibility/risk biomarker validity introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses susceptibility/risk biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in susceptibility/risk biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 63 ; bemo:BEMO_3100023 "596927f557190db71a0b686158bde6134cafa9cdb9c1876784270d91a80452f5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 64" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Biomarker development, qualification, endpoint and surrogate validation studies\", \"Category\": \"Biomarker and Endpoint Validation\", \"Closely Related Metrics\": \"Individual-Level Surrogacy; Endpoint Validity; Outcome Relevance\", \"Common Misinterpretations\": \"Treating trial-level surrogacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Common within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Trial-Level Surrogacy\", \"References or Origin\": \"https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"FDA Biomarker; BEST; EMA E16; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of trial-level surrogacy.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses trial-level surrogacy using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in trial-level surrogacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 64 ; bemo:BEMO_3100023 "977d5f2b7e02b5e90f442ea4e8788e2fe539316cddda3ae61da29b0fa71c5325" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 65" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Processing Delay Control; Pathology Confirmation; Tumor Purity\", \"Common Misinterpretations\": \"Treating anatomical site fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Anatomical Site Fidelity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of anatomical site fidelity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses anatomical site fidelity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in anatomical site fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 65 ; bemo:BEMO_3100023 "8fa3b411fb892fff8cc31c078e25770eb74980a525cbc8e76d63bcb0f15bdaf8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 66" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Biospecimen Provenance Completeness; Collection Procedure Consistency\", \"Common Misinterpretations\": \"Treating biospecimen integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biospecimen Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biospecimen integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses biospecimen integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biospecimen integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 66 ; bemo:BEMO_3100023 "b89a21b15f8ca110af0a2e2a28ae4ce7939819f7d62769c459c1cd5dc9b712cc" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 67" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Biospecimen Integrity; Collection Procedure Consistency; Warm Ischemia Control\", \"Common Misinterpretations\": \"Treating biospecimen provenance completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations.\", \"Metric\": \"Biospecimen Provenance Completeness\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"The extent to which all scientifically necessary components of biospecimen provenance are present, documented, and evaluable.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses biospecimen provenance completeness using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biospecimen provenance completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 67 ; bemo:BEMO_3100023 "c859051c1fe5f3cb60cda0bb4dcf804459be135ee18bb1bb44d89345dea50253" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 68" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Tumor Purity; Necrosis Burden; Hemolysis Burden\", \"Common Misinterpretations\": \"Treating cellularity adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Cellularity Adequacy\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"The extent to which cellularity is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses cellularity adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cellularity adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 68 ; bemo:BEMO_3100023 "de5efa73121b798bb0e1a53bddae9ef743d4a522e6df52007a5b7569bc63e020" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 69" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Microbial Contamination; Matched-Sample Integrity\", \"Common Misinterpretations\": \"Treating chain-of-custody integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Chain-of-Custody Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of chain-of-custody integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses chain-of-custody integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in chain-of-custody integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 69 ; bemo:BEMO_3100023 "38ecb99023f4b12b1bfca7d66221917ae384546ef170c868cd32fb2eb70f3f40" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 70" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Warm Ischemia Control; Time-to-Fixation Adequacy; Fixation Adequacy\", \"Common Misinterpretations\": \"Treating cold ischemia control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Cold Ischemia Control\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cold ischemia control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses cold ischemia control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in cold ischemia control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 70 ; bemo:BEMO_3100023 "450f9e94b009036abe7a13fe3055116e7c4959857a7291ed7e337a746d7bf722" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 71" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Biospecimen Provenance Completeness; Warm Ischemia Control; Cold Ischemia Control\", \"Common Misinterpretations\": \"Treating collection procedure consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Collection Procedure Consistency\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"The degree of agreement in collection procedure across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses collection procedure consistency using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in collection procedure consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 71 ; bemo:BEMO_3100023 "c748a49d52923f74e8e31a0f69a4e91ee50970289d8b43c903a638e0573cc828" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 72" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"RNA Integrity; Protein Integrity; Microbial Contamination\", \"Common Misinterpretations\": \"Treating dna integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"DNA Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dna integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses dna integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dna integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 72 ; bemo:BEMO_3100023 "494036e6478a34bfe608bc3b1267e04a777d16e96430109ab2ba9b01e99c6693" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 73" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Time-to-Fixation Adequacy; Preservation Adequacy; Storage Temperature Control\", \"Common Misinterpretations\": \"Treating fixation adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Fixation Adequacy\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"The extent to which fixation is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses fixation adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in fixation adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 73 ; bemo:BEMO_3100023 "c08e61688a36fec680e9073fc8888dbfd98852919e3f7ccf7c3180ed49d1e921" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 74" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Storage Temperature Control; Transport Condition Integrity; Processing Delay Control\", \"Common Misinterpretations\": \"Treating freeze–thaw burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Freeze–Thaw Burden\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of freeze–thaw burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses freeze–thaw burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in freeze–thaw burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 74 ; bemo:BEMO_3100023 "40c5c886eacc67a9addeaa92c47d69bf9fbd4b1d2a0042a2efd3611fd5cebb4b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 75" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Necrosis Burden; Lipemia Burden; Icterus Interference\", \"Common Misinterpretations\": \"Treating hemolysis burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Hemolysis Burden\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of hemolysis burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses hemolysis burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in hemolysis burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 75 ; bemo:BEMO_3100023 "1b0946c6b109834d9e6fa6dc5ae7dde1ce95bc65f999a58a3c5a88bc66c6a47c" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 76" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Lipemia Burden; RNA Integrity; DNA Integrity\", \"Common Misinterpretations\": \"Treating icterus interference as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Icterus Interference\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of icterus interference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses icterus interference using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in icterus interference can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 76 ; bemo:BEMO_3100023 "d0f3346c9caa8abb9b49bded0ab6e26e5f13d5a8fb5a20971f64067dd82054ea" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 77" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Hemolysis Burden; Icterus Interference; RNA Integrity\", \"Common Misinterpretations\": \"Treating lipemia burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Lipemia Burden\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of lipemia burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses lipemia burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in lipemia burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 77 ; bemo:BEMO_3100023 "572ca1cf50802a5447be4c1286cdad2930a7ec08e97e7b9af663a3cb66e1d788" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 78" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Chain-of-Custody Integrity\", \"Common Misinterpretations\": \"Treating matched-sample integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Matched-Sample Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of matched-sample integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses matched-sample integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in matched-sample integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 78 ; bemo:BEMO_3100023 "daf35eaf7e6632e499a494b9ba629171cde4aa96d4d637ad7669da2f69668fd5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 79" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Protein Integrity; Chain-of-Custody Integrity; Matched-Sample Integrity\", \"Common Misinterpretations\": \"Treating microbial contamination as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Microbial Contamination\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of microbial contamination.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses microbial contamination using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in microbial contamination can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 79 ; bemo:BEMO_3100023 "a7e7bf9a47cefd808a5ba122413c735b8b095ffc84592451f9857f4fe080e389" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 8" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Off-Target Liability Evidence; Homeostatic Compensation Assessment; Network Context Support\", \"Common Misinterpretations\": \"Treating biological gradient as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biological Gradient\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biological gradient.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses biological gradient using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biological gradient can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 8 ; bemo:BEMO_3100023 "6471dcf670c9dd05424f4606389decf6b51812d07c0a0680842d77bda957b0f3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 80" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Cellularity Adequacy; Hemolysis Burden; Lipemia Burden\", \"Common Misinterpretations\": \"Treating necrosis burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Necrosis Burden\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of necrosis burden.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses necrosis burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in necrosis burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 80 ; bemo:BEMO_3100023 "33466881e023e8dc75d5f189be9da266f95f3bf8283fa46f9f4cff10e5af6f95" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 81" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Anatomical Site Fidelity; Tumor Purity; Cellularity Adequacy\", \"Common Misinterpretations\": \"Treating pathology confirmation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Pathology Confirmation\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of pathology confirmation.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses pathology confirmation using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in pathology confirmation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 81 ; bemo:BEMO_3100023 "e470a75855d7bb24a7f3957922ccdf78961ef4c923b6f754c0006ebb46c0367e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 82" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Fixation Adequacy; Storage Temperature Control; Freeze–Thaw Burden\", \"Common Misinterpretations\": \"Treating preservation adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Preservation Adequacy\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"The extent to which preservation is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses preservation adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in preservation adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 82 ; bemo:BEMO_3100023 "de3923232eba7ea0cab4f8eddc6a1539eac9f06416d7c31e6d2ce8fbf8492ba5" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 83" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Transport Condition Integrity; Anatomical Site Fidelity; Pathology Confirmation\", \"Common Misinterpretations\": \"Treating processing delay control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Processing Delay Control\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of processing delay control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses processing delay control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in processing delay control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 83 ; bemo:BEMO_3100023 "575df935e8ca0edd1975c05772eaa99f38b63f196b0ee598cef40ebcb4554aaf" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 84" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"DNA Integrity; Microbial Contamination; Chain-of-Custody Integrity\", \"Common Misinterpretations\": \"Treating protein integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Protein Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protein integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses protein integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in protein integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 84 ; bemo:BEMO_3100023 "f776649240f851879898d488bb90516491936e0936f6f03ac5946be6c8b62a20" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 85" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Icterus Interference; DNA Integrity; Protein Integrity\", \"Common Misinterpretations\": \"Treating rna integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"RNA Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of rna integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses rna integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in rna integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 85 ; bemo:BEMO_3100023 "98ac509f170b3163d862e8e08cc16dad8b915df5508f4e7394a8627d881f7350" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 86" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Preservation Adequacy; Freeze–Thaw Burden; Transport Condition Integrity\", \"Common Misinterpretations\": \"Treating storage temperature control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Storage Temperature Control\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of storage temperature control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses storage temperature control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in storage temperature control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 86 ; bemo:BEMO_3100023 "b39a92acfa55bd840331823c88476d9d65ca0179f68f0f37ed8d7677a63d2193" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 87" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Cold Ischemia Control; Fixation Adequacy; Preservation Adequacy\", \"Common Misinterpretations\": \"Treating time-to-fixation adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions.\", \"Metric\": \"Time-to-Fixation Adequacy\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"The extent to which time-to-fixation is sufficient and fit for the stated biomedical inference.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses time-to-fixation adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in time-to-fixation adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 87 ; bemo:BEMO_3100023 "49559a7ae628351af963a27a55893cf501098be34876ce35bdc2d4969fd4f94b" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 88" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Freeze–Thaw Burden; Processing Delay Control; Anatomical Site Fidelity\", \"Common Misinterpretations\": \"Treating transport condition integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Transport Condition Integrity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of transport condition integrity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses transport condition integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in transport condition integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 88 ; bemo:BEMO_3100023 "81f1c97831f3ffbcc8b4e89c16604f987d3fa2baac750496d710981c68a60598" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 89" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Pathology Confirmation; Cellularity Adequacy; Necrosis Burden\", \"Common Misinterpretations\": \"Treating tumor purity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Tumor Purity\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of tumor purity.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses tumor purity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in tumor purity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 89 ; bemo:BEMO_3100023 "e7836bb1f6728d199c8634dbdbf560dae6243a3932920cc82164935a37c9180e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 9" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Molecular, cellular, animal, translational, pharmacologic, and human studies\", \"Category\": \"Biological Plausibility and Mechanism\", \"Closely Related Metrics\": \"Mechanistic Support; Mechanistic Coverage\", \"Common Misinterpretations\": \"Treating biological plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Biological Plausibility\", \"References or Origin\": \"https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm\", \"Related Frameworks\": \"GRADE; FDA Biomarker; ClinGen; OHAT; OECD\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biological plausibility.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses biological plausibility using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in biological plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 9 ; bemo:BEMO_3100023 "6cbc5f525d668cebb0928b8428848a625103a7b6492d0a2a618adb116f200bd3" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 90" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"All studies using human or animal biospecimens\", \"Category\": \"Biospecimen and Preanalytical Quality\", \"Closely Related Metrics\": \"Collection Procedure Consistency; Cold Ischemia Control; Time-to-Fixation Adequacy\", \"Common Misinterpretations\": \"Treating warm ischemia control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Specimen / assay / run / laboratory / study\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Warm Ischemia Control\", \"References or Origin\": \"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/\", \"Related Frameworks\": \"BRISQ; ISO 15189; REMARK\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of warm ischemia control.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses warm ischemia control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in warm ischemia control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 90 ; bemo:BEMO_3100023 "293c5ebda3d3695852f06644549a5b920266b83358bf49b383b5d90078fcdde6" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 91" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"E-value Strength; Falsification Test Support\", \"Common Misinterpretations\": \"Treating assumption sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment.\", \"Metric\": \"Assumption Sensitivity\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of assumption sensitivity.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Proportion or percentage (0–1 or 0–100%)\", \"What It Measures\": \"Assesses assumption sensitivity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in assumption sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 91 ; bemo:BEMO_3100023 "b75d62759fbd8f126f27997543f0f46dde1cb8c2484d156a08c9925c9476aa63" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 92" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Correct Temporal Ordering; Target Trial Emulation Fidelity; Instrument Validity\", \"Common Misinterpretations\": \"Treating causal contrast clarity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Causal Contrast Clarity\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of causal contrast clarity.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses causal contrast clarity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in causal contrast clarity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 92 ; bemo:BEMO_3100023 "d81e7f98cb339c656ef93d3243144295a2c872dc2bcb50f64863414984f27993" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 93" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Confounding Risk; Residual Confounding Risk\", \"Common Misinterpretations\": \"Treating causal identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Causal Identifiability\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of causal identifiability.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses causal identifiability using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in causal identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 93 ; bemo:BEMO_3100023 "a6559bfe5ff78dd7455ed538b35cec6508c7c5507441bc614a71e2140188258e" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 94" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Effect-Modification Credibility; Time-Varying Confounding Control; Immortal-Time Bias Risk\", \"Common Misinterpretations\": \"Treating collider bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Mature\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Collider Bias Risk\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The probability or degree that collider bias introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses collider bias risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in collider bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 94 ; bemo:BEMO_3100023 "0d0ee23715a02b538d00c3772dc0b2a1a64aba9fb6a21ecd62845d74c88b63ca" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 95" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Causal Identifiability; Residual Confounding Risk; Unmeasured Confounding Sensitivity\", \"Common Misinterpretations\": \"Treating confounding risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias.\", \"Metric\": \"Confounding Risk\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The probability or degree that confounding introduces systematic distortion into a biomedical estimate or conclusion.\", \"Scientific Importance (1–10)\": \"10\", \"Typical Methods of Assessment\": \"Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses.\", \"Units or Scale (if applicable)\": \"Ordinal risk rating or quantitative percentage/probability; lower is generally better\", \"What It Measures\": \"Assesses confounding risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in confounding risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 95 ; bemo:BEMO_3100023 "cebd58c93ed86b363870e131c5d23217522d15af0abb7eac8956ec81e8515565" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 96" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Positivity Adequacy; No-Interference Plausibility; Correct Temporal Ordering\", \"Common Misinterpretations\": \"Treating consistency assumption plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Consistency Assumption Plausibility\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The degree of agreement in consistency assumption plausibility across measurements, studies, methods, populations, or biological levels.\", \"Scientific Importance (1–10)\": \"9\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses consistency assumption plausibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in consistency assumption plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 96 ; bemo:BEMO_3100023 "1bec3d5308662b9b5fad28978574efe7573d32766cf45ac34286863d2d2267a8" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 97" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"No-Interference Plausibility; Causal Contrast Clarity; Target Trial Emulation Fidelity\", \"Common Misinterpretations\": \"Treating correct temporal ordering as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Correct Temporal Ordering\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of correct temporal ordering.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Metric-specific continuous, categorical, or ordinal scale\", \"What It Measures\": \"Assesses correct temporal ordering using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in correct temporal ordering can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 97 ; bemo:BEMO_3100023 "b11d505f3985b03d1ab78fe50a79558d187aeacc3fabbc39b5dc3da61a0cfbe2" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 98" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Dose–Response Support; Mediation Evidence Strength; Effect-Modification Credibility\", \"Common Misinterpretations\": \"Treating dechallenge–rechallenge support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Dechallenge–Rechallenge Support\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting dechallenge–rechallenge.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Ordinal rubric, domain judgment, or normalized score\", \"What It Measures\": \"Assesses dechallenge–rechallenge support using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dechallenge–rechallenge support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 98 ; bemo:BEMO_3100023 "9e166f37b12b35c895b18fc7e56e04526e22004c0b70dee562c1cf80c5d17e69" . a prov:Entity ; rdfs:label "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 99" ; dcterms:source "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; prov:value "{\"Applicable Study Types\": \"Randomized and observational etiologic studies, natural experiments, target-trial emulations\", \"Category\": \"Causal Inference\", \"Closely Related Metrics\": \"Negative-Control Validation; Dechallenge–Rechallenge Support; Mediation Evidence Strength\", \"Common Misinterpretations\": \"Treating dose–response support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.\", \"Evidence Level Where Used\": \"Result / experiment / study / body of evidence, as applicable\", \"Frequency of Use\": \"Established within specialty\", \"Limitations\": \"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.\", \"Maturity of Metric\": \"Established\", \"Measurement Criteria\": \"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.\", \"Metric\": \"Dose–Response Support\", \"References or Origin\": \"https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf\", \"Related Frameworks\": \"ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9\", \"Scientific Definition\": \"The magnitude and credibility of independent evidence supporting dose–response.\", \"Scientific Importance (1–10)\": \"8\", \"Typical Methods of Assessment\": \"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.\", \"Units or Scale (if applicable)\": \"Method- and analyte-specific physical units\", \"What It Measures\": \"Assesses dose–response support using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error.\", \"Why It Matters\": \"Material weakness in dose–response support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.\"}" ; bemo:BEMO_3100022 99 ; bemo:BEMO_3100023 "75f662d9e2ee059c317733c8704b2f0f1f234146f1b2920ed572ec892b5a2d41" . bemo:BEMO_0000403 a owl:Class ; rdfs:label "formula status"@en ; iao:0000115 "A controlled concept describing whether a formula is defined, generic, method-specific, or context-specific."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000403" ; rdfs:subClassOf skos:Concept ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000002 a owl:Class ; rdfs:label "Study Design, Statistical Validity, and Causal Inference metric"@en ; iao:0000115 "Metrics assessing internal validity, statistical inference, causal identification, bias, and study design."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000002" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1000005 a owl:Class ; rdfs:label "External Validity, Biomarkers, and Clinical Evidence metric"@en ; iao:0000115 "Metrics assessing generalizability, diagnostic or prognostic evidence, biomarkers, endpoints, and clinical applicability."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000005" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_2000014 a owl:Class ; rdfs:label "Mechanistic Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting mechanistic."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000014" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000014" ; bemo:BEMO_3100022 21 ; bemo:BEMO_3100023 "d05eb179325de1077bb0eedc4d22a5f8c9cc2049d4ca5a5830b380984606cc90" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses mechanistic support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mechanistic support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mechanistic support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000002, bemo:BEMO_2000011, bemo:BEMO_2000012 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000024 a owl:Class ; rdfs:label "Systems-Level Emergence Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting systems-level emergence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000024" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000024" ; bemo:BEMO_3100022 31 ; bemo:BEMO_3100023 "07df8f6070c405006e36806e8ccb515126dc2c7269ea9cf3934662d28e9264c6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses systems-level emergence support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in systems-level emergence support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating systems-level emergence support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000016 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000033 a owl:Class ; rdfs:label "Biomarker-Outcome Association Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting biomarker-outcome association."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000033" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000033" ; bemo:BEMO_3100022 40 ; bemo:BEMO_3100023 "d54499df144e3534026302c035690746b731c0abf25107f5fccdd8bada0bd79a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biomarker-outcome association strength using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biomarker-outcome association strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biomarker-outcome association strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000028, bemo:BEMO_2000034, bemo:BEMO_2000037 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000047 a owl:Class ; rdfs:label "Minimal Clinically Important Difference Validity"@en ; iao:0000115 "The degree to which minimal clinically important difference supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000047" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000047" ; bemo:BEMO_3100022 54 ; bemo:BEMO_3100023 "604e83a95f413c6c8ddc8abe7ad03f24c441ede8e65d506baef0410866c23fa7" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses minimal clinically important difference validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in minimal clinically important difference validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating minimal clinically important difference validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000043 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000060 a owl:Class ; rdfs:label "Biospecimen Provenance Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of biospecimen provenance are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000060" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000060" ; bemo:BEMO_3100022 67 ; bemo:BEMO_3100023 "c859051c1fe5f3cb60cda0bb4dcf804459be135ee18bb1bb44d89345dea50253" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses biospecimen provenance completeness using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biospecimen provenance completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biospecimen provenance completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000059, bemo:BEMO_2000064, bemo:BEMO_2000083 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000071 a owl:Class ; rdfs:label "Matched-Sample Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of matched-sample integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000071" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000071" ; bemo:BEMO_3100022 78 ; bemo:BEMO_3100023 "daf35eaf7e6632e499a494b9ba629171cde4aa96d4d637ad7669da2f69668fd5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses matched-sample integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in matched-sample integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating matched-sample integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000062 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000088 a owl:Class ; rdfs:label "Confounding Risk"@en ; iao:0000115 "The probability or degree that confounding introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000088" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000088" ; bemo:BEMO_3100022 95 ; bemo:BEMO_3100023 "cebd58c93ed86b363870e131c5d23217522d15af0abb7eac8956ec81e8515565" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses confounding risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in confounding risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating confounding risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000086, bemo:BEMO_2000104, bemo:BEMO_2000109 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000096 a owl:Class ; rdfs:label "Falsification Test Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting falsification test."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000096" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000096" ; bemo:BEMO_3100022 103 ; bemo:BEMO_3100023 "280760fd65dbda26ef711b182bed36c1b7e3679af41be52e50dfca26f92b3400" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses falsification test support using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in falsification test support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating falsification test support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000084 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000114 a owl:Class ; rdfs:label "Competing-Risk Model Validity"@en ; iao:0000115 "The probability or degree that competing-risk model validity introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000114" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000114" ; bemo:BEMO_3100022 121 ; bemo:BEMO_3100023 "6f322698057cc9561b413498181b8f2503720420a935d144d2173ae5298a3b2f" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses competing-risk model validity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in competing-risk model validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating competing-risk model validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000137 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000117 a owl:Class ; rdfs:label "Diagnostic Specificity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of diagnostic specificity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000117" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000117" ; bemo:BEMO_3100022 124 ; bemo:BEMO_3100023 "14be8f0b88f11902e6b1562a38b9cb710840858fc59f748048f96b74c8f6c2b2" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses diagnostic specificity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in diagnostic specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating diagnostic specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000116, bemo:BEMO_2000123, bemo:BEMO_2000128 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000151 a owl:Class ; rdfs:label "Evidence Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000151" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000151" ; bemo:BEMO_3100022 158 ; bemo:BEMO_3100023 "f4e08b1965ce7d1832ff4c5191f1e7298781d9bec3cb9a96c09198d6faaa1339" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence quality using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000144, bemo:BEMO_2000154, bemo:BEMO_2000160 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000159 a owl:Class ; rdfs:label "Multiplicity-Adjusted Credibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of multiplicity-adjusted credibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000159" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000159" ; bemo:BEMO_3100022 166 ; bemo:BEMO_3100023 "40900cc3965adf1a4a61ca1880158e0ed27ede5d1a6163f63eb4f6d38b99a3b8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses multiplicity-adjusted credibility using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in multiplicity-adjusted credibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating multiplicity-adjusted credibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000157 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000171 a owl:Class ; rdfs:label "Biological Replicate Adequacy"@en ; iao:0000115 "The extent to which biological replicate is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000171" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000171" ; bemo:BEMO_3100022 178 ; bemo:BEMO_3100023 "74976e4cf57f53c444f4721c04fc26fb7298cad4ac743db45feeb9a0be34587a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biological replicate adequacy using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biological replicate adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biological replicate adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000176, bemo:BEMO_2000185, bemo:BEMO_2000189 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000188 a owl:Class ; rdfs:label "Technical Artifact Exclusion"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of technical artifact exclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000188" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000188" ; bemo:BEMO_3100022 195 ; bemo:BEMO_3100023 "8d21017136fa388d87b531d9b552fc3f6787a0b2615866e0c0a1ca9ae2fb0bbf" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses technical artifact exclusion using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in technical artifact exclusion can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating technical artifact exclusion as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000182 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000203 a owl:Class ; rdfs:label "Population Representativeness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population representativeness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000203" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000203" ; bemo:BEMO_3100022 210 ; bemo:BEMO_3100023 "efa730876069251ed2dde336a59f381b8c109c4ee429da0b68bf8bae61b0ba48" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses population representativeness using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in population representativeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating population representativeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000197, bemo:BEMO_2000205, bemo:BEMO_2000210 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000204 a owl:Class ; rdfs:label "Real-World Evidence Alignment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of real-world evidence alignment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000204" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000204" ; bemo:BEMO_3100022 211 ; bemo:BEMO_3100023 "2bcc973aa3f12efded260e2aef1541636262ee110856a34255ce0823d91dfb20" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses real-world evidence alignment using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in real-world evidence alignment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating real-world evidence alignment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000196 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000216 a owl:Class ; rdfs:label "Conflicting Interpretation Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of conflicting interpretation burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000216" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000216" ; bemo:BEMO_3100022 223 ; bemo:BEMO_3100023 "54567aec6ae0bbdadfae015005c07328ab45d161c0cc6d36f9e5198150b2b29e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses conflicting interpretation burden using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in conflicting interpretation burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating conflicting interpretation burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000234 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000235 a owl:Class ; rdfs:label "Variant Pathogenicity Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting variant pathogenicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000235" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000235" ; bemo:BEMO_3100022 242 ; bemo:BEMO_3100023 "ce239eedae0622eb1018ab2bfc52cd2d32ef0a5f6a874008c2d8838deb99bd4a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses variant pathogenicity evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in variant pathogenicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating variant pathogenicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000221, bemo:BEMO_2000230, bemo:BEMO_2000232 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000243 a owl:Class ; rdfs:label "Cross-Platform Genomic Concordance"@en ; iao:0000115 "The degree of agreement in cross-platform genomic across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000243" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000243" ; bemo:BEMO_3100022 250 ; bemo:BEMO_3100023 "91130249c6d3c5254de370a79251a5dce82ecc1afbe7b1276235f59ee93b7b5a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cross-platform genomic concordance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-platform genomic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-platform genomic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000263 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000246 a owl:Class ; rdfs:label "Genome Coverage Uniformity"@en ; iao:0000115 "The proportion and representativeness of the relevant genome uniformity captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000246" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000246" ; bemo:BEMO_3100022 253 ; bemo:BEMO_3100023 "c86e8ba8cbfb79ea4dbc1a9a4cd5da76837e35c7f45f5966b51b9734760bdf1f" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses genome coverage uniformity using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in genome coverage uniformity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating genome coverage uniformity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000250, bemo:BEMO_2000253, bemo:BEMO_2000257 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000267 a owl:Class ; rdfs:label "Accuracy"@en ; iao:0000115 "The closeness of accuracy to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000267" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000267" ; bemo:BEMO_3100022 274 ; bemo:BEMO_3100023 "35d988975cf78a06cb70788f89a4196551552de36a3cf47e57d2d96fc8cf41fd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses accuracy using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000269, bemo:BEMO_2000272, bemo:BEMO_2000302 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000292 a owl:Class ; rdfs:label "Postanalytical Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of postanalytical integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000292" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000292" ; bemo:BEMO_3100022 299 ; bemo:BEMO_3100023 "b1cf2cbf0a36602510f89d4d570874b9d2148d8bd132ef3b47e7be72655f9ff3" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses postanalytical integrity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in postanalytical integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating postanalytical integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000293 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000305 a owl:Class ; rdfs:label "Cross-Omics Replication"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cross-omics replication."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000305" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000305" ; bemo:BEMO_3100022 312 ; bemo:BEMO_3100023 "5b9be25d7af680eef194d1d2e393dbdeaaf607f62c516cb41c75f5dfd1ba50b9" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses cross-omics replication using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-omics replication can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-omics replication as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000303, bemo:BEMO_2000304, bemo:BEMO_2000312 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000307 a owl:Class ; rdfs:label "Emergent-Property Reproducibility"@en ; iao:0000115 "The degree to which emergent-property reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000307" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000307" ; bemo:BEMO_3100022 314 ; bemo:BEMO_3100023 "e554ab3ba02f294f767076d372c3967762b850eccc356bf4d7c243480641cd98" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses emergent-property reproducibility using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in emergent-property reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating emergent-property reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000324 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Specialized / infrequent" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000337 a owl:Class ; rdfs:label "Exposure–Response Relationship"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of exposure–response relationship."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000337" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000337" ; bemo:BEMO_3100022 344 ; bemo:BEMO_3100023 "882d0346f9d5903a7e9b6a2b5ae992e9e24bd2be9c7e249168f2f9e157dc0354" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses exposure–response relationship using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in exposure–response relationship can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating exposure–response relationship as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000346, bemo:BEMO_2000347, bemo:BEMO_2000348 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000343 a owl:Class ; rdfs:label "Mixture Interaction Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mixture interaction assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000343" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000343" ; bemo:BEMO_3100022 350 ; bemo:BEMO_3100023 "241ffa4364ee9325fbb3832728344d8484375a1aca172f524b6f871b9dc07687" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses mixture interaction assessment using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mixture interaction assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mixture interaction assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000339 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000359 a owl:Class ; rdfs:label "Cross-Omics Concordance"@en ; iao:0000115 "The degree of agreement in cross-omics across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000359" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000359" ; bemo:BEMO_3100022 366 ; bemo:BEMO_3100023 "447ad3207c1d5333015f6a5189727d810a3a517e4d6a4351f8dc28acbe93a5f0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cross-omics concordance using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-omics concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-omics concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000373 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000377 a owl:Class ; rdfs:label "Protein Identification Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to protein identification given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000377" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000377" ; bemo:BEMO_3100022 384 ; bemo:BEMO_3100023 "86cf8ad175ebd274f625e908935f946750c2c41a33f40e7a8dc33224d8db7d28" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses protein identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protein identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating protein identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000363, bemo:BEMO_2000374, bemo:BEMO_2000375 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000392 a owl:Class ; rdfs:label "Direct Replication Success"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of direct replication success."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000392" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000392" ; bemo:BEMO_3100022 399 ; bemo:BEMO_3100023 "e6b0ec1b803bb2c7cb8becab175dbb88ab91c9d8ccd3f713a814c836846ea547" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses direct replication success using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in direct replication success can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating direct replication success as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000386, bemo:BEMO_2000389, bemo:BEMO_2000394 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000406 a owl:Class ; rdfs:label "Specification-Curve Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of specification-curve robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000406" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000406" ; bemo:BEMO_3100022 413 ; bemo:BEMO_3100023 "290b2551a20c17c23c05ae84270ce7ac2c9d4a43b9817050cdbe8a353ce743ac" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses specification-curve robustness using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in specification-curve robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating specification-curve robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000400 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Specialized / infrequent" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000425 a owl:Class ; rdfs:label "Prospective Registration"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prospective registration."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000425" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000425" ; bemo:BEMO_3100022 432 ; bemo:BEMO_3100023 "32ae2352b0f17339d30893a08c10c681c7fa3992e6b60a3343dae6e95aa8dda5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prospective registration using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prospective registration can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prospective registration as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000421, bemo:BEMO_2000423, bemo:BEMO_2000426 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000430 a owl:Class ; rdfs:label "Reproducibility Information Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of reproducibility information are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000430" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000430" ; bemo:BEMO_3100022 437 ; bemo:BEMO_3100023 "3aaeec4ac26a2a3b26b615c686a2f19768e2153bd9e1e676bdcd1f2ba2812fc8" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses reproducibility information completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reproducibility information completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reproducibility information completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000411 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000441 a owl:Class ; rdfs:label "Estimate Precision"@en ; iao:0000115 "The closeness of repeated estimates or measurements and the narrowness of uncertainty around estimate."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000441" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000441" ; bemo:BEMO_3100022 448 ; bemo:BEMO_3100023 "9458d6e4371d11a80963339d3a9a6c5dcc187a36080cf18d964ecb5827c41820" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses estimate precision using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in estimate precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating estimate precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000435, bemo:BEMO_2000439, bemo:BEMO_2000459 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000452 a owl:Class ; rdfs:label "Noninferiority Margin Validity"@en ; iao:0000115 "The degree to which noninferiority margin supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000452" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000452" ; bemo:BEMO_3100022 459 ; bemo:BEMO_3100023 "5c494db875d0f3ad6860a3bba83e6ac01d9f571b40aa89617a37a42c1c489cab" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses noninferiority margin validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in noninferiority margin validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating noninferiority margin validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000440 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000464 a owl:Class ; rdfs:label "Allocation Concealment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of allocation concealment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000464" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000464" ; bemo:BEMO_3100022 471 ; bemo:BEMO_3100023 "3367e7e58461dcb460260b263a504d906f8c26af8608d0cf2767790d3843a2e7" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses allocation concealment using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in allocation concealment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating allocation concealment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000466, bemo:BEMO_2000467, bemo:BEMO_2000485 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000475 a owl:Class ; rdfs:label "Differential Follow-up Risk"@en ; iao:0000115 "The probability or degree that differential follow-up introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000475" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000475" ; bemo:BEMO_3100022 482 ; bemo:BEMO_3100023 "ccfe7e445aeb97f5f6fbabfec00706b7cd315705f68e05e908e47860b40d8ad4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses differential follow-up risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in differential follow-up risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating differential follow-up risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000478 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_1000007 a owl:Class ; rdfs:label "Genetics, Omics, and Systems Biology metric"@en ; iao:0000115 "Metrics assessing genetic, genomic, transcriptomic, proteomic, metabolomic, multi-omic, and systems-level evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1000007" ; rdfs:subClassOf bemo:BEMO_0000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_2000001 a owl:Class ; rdfs:label "Biological Gradient"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biological gradient."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000001" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000001" ; bemo:BEMO_3100022 8 ; bemo:BEMO_3100023 "6471dcf670c9dd05424f4606389decf6b51812d07c0a0680842d77bda957b0f3" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biological gradient using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biological gradient can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biological gradient as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000007, bemo:BEMO_2000016, bemo:BEMO_2000017 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000003 a owl:Class ; rdfs:label "Cell-Type Specificity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cell-type specificity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000003" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000003" ; bemo:BEMO_3100022 10 ; bemo:BEMO_3100023 "8fcb10135485d0dff26bef51519f2178a09a543c766f354a728ca79b2c39c582" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses cell-type specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cell-type specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cell-type specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000019, bemo:BEMO_2000023, bemo:BEMO_2000027 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000004 a owl:Class ; rdfs:label "Cross-Species Biological Concordance"@en ; iao:0000115 "The degree of agreement in cross-species biological across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000004" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000004" ; bemo:BEMO_3100022 11 ; bemo:BEMO_3100023 "6f883b8ebe7aa3d7407688c8b2390b245a894c21f5c21ffef99fe634674c5fd3" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cross-species biological concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-species biological concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-species biological concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000015, bemo:BEMO_2000021, bemo:BEMO_2000026 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000005 a owl:Class ; rdfs:label "Epistasis Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting epistasis."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000005" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000005" ; bemo:BEMO_3100022 12 ; bemo:BEMO_3100023 "cd57f610728234561644257a8387987f0aa8934688593c5fbd817b3779032054" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses epistasis support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in epistasis support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating epistasis support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000018, bemo:BEMO_2000022, bemo:BEMO_2000025 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000006 a owl:Class ; rdfs:label "Gain-of-Function Validation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of gain-of-function validation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000006" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000006" ; bemo:BEMO_3100022 13 ; bemo:BEMO_3100023 "5c02cfac370a9d2c1514479546d6e291e60bffe1758412ceec02bbf8edaab2dc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses gain-of-function validation using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in gain-of-function validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating gain-of-function validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000005, bemo:BEMO_2000008, bemo:BEMO_2000022 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000007 a owl:Class ; rdfs:label "Homeostatic Compensation Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of homeostatic compensation assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000007" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000007" ; bemo:BEMO_3100022 14 ; bemo:BEMO_3100023 "61aaa3d7ba71760f01fcbbb79304031b61f416940944ef459f48b6d07dc0628d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses homeostatic compensation assessment using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in homeostatic compensation assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating homeostatic compensation assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000001, bemo:BEMO_2000016, bemo:BEMO_2000024 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000008 a owl:Class ; rdfs:label "Loss-of-Function Validation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of loss-of-function validation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000008" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000008" ; bemo:BEMO_3100022 15 ; bemo:BEMO_3100023 "7b09e166eefa32f832c89264de2b3521f93b540fbc674d78fc625fd792779d09" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses loss-of-function validation using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in loss-of-function validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating loss-of-function validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000006, bemo:BEMO_2000020, bemo:BEMO_2000022 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000009 a owl:Class ; rdfs:label "Mechanistic Causality Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting mechanistic causality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000009" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000009" ; bemo:BEMO_3100022 16 ; bemo:BEMO_3100023 "114851a566f6667271761fd50b701ab810f623c4ee0ecdabe88d5bbacc5941db" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses mechanistic causality strength using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mechanistic causality strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating mechanistic causality strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000003, bemo:BEMO_2000013, bemo:BEMO_2000019 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000010 a owl:Class ; rdfs:label "Mechanistic Coherence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mechanistic coherence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000010" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000010" ; bemo:BEMO_3100022 17 ; bemo:BEMO_3100023 "dc1b3b375698d0aec42693d5a0b2f87405e7e7bf90759105797ad714ab4e9ab2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses mechanistic coherence using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mechanistic coherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mechanistic coherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000009, bemo:BEMO_2000011, bemo:BEMO_2000013 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000011 a owl:Class ; rdfs:label "Mechanistic Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of mechanistic are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000011" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000011" ; bemo:BEMO_3100022 18 ; bemo:BEMO_3100023 "70dc43fe10f07fb6cf3546a825ad424f5db2e21cc1b19a9f92b47d758bf660bd" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses mechanistic completeness using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mechanistic completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mechanistic completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000010, bemo:BEMO_2000012, bemo:BEMO_2000013 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000012 a owl:Class ; rdfs:label "Mechanistic Coverage"@en ; iao:0000115 "The proportion and representativeness of the relevant mechanistic captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000012" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000012" ; bemo:BEMO_3100022 19 ; bemo:BEMO_3100023 "8582aac321a237f1dd1db68f0893021d3bc987b71b373d1879cc2dfb098adbdb" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses mechanistic coverage using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mechanistic coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mechanistic coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000010, bemo:BEMO_2000011, bemo:BEMO_2000014 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000013 a owl:Class ; rdfs:label "Mechanistic Specificity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mechanistic specificity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000013" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000013" ; bemo:BEMO_3100022 20 ; bemo:BEMO_3100023 "29074cf2dac765628d0a639b922f2e3313846aa414af9c4ef760ea93c86819ca" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses mechanistic specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mechanistic specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mechanistic specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000009, bemo:BEMO_2000010, bemo:BEMO_2000019 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000015 a owl:Class ; rdfs:label "Molecular-Phenotypic Concordance"@en ; iao:0000115 "The degree of agreement in molecular-phenotypic across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000015" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000015" ; bemo:BEMO_3100022 22 ; bemo:BEMO_3100023 "81a78e88eaa62f6e2bb0ae947aba28fe819150032abcf9264f9205803cc7dfd1" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses molecular-phenotypic concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in molecular-phenotypic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating molecular-phenotypic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000008, bemo:BEMO_2000020, bemo:BEMO_2000021 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000016 a owl:Class ; rdfs:label "Network Context Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting network context."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000016" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000016" ; bemo:BEMO_3100022 23 ; bemo:BEMO_3100023 "d14cae7a1ae4e812a18da95395619423ade3837794dc32beea80cb11af0003f0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses network context support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in network context support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating network context support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000007, bemo:BEMO_2000024 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000017 a owl:Class ; rdfs:label "Off-Target Liability Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of off-target liability evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000017" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000017" ; bemo:BEMO_3100022 24 ; bemo:BEMO_3100023 "688a2bdbd29ad4b59eca6350cf3462f2bc158ee3d70ef4de59f338b6e6c797a6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses off-target liability evidence using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in off-target liability evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating off-target liability evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000001, bemo:BEMO_2000007, bemo:BEMO_2000018 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000018 a owl:Class ; rdfs:label "On-Target Specificity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of on-target specificity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000018" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000018" ; bemo:BEMO_3100022 25 ; bemo:BEMO_3100023 "5b75004715c78ae57eb0dfbf1a6fe3b6212289ca6b06f39e35b36270d16b13e5" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses on-target specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in on-target specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating on-target specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000001, bemo:BEMO_2000017, bemo:BEMO_2000025 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000019 a owl:Class ; rdfs:label "Pathway-Level Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting pathway-level."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000019" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000019" ; bemo:BEMO_3100022 26 ; bemo:BEMO_3100023 "a1a0e0a377d9f949a45a0ad0a040b0443e29f24bfe701f3b015420b52cd21ab2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pathway-level support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pathway-level support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pathway-level support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000003, bemo:BEMO_2000009, bemo:BEMO_2000027 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000020 a owl:Class ; rdfs:label "Perturbational Validation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of perturbational validation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000020" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000020" ; bemo:BEMO_3100022 27 ; bemo:BEMO_3100023 "e56c259480c9a3f5c7efe467a62a9721824469292b9aeb900d1804f2bbfb7983" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses perturbational validation using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in perturbational validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating perturbational validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000006, bemo:BEMO_2000008, bemo:BEMO_2000015 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000021 a owl:Class ; rdfs:label "Phenotypic Concordance"@en ; iao:0000115 "The degree of agreement in phenotypic across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000021" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000021" ; bemo:BEMO_3100022 28 ; bemo:BEMO_3100023 "d6b2622e1418a4a4c75dd4e74edee6d3fe7ea5ecac7eb6c453c614421e29173a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses phenotypic concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in phenotypic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating phenotypic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000004, bemo:BEMO_2000015, bemo:BEMO_2000020 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000022 a owl:Class ; rdfs:label "Rescue Experiment Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting rescue experiment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000022" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000022" ; bemo:BEMO_3100022 29 ; bemo:BEMO_3100023 "9f3de30fb4252544b664477f26ad879c47cffd18e4a902652a07ca5b9fa59ec2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses rescue experiment support using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in rescue experiment support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating rescue experiment support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000005, bemo:BEMO_2000006, bemo:BEMO_2000025 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000023 a owl:Class ; rdfs:label "Spatial Biological Concordance"@en ; iao:0000115 "The degree of agreement in spatial biological across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000023" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000023" ; bemo:BEMO_3100022 30 ; bemo:BEMO_3100023 "6c08ba26b1257f37b62212d7633a9e83166a0f74706ae3ffbb9de90cd98613f7" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses spatial biological concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in spatial biological concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating spatial biological concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000004, bemo:BEMO_2000026, bemo:BEMO_2000027 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000025 a owl:Class ; rdfs:label "Target Engagement Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of target engagement evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000025" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000025" ; bemo:BEMO_3100022 32 ; bemo:BEMO_3100023 "a51c69d24f2bf9ef711f1d3b54d2086032245754bf1992c1b5999a88e3ca185f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses target engagement evidence using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in target engagement evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating target engagement evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000005, bemo:BEMO_2000017, bemo:BEMO_2000018 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000026 a owl:Class ; rdfs:label "Temporal Biological Concordance"@en ; iao:0000115 "The degree of agreement in temporal biological across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000026" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000026" ; bemo:BEMO_3100022 33 ; bemo:BEMO_3100023 "57d68c3c49543e85a4a6ee1a26a1705e9e0e05df169673d5a8f0a00632bfa39b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses temporal biological concordance using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in temporal biological concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating temporal biological concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000004, bemo:BEMO_2000021, bemo:BEMO_2000023 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000027 a owl:Class ; rdfs:label "Tissue Specificity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of tissue specificity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000027" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100001 ; bemo:BEMO_3100001 "BEMO:2000027" ; bemo:BEMO_3100022 34 ; bemo:BEMO_3100023 "e3cc6b49f3bcbfabd500e6222a7c3cc053aca55c824a6afddd04a9b448378651" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses tissue specificity using evidence appropriate to biological plausibility and mechanism, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in tissue specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating tissue specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Molecular, cellular, animal, translational, pharmacologic, and human studies"@en ; bemo:BEMO_3200010 "GRADE; FDA Biomarker; ClinGen; OHAT; OECD"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.fda.gov/media/119271/download | https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000003, bemo:BEMO_2000023, bemo:BEMO_2000026 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000028 a owl:Class ; rdfs:label "Biomarker Clinical Relevance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker clinical relevance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000028" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000028" ; bemo:BEMO_3100022 35 ; bemo:BEMO_3100023 "70bbbca5f05350dbfed193659c18ff0eef66a6552528618a931911c0bbfe7878" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses biomarker clinical relevance using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biomarker clinical relevance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biomarker clinical relevance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000029, bemo:BEMO_2000033, bemo:BEMO_2000037 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000029 a owl:Class ; rdfs:label "Biomarker Qualification Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting biomarker qualification."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000029" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000029" ; bemo:BEMO_3100022 36 ; bemo:BEMO_3100023 "35003a5d4be2844c7914597bb95d8d44ce388ce934a6b5067c8e498ac9e8de35" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biomarker qualification strength using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biomarker qualification strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biomarker qualification strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000030, bemo:BEMO_2000031, bemo:BEMO_2000037 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000030 a owl:Class ; rdfs:label "Biomarker Reliability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker reliability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000030" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000030" ; bemo:BEMO_3100022 37 ; bemo:BEMO_3100023 "74c0c7f33ecc210cbe2fa1dd5ddc15c31273005f3e5caaa4afc370a3f6c94a4e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biomarker reliability using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biomarker reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biomarker reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000029, bemo:BEMO_2000031, bemo:BEMO_2000032 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000031 a owl:Class ; rdfs:label "Biomarker Responsiveness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker responsiveness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000031" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000031" ; bemo:BEMO_3100022 38 ; bemo:BEMO_3100023 "19a54854b5dfb7168eddad304da95ddbab2e1ad34992146fcedfd650dfe09548" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses biomarker responsiveness using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biomarker responsiveness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biomarker responsiveness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000030, bemo:BEMO_2000032, bemo:BEMO_2000046 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000032 a owl:Class ; rdfs:label "Biomarker Sensitivity to Change"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of biomarker sensitivity to change."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000032" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000032" ; bemo:BEMO_3100022 39 ; bemo:BEMO_3100023 "80beed232e03f65da1843b394120d8baef7fb4428401374caac926260837e2b2" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses biomarker sensitivity to change using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in biomarker sensitivity to change can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating biomarker sensitivity to change as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000031, bemo:BEMO_2000038, bemo:BEMO_2000046 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000035 a owl:Class ; rdfs:label "Construct Validity"@en ; iao:0000115 "The degree to which construct supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000035" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000035" ; bemo:BEMO_3100022 42 ; bemo:BEMO_3100023 "5bd558ed006f260bde44545e9ab38951fc6c2e450b4d3cb07f929d1fcb479f4e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses construct validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in construct validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating construct validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000036, bemo:BEMO_2000039, bemo:BEMO_2000051 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000036 a owl:Class ; rdfs:label "Content Validity"@en ; iao:0000115 "The degree to which content supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000036" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000036" ; bemo:BEMO_3100022 43 ; bemo:BEMO_3100023 "1ceb580fd3a672a7c14d44163bda2886dd03d14b99ce004f1db40aa485bb3e1b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses content validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in content validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating content validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000035, bemo:BEMO_2000051, bemo:BEMO_2000052 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000037 a owl:Class ; rdfs:label "Context-of-Use Validity"@en ; iao:0000115 "The degree to which context-of-use supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000037" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000037" ; bemo:BEMO_3100022 44 ; bemo:BEMO_3100023 "170c4bee423f9901b11abd5c6c7203f1253da40dbd46a33c459bac07471058e8" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses context-of-use validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in context-of-use validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating context-of-use validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000028, bemo:BEMO_2000029, bemo:BEMO_2000030 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000038 a owl:Class ; rdfs:label "Convergent Validity"@en ; iao:0000115 "The degree to which convergent supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000038" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000038" ; bemo:BEMO_3100022 45 ; bemo:BEMO_3100023 "4ad4866845885f677cad74042f65b0303f2d26597ea694b76dfed4bc71fedd68" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses convergent validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in convergent validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating convergent validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000039, bemo:BEMO_2000041, bemo:BEMO_2000046 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000039 a owl:Class ; rdfs:label "Criterion Validity"@en ; iao:0000115 "The degree to which criterion supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000039" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000039" ; bemo:BEMO_3100022 46 ; bemo:BEMO_3100023 "04af58cc2d88f851cf92e0d1960d29a74b3d8a5cf3525dda9579101a813732b2" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses criterion validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in criterion validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating criterion validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000035, bemo:BEMO_2000036, bemo:BEMO_2000041 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000040 a owl:Class ; rdfs:label "Diagnostic Biomarker Validity"@en ; iao:0000115 "The degree to which diagnostic biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000040" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000040" ; bemo:BEMO_3100022 47 ; bemo:BEMO_3100023 "b87f6768315d9d24a6505cd78867a8b0dc9310fbd10aa04b46856994c12562e5" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses diagnostic biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in diagnostic biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating diagnostic biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000048, bemo:BEMO_2000050, bemo:BEMO_2000052 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000041 a owl:Class ; rdfs:label "Discriminant Validity"@en ; iao:0000115 "The degree to which discriminant supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000041" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000041" ; bemo:BEMO_3100022 48 ; bemo:BEMO_3100023 "c0e22c7d45b8b17a4c9f1de5c7c7bb4e085d98eb667da8d43e452ea31955900b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses discriminant validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in discriminant validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating discriminant validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000035, bemo:BEMO_2000038, bemo:BEMO_2000039 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000042 a owl:Class ; rdfs:label "Endpoint Reliability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of endpoint reliability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000042" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000042" ; bemo:BEMO_3100022 49 ; bemo:BEMO_3100023 "e147bf4116de09d3c1bd6b5fb8081223589d31f54f697b6e869790830619757d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses endpoint reliability using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in endpoint reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating endpoint reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000043, bemo:BEMO_2000047, bemo:BEMO_2000049 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000043 a owl:Class ; rdfs:label "Endpoint Responsiveness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of endpoint responsiveness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000043" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000043" ; bemo:BEMO_3100022 50 ; bemo:BEMO_3100023 "3cb1f45a15a5daa5f6b98c2d745a57440f42e5840e757c82a744e9f010f76df0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses endpoint responsiveness using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in endpoint responsiveness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating endpoint responsiveness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000042, bemo:BEMO_2000047 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000044 a owl:Class ; rdfs:label "Endpoint Validity"@en ; iao:0000115 "The degree to which endpoint supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000044" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000044" ; bemo:BEMO_3100022 51 ; bemo:BEMO_3100023 "f79c486fa1f56b17619593da318c44a3704cbd1294be41ae30a2b38ceb9410d1" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses endpoint validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in endpoint validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating endpoint validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000042, bemo:BEMO_2000049, bemo:BEMO_2000057 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000045 a owl:Class ; rdfs:label "Individual-Level Surrogacy"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of individual-level surrogacy."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000045" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000045" ; bemo:BEMO_3100022 52 ; bemo:BEMO_3100023 "4d46697f970727d741077ee1e1f9eeeaed4beee8d6ef96a339ca927181b91ef5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses individual-level surrogacy using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in individual-level surrogacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating individual-level surrogacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000044, bemo:BEMO_2000055, bemo:BEMO_2000057 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000046 a owl:Class ; rdfs:label "Known-Groups Validity"@en ; iao:0000115 "The degree to which known-groups supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000046" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000046" ; bemo:BEMO_3100022 53 ; bemo:BEMO_3100023 "8e195ef346deba393b7a3adaf4c77bfbd949dbf0f057cd9af26312568cb85421" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses known-groups validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in known-groups validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating known-groups validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000032, bemo:BEMO_2000038, bemo:BEMO_2000041 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000048 a owl:Class ; rdfs:label "Monitoring Biomarker Validity"@en ; iao:0000115 "The degree to which monitoring biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000048" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000048" ; bemo:BEMO_3100022 55 ; bemo:BEMO_3100023 "cc605972d7119b4dabf5e0bc927d29fa05979e706703654bb3ea93c2ebe95461" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses monitoring biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in monitoring biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating monitoring biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000050, bemo:BEMO_2000054, bemo:BEMO_2000056 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000049 a owl:Class ; rdfs:label "Outcome Relevance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of outcome relevance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000049" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000049" ; bemo:BEMO_3100022 56 ; bemo:BEMO_3100023 "1adca583ee04c245cdae3428bd050f3ed8796d29bf4b214b5880769da8977172" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses outcome relevance using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in outcome relevance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating outcome relevance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000042, bemo:BEMO_2000043, bemo:BEMO_2000044 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000050 a owl:Class ; rdfs:label "Pharmacodynamic Biomarker Validity"@en ; iao:0000115 "The degree to which pharmacodynamic biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000050" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000050" ; bemo:BEMO_3100022 57 ; bemo:BEMO_3100023 "4eb497c772907b7927e32ee929fba9a804b1c75888594041caa61dfab977440a" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses pharmacodynamic biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pharmacodynamic biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pharmacodynamic biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000040, bemo:BEMO_2000048, bemo:BEMO_2000054 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000051 a owl:Class ; rdfs:label "Predictive Biomarker Validity"@en ; iao:0000115 "The degree to which predictive biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000051" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000051" ; bemo:BEMO_3100022 58 ; bemo:BEMO_3100023 "c5c7cbb5b7738940f61731df207186f05f8ae71ecab7ca3c5588c823af8d00eb" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses predictive biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in predictive biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating predictive biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000036, bemo:BEMO_2000040, bemo:BEMO_2000052 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000052 a owl:Class ; rdfs:label "Prognostic Biomarker Validity"@en ; iao:0000115 "The degree to which prognostic biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000052" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000052" ; bemo:BEMO_3100022 59 ; bemo:BEMO_3100023 "2dd804ff14e01e089d83a5d2d6ef790d24cf90ca54d3426049116e4e7aeb095f" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses prognostic biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prognostic biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prognostic biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000040, bemo:BEMO_2000050, bemo:BEMO_2000051 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000053 a owl:Class ; rdfs:label "Response Biomarker Validity"@en ; iao:0000115 "The degree to which response biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000053" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000053" ; bemo:BEMO_3100022 60 ; bemo:BEMO_3100023 "a8e8ef21a701fbb547c028557e4678bc79ebeda610eb6926bf0061b6e9a016c4" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses response biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in response biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating response biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000045, bemo:BEMO_2000055, bemo:BEMO_2000056 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000054 a owl:Class ; rdfs:label "Safety Biomarker Validity"@en ; iao:0000115 "The degree to which safety biomarker supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000054" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000054" ; bemo:BEMO_3100022 61 ; bemo:BEMO_3100023 "a6b6c6cf8ada87a1112583df9bc78595f4f0975ec0e8bbfc01ca6f00c2c0adf1" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses safety biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in safety biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating safety biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000048, bemo:BEMO_2000053, bemo:BEMO_2000056 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000055 a owl:Class ; rdfs:label "Surrogate Endpoint Validity"@en ; iao:0000115 "The degree to which surrogate endpoint supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000055" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000055" ; bemo:BEMO_3100022 62 ; bemo:BEMO_3100023 "880b1c4a9fa2a25e2876679a2a7e759365591c8d0d0ae431e9a6e89a9d327bd9" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses surrogate endpoint validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in surrogate endpoint validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating surrogate endpoint validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000045, bemo:BEMO_2000053, bemo:BEMO_2000057 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000056 a owl:Class ; rdfs:label "Susceptibility/Risk Biomarker Validity"@en ; iao:0000115 "The probability or degree that susceptibility/risk biomarker validity introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000056" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000056" ; bemo:BEMO_3100022 63 ; bemo:BEMO_3100023 "596927f557190db71a0b686158bde6134cafa9cdb9c1876784270d91a80452f5" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses susceptibility/risk biomarker validity using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in susceptibility/risk biomarker validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating susceptibility/risk biomarker validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000053, bemo:BEMO_2000054, bemo:BEMO_2000055 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000057 a owl:Class ; rdfs:label "Trial-Level Surrogacy"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of trial-level surrogacy."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000057" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100002 ; bemo:BEMO_3100001 "BEMO:2000057" ; bemo:BEMO_3100022 64 ; bemo:BEMO_3100023 "977d5f2b7e02b5e90f442ea4e8788e2fe539316cddda3ae61da29b0fa71c5325" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses trial-level surrogacy using evidence appropriate to biomarker and endpoint validation, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in trial-level surrogacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating trial-level surrogacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Biomarker development, qualification, endpoint and surrogate validation studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; BEST; EMA E16; REMARK"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://www.ncbi.nlm.nih.gov/books/NBK326791/ | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000044, bemo:BEMO_2000045, bemo:BEMO_2000049 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000058 a owl:Class ; rdfs:label "Anatomical Site Fidelity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of anatomical site fidelity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000058" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000058" ; bemo:BEMO_3100022 65 ; bemo:BEMO_3100023 "8fa3b411fb892fff8cc31c078e25770eb74980a525cbc8e76d63bcb0f15bdaf8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses anatomical site fidelity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in anatomical site fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating anatomical site fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000074, bemo:BEMO_2000076, bemo:BEMO_2000082 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000061 a owl:Class ; rdfs:label "Cellularity Adequacy"@en ; iao:0000115 "The extent to which cellularity is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000061" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000061" ; bemo:BEMO_3100022 68 ; bemo:BEMO_3100023 "de5efa73121b798bb0e1a53bddae9ef743d4a522e6df52007a5b7569bc63e020" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cellularity adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cellularity adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cellularity adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000068, bemo:BEMO_2000073, bemo:BEMO_2000082 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000062 a owl:Class ; rdfs:label "Chain-of-Custody Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of chain-of-custody integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000062" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000062" ; bemo:BEMO_3100022 69 ; bemo:BEMO_3100023 "38ecb99023f4b12b1bfca7d66221917ae384546ef170c868cd32fb2eb70f3f40" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses chain-of-custody integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in chain-of-custody integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating chain-of-custody integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000071, bemo:BEMO_2000072 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000063 a owl:Class ; rdfs:label "Cold Ischemia Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cold ischemia control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000063" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000063" ; bemo:BEMO_3100022 70 ; bemo:BEMO_3100023 "450f9e94b009036abe7a13fe3055116e7c4959857a7291ed7e337a746d7bf722" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cold ischemia control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cold ischemia control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cold ischemia control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000066, bemo:BEMO_2000080, bemo:BEMO_2000083 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000064 a owl:Class ; rdfs:label "Collection Procedure Consistency"@en ; iao:0000115 "The degree of agreement in collection procedure across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000064" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000064" ; bemo:BEMO_3100022 71 ; bemo:BEMO_3100023 "c748a49d52923f74e8e31a0f69a4e91ee50970289d8b43c903a638e0573cc828" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses collection procedure consistency using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in collection procedure consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating collection procedure consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000060, bemo:BEMO_2000063, bemo:BEMO_2000083 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000065 a owl:Class ; rdfs:label "DNA Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dna integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000065" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000065" ; bemo:BEMO_3100022 72 ; bemo:BEMO_3100023 "494036e6478a34bfe608bc3b1267e04a777d16e96430109ab2ba9b01e99c6693" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses dna integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dna integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dna integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000072, bemo:BEMO_2000077, bemo:BEMO_2000078 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000066 a owl:Class ; rdfs:label "Fixation Adequacy"@en ; iao:0000115 "The extent to which fixation is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000066" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000066" ; bemo:BEMO_3100022 73 ; bemo:BEMO_3100023 "c08e61688a36fec680e9073fc8888dbfd98852919e3f7ccf7c3180ed49d1e921" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses fixation adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in fixation adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating fixation adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000075, bemo:BEMO_2000079, bemo:BEMO_2000080 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000067 a owl:Class ; rdfs:label "Freeze–Thaw Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of freeze–thaw burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000067" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000067" ; bemo:BEMO_3100022 74 ; bemo:BEMO_3100023 "40c5c886eacc67a9addeaa92c47d69bf9fbd4b1d2a0042a2efd3611fd5cebb4b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses freeze–thaw burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in freeze–thaw burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating freeze–thaw burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000076, bemo:BEMO_2000079, bemo:BEMO_2000081 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000068 a owl:Class ; rdfs:label "Hemolysis Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of hemolysis burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000068" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000068" ; bemo:BEMO_3100022 75 ; bemo:BEMO_3100023 "1b0946c6b109834d9e6fa6dc5ae7dde1ce95bc65f999a58a3c5a88bc66c6a47c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses hemolysis burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in hemolysis burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating hemolysis burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000069, bemo:BEMO_2000070, bemo:BEMO_2000073 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000069 a owl:Class ; rdfs:label "Icterus Interference"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of icterus interference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000069" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000069" ; bemo:BEMO_3100022 76 ; bemo:BEMO_3100023 "d0f3346c9caa8abb9b49bded0ab6e26e5f13d5a8fb5a20971f64067dd82054ea" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses icterus interference using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in icterus interference can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating icterus interference as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000065, bemo:BEMO_2000070, bemo:BEMO_2000078 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000070 a owl:Class ; rdfs:label "Lipemia Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of lipemia burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000070" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000070" ; bemo:BEMO_3100022 77 ; bemo:BEMO_3100023 "572ca1cf50802a5447be4c1286cdad2930a7ec08e97e7b9af663a3cb66e1d788" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses lipemia burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in lipemia burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating lipemia burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000068, bemo:BEMO_2000069, bemo:BEMO_2000078 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000072 a owl:Class ; rdfs:label "Microbial Contamination"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of microbial contamination."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000072" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000072" ; bemo:BEMO_3100022 79 ; bemo:BEMO_3100023 "a7e7bf9a47cefd808a5ba122413c735b8b095ffc84592451f9857f4fe080e389" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses microbial contamination using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in microbial contamination can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating microbial contamination as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000062, bemo:BEMO_2000071, bemo:BEMO_2000077 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000073 a owl:Class ; rdfs:label "Necrosis Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of necrosis burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000073" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000073" ; bemo:BEMO_3100022 80 ; bemo:BEMO_3100023 "33466881e023e8dc75d5f189be9da266f95f3bf8283fa46f9f4cff10e5af6f95" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses necrosis burden using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in necrosis burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating necrosis burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000061, bemo:BEMO_2000068, bemo:BEMO_2000070 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000074 a owl:Class ; rdfs:label "Pathology Confirmation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of pathology confirmation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000074" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000074" ; bemo:BEMO_3100022 81 ; bemo:BEMO_3100023 "e470a75855d7bb24a7f3957922ccdf78961ef4c923b6f754c0006ebb46c0367e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pathology confirmation using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pathology confirmation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pathology confirmation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000058, bemo:BEMO_2000061, bemo:BEMO_2000082 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000075 a owl:Class ; rdfs:label "Preservation Adequacy"@en ; iao:0000115 "The extent to which preservation is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000075" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000075" ; bemo:BEMO_3100022 82 ; bemo:BEMO_3100023 "de3923232eba7ea0cab4f8eddc6a1539eac9f06416d7c31e6d2ce8fbf8492ba5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses preservation adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in preservation adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating preservation adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000066, bemo:BEMO_2000067, bemo:BEMO_2000079 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000076 a owl:Class ; rdfs:label "Processing Delay Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of processing delay control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000076" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000076" ; bemo:BEMO_3100022 83 ; bemo:BEMO_3100023 "575df935e8ca0edd1975c05772eaa99f38b63f196b0ee598cef40ebcb4554aaf" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses processing delay control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in processing delay control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating processing delay control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000058, bemo:BEMO_2000074, bemo:BEMO_2000081 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000077 a owl:Class ; rdfs:label "Protein Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protein integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000077" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000077" ; bemo:BEMO_3100022 84 ; bemo:BEMO_3100023 "f776649240f851879898d488bb90516491936e0936f6f03ac5946be6c8b62a20" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses protein integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protein integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating protein integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000062, bemo:BEMO_2000065, bemo:BEMO_2000072 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000078 a owl:Class ; rdfs:label "RNA Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of rna integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000078" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000078" ; bemo:BEMO_3100022 85 ; bemo:BEMO_3100023 "98ac509f170b3163d862e8e08cc16dad8b915df5508f4e7394a8627d881f7350" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses rna integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in rna integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating rna integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000065, bemo:BEMO_2000069, bemo:BEMO_2000077 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000079 a owl:Class ; rdfs:label "Storage Temperature Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of storage temperature control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000079" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000079" ; bemo:BEMO_3100022 86 ; bemo:BEMO_3100023 "b39a92acfa55bd840331823c88476d9d65ca0179f68f0f37ed8d7677a63d2193" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses storage temperature control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in storage temperature control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating storage temperature control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000067, bemo:BEMO_2000075, bemo:BEMO_2000081 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000080 a owl:Class ; rdfs:label "Time-to-Fixation Adequacy"@en ; iao:0000115 "The extent to which time-to-fixation is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000080" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000080" ; bemo:BEMO_3100022 87 ; bemo:BEMO_3100023 "49559a7ae628351af963a27a55893cf501098be34876ce35bdc2d4969fd4f94b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses time-to-fixation adequacy using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in time-to-fixation adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating time-to-fixation adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000063, bemo:BEMO_2000066, bemo:BEMO_2000075 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000081 a owl:Class ; rdfs:label "Transport Condition Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of transport condition integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000081" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000081" ; bemo:BEMO_3100022 88 ; bemo:BEMO_3100023 "81f1c97831f3ffbcc8b4e89c16604f987d3fa2baac750496d710981c68a60598" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses transport condition integrity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in transport condition integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating transport condition integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000058, bemo:BEMO_2000067, bemo:BEMO_2000076 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000082 a owl:Class ; rdfs:label "Tumor Purity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of tumor purity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000082" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000082" ; bemo:BEMO_3100022 89 ; bemo:BEMO_3100023 "e7836bb1f6728d199c8634dbdbf560dae6243a3932920cc82164935a37c9180e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses tumor purity using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in tumor purity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating tumor purity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000061, bemo:BEMO_2000073, bemo:BEMO_2000074 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000083 a owl:Class ; rdfs:label "Warm Ischemia Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of warm ischemia control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000083" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100003 ; bemo:BEMO_3100001 "BEMO:2000083" ; bemo:BEMO_3100022 90 ; bemo:BEMO_3100023 "293c5ebda3d3695852f06644549a5b920266b83358bf49b383b5d90078fcdde6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses warm ischemia control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in warm ischemia control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating warm ischemia control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "All studies using human or animal biospecimens"@en ; bemo:BEMO_3200010 "BRISQ; ISO 15189; REMARK"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000063, bemo:BEMO_2000064, bemo:BEMO_2000080 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000084 a owl:Class ; rdfs:label "Assumption Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of assumption sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000084" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000084" ; bemo:BEMO_3100022 91 ; bemo:BEMO_3100023 "b75d62759fbd8f126f27997543f0f46dde1cb8c2484d156a08c9925c9476aa63" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses assumption sensitivity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in assumption sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating assumption sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000093, bemo:BEMO_2000096 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000085 a owl:Class ; rdfs:label "Causal Contrast Clarity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of causal contrast clarity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000085" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000085" ; bemo:BEMO_3100022 92 ; bemo:BEMO_3100023 "d81e7f98cb339c656ef93d3243144295a2c872dc2bcb50f64863414984f27993" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses causal contrast clarity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in causal contrast clarity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating causal contrast clarity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000090, bemo:BEMO_2000098, bemo:BEMO_2000107 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000087 a owl:Class ; rdfs:label "Collider Bias Risk"@en ; iao:0000115 "The probability or degree that collider bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000087" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000087" ; bemo:BEMO_3100022 94 ; bemo:BEMO_3100023 "0d0ee23715a02b538d00c3772dc0b2a1a64aba9fb6a21ecd62845d74c88b63ca" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses collider bias risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in collider bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating collider bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000094, bemo:BEMO_2000097, bemo:BEMO_2000108 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000089 a owl:Class ; rdfs:label "Consistency Assumption Plausibility"@en ; iao:0000115 "The degree of agreement in consistency assumption plausibility across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000089" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000089" ; bemo:BEMO_3100022 96 ; bemo:BEMO_3100023 "1bec3d5308662b9b5fad28978574efe7573d32766cf45ac34286863d2d2267a8" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses consistency assumption plausibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in consistency assumption plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating consistency assumption plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000090, bemo:BEMO_2000101, bemo:BEMO_2000102 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000090 a owl:Class ; rdfs:label "Correct Temporal Ordering"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of correct temporal ordering."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000090" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000090" ; bemo:BEMO_3100022 97 ; bemo:BEMO_3100023 "b11d505f3985b03d1ab78fe50a79558d187aeacc3fabbc39b5dc3da61a0cfbe2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses correct temporal ordering using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in correct temporal ordering can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating correct temporal ordering as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000085, bemo:BEMO_2000101, bemo:BEMO_2000107 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000091 a owl:Class ; rdfs:label "Dechallenge–Rechallenge Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting dechallenge–rechallenge."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000091" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000091" ; bemo:BEMO_3100022 98 ; bemo:BEMO_3100023 "9e166f37b12b35c895b18fc7e56e04526e22004c0b70dee562c1cf80c5d17e69" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses dechallenge–rechallenge support using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dechallenge–rechallenge support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dechallenge–rechallenge support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000092, bemo:BEMO_2000094, bemo:BEMO_2000099 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000092 a owl:Class ; rdfs:label "Dose–Response Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting dose–response."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000092" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000092" ; bemo:BEMO_3100022 99 ; bemo:BEMO_3100023 "75f662d9e2ee059c317733c8704b2f0f1f234146f1b2920ed572ec892b5a2d41" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses dose–response support using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dose–response support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dose–response support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000091, bemo:BEMO_2000099, bemo:BEMO_2000100 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000093 a owl:Class ; rdfs:label "E-value Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting e-value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000093" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000093" ; bemo:BEMO_3100022 100 ; bemo:BEMO_3100023 "8587ae49790e995db7d3bf84506f3bebdce4263532f6e5dcbd136229f5da442f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses e-value strength using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in e-value strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating e-value strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000084, bemo:BEMO_2000096, bemo:BEMO_2000103 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Specialized / infrequent" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000094 a owl:Class ; rdfs:label "Effect-Modification Credibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of effect-modification credibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000094" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000094" ; bemo:BEMO_3100022 101 ; bemo:BEMO_3100023 "f66521085db07e7bd17f7b93b07cf74e57b1c85461a2555c1146f672069098b2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses effect-modification credibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in effect-modification credibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating effect-modification credibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000087, bemo:BEMO_2000099, bemo:BEMO_2000108 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000095 a owl:Class ; rdfs:label "Exchangeability Plausibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of exchangeability plausibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000095" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000095" ; bemo:BEMO_3100022 102 ; bemo:BEMO_3100023 "7f4004986e0cd5fd0b8462346aec167d3be6e60fe67bb8a5838de7a005fd58d1" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses exchangeability plausibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in exchangeability plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating exchangeability plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000089, bemo:BEMO_2000102, bemo:BEMO_2000109 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000097 a owl:Class ; rdfs:label "Immortal-Time Bias Risk"@en ; iao:0000115 "The probability or degree that immortal-time bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000097" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000097" ; bemo:BEMO_3100022 104 ; bemo:BEMO_3100023 "21a510319cb99a940f9fc99111522f80932b8a874f1ea984fb332f8f218483c8" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses immortal-time bias risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in immortal-time bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating immortal-time bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000105, bemo:BEMO_2000106, bemo:BEMO_2000108 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000098 a owl:Class ; rdfs:label "Instrument Validity"@en ; iao:0000115 "The degree to which instrument supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000098" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000098" ; bemo:BEMO_3100022 105 ; bemo:BEMO_3100023 "e7033f91a59f115f9fba748b04cab66664ac151f4c8d653ea61aa823a8c6cce4" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses instrument validity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in instrument validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating instrument validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000092, bemo:BEMO_2000100, bemo:BEMO_2000107 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000099 a owl:Class ; rdfs:label "Mediation Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting mediation evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000099" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000099" ; bemo:BEMO_3100022 106 ; bemo:BEMO_3100023 "b7abd5f34cd2addb34f26d923a9c80b402d8914f57510a7f5fe8c4ed41659c58" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses mediation evidence strength using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mediation evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating mediation evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000087, bemo:BEMO_2000091, bemo:BEMO_2000094 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000100 a owl:Class ; rdfs:label "Negative-Control Validation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative-control validation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000100" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000100" ; bemo:BEMO_3100022 107 ; bemo:BEMO_3100023 "63bedc3fc09ef48160a8d522d76618e50e47197d3d502ae109f1015d0fbcb67e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses negative-control validation using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in negative-control validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating negative-control validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000091, bemo:BEMO_2000092, bemo:BEMO_2000098 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000101 a owl:Class ; rdfs:label "No-Interference Plausibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of no-interference plausibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000101" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000101" ; bemo:BEMO_3100022 108 ; bemo:BEMO_3100023 "8aa9a1ba76fa5fd8217fff1b4352656d262602a1040dc8618b138b2e37a93d9a" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses no-interference plausibility using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in no-interference plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating no-interference plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000085, bemo:BEMO_2000089, bemo:BEMO_2000090 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000102 a owl:Class ; rdfs:label "Positivity Adequacy"@en ; iao:0000115 "The extent to which positivity is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000102" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000102" ; bemo:BEMO_3100022 109 ; bemo:BEMO_3100023 "be2ac5c0345d954f0ccc1ce41f05b792425f3fb9c158083a6db1928102b69608" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses positivity adequacy using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in positivity adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating positivity adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000089, bemo:BEMO_2000095, bemo:BEMO_2000101 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000103 a owl:Class ; rdfs:label "Quantitative Bias Analysis Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of quantitative bias analysis robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000103" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000103" ; bemo:BEMO_3100022 110 ; bemo:BEMO_3100023 "7ee1bd197cfd8211ed7ac785b0e49ec8e73324814e415213789e479477f73c74" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses quantitative bias analysis robustness using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in quantitative bias analysis robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating quantitative bias analysis robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000084, bemo:BEMO_2000093, bemo:BEMO_2000106 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000104 a owl:Class ; rdfs:label "Residual Confounding Risk"@en ; iao:0000115 "The probability or degree that residual confounding introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000104" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000104" ; bemo:BEMO_3100022 111 ; bemo:BEMO_3100023 "fef3c7d8a6ff0d0d4088a08abb2cfe7420127e6170b4998b7b5ce06d44124e81" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses residual confounding risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in residual confounding risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating residual confounding risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000088, bemo:BEMO_2000095, bemo:BEMO_2000109 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000105 a owl:Class ; rdfs:label "Reverse-Causation Risk"@en ; iao:0000115 "The probability or degree that reverse-causation introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000105" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000105" ; bemo:BEMO_3100022 112 ; bemo:BEMO_3100023 "17fc4b74f3434a4ae22f908b09530b9a1be33f82af499c89239235d78d7e1375" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses reverse-causation risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reverse-causation risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reverse-causation risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000097, bemo:BEMO_2000103, bemo:BEMO_2000106 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000106 a owl:Class ; rdfs:label "Selection-on-Survival Bias Risk"@en ; iao:0000115 "The probability or degree that selection-on-survival bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000106" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000106" ; bemo:BEMO_3100022 113 ; bemo:BEMO_3100023 "ba5e2bde29a386ccb9cae3afe1f1c9476a350f65371bc1aebd58a3579e6e702c" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses selection-on-survival bias risk using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in selection-on-survival bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating selection-on-survival bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000093, bemo:BEMO_2000103, bemo:BEMO_2000105 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000107 a owl:Class ; rdfs:label "Target Trial Emulation Fidelity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of target trial emulation fidelity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000107" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000107" ; bemo:BEMO_3100022 114 ; bemo:BEMO_3100023 "7a907a8dc4fe2c40df0aa3c333c85c8e7231c1e33d26321171335bcd3464b6a6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses target trial emulation fidelity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in target trial emulation fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating target trial emulation fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000085, bemo:BEMO_2000098, bemo:BEMO_2000100 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000108 a owl:Class ; rdfs:label "Time-Varying Confounding Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of time-varying confounding control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000108" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000108" ; bemo:BEMO_3100022 115 ; bemo:BEMO_3100023 "f46690f0cea7611ea5bb0e9a0e5c1b90d25ecad9c8f28f3083cc2a71b53ce7f0" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses time-varying confounding control using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in time-varying confounding control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating time-varying confounding control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000087, bemo:BEMO_2000097, bemo:BEMO_2000105 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000109 a owl:Class ; rdfs:label "Unmeasured Confounding Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of unmeasured confounding sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000109" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100004 ; bemo:BEMO_3100001 "BEMO:2000109" ; bemo:BEMO_3100022 116 ; bemo:BEMO_3100023 "50677da95ed69c14f1f1ec5786cb5c4d590d6e339c1a13fdedfd18d811ffc8f4" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses unmeasured confounding sensitivity using evidence appropriate to causal inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in unmeasured confounding sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Directed acyclic graphs; design emulation; balance diagnostics; negative controls; quantitative bias analysis; sensitivity and falsification analyses."@en ; bemo:BEMO_3200006 "Treating unmeasured confounding sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized and observational etiologic studies, natural experiments, target-trial emulations"@en ; bemo:BEMO_3200010 "ROBINS-I; ROBINS-E; GRADE; STROBE; ICH E9"@en ; bemo:BEMO_3200011 "https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.gradeworkinggroup.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000095, bemo:BEMO_2000102, bemo:BEMO_2000104 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000110 a owl:Class ; rdfs:label "Area Under the Receiver Operating Characteristic Curve"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of area under the receiver operating characteristic curve."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000110" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000110" ; bemo:BEMO_3100022 117 ; bemo:BEMO_3100023 "5c4feaae4c2a565042108ac4cb807678f9be09f3e84e62f596afd3338e3ceec6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses area under the receiver operating characteristic curve using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in area under the receiver operating characteristic curve can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating area under the receiver operating characteristic curve as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000115, bemo:BEMO_2000125, bemo:BEMO_2000136 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000111 a owl:Class ; rdfs:label "Calibration Slope"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration slope."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000111" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000111" ; bemo:BEMO_3100022 118 ; bemo:BEMO_3100023 "44bfcfec74d2b98de3507998b5e63f6506912c93210fea4df7a678aed4417a75" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses calibration slope using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in calibration slope can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating calibration slope as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000112, bemo:BEMO_2000124, bemo:BEMO_2000130 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000112 a owl:Class ; rdfs:label "Calibration-in-the-Large"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration-in-the-large."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000112" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000112" ; bemo:BEMO_3100022 119 ; bemo:BEMO_3100023 "4a117ceb82993be69cf387d42f6626e25d4ff682e98eb458d01d55a60ca6f29d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses calibration-in-the-large using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in calibration-in-the-large can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating calibration-in-the-large as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000111, bemo:BEMO_2000124, bemo:BEMO_2000129 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000113 a owl:Class ; rdfs:label "Comparative Test Accuracy"@en ; iao:0000115 "The closeness of comparative test to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000113" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000113" ; bemo:BEMO_3100022 120 ; bemo:BEMO_3100023 "01f4b65430acfaca391e550bb1550450d424a1dd47aebe4ed0f6dd9d60fe28ab" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses comparative test accuracy using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in comparative test accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating comparative test accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000120, bemo:BEMO_2000133, bemo:BEMO_2000135 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000115 a owl:Class ; rdfs:label "Diagnostic Odds Ratio"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of diagnostic odds ratio."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000115" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000115" ; bemo:BEMO_3100022 122 ; bemo:BEMO_3100023 "a903f03627bce43e756f3c1d10c27c552a53bce0346a40196ea1cd72afe63de0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses diagnostic odds ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in diagnostic odds ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating diagnostic odds ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000110, bemo:BEMO_2000122, bemo:BEMO_2000125 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000118 a owl:Class ; rdfs:label "Differential Verification Bias Risk"@en ; iao:0000115 "The probability or degree that differential verification bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000118" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000118" ; bemo:BEMO_3100022 125 ; bemo:BEMO_3100023 "2805e0d0838d99254f4675a5517e72c35cb3e1cb875fbc214edb03376568c858" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses differential verification bias risk using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in differential verification bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating differential verification bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000119, bemo:BEMO_2000126, bemo:BEMO_2000138 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000119 a owl:Class ; rdfs:label "Incorporation Bias Risk"@en ; iao:0000115 "The probability or degree that incorporation bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000119" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000119" ; bemo:BEMO_3100022 126 ; bemo:BEMO_3100023 "00ceeb2a9486ba76c68ad0f07ad3fe11fadf573e3b3b3fb37898281142b34a91" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses incorporation bias risk using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in incorporation bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating incorporation bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000118, bemo:BEMO_2000126, bemo:BEMO_2000135 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000120 a owl:Class ; rdfs:label "Incremental Diagnostic Value"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of incremental diagnostic value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000120" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000120" ; bemo:BEMO_3100022 127 ; bemo:BEMO_3100023 "8c0d8dc6983b3100a525f45a2c3c327af7d21cf2d155dc05a19b99e0d7f43578" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses incremental diagnostic value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in incremental diagnostic value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating incremental diagnostic value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000113, bemo:BEMO_2000131, bemo:BEMO_2000133 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000121 a owl:Class ; rdfs:label "Index-Test Blinding"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of index-test blinding."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000121" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000121" ; bemo:BEMO_3100022 128 ; bemo:BEMO_3100023 "3bc623a30f8cb3956f6d71196888c1021137e72c87604513c9fc1e352f98bb4c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses index-test blinding using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in index-test blinding can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating index-test blinding as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000118, bemo:BEMO_2000134, bemo:BEMO_2000138 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000122 a owl:Class ; rdfs:label "Negative Likelihood Ratio"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative likelihood ratio."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000122" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000122" ; bemo:BEMO_3100022 129 ; bemo:BEMO_3100023 "6dc29889e79017542636c8b841aff4c0f5947b19dec51307e00a9c51cdc593cc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses negative likelihood ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in negative likelihood ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating negative likelihood ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000110, bemo:BEMO_2000115, bemo:BEMO_2000127 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000123 a owl:Class ; rdfs:label "Negative Predictive Value"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative predictive value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000123" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000123" ; bemo:BEMO_3100022 130 ; bemo:BEMO_3100023 "9f42e5362ad2e55445a028ec6d3cc9c062886d8c9272f983b0c1acec345502f7" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses negative predictive value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in negative predictive value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating negative predictive value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000122, bemo:BEMO_2000127, bemo:BEMO_2000128 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000124 a owl:Class ; rdfs:label "Observed-to-Expected Ratio"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of observed-to-expected ratio."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000124" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000124" ; bemo:BEMO_3100022 131 ; bemo:BEMO_3100023 "cdf33871a90f7426da799fbf8148672bff9e925c7981ff58372c39511bd4050e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses observed-to-expected ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in observed-to-expected ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating observed-to-expected ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000112, bemo:BEMO_2000129, bemo:BEMO_2000132 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000125 a owl:Class ; rdfs:label "Partial Area Under the Receiver Operating Characteristic Curve"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of partial area under the receiver operating characteristic curve."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000125" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000125" ; bemo:BEMO_3100022 132 ; bemo:BEMO_3100023 "79f6b607e0d7504f46e1d3842fa8966ae929db7058236a6b4ed553277ad444b5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses partial area under the receiver operating characteristic curve using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in partial area under the receiver operating characteristic curve can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating partial area under the receiver operating characteristic curve as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000110, bemo:BEMO_2000134, bemo:BEMO_2000136 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000126 a owl:Class ; rdfs:label "Patient Flow Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of patient flow integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000126" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000126" ; bemo:BEMO_3100022 133 ; bemo:BEMO_3100023 "67544e05c38d184f5e9fa9830136b1408e7835e115b1fa9c54147ad65e14b99c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses patient flow integrity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in patient flow integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating patient flow integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000113, bemo:BEMO_2000119, bemo:BEMO_2000135 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000127 a owl:Class ; rdfs:label "Positive Likelihood Ratio"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of positive likelihood ratio."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000127" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000127" ; bemo:BEMO_3100022 134 ; bemo:BEMO_3100023 "65ab6bc3c7bfa89dbab942e4977888e1ec5d3ea554c360ceffa76f4daab1fd7e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses positive likelihood ratio using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in positive likelihood ratio can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating positive likelihood ratio as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000115, bemo:BEMO_2000122, bemo:BEMO_2000123 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000128 a owl:Class ; rdfs:label "Positive Predictive Value"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of positive predictive value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000128" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000128" ; bemo:BEMO_3100022 135 ; bemo:BEMO_3100023 "89034784369de0142956f172eb3ca87ccad9b4cc69ac8a45b8a92adf9cc1731f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses positive predictive value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in positive predictive value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Two-by-two tables; binomial confidence intervals; hierarchical diagnostic meta-analysis; threshold and prevalence analyses."@en ; bemo:BEMO_3200006 "Treating positive predictive value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000117, bemo:BEMO_2000123, bemo:BEMO_2000127 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000129 a owl:Class ; rdfs:label "Prognostic Added Value"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic added value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000129" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000129" ; bemo:BEMO_3100022 136 ; bemo:BEMO_3100023 "6a8e54c8d71bbaa2bc8361d6fc19eb1f50b8f4acd2b6d09e2b648f2337fa9298" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prognostic added value using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prognostic added value can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prognostic added value as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000124, bemo:BEMO_2000132, bemo:BEMO_2000137 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000130 a owl:Class ; rdfs:label "Prognostic Calibration"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic calibration."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000130" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000130" ; bemo:BEMO_3100022 137 ; bemo:BEMO_3100023 "bddeb4ff61529649f6f5d81ae9a9ab5588a6f6aed10ca70d0d400119d6c2e940" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prognostic calibration using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prognostic calibration can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prognostic calibration as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000111, bemo:BEMO_2000112, bemo:BEMO_2000131 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000131 a owl:Class ; rdfs:label "Prognostic Discrimination"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic discrimination."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000131" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000131" ; bemo:BEMO_3100022 138 ; bemo:BEMO_3100023 "b58deaf6b24f17f45025c2e10bd742dcb00a937cc0410366fbe092bfbfd13882" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prognostic discrimination using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prognostic discrimination can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prognostic discrimination as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000111, bemo:BEMO_2000130, bemo:BEMO_2000133 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000132 a owl:Class ; rdfs:label "Prognostic Transportability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prognostic transportability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000132" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000132" ; bemo:BEMO_3100022 139 ; bemo:BEMO_3100023 "c2720768cdf2be8ed6a3b935c205e9cb522ea1c958d036e680eee5e7cba4038e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prognostic transportability using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prognostic transportability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prognostic transportability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000114, bemo:BEMO_2000129, bemo:BEMO_2000137 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000133 a owl:Class ; rdfs:label "Reclassification Improvement"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of reclassification improvement."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000133" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000133" ; bemo:BEMO_3100022 140 ; bemo:BEMO_3100023 "74d83029c18dff3247c8fb9baae1d6aba52c9b7328d218dd0210458cbd5ad7d5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses reclassification improvement using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reclassification improvement can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reclassification improvement as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000120, bemo:BEMO_2000130, bemo:BEMO_2000131 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000134 a owl:Class ; rdfs:label "Reference Standard Validity"@en ; iao:0000115 "The degree to which reference standard supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000134" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000134" ; bemo:BEMO_3100022 141 ; bemo:BEMO_3100023 "3bd12b9aed8e6e227ec8b1e5082fc9060b988babbc4204f8a360bb7503e6ad49" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses reference standard validity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reference standard validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reference standard validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000121, bemo:BEMO_2000136, bemo:BEMO_2000138 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000135 a owl:Class ; rdfs:label "Test-Timing Appropriateness"@en ; iao:0000115 "The extent to which test-timing is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000135" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000135" ; bemo:BEMO_3100022 142 ; bemo:BEMO_3100023 "ffb2707e3bed89aca5f5c790dc5a9b0312e89c5a1dba27ebac908e4597a355bd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses test-timing appropriateness using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in test-timing appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating test-timing appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000113, bemo:BEMO_2000120, bemo:BEMO_2000126 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000136 a owl:Class ; rdfs:label "Threshold Validity"@en ; iao:0000115 "The degree to which threshold supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000136" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000136" ; bemo:BEMO_3100022 143 ; bemo:BEMO_3100023 "c27bfe6217acf4b748aeb85aa4e9c4176c8256e12b7c61ff84a201b6fd374c82" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses threshold validity using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in threshold validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating threshold validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000121, bemo:BEMO_2000125, bemo:BEMO_2000134 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000137 a owl:Class ; rdfs:label "Time-Dependent Discrimination"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of time-dependent discrimination."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000137" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000137" ; bemo:BEMO_3100022 144 ; bemo:BEMO_3100023 "5232bfe9f1dc1ddd88662ddb65a550d0d1fc5338bb4a530ed1072ed6078116bf" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses time-dependent discrimination using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in time-dependent discrimination can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating time-dependent discrimination as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000114, bemo:BEMO_2000132 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000138 a owl:Class ; rdfs:label "Verification Bias Risk"@en ; iao:0000115 "The probability or degree that verification bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000138" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100005 ; bemo:BEMO_3100001 "BEMO:2000138" ; bemo:BEMO_3100022 145 ; bemo:BEMO_3100023 "2f165758b70b1e482bfb8517e1a69a7d4e05ba84cd41dc36c2f346f991371034" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses verification bias risk using evidence appropriate to diagnostic and prognostic evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in verification bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating verification bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Diagnostic accuracy, screening, prognostic-factor, and prediction-model studies"@en ; bemo:BEMO_3200010 "QUADAS-2; STARD; TRIPOD; REMARK"@en ; bemo:BEMO_3200011 "https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000118, bemo:BEMO_2000119, bemo:BEMO_2000121 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000139 a owl:Class ; rdfs:label "Between-Study Variance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of between-study variance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000139" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000139" ; bemo:BEMO_3100022 146 ; bemo:BEMO_3100023 "167d33dabeef5837833710d7e97d42ff17e46ede74b98e0e88db46e921ff811e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses between-study variance using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in between-study variance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses."@en ; bemo:BEMO_3200006 "Treating between-study variance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000141, bemo:BEMO_2000161, bemo:BEMO_2000165 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000140 a owl:Class ; rdfs:label "Counterevidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting counterevidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000140" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000140" ; bemo:BEMO_3100022 147 ; bemo:BEMO_3100023 "d4c1d3bbceb7e86e058c678a7bbc386dd5980f93dcbc9a60ebc6c6d39231fcdb" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses counterevidence strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in counterevidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating counterevidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000156, bemo:BEMO_2000158, bemo:BEMO_2000162 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000141 a owl:Class ; rdfs:label "Cumulative Evidence Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cumulative evidence stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000141" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000141" ; bemo:BEMO_3100022 148 ; bemo:BEMO_3100023 "e87943e84aae44a1eeb6300f5a52416f0528fe0f3bf76f40f0a2a4486c87ea6a" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses cumulative evidence stability using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cumulative evidence stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cumulative evidence stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000157, bemo:BEMO_2000159, bemo:BEMO_2000161 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000142 a owl:Class ; rdfs:label "Evidence Coherence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence coherence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000142" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000142" ; bemo:BEMO_3100022 149 ; bemo:BEMO_3100023 "573628981de9da600edff4f13001018973ec4403d9ad58179a02f6958d0404dd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence coherence using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence coherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence coherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000145, bemo:BEMO_2000150, bemo:BEMO_2000155 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000143 a owl:Class ; rdfs:label "Evidence Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of evidence are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000143" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000143" ; bemo:BEMO_3100022 150 ; bemo:BEMO_3100023 "263bd485141b0cc75ee285fb1989c667b83eb378666886a960ed5bd2a610f232" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses evidence completeness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000147, bemo:BEMO_2000149, bemo:BEMO_2000155 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000144 a owl:Class ; rdfs:label "Evidence Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to evidence given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000144" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000144" ; bemo:BEMO_3100022 151 ; bemo:BEMO_3100023 "a6abc5b380d07d44d4ec1e48b63cf0e3bf7299ab7264d6edcc898627f3bd0952" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses evidence confidence using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000146, bemo:BEMO_2000153, bemo:BEMO_2000154 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000145 a owl:Class ; rdfs:label "Evidence Consensus Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting evidence consensus."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000145" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000145" ; bemo:BEMO_3100022 152 ; bemo:BEMO_3100023 "f207ed4da0508b76cb7e86f43fc62efc4861d327760c860608fc73ff3f4a6da8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence consensus strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence consensus strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence consensus strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000142, bemo:BEMO_2000143, bemo:BEMO_2000155 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000146 a owl:Class ; rdfs:label "Evidence Consistency"@en ; iao:0000115 "The degree of agreement in evidence across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000146" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000146" ; bemo:BEMO_3100022 153 ; bemo:BEMO_3100023 "f74a279906eee7e4453803727494ade321b94fc1d6196fb1882daae7f1abcf75" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence consistency using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000148, bemo:BEMO_2000150, bemo:BEMO_2000153 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000147 a owl:Class ; rdfs:label "Evidence Coverage"@en ; iao:0000115 "The proportion and representativeness of the relevant evidence captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000147" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000147" ; bemo:BEMO_3100022 154 ; bemo:BEMO_3100023 "a64cee9a2114ea7d5580ea8d59eaef0691fce1d63dd3e4fd9f3d63e0dac86a3d" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses evidence coverage using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000143, bemo:BEMO_2000149, bemo:BEMO_2000152 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000148 a owl:Class ; rdfs:label "Evidence Directness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence directness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000148" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000148" ; bemo:BEMO_3100022 155 ; bemo:BEMO_3100023 "880de5f192c9dc60c14576e428f1c46fbdcda3180afe950bcde297920e65c6df" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence directness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence directness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence directness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000142, bemo:BEMO_2000146, bemo:BEMO_2000150 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000149 a owl:Class ; rdfs:label "Evidence Freshness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence freshness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000149" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000149" ; bemo:BEMO_3100022 156 ; bemo:BEMO_3100023 "2dc879dd1ad8ed3ebf228b83983e7de95e06b9c72131b584ccaa785f551eea2b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence freshness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence freshness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence freshness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000147, bemo:BEMO_2000152, bemo:BEMO_2000156 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000150 a owl:Class ; rdfs:label "Evidence Precision"@en ; iao:0000115 "The closeness of repeated estimates or measurements and the narrowness of uncertainty around evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000150" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000150" ; bemo:BEMO_3100022 157 ; bemo:BEMO_3100023 "fed12d9ff25f08fc6db399dc5bed2e8d719fc0db8bcefb33987a3ef3db40f55c" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses evidence precision using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000142, bemo:BEMO_2000145, bemo:BEMO_2000148 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000152 a owl:Class ; rdfs:label "Evidence Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000152" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000152" ; bemo:BEMO_3100022 159 ; bemo:BEMO_3100023 "59315ce160586081fc3fd71f96646716829d26fde9e0a21aa0afec923b5083d6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence robustness using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000140, bemo:BEMO_2000149, bemo:BEMO_2000156 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000153 a owl:Class ; rdfs:label "Evidence Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000153" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000153" ; bemo:BEMO_3100022 160 ; bemo:BEMO_3100023 "1f9ca5bc5be56489e2caf9d2f3eaaf37b12ae4271716853fb373d2db6aa8d657" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses evidence stability using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000144, bemo:BEMO_2000146, bemo:BEMO_2000148 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000154 a owl:Class ; rdfs:label "Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000154" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000154" ; bemo:BEMO_3100022 161 ; bemo:BEMO_3100023 "d0050ec2d0692a0a792ec941fce4c076cf8613142effd9ef06a03cab99fa82fe" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000144, bemo:BEMO_2000151, bemo:BEMO_2000153 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000155 a owl:Class ; rdfs:label "Evidence Sufficiency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of evidence sufficiency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000155" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000155" ; bemo:BEMO_3100022 162 ; bemo:BEMO_3100023 "516f7f59fc37d19455d99f12f79cf9f0baf5cd671807c3364f013a016d7ec68a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence sufficiency using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence sufficiency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence sufficiency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000143, bemo:BEMO_2000145, bemo:BEMO_2000147 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000156 a owl:Class ; rdfs:label "Evidence Triangulation Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting evidence triangulation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000156" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000156" ; bemo:BEMO_3100022 163 ; bemo:BEMO_3100023 "b9d887ba211f3aea4699afd087a0aa12fb8ca924209ee34ccda2bfd968c02a4a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses evidence triangulation strength using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in evidence triangulation strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating evidence triangulation strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000140, bemo:BEMO_2000152, bemo:BEMO_2000158 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000157 a owl:Class ; rdfs:label "Information Size Adequacy"@en ; iao:0000115 "The extent to which information size is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000157" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000157" ; bemo:BEMO_3100022 164 ; bemo:BEMO_3100023 "1349313eaf86ad90454f8dbf26aa9cb5389132fc9ac2e44b703024851df5136c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses information size adequacy using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in information size adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating information size adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000141, bemo:BEMO_2000159 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000158 a owl:Class ; rdfs:label "Missing Evidence Risk"@en ; iao:0000115 "The probability or degree that missing evidence introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000158" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000158" ; bemo:BEMO_3100022 165 ; bemo:BEMO_3100023 "ffec67315125f9639a3601d51e352906c34b1c9847a274942f934888c1188977" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses missing evidence risk using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in missing evidence risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating missing evidence risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000140, bemo:BEMO_2000162, bemo:BEMO_2000163 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000161 a owl:Class ; rdfs:label "Prediction Interval Adequacy"@en ; iao:0000115 "The extent to which prediction interval is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000161" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000161" ; bemo:BEMO_3100022 168 ; bemo:BEMO_3100023 "0acc1464b5d065a6f38744191dff4d933036cf918aeac3f16274b9cdb9dd1059" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prediction interval adequacy using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prediction interval adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prediction interval adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000139, bemo:BEMO_2000141, bemo:BEMO_2000157 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000162 a owl:Class ; rdfs:label "Publication Bias Risk"@en ; iao:0000115 "The probability or degree that publication bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000162" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000162" ; bemo:BEMO_3100022 169 ; bemo:BEMO_3100023 "ae14a6a3126f2ecd31144006a017263d5e10df0fcde0e6bd8cc0872e93853a7a" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses publication bias risk using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in publication bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses."@en ; bemo:BEMO_3200006 "Treating publication bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000158, bemo:BEMO_2000163, bemo:BEMO_2000164 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000163 a owl:Class ; rdfs:label "Selective Nonreporting Risk"@en ; iao:0000115 "The probability or degree that selective nonreporting introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000163" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000163" ; bemo:BEMO_3100022 170 ; bemo:BEMO_3100023 "8c42609174eeba28064b2f75bd158a40f97b17f9cdaa32aed81219eddf87ef89" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses selective nonreporting risk using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in selective nonreporting risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating selective nonreporting risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000162, bemo:BEMO_2000164, bemo:BEMO_2000165 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000164 a owl:Class ; rdfs:label "Small-Study Effects"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of small-study effects."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000164" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000164" ; bemo:BEMO_3100022 171 ; bemo:BEMO_3100023 "ec5ee159f748d5035209ae456b71092c6724bc73af9b720bf70afe3ffc41f242" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses small-study effects using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in small-study effects can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses."@en ; bemo:BEMO_3200006 "Treating small-study effects as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000139, bemo:BEMO_2000163, bemo:BEMO_2000165 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000165 a owl:Class ; rdfs:label "Study Heterogeneity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of study heterogeneity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000165" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100006 ; bemo:BEMO_3100001 "BEMO:2000165" ; bemo:BEMO_3100022 172 ; bemo:BEMO_3100023 "93fce0e52f596e9f5e6b6636a82da697803846e686e6144faa894115a270196a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses study heterogeneity using evidence appropriate to evidence certainty and synthesis, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in study heterogeneity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses."@en ; bemo:BEMO_3200006 "Treating study heterogeneity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Systematic reviews, meta-analyses, evidence profiles, guidelines"@en ; bemo:BEMO_3200010 "GRADE; PRISMA; AMSTAR 2; RoB"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.bmj.com/content/358/bmj.j4008 | https://www.riskofbias.info/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000139, bemo:BEMO_2000161, bemo:BEMO_2000164 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000166 a owl:Class ; rdfs:label "Age Appropriateness"@en ; iao:0000115 "The extent to which age is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000166" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000166" ; bemo:BEMO_3100022 173 ; bemo:BEMO_3100023 "6f50922de3489bf44a56c621fcc8933973821a524b4c3ba13cb746276b4a9bea" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses age appropriateness using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in age appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating age appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000177, bemo:BEMO_2000178, bemo:BEMO_2000186 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000167 a owl:Class ; rdfs:label "Animal Model Construct Validity"@en ; iao:0000115 "The degree to which animal model construct supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000167" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000167" ; bemo:BEMO_3100022 174 ; bemo:BEMO_3100023 "f8c928bcc279a4856d6377104c402fb4a00d102300c3c3fa14181f174b53f974" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses animal model construct validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in animal model construct validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating animal model construct validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000168, bemo:BEMO_2000169, bemo:BEMO_2000187 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000168 a owl:Class ; rdfs:label "Animal Model Face Validity"@en ; iao:0000115 "The degree to which animal model face supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000168" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000168" ; bemo:BEMO_3100022 175 ; bemo:BEMO_3100023 "1bc9d94635678f728d2a96fd7016f3d61e24c78d9e33c5093213c9d715511534" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses animal model face validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in animal model face validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating animal model face validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000167, bemo:BEMO_2000169, bemo:BEMO_2000172 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000169 a owl:Class ; rdfs:label "Animal Model Predictive Validity"@en ; iao:0000115 "The degree to which animal model predictive supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000169" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000169" ; bemo:BEMO_3100022 176 ; bemo:BEMO_3100023 "ae7f68af5b958c01b88066cf76664c77d333abaff4414b63760b817bf19359d0" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses animal model predictive validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in animal model predictive validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating animal model predictive validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000167, bemo:BEMO_2000186, bemo:BEMO_2000187 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000170 a owl:Class ; rdfs:label "Attrition Accounting in Animal Studies"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of attrition accounting in animal studies."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000170" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000170" ; bemo:BEMO_3100022 177 ; bemo:BEMO_3100023 "bfb6735bf1e0494f94802ec087edc274ccdaea50558f3ea043f6f21ae9210505" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses attrition accounting in animal studies using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in attrition accounting in animal studies can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating attrition accounting in animal studies as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000174, bemo:BEMO_2000175, bemo:BEMO_2000179 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000172 a owl:Class ; rdfs:label "Blinding in Experimental Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of blinding in experimental assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000172" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000172" ; bemo:BEMO_3100022 179 ; bemo:BEMO_3100023 "2a7451a420224db55e7f75f4a33818fc20cbc59d2bbc81f21fd652f7ea1a7931" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses blinding in experimental assessment using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in blinding in experimental assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating blinding in experimental assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000167, bemo:BEMO_2000168, bemo:BEMO_2000184 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000173 a owl:Class ; rdfs:label "Environmental Standardization"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of environmental standardization."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000173" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000173" ; bemo:BEMO_3100022 180 ; bemo:BEMO_3100023 "432e96e9d5c02fcda1a353b0ddb2e18d1019ff594f33c248eedfbe337bf31fae" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses environmental standardization using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in environmental standardization can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating environmental standardization as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000178, bemo:BEMO_2000179, bemo:BEMO_2000180 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000174 a owl:Class ; rdfs:label "Exclusion-Criteria Prespecification"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of exclusion-criteria prespecification."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000174" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000174" ; bemo:BEMO_3100022 181 ; bemo:BEMO_3100023 "9718ea523adf00e3cd776b8e22423abc28cf080bd659786c7568ddd524ab9208" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses exclusion-criteria prespecification using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in exclusion-criteria prespecification can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating exclusion-criteria prespecification as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000170, bemo:BEMO_2000175, bemo:BEMO_2000183 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000175 a owl:Class ; rdfs:label "Experimental Batch Randomization"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of experimental batch randomization."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000175" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000175" ; bemo:BEMO_3100022 182 ; bemo:BEMO_3100023 "1291027c6f53e5902a86a2cf22b3cca02564dbc940590bb8b8bcfd5004b998b7" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses experimental batch randomization using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in experimental batch randomization can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating experimental batch randomization as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000174, bemo:BEMO_2000181, bemo:BEMO_2000183 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000177 a owl:Class ; rdfs:label "Genetic Background Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of genetic background control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000177" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000177" ; bemo:BEMO_3100022 184 ; bemo:BEMO_3100023 "3f6791503c2895971802b5fb5573311999fc32cde51839dc771c56e4855ceb83" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses genetic background control using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in genetic background control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating genetic background control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000166, bemo:BEMO_2000173, bemo:BEMO_2000178 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000178 a owl:Class ; rdfs:label "Housing and Husbandry Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of housing and husbandry control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000178" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000178" ; bemo:BEMO_3100022 185 ; bemo:BEMO_3100023 "d4c26e56573de7f55de0caafd1e2880580fe66b8b4d599787ebf0b2bb3808344" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses housing and husbandry control using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in housing and husbandry control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating housing and husbandry control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000173, bemo:BEMO_2000177, bemo:BEMO_2000180 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000179 a owl:Class ; rdfs:label "Humane Endpoint Appropriateness"@en ; iao:0000115 "The extent to which humane endpoint is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000179" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000179" ; bemo:BEMO_3100022 186 ; bemo:BEMO_3100023 "efafe26c06dac15c0d485bfb264933c40fe9cf7ca97c5195ea92c9cfeb3f7a98" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses humane endpoint appropriateness using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in humane endpoint appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating humane endpoint appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000170, bemo:BEMO_2000174, bemo:BEMO_2000180 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000180 a owl:Class ; rdfs:label "Intervention Fidelity in Animal Studies"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of intervention fidelity in animal studies."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000180" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000180" ; bemo:BEMO_3100022 187 ; bemo:BEMO_3100023 "f4ebc6af400b7084f27d64f43d25beed78acdab6caf4a03c3179cab231054034" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses intervention fidelity in animal studies using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in intervention fidelity in animal studies can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating intervention fidelity in animal studies as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000170, bemo:BEMO_2000173, bemo:BEMO_2000179 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000181 a owl:Class ; rdfs:label "Negative-Control Performance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative-control performance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000181" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000181" ; bemo:BEMO_3100022 188 ; bemo:BEMO_3100023 "0095c2122f8f2e2a2aa6070b8c33f6576321db691574400350300c93ce956830" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses negative-control performance using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in negative-control performance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating negative-control performance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000182, bemo:BEMO_2000183, bemo:BEMO_2000190 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000182 a owl:Class ; rdfs:label "Orthogonal Validation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of orthogonal validation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000182" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000182" ; bemo:BEMO_3100022 189 ; bemo:BEMO_3100023 "86d52a57d493edc61e94352ed7d2d8f4feaaa492b37b0afb047315bb8706c00e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses orthogonal validation using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in orthogonal validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating orthogonal validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000188, bemo:BEMO_2000190 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000183 a owl:Class ; rdfs:label "Positive-Control Performance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of positive-control performance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000183" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000183" ; bemo:BEMO_3100022 190 ; bemo:BEMO_3100023 "98f43a472c5bc9ced611ad7ff89ac485c18a5c20ba0a8428164700738b649f75" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses positive-control performance using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in positive-control performance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating positive-control performance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000175, bemo:BEMO_2000181, bemo:BEMO_2000190 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000184 a owl:Class ; rdfs:label "Randomization in Experimental Allocation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of randomization in experimental allocation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000184" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000184" ; bemo:BEMO_3100022 191 ; bemo:BEMO_3100023 "5cc94b6085b9c596d4f74c18712e9f8177db4335ab703b2218b9c3a63209c113" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses randomization in experimental allocation using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in randomization in experimental allocation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating randomization in experimental allocation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000168, bemo:BEMO_2000172, bemo:BEMO_2000185 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000185 a owl:Class ; rdfs:label "Sample Size Justification"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of sample size justification."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000185" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000185" ; bemo:BEMO_3100022 192 ; bemo:BEMO_3100023 "9c4289123cb7c0f9d87fa9453151e360a9b6781cd9fbb6f6b26a09f4543b0dab" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses sample size justification using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sample size justification can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sample size justification as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000172, bemo:BEMO_2000184, bemo:BEMO_2000189 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000186 a owl:Class ; rdfs:label "Sex as a Biological Variable Adequacy"@en ; iao:0000115 "The extent to which sex as a biological variable is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000186" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000186" ; bemo:BEMO_3100022 193 ; bemo:BEMO_3100023 "67d1bc84f2c2d0324ee734ed3d2df1c72cd4820b21290b5a8b136d75863a4866" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses sex as a biological variable adequacy using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sex as a biological variable adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sex as a biological variable adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000166, bemo:BEMO_2000177, bemo:BEMO_2000187 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000187 a owl:Class ; rdfs:label "Species Appropriateness"@en ; iao:0000115 "The extent to which species is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000187" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000187" ; bemo:BEMO_3100022 194 ; bemo:BEMO_3100023 "93f7de14ca784e8a47e3c6ab351c1e75c21a4c3e26305cfe63e0d4fef2122575" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses species appropriateness using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in species appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating species appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000166, bemo:BEMO_2000169, bemo:BEMO_2000186 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000189 a owl:Class ; rdfs:label "Technical Replicate Adequacy"@en ; iao:0000115 "The extent to which technical replicate is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000189" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000189" ; bemo:BEMO_3100022 196 ; bemo:BEMO_3100023 "8f5bd5eed372632eafdff28f1c8035067d4634c207012fb089ff55a67d705176" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses technical replicate adequacy using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in technical replicate adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating technical replicate adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000171, bemo:BEMO_2000184, bemo:BEMO_2000185 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000190 a owl:Class ; rdfs:label "Vehicle-Control Validity"@en ; iao:0000115 "The degree to which vehicle-control supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000190" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100007 ; bemo:BEMO_3100001 "BEMO:2000190" ; bemo:BEMO_3100022 197 ; bemo:BEMO_3100023 "b1aee501d417f186bec79f011141586c66408c5b9c272dd6db3a4fa3a34f419d" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses vehicle-control validity using evidence appropriate to experimental biology and animal research, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in vehicle-control validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating vehicle-control validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "In vitro, ex vivo, organoid, animal, and preclinical experiments"@en ; bemo:BEMO_3200010 "ARRIVE 2.0; SYRCLE; OECD"@en ; bemo:BEMO_3200011 "https://arriveguidelines.org/arrive-guidelines | https://www.radboudumc.nl/en/research/departments/health-evidence/systematic-review-center-for-laboratory-animal-experimentation | https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000181, bemo:BEMO_2000182, bemo:BEMO_2000188 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000191 a owl:Class ; rdfs:label "Care-Pathway Independence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of care-pathway independence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000191" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000191" ; bemo:BEMO_3100022 198 ; bemo:BEMO_3100023 "e39c9004563f895f591d754f0c2c01d5cfe45a0e26d44584ecb91c07d72c494a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses care-pathway independence using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in care-pathway independence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating care-pathway independence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000193, bemo:BEMO_2000195, bemo:BEMO_2000196 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000192 a owl:Class ; rdfs:label "Comparator Applicability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of comparator applicability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000192" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000192" ; bemo:BEMO_3100022 199 ; bemo:BEMO_3100023 "607cceee390b7cb8ce577becf5db87c7c9a4643da6c8fbe5bd44948e1b9e3853" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses comparator applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in comparator applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating comparator applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000200, bemo:BEMO_2000201, bemo:BEMO_2000207 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000193 a owl:Class ; rdfs:label "Context Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of context sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000193" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000193" ; bemo:BEMO_3100022 200 ; bemo:BEMO_3100023 "84e49bfba34c254503c96b181528bf2beab33e58bfa3d6d711b6afaa740ea566" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses context sensitivity using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in context sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating context sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000191, bemo:BEMO_2000196, bemo:BEMO_2000204 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000194 a owl:Class ; rdfs:label "Demographic Generalizability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of demographic generalizability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000194" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000194" ; bemo:BEMO_3100022 201 ; bemo:BEMO_3100023 "e22341c32d6f7aad19740ed4b08e7f5ffc168107f1e04a79ba4ec60f6b92c463" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses demographic generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in demographic generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating demographic generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000191, bemo:BEMO_2000195, bemo:BEMO_2000209 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000195 a owl:Class ; rdfs:label "Disease-Severity Generalizability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of disease-severity generalizability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000195" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000195" ; bemo:BEMO_3100022 202 ; bemo:BEMO_3100023 "867ff07055e7596b98039def11c9ce9ca056af7a3a11134bb8f46a0bd5adc97a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses disease-severity generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in disease-severity generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating disease-severity generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000191, bemo:BEMO_2000193, bemo:BEMO_2000194 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000196 a owl:Class ; rdfs:label "Ecological Validity"@en ; iao:0000115 "The degree to which ecological supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000196" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000196" ; bemo:BEMO_3100022 203 ; bemo:BEMO_3100023 "04e73707dc619457f6718e0be03029ef6e99208f68cbcad30d9f5bb20b2cd94b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses ecological validity using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in ecological validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating ecological validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000193, bemo:BEMO_2000204 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000198 a owl:Class ; rdfs:label "Generalizability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of generalizability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000198" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000198" ; bemo:BEMO_3100022 205 ; bemo:BEMO_3100023 "27f8a61447192cbdeaaa7e84078183a3604b2e6ac6c0df13be6cfe9e4a09224a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000202, bemo:BEMO_2000206, bemo:BEMO_2000210 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000199 a owl:Class ; rdfs:label "Geographic Consistency"@en ; iao:0000115 "The degree of agreement in geographic across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000199" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000199" ; bemo:BEMO_3100022 206 ; bemo:BEMO_3100023 "22cb03e816656f6f9ad7a2acb4c32a01ffbc6b40d04a48011cef0a52134d504e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses geographic consistency using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in geographic consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating geographic consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000194, bemo:BEMO_2000208, bemo:BEMO_2000209 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000200 a owl:Class ; rdfs:label "Intervention Applicability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of intervention applicability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000200" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000200" ; bemo:BEMO_3100022 207 ; bemo:BEMO_3100023 "d1cb3929ecc9b0976fba4823cb5a09ca13a634dd6efaa3ee43969eafe3250a95" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses intervention applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in intervention applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating intervention applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000192, bemo:BEMO_2000201, bemo:BEMO_2000202 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000201 a owl:Class ; rdfs:label "Outcome Applicability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of outcome applicability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000201" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000201" ; bemo:BEMO_3100022 208 ; bemo:BEMO_3100023 "5c0db0a0257f7b171655d97624fdf4764d1fabad77716300abc92c2debe71f7d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses outcome applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in outcome applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating outcome applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000192, bemo:BEMO_2000207, bemo:BEMO_2000208 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000202 a owl:Class ; rdfs:label "Population Applicability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population applicability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000202" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000202" ; bemo:BEMO_3100022 209 ; bemo:BEMO_3100023 "9073b7f8b73fc788aa084d5c4ac174d69482c2a1439b22f86a39e465503328bc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses population applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in population applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating population applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000192, bemo:BEMO_2000200, bemo:BEMO_2000206 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000205 a owl:Class ; rdfs:label "Sampling Frame Adequacy"@en ; iao:0000115 "The extent to which sampling frame is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000205" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000205" ; bemo:BEMO_3100022 212 ; bemo:BEMO_3100023 "39b818e971de479787fde11a4523a1b0d31f5dcbc88f645b968cff60fa6bf381" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses sampling frame adequacy using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sampling frame adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sampling frame adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000198, bemo:BEMO_2000203, bemo:BEMO_2000210 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000206 a owl:Class ; rdfs:label "Setting Applicability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of setting applicability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000206" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000206" ; bemo:BEMO_3100022 213 ; bemo:BEMO_3100023 "323f595d53815c626b380456c55c73f7ff5e2e10beb1e0ffc44edb8067c37e86" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses setting applicability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in setting applicability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating setting applicability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000198, bemo:BEMO_2000200, bemo:BEMO_2000202 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000207 a owl:Class ; rdfs:label "Spectrum Representativeness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of spectrum representativeness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000207" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000207" ; bemo:BEMO_3100022 214 ; bemo:BEMO_3100023 "771c727a328004aa438f83d20410cd3600ce67ac5affa57fc6e9aaee55cb7ed9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses spectrum representativeness using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in spectrum representativeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating spectrum representativeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000199, bemo:BEMO_2000201, bemo:BEMO_2000208 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000208 a owl:Class ; rdfs:label "Subgroup Consistency"@en ; iao:0000115 "The degree of agreement in subgroup across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000208" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000208" ; bemo:BEMO_3100022 215 ; bemo:BEMO_3100023 "26cabc1a909ce4ef7d5d54dc609f85f9fea3829985a8f8573b3da07a3e225f5b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses subgroup consistency using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in subgroup consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating subgroup consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000199, bemo:BEMO_2000207, bemo:BEMO_2000209 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000209 a owl:Class ; rdfs:label "Temporal Generalizability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of temporal generalizability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000209" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000209" ; bemo:BEMO_3100022 216 ; bemo:BEMO_3100023 "dc35bc0fc74498ddd3acc1a47faf52ec96fba459b80f9800025d1a3d1e674317" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses temporal generalizability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in temporal generalizability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating temporal generalizability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000194, bemo:BEMO_2000195, bemo:BEMO_2000199 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000210 a owl:Class ; rdfs:label "Transportability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of transportability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000210" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100008 ; bemo:BEMO_3100001 "BEMO:2000210" ; bemo:BEMO_3100022 217 ; bemo:BEMO_3100023 "ef0b46b07942a1780f9e2e890b09b7edc3579f016762848aa46c4d956da3075d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses transportability using evidence appropriate to external validity and applicability, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in transportability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating transportability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Body of evidence / synthesis / outcome"@en ; bemo:BEMO_3200009 "Clinical, epidemiologic, diagnostic, translational, and population studies"@en ; bemo:BEMO_3200010 "GRADE; QUADAS-2; CONSORT; STROBE"@en ; bemo:BEMO_3200011 "https://www.gradeworkinggroup.org/ | https://pubmed.ncbi.nlm.nih.gov/22007046/ | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000198, bemo:BEMO_2000205, bemo:BEMO_2000206 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000211 a owl:Class ; rdfs:label "Allelic Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting allelic evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000211" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000211" ; bemo:BEMO_3100022 218 ; bemo:BEMO_3100023 "2dd4a685750034c6175101f0128d889784cf621fed0cf93a74098e6b4879332b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses allelic evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in allelic evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating allelic evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000212, bemo:BEMO_2000213, bemo:BEMO_2000217 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000212 a owl:Class ; rdfs:label "Case-Control Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting case-control evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000212" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000212" ; bemo:BEMO_3100022 219 ; bemo:BEMO_3100023 "a2868c878aff5e68e6f9aeb87fd5a98fd776f1ca106d2e9dbad34a8cc81ecfd8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses case-control evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in case-control evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating case-control evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000213, bemo:BEMO_2000215, bemo:BEMO_2000220 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000213 a owl:Class ; rdfs:label "Case-Level Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting case-level evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000213" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000213" ; bemo:BEMO_3100022 220 ; bemo:BEMO_3100023 "e9e681d8a3c5b4ca82348a6cd8fe70f3f48bd8351d482c3aa492a6712873c3db" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses case-level evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in case-level evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating case-level evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000211, bemo:BEMO_2000212, bemo:BEMO_2000220 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000214 a owl:Class ; rdfs:label "Co-segregation Likelihood"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of co-segregation likelihood."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000214" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000214" ; bemo:BEMO_3100022 221 ; bemo:BEMO_3100023 "965b0273f9a305e64b50437dcad85ab39818fad51d561d0ac4da1daaf7d204f2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses co-segregation likelihood using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in co-segregation likelihood can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating co-segregation likelihood as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000218, bemo:BEMO_2000227, bemo:BEMO_2000231 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000215 a owl:Class ; rdfs:label "Computational Variant Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of computational variant evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000215" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000215" ; bemo:BEMO_3100022 222 ; bemo:BEMO_3100023 "1f84faa3d8c87f3b1ed44b62077d2c489782ab72b149d6009c127395a0070a10" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses computational variant evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in computational variant evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating computational variant evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000220, bemo:BEMO_2000229, bemo:BEMO_2000236 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000217 a owl:Class ; rdfs:label "De Novo Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting de novo evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000217" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000217" ; bemo:BEMO_3100022 224 ; bemo:BEMO_3100023 "e1a17a41d450c91691b405a890d0fa9af7ecd8fed12385f8124d85b912c16860" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses de novo evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in de novo evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating de novo evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000211, bemo:BEMO_2000213, bemo:BEMO_2000232 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000218 a owl:Class ; rdfs:label "Expressivity Consistency"@en ; iao:0000115 "The degree of agreement in expressivity across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000218" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000218" ; bemo:BEMO_3100022 225 ; bemo:BEMO_3100023 "d100842d4d2c367ecd1122df00784975aa0a773a92bbb5c68a8ff23fbbd4dfc4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses expressivity consistency using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in expressivity consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating expressivity consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000219, bemo:BEMO_2000227, bemo:BEMO_2000228 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000219 a owl:Class ; rdfs:label "Founder-Effect Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of founder-effect assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000219" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000219" ; bemo:BEMO_3100022 226 ; bemo:BEMO_3100023 "6530e53b02059e4bfd6465ae64ac385198a560d8a80df4ba701894a8c5cb0975" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses founder-effect assessment using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in founder-effect assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating founder-effect assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000218, bemo:BEMO_2000224, bemo:BEMO_2000228 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000220 a owl:Class ; rdfs:label "Functional Variant Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of functional variant evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000220" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000220" ; bemo:BEMO_3100022 227 ; bemo:BEMO_3100023 "7a71bec12dfb580d6d32593ad450868d51a755f2a8b35e7eee350ad98d24c73e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses functional variant evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in functional variant evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating functional variant evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000212, bemo:BEMO_2000215, bemo:BEMO_2000229 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000222 a owl:Class ; rdfs:label "Genotype–Phenotype Concordance"@en ; iao:0000115 "The degree of agreement in genotype–phenotype across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000222" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000222" ; bemo:BEMO_3100022 229 ; bemo:BEMO_3100023 "baeee8e900a9ffef8f3ddd054b3a12f2233d89fc626f852fd31efc4b84b81685" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses genotype–phenotype concordance using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in genotype–phenotype concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating genotype–phenotype concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000216, bemo:BEMO_2000224, bemo:BEMO_2000234 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000223 a owl:Class ; rdfs:label "Hotspot/Functional-Domain Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of hotspot/functional-domain evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000223" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000223" ; bemo:BEMO_3100022 230 ; bemo:BEMO_3100023 "d2e72ca269dc077aef430f8efab1ad3e7adf8db5e6aa339468796f69dfaaee12" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses hotspot/functional-domain evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in hotspot/functional-domain evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating hotspot/functional-domain evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000225, bemo:BEMO_2000226, bemo:BEMO_2000233 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000224 a owl:Class ; rdfs:label "Locus Heterogeneity Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of locus heterogeneity assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000224" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000224" ; bemo:BEMO_3100022 231 ; bemo:BEMO_3100023 "bd3af304ec15826df5f67db7f079c0ba66a1f5f5a3e852d600550186267f50cb" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses locus heterogeneity assessment using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in locus heterogeneity assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Forest plots; heterogeneity statistics; tau-squared; prediction intervals; funnel plots; regression or selection models; sensitivity analyses."@en ; bemo:BEMO_3200006 "Treating locus heterogeneity assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000222, bemo:BEMO_2000228, bemo:BEMO_2000234 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000225 a owl:Class ; rdfs:label "Loss-of-Function Mechanism Validity"@en ; iao:0000115 "The degree to which loss-of-function mechanism supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000225" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000225" ; bemo:BEMO_3100022 232 ; bemo:BEMO_3100023 "a389d5411c414282451fe5495bf2c1c444f06ae12cd17457edf93df2953dc32e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses loss-of-function mechanism validity using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in loss-of-function mechanism validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating loss-of-function mechanism validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000223, bemo:BEMO_2000226, bemo:BEMO_2000236 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000226 a owl:Class ; rdfs:label "Null-Variant Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of null-variant quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000226" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000226" ; bemo:BEMO_3100022 233 ; bemo:BEMO_3100023 "de2f4749e64a7014070a28c9c8587efaf4dbb9b3583c2ab6e78cd6826c00de34" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses null-variant quality using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in null-variant quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating null-variant quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000223, bemo:BEMO_2000231, bemo:BEMO_2000233 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000227 a owl:Class ; rdfs:label "Penetrance Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of penetrance evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000227" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000227" ; bemo:BEMO_3100022 234 ; bemo:BEMO_3100023 "83c8ddff797d0831554af5cae66094d559ff9fcf3cefc498edc05f2c18b6ee97" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses penetrance evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in penetrance evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating penetrance evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000214, bemo:BEMO_2000218, bemo:BEMO_2000219 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000228 a owl:Class ; rdfs:label "Phenocopy Risk"@en ; iao:0000115 "The probability or degree that phenocopy introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000228" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000228" ; bemo:BEMO_3100022 235 ; bemo:BEMO_3100023 "eba377fe2c190b6390cd804f64874ad58540debe287184cfa259e70d97d1fcc8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses phenocopy risk using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in phenocopy risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating phenocopy risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000219, bemo:BEMO_2000222, bemo:BEMO_2000224 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000229 a owl:Class ; rdfs:label "Phenotypic Specificity for Variant"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of phenotypic specificity for variant."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000229" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000229" ; bemo:BEMO_3100022 236 ; bemo:BEMO_3100023 "ae0b81578c2487ac58cc25c0925e5e5b5580990b17b1391fc512e266a26a2788" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses phenotypic specificity for variant using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in phenotypic specificity for variant can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating phenotypic specificity for variant as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000215, bemo:BEMO_2000225, bemo:BEMO_2000236 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000230 a owl:Class ; rdfs:label "Population Frequency Compatibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population frequency compatibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000230" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000230" ; bemo:BEMO_3100022 237 ; bemo:BEMO_3100023 "da2b6bc79f60e4e8121c9a5cd9a562fbe0d255feef3ecb78f1de13bffe50a0f4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses population frequency compatibility using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in population frequency compatibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating population frequency compatibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000217, bemo:BEMO_2000232, bemo:BEMO_2000235 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000231 a owl:Class ; rdfs:label "RNA Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting rna evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000231" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000231" ; bemo:BEMO_3100022 238 ; bemo:BEMO_3100023 "8e776a34bb92ed3d093c7eb03481f1c61ce724a0995235355586c28e53418e35" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses rna evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in rna evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating rna evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000214, bemo:BEMO_2000227, bemo:BEMO_2000233 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000232 a owl:Class ; rdfs:label "Segregation Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting segregation evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000232" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000232" ; bemo:BEMO_3100022 239 ; bemo:BEMO_3100023 "4f9bdcfda63260ced3f40796d43228eea03ead68f517bc87939698d4f5d4faf2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses segregation evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in segregation evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating segregation evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000211, bemo:BEMO_2000217, bemo:BEMO_2000230 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000233 a owl:Class ; rdfs:label "Splicing Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting splicing evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000233" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000233" ; bemo:BEMO_3100022 240 ; bemo:BEMO_3100023 "50c6384810a1443b5a98f42466fb8ab2489b57dad29ed2dab35ef7acec1960d2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses splicing evidence strength using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in splicing evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating splicing evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000214, bemo:BEMO_2000226, bemo:BEMO_2000231 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000234 a owl:Class ; rdfs:label "Variant Classification Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of variant classification stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000234" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000234" ; bemo:BEMO_3100022 241 ; bemo:BEMO_3100023 "103d1dc365ad36d3caee0208333084352e814015d8cdbebbb9964106d3315f21" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses variant classification stability using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in variant classification stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating variant classification stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000216, bemo:BEMO_2000222 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000236 a owl:Class ; rdfs:label "Variant Phase Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of variant phase evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000236" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100009 ; bemo:BEMO_3100001 "BEMO:2000236" ; bemo:BEMO_3100022 243 ; bemo:BEMO_3100023 "e63350cbc225389693f86f1ceb6c24e47930b1a6b522574479bcaf1390376503" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses variant phase evidence using evidence appropriate to genetics and variant evidence, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in variant phase evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating variant phase evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mendelian disease, cancer genetics, association, segregation, and functional studies"@en ; bemo:BEMO_3200010 "ClinGen; ACMG AMP; STREGA; Gene Ontology"@en ; bemo:BEMO_3200011 "https://clinicalgenome.org/curation-activities/gene-disease-validity/ | https://pubmed.ncbi.nlm.nih.gov/25741868/ | https://www.equator-network.org/reporting-guidelines/strega/ | https://geneontology.org/docs/guide-go-evidence-codes/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000223, bemo:BEMO_2000225, bemo:BEMO_2000229 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000237 a owl:Class ; rdfs:label "Allelic Balance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of allelic balance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000237" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000237" ; bemo:BEMO_3100022 244 ; bemo:BEMO_3100023 "0857b2292263da43e4b892ac8b30335b2a7fd8730d0baae8269f0919f1da549b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses allelic balance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in allelic balance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating allelic balance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000247, bemo:BEMO_2000254, bemo:BEMO_2000264 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000238 a owl:Class ; rdfs:label "Alternative Splicing Validation"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of alternative splicing validation."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000238" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000238" ; bemo:BEMO_3100022 245 ; bemo:BEMO_3100023 "64b27913521868b5a9491d569eb82729fee0c3cb2133bfc9132e110785fa8847" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses alternative splicing validation using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in alternative splicing validation can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating alternative splicing validation as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000259, bemo:BEMO_2000260, bemo:BEMO_2000265 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000239 a owl:Class ; rdfs:label "Batch-Effect Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of batch-effect control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000239" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000239" ; bemo:BEMO_3100022 246 ; bemo:BEMO_3100023 "0751d3491af658db1257b3b04a366a751c7fd0fdfb5e615ebbae3dab6970c7c9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses batch-effect control using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in batch-effect control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating batch-effect control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000248, bemo:BEMO_2000252, bemo:BEMO_2000255 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000240 a owl:Class ; rdfs:label "Call-Rate Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of call-rate are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000240" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000240" ; bemo:BEMO_3100022 247 ; bemo:BEMO_3100023 "c69a25da4615faa5675944ca32d4c5ec30a0c44f5216034581329797d9a32abc" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses call-rate completeness using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in call-rate completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating call-rate completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000239, bemo:BEMO_2000248, bemo:BEMO_2000254 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000241 a owl:Class ; rdfs:label "Cell-Type Annotation Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to cell-type annotation given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000241" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000241" ; bemo:BEMO_3100022 248 ; bemo:BEMO_3100023 "f7aebc612affb172059739df32608fb7c4d69384f1ff8c565432595eea6b9937" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses cell-type annotation confidence using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cell-type annotation confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cell-type annotation confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000243, bemo:BEMO_2000261, bemo:BEMO_2000263 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000242 a owl:Class ; rdfs:label "Contamination Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of contamination burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000242" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000242" ; bemo:BEMO_3100022 249 ; bemo:BEMO_3100023 "fc0cd98bc92235d469bf2bc025f0d327d8170dfb4df97b973710a8d887eff3f4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses contamination burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in contamination burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating contamination burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000249, bemo:BEMO_2000256, bemo:BEMO_2000258 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000244 a owl:Class ; rdfs:label "Differential Expression Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of differential expression robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000244" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000244" ; bemo:BEMO_3100022 251 ; bemo:BEMO_3100023 "e70802b2991914211c0dcd91213c02319dd673fc93963b9e2064b8bca944c528" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses differential expression robustness using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in differential expression robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating differential expression robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000251, bemo:BEMO_2000255, bemo:BEMO_2000265 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000245 a owl:Class ; rdfs:label "Duplicate Read Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of duplicate read burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000245" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000245" ; bemo:BEMO_3100022 252 ; bemo:BEMO_3100023 "c1d6b63aea87c65750f96b5e3a771c6866843a2e5ba7e8081dd07af03bc0e9c5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses duplicate read burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in duplicate read burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating duplicate read burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000242, bemo:BEMO_2000249, bemo:BEMO_2000253 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000247 a owl:Class ; rdfs:label "Genotype Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of genotype quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000247" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000247" ; bemo:BEMO_3100022 254 ; bemo:BEMO_3100023 "6b3ff41c46f655393bf02a8730b778b41b8fad3c6f62302d7543aef197484ea3" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses genotype quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in genotype quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating genotype quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000237, bemo:BEMO_2000264, bemo:BEMO_2000266 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000248 a owl:Class ; rdfs:label "Hardy–Weinberg Equilibrium Compatibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of hardy–weinberg equilibrium compatibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000248" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000248" ; bemo:BEMO_3100022 255 ; bemo:BEMO_3100023 "158d6abc0d325612b86f33eeb0aa8e0dbdfd4460dc9c1934f90601f28ed25284" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses hardy–weinberg equilibrium compatibility using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in hardy–weinberg equilibrium compatibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating hardy–weinberg equilibrium compatibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000239, bemo:BEMO_2000240, bemo:BEMO_2000252 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000249 a owl:Class ; rdfs:label "Library Complexity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of library complexity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000249" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000249" ; bemo:BEMO_3100022 256 ; bemo:BEMO_3100023 "fb650cc4b9fc46d550895b59d1656dada1a7ec625426686e0a708ba75b6fc5f0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses library complexity using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in library complexity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating library complexity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000242, bemo:BEMO_2000245, bemo:BEMO_2000256 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000250 a owl:Class ; rdfs:label "Mapping Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of mapping quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000250" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000250" ; bemo:BEMO_3100022 257 ; bemo:BEMO_3100023 "aef9eeffa971170a3db3642e806206bdf35806d1d8cc427e16ad9106f7e0207c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses mapping quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mapping quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating mapping quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000245, bemo:BEMO_2000246, bemo:BEMO_2000253 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000251 a owl:Class ; rdfs:label "Normalization Adequacy"@en ; iao:0000115 "The extent to which normalization is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000251" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000251" ; bemo:BEMO_3100022 258 ; bemo:BEMO_3100023 "518f55960ed771c22a0c382ff436c097ae34f4481b35b5a64e7f2cf8493778a4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses normalization adequacy using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in normalization adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating normalization adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000238, bemo:BEMO_2000244, bemo:BEMO_2000265 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000252 a owl:Class ; rdfs:label "Population Stratification Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of population stratification control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000252" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000252" ; bemo:BEMO_3100022 259 ; bemo:BEMO_3100023 "c82d16c5b00c0127f5b02c510a48d677f57d7580cba4dcb68dce1141e1686c1d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses population stratification control using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in population stratification control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating population stratification control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000239, bemo:BEMO_2000244, bemo:BEMO_2000255 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000253 a owl:Class ; rdfs:label "Read Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of read quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000253" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000253" ; bemo:BEMO_3100022 260 ; bemo:BEMO_3100023 "e9483af6db486496b6f4b0c18d333bb38a6c500a6b80dd23beefe82c05de4acc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses read quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in read quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating read quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000245, bemo:BEMO_2000249, bemo:BEMO_2000250 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000254 a owl:Class ; rdfs:label "Reference Bias"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of reference bias."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000254" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000254" ; bemo:BEMO_3100022 261 ; bemo:BEMO_3100023 "7f170b7ac0b632bb15937074f6f54297bd1374274ba7dd6a71c308a1270c144b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses reference bias using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reference bias can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reference bias as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000240, bemo:BEMO_2000248, bemo:BEMO_2000264 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000255 a owl:Class ; rdfs:label "Relatedness Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of relatedness control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000255" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000255" ; bemo:BEMO_3100022 262 ; bemo:BEMO_3100023 "c66c714b8c2b1fb9da08eabc61ab1b346b5733232f7901baf90ed1206b3491ba" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses relatedness control using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in relatedness control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating relatedness control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000244, bemo:BEMO_2000251, bemo:BEMO_2000252 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000256 a owl:Class ; rdfs:label "Sample Identity Concordance"@en ; iao:0000115 "The degree of agreement in sample identity across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000256" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000256" ; bemo:BEMO_3100022 263 ; bemo:BEMO_3100023 "cf22f061ff0a6f0403c89f061c9c86c0fdc0e5186e885958801878829549f2cd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses sample identity concordance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sample identity concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sample identity concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000242, bemo:BEMO_2000258, bemo:BEMO_2000266 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000258 a owl:Class ; rdfs:label "Sex Concordance"@en ; iao:0000115 "The degree of agreement in sex across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000258" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000258" ; bemo:BEMO_3100022 265 ; bemo:BEMO_3100023 "897b2797d8e6449a88906be71f955c7726607e3b28833aef8661c12a890476a4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses sex concordance using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sex concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sex concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000247, bemo:BEMO_2000256, bemo:BEMO_2000266 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000259 a owl:Class ; rdfs:label "Single-Cell Ambient RNA Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell ambient rna burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000259" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000259" ; bemo:BEMO_3100022 266 ; bemo:BEMO_3100023 "1685a23504d9a42b00cb2ea9bdca0c2daeec5f3be11cc0d479a9acb5349c658a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses single-cell ambient rna burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in single-cell ambient rna burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating single-cell ambient rna burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000260, bemo:BEMO_2000261, bemo:BEMO_2000262 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000260 a owl:Class ; rdfs:label "Single-Cell Doublet Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell doublet burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000260" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000260" ; bemo:BEMO_3100022 267 ; bemo:BEMO_3100023 "47e6d4bd3f64b35d8abb9925b05e112fbb1356d383dc641a47f78f8e9bbeb676" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses single-cell doublet burden using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in single-cell doublet burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating single-cell doublet burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000238, bemo:BEMO_2000259, bemo:BEMO_2000262 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000261 a owl:Class ; rdfs:label "Single-Cell Feature Detection Rate"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell feature detection rate."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000261" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000261" ; bemo:BEMO_3100022 268 ; bemo:BEMO_3100023 "1ce87bfa0e14b3c49cdf26e92f3b39ba4ce32c6192d394a99b4f3b80c80031b2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses single-cell feature detection rate using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in single-cell feature detection rate can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating single-cell feature detection rate as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000241, bemo:BEMO_2000262, bemo:BEMO_2000263 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000262 a owl:Class ; rdfs:label "Single-Cell Viability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of single-cell viability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000262" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000262" ; bemo:BEMO_3100022 269 ; bemo:BEMO_3100023 "faf5bedb35b3c8e6f9b571b29c9788bb087192d600f7d5646da266201f76f5dd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses single-cell viability using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in single-cell viability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating single-cell viability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000241, bemo:BEMO_2000259, bemo:BEMO_2000261 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000263 a owl:Class ; rdfs:label "Spatial Transcriptomic Registration Accuracy"@en ; iao:0000115 "The closeness of spatial transcriptomic registration to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000263" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000263" ; bemo:BEMO_3100022 270 ; bemo:BEMO_3100023 "e61d8e9d42dcb8b644bc33652bdf4f396f77ace1c2d848fb684d0c722e5a1598" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses spatial transcriptomic registration accuracy using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in spatial transcriptomic registration accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating spatial transcriptomic registration accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000241, bemo:BEMO_2000243 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000264 a owl:Class ; rdfs:label "Strand Bias"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of strand bias."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000264" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000264" ; bemo:BEMO_3100022 271 ; bemo:BEMO_3100023 "6ac08afc8cf99d9cd5ee94bc247ff32edf260fc542fd5e27409d9c3b702afd66" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses strand bias using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in strand bias can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Read- and variant-level quality-control summaries; replicate concordance; orthogonal confirmation; benchmarking against reference materials."@en ; bemo:BEMO_3200006 "Treating strand bias as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000237, bemo:BEMO_2000240, bemo:BEMO_2000254 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000265 a owl:Class ; rdfs:label "Transcript Quantification Reliability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of transcript quantification reliability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000265" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000265" ; bemo:BEMO_3100022 272 ; bemo:BEMO_3100023 "45c762be688f8b3f57f3b563b58fc816d5802e731de9aee9acb732eea429ea1a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses transcript quantification reliability using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in transcript quantification reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating transcript quantification reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000238, bemo:BEMO_2000251, bemo:BEMO_2000260 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000266 a owl:Class ; rdfs:label "Variant Call Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of variant call quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000266" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100010 ; bemo:BEMO_3100001 "BEMO:2000266" ; bemo:BEMO_3100022 273 ; bemo:BEMO_3100023 "45320c5b96fc37b8148ee2721453c92e6bec79491a4ed2d2f6fedbc2cb99cb01" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses variant call quality using evidence appropriate to genomics and transcriptomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in variant call quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "ClinGen/ACMG evidence scoring; pedigree analysis; population databases; case-control data; functional assays; expert-panel review."@en ; bemo:BEMO_3200006 "Treating variant call quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Whole-genome, exome, panel, bulk/single-cell/spatial transcriptomic studies"@en ; bemo:BEMO_3200010 "MIAME; MINSEQE; STROBE-ME; GA4GH; HCA"@en ; bemo:BEMO_3200011 "https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.equator-network.org/reporting-guidelines/strobe-me/ | https://www.ga4gh.org/ | https://www.humancellatlas.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000237, bemo:BEMO_2000247, bemo:BEMO_2000258 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000268 a owl:Class ; rdfs:label "Analytical Measurement Range"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of analytical measurement range."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000268" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000268" ; bemo:BEMO_3100022 275 ; bemo:BEMO_3100023 "40562e2bdf0f0c373312aa0a75941fd6a83f056ba5201b300a46242b3f5457df" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses analytical measurement range using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in analytical measurement range can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating analytical measurement range as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000280, bemo:BEMO_2000287, bemo:BEMO_2000298 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000269 a owl:Class ; rdfs:label "Analytical Precision"@en ; iao:0000115 "The closeness of repeated estimates or measurements and the narrowness of uncertainty around analytical."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000269" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000269" ; bemo:BEMO_3100022 276 ; bemo:BEMO_3100023 "7c4987f5f8c3c9cca41bb28896f2392e5c664fc505d3f5db2c63ad7c10e1d04d" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses analytical precision using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in analytical precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating analytical precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000284, bemo:BEMO_2000297, bemo:BEMO_2000302 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000270 a owl:Class ; rdfs:label "Analytical Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of analytical sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000270" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000270" ; bemo:BEMO_3100022 277 ; bemo:BEMO_3100023 "193a9fb566dfa18750368d0657f7d1e8c3de7251eea014f0d99b1b3e73df3afa" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses analytical sensitivity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in analytical sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating analytical sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000271, bemo:BEMO_2000285, bemo:BEMO_2000299 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000271 a owl:Class ; rdfs:label "Analytical Specificity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of analytical specificity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000271" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000271" ; bemo:BEMO_3100022 278 ; bemo:BEMO_3100023 "f6458dae6787eecc6dbfe775e26236c89d02f80c2f92e3575c7f9ddfa0e84b0e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses analytical specificity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in analytical specificity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating analytical specificity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000270, bemo:BEMO_2000285, bemo:BEMO_2000286 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000273 a owl:Class ; rdfs:label "Batch-Effect Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of batch-effect sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000273" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000273" ; bemo:BEMO_3100022 280 ; bemo:BEMO_3100023 "7222c30713cc035f86bae406549aaf0d4751a919d50ae68b917efd9629244d28" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses batch-effect sensitivity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in batch-effect sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating batch-effect sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000292, bemo:BEMO_2000293, bemo:BEMO_2000301 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000274 a owl:Class ; rdfs:label "Calibration Traceability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration traceability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000274" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000274" ; bemo:BEMO_3100022 281 ; bemo:BEMO_3100023 "7d6efe540a48fdb6c1d86b381d867ad016fd03d3ba3039e34ba0dd8d59bcbf8d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses calibration traceability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in calibration traceability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating calibration traceability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000278, bemo:BEMO_2000281, bemo:BEMO_2000296 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000275 a owl:Class ; rdfs:label "Carryover"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of carryover."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000275" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000275" ; bemo:BEMO_3100022 282 ; bemo:BEMO_3100023 "0e987b7e93f5f6b586140ce3b08eb3d87acd863bc4cb825ee0d1e4b7b1bb3994" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses carryover using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in carryover can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating carryover as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000274, bemo:BEMO_2000277, bemo:BEMO_2000281 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000276 a owl:Class ; rdfs:label "Commutability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of commutability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000276" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000276" ; bemo:BEMO_3100022 283 ; bemo:BEMO_3100023 "0d8876821c8ce33e4a6f72fcdd334c759d21fb2784bd7f9f779179758d7849c8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses commutability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in commutability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating commutability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000290, bemo:BEMO_2000294, bemo:BEMO_2000300 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000277 a owl:Class ; rdfs:label "Cross-Reactivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of cross-reactivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000277" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000277" ; bemo:BEMO_3100022 284 ; bemo:BEMO_3100023 "1de0ffae2d83059ba1d111ea3bf309f20078d963ac7b7f912a42e8b4e10e5e32" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cross-reactivity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-reactivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-reactivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000275, bemo:BEMO_2000281, bemo:BEMO_2000283 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000278 a owl:Class ; rdfs:label "Cutoff Validity"@en ; iao:0000115 "The degree to which cutoff supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000278" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000278" ; bemo:BEMO_3100022 285 ; bemo:BEMO_3100023 "f74e484a95fd67b9bd73e0f0c112bc85ddaf01e7476f82b9c24c9382fe2bfe48" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses cutoff validity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cutoff validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cutoff validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000289, bemo:BEMO_2000290, bemo:BEMO_2000296 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000279 a owl:Class ; rdfs:label "Dilution Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dilution integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000279" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000279" ; bemo:BEMO_3100022 286 ; bemo:BEMO_3100023 "a31ef0b724223ebc3d1ad0dbe731b0b7823f6b347840ea43769f01a33866757b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses dilution integrity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dilution integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dilution integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000283, bemo:BEMO_2000288, bemo:BEMO_2000295 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000280 a owl:Class ; rdfs:label "Dynamic Range"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dynamic range."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000280" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000280" ; bemo:BEMO_3100022 287 ; bemo:BEMO_3100023 "41309e5f36c397d08d76621c273137352b099c93484f2a2eca025bcf85ccffdc" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses dynamic range using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dynamic range can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dynamic range as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000279, bemo:BEMO_2000295, bemo:BEMO_2000298 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000281 a owl:Class ; rdfs:label "Hook Effect Risk"@en ; iao:0000115 "The probability or degree that hook effect introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000281" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000281" ; bemo:BEMO_3100022 288 ; bemo:BEMO_3100023 "3d6a1547d736b7a958bf1c94a2df8cb5599400f10305a91c657ae1dce184650b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses hook effect risk using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in hook effect risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating hook effect risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000274, bemo:BEMO_2000275, bemo:BEMO_2000296 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000282 a owl:Class ; rdfs:label "Instrument Drift"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of instrument drift."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000282" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000282" ; bemo:BEMO_3100022 289 ; bemo:BEMO_3100023 "39eec82dab659b7826d3bea8f3227e8afeb55e0f15214b02955200cb8a59a8ba" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses instrument drift using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in instrument drift can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating instrument drift as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000291, bemo:BEMO_2000294, bemo:BEMO_2000301 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000283 a owl:Class ; rdfs:label "Interference Susceptibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of interference susceptibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000283" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000283" ; bemo:BEMO_3100022 290 ; bemo:BEMO_3100023 "af7341a32f2656e5638dc5bce7ac126974e88c78554d2916a696247ebbe11d2b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses interference susceptibility using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in interference susceptibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating interference susceptibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000275, bemo:BEMO_2000277, bemo:BEMO_2000288 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000284 a owl:Class ; rdfs:label "Intermediate Precision"@en ; iao:0000115 "The closeness of repeated estimates or measurements and the narrowness of uncertainty around intermediate."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000284" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000284" ; bemo:BEMO_3100022 291 ; bemo:BEMO_3100023 "543dc6e95f52dce066f892ad8d141154500ea9d0cf35d11564c84cc551f70c3b" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses intermediate precision using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in intermediate precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating intermediate precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000270, bemo:BEMO_2000297, bemo:BEMO_2000299 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000285 a owl:Class ; rdfs:label "Limit of Detection"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of limit of detection."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000285" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000285" ; bemo:BEMO_3100022 292 ; bemo:BEMO_3100023 "32751f0c3f93a66c901d3c5cea950ee45482dac2a524a6e4ed0ddc20000649d1" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses limit of detection using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in limit of detection can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating limit of detection as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000271, bemo:BEMO_2000286, bemo:BEMO_2000287 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000286 a owl:Class ; rdfs:label "Limit of Quantification"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of limit of quantification."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000286" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000286" ; bemo:BEMO_3100022 293 ; bemo:BEMO_3100023 "e110a21f976b308d8a01ff42efac55157e3af426e1182c74cf700e2fb4ce3595" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses limit of quantification using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in limit of quantification can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating limit of quantification as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000268, bemo:BEMO_2000285, bemo:BEMO_2000287 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000287 a owl:Class ; rdfs:label "Linearity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of linearity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000287" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000287" ; bemo:BEMO_3100022 294 ; bemo:BEMO_3100023 "511e3fb111714ad52a916859d22dfd9a9aa36539d615e5b295fdf52500ac32e5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses linearity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in linearity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating linearity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000268, bemo:BEMO_2000286, bemo:BEMO_2000298 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000288 a owl:Class ; rdfs:label "Matrix Effect"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of matrix effect."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000288" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000288" ; bemo:BEMO_3100022 295 ; bemo:BEMO_3100023 "e901d4ca31939164c2ecbe0d0bed735b156c8e09a3c3f28444f5359947798b49" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses matrix effect using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in matrix effect can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating matrix effect as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000277, bemo:BEMO_2000279, bemo:BEMO_2000283 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000289 a owl:Class ; rdfs:label "Measurement Uncertainty"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of measurement uncertainty."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000289" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000289" ; bemo:BEMO_3100022 296 ; bemo:BEMO_3100023 "02b8d5d020f47fcd1190b0fa52a15a86a5dd04748bbf2908e8c4e87ccdb4670f" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses measurement uncertainty using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in measurement uncertainty can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating measurement uncertainty as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000276, bemo:BEMO_2000278, bemo:BEMO_2000290 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000290 a owl:Class ; rdfs:label "Method Comparison Agreement"@en ; iao:0000115 "The degree of agreement in method comparison across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000290" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000290" ; bemo:BEMO_3100022 297 ; bemo:BEMO_3100023 "8f2dfbddd616818e03a89990f48f31b1db69460f1919bb65cc71ee0d68b7b4f6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses method comparison agreement using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in method comparison agreement can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating method comparison agreement as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000276, bemo:BEMO_2000289, bemo:BEMO_2000300 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000291 a owl:Class ; rdfs:label "Operator Variability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of operator variability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000291" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000291" ; bemo:BEMO_3100022 298 ; bemo:BEMO_3100023 "ae9e50b8f8857543ecb1eb315c23fc88dd3a028cfd40ee4377e1039431544ca0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses operator variability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in operator variability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating operator variability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000273, bemo:BEMO_2000282, bemo:BEMO_2000301 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000293 a owl:Class ; rdfs:label "Preanalytical Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of preanalytical robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000293" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000293" ; bemo:BEMO_3100022 300 ; bemo:BEMO_3100023 "b76350bac6098346689193598ba9a67fbdcf0cc16c9a9abb5e49d8238a97798b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses preanalytical robustness using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in preanalytical robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating preanalytical robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000273, bemo:BEMO_2000292 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000294 a owl:Class ; rdfs:label "Reagent Lot Consistency"@en ; iao:0000115 "The degree of agreement in reagent lot across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000294" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000294" ; bemo:BEMO_3100022 301 ; bemo:BEMO_3100023 "66143063e8139ffa9de4cc6fb03a0eb1778bd92be05c901387fc7af071b0e433" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses reagent lot consistency using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reagent lot consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reagent lot consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000282, bemo:BEMO_2000291, bemo:BEMO_2000300 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000295 a owl:Class ; rdfs:label "Recovery"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of recovery."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000295" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000295" ; bemo:BEMO_3100022 302 ; bemo:BEMO_3100023 "5e396bd1803ce209b22910e5705b5bf0dc26bd235bba5ac5c904b2514e3f7ea8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses recovery using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in recovery can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating recovery as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000279, bemo:BEMO_2000280, bemo:BEMO_2000288 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000296 a owl:Class ; rdfs:label "Reference Interval Validity"@en ; iao:0000115 "The degree to which reference interval supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000296" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000296" ; bemo:BEMO_3100022 303 ; bemo:BEMO_3100023 "3706e41c2a6c519ccdfb2643facf47ec1d2a45cc4b5b902e54040a5a53624b7e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses reference interval validity using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reference interval validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reference interval validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000274, bemo:BEMO_2000278, bemo:BEMO_2000289 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000297 a owl:Class ; rdfs:label "Repeatability"@en ; iao:0000115 "The degree to which repeatability yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000297" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000297" ; bemo:BEMO_3100022 304 ; bemo:BEMO_3100023 "289ee6101d32dc64bb4644380815480f0d1de4b3d0512c355bf6d1bb8e30c7f2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses repeatability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in repeatability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating repeatability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000269, bemo:BEMO_2000284, bemo:BEMO_2000299 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000298 a owl:Class ; rdfs:label "Reportable Range"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of reportable range."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000298" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000298" ; bemo:BEMO_3100022 305 ; bemo:BEMO_3100023 "1958a10669f076f26b0e434840fd948f2a615d7e3a768038db89230b0e148857" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses reportable range using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reportable range can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reportable range as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000268, bemo:BEMO_2000280, bemo:BEMO_2000295 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000299 a owl:Class ; rdfs:label "Reproducibility of Measurement"@en ; iao:0000115 "The degree to which reproducibility of measurement yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000299" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000299" ; bemo:BEMO_3100022 306 ; bemo:BEMO_3100023 "83e10528c5f3255388bb807d6bfc99c4e2c93d4f418421fcd184c242521982d5" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses reproducibility of measurement using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reproducibility of measurement can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reproducibility of measurement as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000270, bemo:BEMO_2000271, bemo:BEMO_2000284 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000300 a owl:Class ; rdfs:label "Sample Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of sample stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000300" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000300" ; bemo:BEMO_3100022 307 ; bemo:BEMO_3100023 "42f10127b0bb2f21e12bfaaba11ee2a6c8335cd39935669d6733741eadfc7015" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses sample stability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sample stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sample stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000276, bemo:BEMO_2000282, bemo:BEMO_2000294 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000301 a owl:Class ; rdfs:label "Site-to-Site Assay Portability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of site-to-site assay portability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000301" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000301" ; bemo:BEMO_3100022 308 ; bemo:BEMO_3100023 "c0e7317023f6c1fc290d021e4b38163503a72ee411cc671fe6aae25ee84d1ee5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses site-to-site assay portability using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in site-to-site assay portability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating site-to-site assay portability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000273, bemo:BEMO_2000291, bemo:BEMO_2000293 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000302 a owl:Class ; rdfs:label "Trueness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of trueness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000302" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100011 ; bemo:BEMO_3100001 "BEMO:2000302" ; bemo:BEMO_3100022 309 ; bemo:BEMO_3100023 "9094cf98fb975c34384185560acacc946dab62ebd8f1815100dcaac099d9df1b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses trueness using evidence appropriate to measurement and assay analytical validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in trueness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating trueness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Specimen / assay / run / laboratory / study"@en ; bemo:BEMO_3200009 "Laboratory-developed tests, molecular assays, imaging, pathology, biomarker studies"@en ; bemo:BEMO_3200010 "FDA Biomarker; CLSI; ISO 15189; MIQE"@en ; bemo:BEMO_3200011 "https://www.fda.gov/media/119271/download | https://clsi.org/standards/products/method-evaluation/ | https://www.iso.org/standard/76677.html | https://pubmed.ncbi.nlm.nih.gov/19246619/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000267, bemo:BEMO_2000269, bemo:BEMO_2000297 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000303 a owl:Class ; rdfs:label "Cross-Layer Directional Concordance"@en ; iao:0000115 "The degree of agreement in cross-layer directional across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000303" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000303" ; bemo:BEMO_3100022 310 ; bemo:BEMO_3100023 "89f675805a18a02e8214d03853d6a7cdcea2d29079ee839babae7605cea7a581" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses cross-layer directional concordance using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cross-layer directional concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cross-layer directional concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000305, bemo:BEMO_2000312, bemo:BEMO_2000317 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000306 a owl:Class ; rdfs:label "Dynamical Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dynamical stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000306" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000306" ; bemo:BEMO_3100022 313 ; bemo:BEMO_3100023 "d58852cf510c70b8fcfa12f792791c36728adc16d59c5b9bb4b7a9b129c39f52" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses dynamical stability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dynamical stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dynamical stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000309, bemo:BEMO_2000325, bemo:BEMO_2000327 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000308 a owl:Class ; rdfs:label "Entity Resolution Accuracy"@en ; iao:0000115 "The closeness of entity resolution to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000308" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000308" ; bemo:BEMO_3100022 315 ; bemo:BEMO_3100023 "81ae3d3ac205c8d1258be22f4b5818a5c36df354b19605060eb458cfdfef682e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses entity resolution accuracy using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in entity resolution accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating entity resolution accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000311, bemo:BEMO_2000318, bemo:BEMO_2000326 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000309 a owl:Class ; rdfs:label "Flux-Balance Consistency"@en ; iao:0000115 "The degree of agreement in flux-balance across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000309" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000309" ; bemo:BEMO_3100022 316 ; bemo:BEMO_3100023 "f8d3b19efd68e0150e437c71bac90ab2bb80f33877b4a0e74bc52542a0fd3c26" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses flux-balance consistency using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in flux-balance consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating flux-balance consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000307, bemo:BEMO_2000324, bemo:BEMO_2000327 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000310 a owl:Class ; rdfs:label "Knowledge-Graph Evidence Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of knowledge-graph evidence are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000310" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000310" ; bemo:BEMO_3100022 317 ; bemo:BEMO_3100023 "082de1cac908d5d8b791ddee2974743d0e0eae71997e72080a5d978e931f8b6c" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses knowledge-graph evidence completeness using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in knowledge-graph evidence completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating knowledge-graph evidence completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000308, bemo:BEMO_2000311, bemo:BEMO_2000323 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000311 a owl:Class ; rdfs:label "Knowledge-Graph Provenance Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of knowledge-graph provenance quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000311" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000311" ; bemo:BEMO_3100022 318 ; bemo:BEMO_3100023 "50aaf6749314a5ad4694891f48d60c74feaa99da022b5cc91c17f4221f0696a2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses knowledge-graph provenance quality using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in knowledge-graph provenance quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating knowledge-graph provenance quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000308, bemo:BEMO_2000310, bemo:BEMO_2000326 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000312 a owl:Class ; rdfs:label "Latent-Factor Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of latent-factor stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000312" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000312" ; bemo:BEMO_3100022 319 ; bemo:BEMO_3100023 "be1e726b2fd3735d5492ec8f375d473b36cbff860abc6d682d2065974c115c50" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses latent-factor stability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in latent-factor stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating latent-factor stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000303, bemo:BEMO_2000315, bemo:BEMO_2000317 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000313 a owl:Class ; rdfs:label "Model–Experiment Concordance"@en ; iao:0000115 "The degree of agreement in model–experiment across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000313" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000313" ; bemo:BEMO_3100022 320 ; bemo:BEMO_3100023 "433f97851837c60d123f8a332258d7d5b3872aa7c5564c19691b4c4c00871a8b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses model–experiment concordance using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in model–experiment concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating model–experiment concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000319, bemo:BEMO_2000320, bemo:BEMO_2000321 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000314 a owl:Class ; rdfs:label "Module Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of module stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000314" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000314" ; bemo:BEMO_3100022 321 ; bemo:BEMO_3100023 "191acd0c1abb112365dc2e82b9a1c639642c0798eb52983d078ac92e3f0fbeec" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses module stability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in module stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating module stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000316, bemo:BEMO_2000322, bemo:BEMO_2000323 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000315 a owl:Class ; rdfs:label "Network Edge Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to network edge given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000315" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000315" ; bemo:BEMO_3100022 322 ; bemo:BEMO_3100023 "6118b228a2af4e149e82150fb026ef08cdd6d05b9748a0128d6e8c14f147784c" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses network edge confidence using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in network edge confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating network edge confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000314, bemo:BEMO_2000316, bemo:BEMO_2000317 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000316 a owl:Class ; rdfs:label "Network Node Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to network node given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000316" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000316" ; bemo:BEMO_3100022 323 ; bemo:BEMO_3100023 "79eaf0a8e6c6fc3012d48e379c545c17d89aecf6de033d40ae6399ec89441a3b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses network node confidence using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in network node confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating network node confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000314, bemo:BEMO_2000315, bemo:BEMO_2000322 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000317 a owl:Class ; rdfs:label "Network Reconstruction Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of network reconstruction robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000317" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000317" ; bemo:BEMO_3100022 324 ; bemo:BEMO_3100023 "0b4f2bdfa3ccc3b3abdb67b1f3be15b6d8479743942152580ad3f1929db67d5f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses network reconstruction robustness using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in network reconstruction robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating network reconstruction robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000312, bemo:BEMO_2000315, bemo:BEMO_2000316 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000318 a owl:Class ; rdfs:label "Ontology Annotation Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of ontology annotation are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000318" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000318" ; bemo:BEMO_3100022 325 ; bemo:BEMO_3100023 "b8714924720c209e415f9bf2c9aaf707f6bf0edbbbf6ca8da11d2546f9da563d" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses ontology annotation completeness using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in ontology annotation completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating ontology annotation completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000313, bemo:BEMO_2000319, bemo:BEMO_2000326 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000319 a owl:Class ; rdfs:label "Ontology Evidence-Code Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting ontology evidence-code."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000319" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000319" ; bemo:BEMO_3100022 326 ; bemo:BEMO_3100023 "98cc3b5d977b0d0bd7a309c477d2653f05eeb7554078021a2d0b2bf21036d891" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses ontology evidence-code strength using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in ontology evidence-code strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating ontology evidence-code strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000313, bemo:BEMO_2000318, bemo:BEMO_2000320 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000320 a owl:Class ; rdfs:label "Parameter Identifiability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of parameter identifiability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000320" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000320" ; bemo:BEMO_3100022 327 ; bemo:BEMO_3100023 "e1eaab072c302dca725ea1fb92e565c0aead2c5a6ddd49490dbfa43ad163dd03" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses parameter identifiability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in parameter identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating parameter identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000313, bemo:BEMO_2000321, bemo:BEMO_2000328 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000321 a owl:Class ; rdfs:label "Parameter Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of parameter sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000321" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000321" ; bemo:BEMO_3100022 328 ; bemo:BEMO_3100023 "9735c06335e80bafcbeea74ccb7b405e18e8684330b82448424f6e83ef3974ba" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses parameter sensitivity using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in parameter sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating parameter sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000320, bemo:BEMO_2000325, bemo:BEMO_2000328 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000322 a owl:Class ; rdfs:label "Pathway Enrichment Consistency"@en ; iao:0000115 "The degree of agreement in pathway enrichment across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000322" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000322" ; bemo:BEMO_3100022 329 ; bemo:BEMO_3100023 "d7e323b8eddcaff29fe662695a2fa9bae2a0f04120cfdf422fa3e2d1cd3b117e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pathway enrichment consistency using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pathway enrichment consistency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pathway enrichment consistency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000310, bemo:BEMO_2000314, bemo:BEMO_2000323 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000323 a owl:Class ; rdfs:label "Pathway Topology Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting pathway topology."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000323" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000323" ; bemo:BEMO_3100022 330 ; bemo:BEMO_3100023 "f408d8b817c9e3179698dad395d8e94ea187b92ae192e0ab52e026106d82f40a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pathway topology support using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pathway topology support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pathway topology support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000310, bemo:BEMO_2000311, bemo:BEMO_2000322 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000324 a owl:Class ; rdfs:label "Perturbation Prediction Accuracy"@en ; iao:0000115 "The closeness of perturbation prediction to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000324" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000324" ; bemo:BEMO_3100022 331 ; bemo:BEMO_3100023 "5cc466b3de703eb697570667c57a9230690c56d69b5cf6ec528e42740ec621e9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses perturbation prediction accuracy using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in perturbation prediction accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating perturbation prediction accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000307, bemo:BEMO_2000309 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000325 a owl:Class ; rdfs:label "Practical Identifiability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of practical identifiability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000325" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000325" ; bemo:BEMO_3100022 332 ; bemo:BEMO_3100023 "cb110edeb57b36960477192ea5d1484823905d046fc0f22c33bc8eb340c3c4c3" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses practical identifiability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in practical identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating practical identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000306, bemo:BEMO_2000327, bemo:BEMO_2000328 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000326 a owl:Class ; rdfs:label "Relation Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting relation evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000326" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000326" ; bemo:BEMO_3100022 333 ; bemo:BEMO_3100023 "9009911ac3f6266273d49aa664b528314dd25468ab2969a5c3dfb8593502a99c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses relation evidence strength using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in relation evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating relation evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000308, bemo:BEMO_2000318, bemo:BEMO_2000319 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000327 a owl:Class ; rdfs:label "Steady-State Validity"@en ; iao:0000115 "The degree to which steady-state supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000327" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000327" ; bemo:BEMO_3100022 334 ; bemo:BEMO_3100023 "3a349724361b2712b35c94baaaa135ce8e313533d3edafc463242f1cddef411b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses steady-state validity using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in steady-state validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating steady-state validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000306, bemo:BEMO_2000309, bemo:BEMO_2000324 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000328 a owl:Class ; rdfs:label "Structural Identifiability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of structural identifiability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000328" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100012 ; bemo:BEMO_3100001 "BEMO:2000328" ; bemo:BEMO_3100022 335 ; bemo:BEMO_3100023 "36fbdf592582d2c048b53d43d95edfca8afe5d6c7c93d352f32f2a7d7644cfbe" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses structural identifiability using evidence appropriate to multi-omics and systems biology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in structural identifiability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating structural identifiability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Dataset / model / pathway / network / evidence body"@en ; bemo:BEMO_3200009 "Integrated omics, networks, pathways, mechanistic and dynamic systems models"@en ; bemo:BEMO_3200010 "Gene Ontology; Reactome; UniProt; GA4GH"@en ; bemo:BEMO_3200011 "https://geneontology.org/docs/guide-go-evidence-codes/ | https://reactome.org/ | https://www.uniprot.org/help/evidences | https://www.ga4gh.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000306, bemo:BEMO_2000321, bemo:BEMO_2000325 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000329 a owl:Class ; rdfs:label "Adverse Outcome Pathway Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting adverse outcome pathway."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000329" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000329" ; bemo:BEMO_3100022 336 ; bemo:BEMO_3100023 "8935703e7b30761e4213b86ddafc1aecae0696f4523a201860d9e64493990a74" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses adverse outcome pathway support using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in adverse outcome pathway support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating adverse outcome pathway support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000338, bemo:BEMO_2000345, bemo:BEMO_2000358 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000330 a owl:Class ; rdfs:label "Benchmark Dose Reliability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of benchmark dose reliability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000330" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000330" ; bemo:BEMO_3100022 337 ; bemo:BEMO_3100023 "43d4a4ce7127bc52167a879f611c41413072f25e775dbe7c9446cf4028783b10" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses benchmark dose reliability using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in benchmark dose reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating benchmark dose reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000329, bemo:BEMO_2000341, bemo:BEMO_2000358 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000331 a owl:Class ; rdfs:label "Bioavailability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of bioavailability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000331" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000331" ; bemo:BEMO_3100022 338 ; bemo:BEMO_3100023 "1dbec5a00f53d17cad5a3a88dd4dfde9ceab9bbbe33a898c76c7086698d1a0a2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses bioavailability using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in bioavailability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating bioavailability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000334, bemo:BEMO_2000346, bemo:BEMO_2000356 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000332 a owl:Class ; rdfs:label "Carcinogenicity Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting carcinogenicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000332" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000332" ; bemo:BEMO_3100022 339 ; bemo:BEMO_3100023 "a171459b41fd9ad0436588a80669a48227118c77c3d87194654b56ab6dfa6ad7" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses carcinogenicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in carcinogenicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating carcinogenicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000333, bemo:BEMO_2000338, bemo:BEMO_2000351 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000333 a owl:Class ; rdfs:label "Developmental Toxicity Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting developmental toxicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000333" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000333" ; bemo:BEMO_3100022 340 ; bemo:BEMO_3100023 "f5636ed02b8746eb48d98671b027c695a8940399bff60ebeae8ca955d99bae6a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses developmental toxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in developmental toxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating developmental toxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000340, bemo:BEMO_2000351, bemo:BEMO_2000357 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000334 a owl:Class ; rdfs:label "Dose Proportionality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of dose proportionality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000334" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000334" ; bemo:BEMO_3100022 341 ; bemo:BEMO_3100023 "6d7bafb114f62ee059333139662f0dfa2a0fb0aaab829ac8fcdb03ed2fbd0708" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses dose proportionality using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dose proportionality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dose proportionality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000331, bemo:BEMO_2000342, bemo:BEMO_2000356 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000335 a owl:Class ; rdfs:label "Drug–Drug Interaction Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of drug–drug interaction evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000335" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000335" ; bemo:BEMO_3100022 342 ; bemo:BEMO_3100023 "3a82aa8a1751fa8372cd9735fd975781682a359be68aacfb1d0d78e896d96ce5" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses drug–drug interaction evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in drug–drug interaction evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating drug–drug interaction evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000342, bemo:BEMO_2000350, bemo:BEMO_2000353 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000336 a owl:Class ; rdfs:label "Efficacy Reproducibility"@en ; iao:0000115 "The degree to which efficacy reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000336" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000336" ; bemo:BEMO_3100022 343 ; bemo:BEMO_3100023 "e3d46320b779b7100a656dae6dcb02f7b9eae6762c1680f48b9313843cb64c84" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses efficacy reproducibility using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in efficacy reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating efficacy reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000349, bemo:BEMO_2000352, bemo:BEMO_2000355 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000338 a owl:Class ; rdfs:label "Genotoxicity Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting genotoxicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000338" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000338" ; bemo:BEMO_3100022 345 ; bemo:BEMO_3100023 "e40592e267890e51ad35407c7dc2af7775fdac9174afe2f08486d28a5e2901b8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses genotoxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in genotoxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating genotoxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000332, bemo:BEMO_2000345, bemo:BEMO_2000351 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000339 a owl:Class ; rdfs:label "Human-Relevance of Toxicological Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of human-relevance of toxicological evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000339" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000339" ; bemo:BEMO_3100022 346 ; bemo:BEMO_3100023 "32b4aadfeeab004a7a018b1fe09f04f0b2283eb92e7749123f8ac828db8cfce6" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses human-relevance of toxicological evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in human-relevance of toxicological evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating human-relevance of toxicological evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000343, bemo:BEMO_2000354 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000340 a owl:Class ; rdfs:label "Immunotoxicity Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting immunotoxicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000340" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000340" ; bemo:BEMO_3100022 347 ; bemo:BEMO_3100023 "577a4370c7a1dc270882fc655889fdc7a0b8ee20d5e6f81f1f733233db939fbd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses immunotoxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in immunotoxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating immunotoxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000333, bemo:BEMO_2000354, bemo:BEMO_2000357 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000341 a owl:Class ; rdfs:label "Lowest-Observed-Adverse-Effect Level Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of lowest-observed-adverse-effect level robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000341" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000341" ; bemo:BEMO_3100022 348 ; bemo:BEMO_3100023 "cd00c7765086fbbe65040e649de98f22bdf10298c91d8da0f6e7300a18f0ba9f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses lowest-observed-adverse-effect level robustness using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in lowest-observed-adverse-effect level robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating lowest-observed-adverse-effect level robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000330, bemo:BEMO_2000344, bemo:BEMO_2000358 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000342 a owl:Class ; rdfs:label "Metabolite Coverage"@en ; iao:0000115 "The proportion and representativeness of the relevant metabolite captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000342" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000342" ; bemo:BEMO_3100022 349 ; bemo:BEMO_3100023 "4bb05358971c228c81cd2238f505b14da043cabfc3f68e3d2dd07884c7f72bc5" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses metabolite coverage using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in metabolite coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating metabolite coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000335, bemo:BEMO_2000350, bemo:BEMO_2000356 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000344 a owl:Class ; rdfs:label "No-Observed-Adverse-Effect Level Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of no-observed-adverse-effect level robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000344" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000344" ; bemo:BEMO_3100022 351 ; bemo:BEMO_3100023 "f5f71661574e809d9eb1b7625ffde603665b4c0d25ddbb968f6b8d1a88c38a42" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses no-observed-adverse-effect level robustness using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in no-observed-adverse-effect level robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating no-observed-adverse-effect level robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000330, bemo:BEMO_2000341, bemo:BEMO_2000352 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000345 a owl:Class ; rdfs:label "Organ-Specific Toxicity Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of organ-specific toxicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000345" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000345" ; bemo:BEMO_3100022 352 ; bemo:BEMO_3100023 "277a918d22b52db9e79eabf5451f64320f342f326be1cc2382f16c69ec72f0a9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses organ-specific toxicity evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in organ-specific toxicity evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating organ-specific toxicity evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000329, bemo:BEMO_2000332, bemo:BEMO_2000338 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000346 a owl:Class ; rdfs:label "Pharmacodynamic Adequacy"@en ; iao:0000115 "The extent to which pharmacodynamic is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000346" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000346" ; bemo:BEMO_3100022 353 ; bemo:BEMO_3100023 "99eef93672d2993b0ec131c09788c14463fd2a5166870e81b6b8d81c3637506b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pharmacodynamic adequacy using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pharmacodynamic adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pharmacodynamic adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000331, bemo:BEMO_2000334, bemo:BEMO_2000347 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000347 a owl:Class ; rdfs:label "Pharmacokinetic Adequacy"@en ; iao:0000115 "The extent to which pharmacokinetic is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000347" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000347" ; bemo:BEMO_3100022 354 ; bemo:BEMO_3100023 "2b02efdd0f6a774096cee910d90b575b8f28f136a8ee594876642fb213f66330" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pharmacokinetic adequacy using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pharmacokinetic adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pharmacokinetic adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000331, bemo:BEMO_2000337, bemo:BEMO_2000346 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000349 a owl:Class ; rdfs:label "Potency Reproducibility"@en ; iao:0000115 "The degree to which potency reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000349" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000349" ; bemo:BEMO_3100022 356 ; bemo:BEMO_3100023 "2199b92ac6c23ce1866fa6fdae782c65a478ec51834e2f0193f79d608ea4c3e7" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses potency reproducibility using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in potency reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating potency reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000336, bemo:BEMO_2000353, bemo:BEMO_2000355 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000350 a owl:Class ; rdfs:label "Receptor Occupancy Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of receptor occupancy evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000350" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000350" ; bemo:BEMO_3100022 357 ; bemo:BEMO_3100023 "5025e34702ce03c8ed7e7aa3ed95dd9bde6bac1786183651ce608b34ffcc6a28" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses receptor occupancy evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in receptor occupancy evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating receptor occupancy evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000335, bemo:BEMO_2000349, bemo:BEMO_2000353 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000351 a owl:Class ; rdfs:label "Reproductive Toxicity Evidence Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting reproductive toxicity evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000351" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000351" ; bemo:BEMO_3100022 358 ; bemo:BEMO_3100023 "1725f0845040d88689ff2869cde10ea44454b5cfaa1c303d02071f7ff5ccb751" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses reproductive toxicity evidence strength using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reproductive toxicity evidence strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reproductive toxicity evidence strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000332, bemo:BEMO_2000333, bemo:BEMO_2000340 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000352 a owl:Class ; rdfs:label "Safety Margin Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of safety margin evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000352" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000352" ; bemo:BEMO_3100022 359 ; bemo:BEMO_3100023 "51ce0324d6952becbbadfd71ba2913a1f56afbcc33aa0148093d10994d18697d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses safety margin evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in safety margin evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating safety margin evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000341, bemo:BEMO_2000344, bemo:BEMO_2000355 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000353 a owl:Class ; rdfs:label "Selectivity Profile"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of selectivity profile."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000353" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000353" ; bemo:BEMO_3100022 360 ; bemo:BEMO_3100023 "2957579a3d734fc808c8a89eb160fb182b5f5a0f68ba40c4eecc1921dea93153" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses selectivity profile using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in selectivity profile can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating selectivity profile as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000336, bemo:BEMO_2000349, bemo:BEMO_2000350 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000354 a owl:Class ; rdfs:label "Species Extrapolation Validity"@en ; iao:0000115 "The degree to which species extrapolation supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000354" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000354" ; bemo:BEMO_3100022 361 ; bemo:BEMO_3100023 "f3eb077ab3d21773df18d06eb29c8a11272ed7cbfe8f22da0ffedd8a171bc393" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses species extrapolation validity using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in species extrapolation validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating species extrapolation validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000339, bemo:BEMO_2000343, bemo:BEMO_2000357 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000355 a owl:Class ; rdfs:label "Therapeutic Window Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of therapeutic window evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000355" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000355" ; bemo:BEMO_3100022 362 ; bemo:BEMO_3100023 "34f5d4730ddbb7e269fc6713d96c49c0fba2d2f738ddbfb47d339a6ed5f8cf6e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses therapeutic window evidence using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in therapeutic window evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating therapeutic window evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000336, bemo:BEMO_2000344, bemo:BEMO_2000352 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000356 a owl:Class ; rdfs:label "Time–Concentration Profile Adequacy"@en ; iao:0000115 "The extent to which time–concentration profile is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000356" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000356" ; bemo:BEMO_3100022 363 ; bemo:BEMO_3100023 "8bfcea065494f7118cb14f95a9459e3f35fa404437872877955c4fdff069147a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses time–concentration profile adequacy using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in time–concentration profile adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating time–concentration profile adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000334, bemo:BEMO_2000335, bemo:BEMO_2000342 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000357 a owl:Class ; rdfs:label "Toxicokinetic Concordance"@en ; iao:0000115 "The degree of agreement in toxicokinetic across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000357" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000357" ; bemo:BEMO_3100022 364 ; bemo:BEMO_3100023 "6cda2f6cb167ccc21d05523345b2fef382432ceed6ebbcbe84fa383cddc4562e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses toxicokinetic concordance using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in toxicokinetic concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating toxicokinetic concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000339, bemo:BEMO_2000340, bemo:BEMO_2000354 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000358 a owl:Class ; rdfs:label "Toxicological Mode-of-Action Support"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting toxicological mode-of-action."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000358" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100013 ; bemo:BEMO_3100001 "BEMO:2000358" ; bemo:BEMO_3100022 365 ; bemo:BEMO_3100023 "05b74bda1c6ce0d8b99d4d0ffdc239f28a207c0631f25d1605f8d1438c74148a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses toxicological mode-of-action support using evidence appropriate to pharmacology and toxicology, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in toxicological mode-of-action support can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating toxicological mode-of-action support as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Pharmacology, pharmacokinetics, toxicology, safety and mode-of-action studies"@en ; bemo:BEMO_3200010 "OECD; OHAT; FDA Biomarker; EMA E16"@en ; bemo:BEMO_3200011 "https://www.oecd.org/chemicalsafety/testing/oecd-guidelines-testing-chemicals-related-documents.htm | https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook | https://www.fda.gov/media/119271/download | https://www.ema.europa.eu/en/ich-e16-genomic-biomarkers-related-drug-response-context-structure-format-qualification-submissions-scientific-guideline" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000329, bemo:BEMO_2000330, bemo:BEMO_2000345 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000360 a owl:Class ; rdfs:label "Derivatization Efficiency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of derivatization efficiency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000360" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000360" ; bemo:BEMO_3100022 367 ; bemo:BEMO_3100023 "d83b78fc8beda508a5c18da8dbb9e284c948a9741d4fb8d070f9f30bc9267827" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses derivatization efficiency using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in derivatization efficiency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating derivatization efficiency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000362, bemo:BEMO_2000369, bemo:BEMO_2000373 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000361 a owl:Class ; rdfs:label "Dynamic Range Coverage"@en ; iao:0000115 "The proportion and representativeness of the relevant dynamic range captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000361" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000361" ; bemo:BEMO_3100022 368 ; bemo:BEMO_3100023 "57e4c77ea2a48565f0758aadf8529c7db52bab9beb67f6e9c8366f0f3232e753" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses dynamic range coverage using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in dynamic range coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating dynamic range coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000366, bemo:BEMO_2000372, bemo:BEMO_2000381 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000362 a owl:Class ; rdfs:label "Extraction Recovery"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of extraction recovery."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000362" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000362" ; bemo:BEMO_3100022 369 ; bemo:BEMO_3100023 "5024c9034e231e8bc296cf1d9092cc063fe94890f4856d8bf70ac077514b55f9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses extraction recovery using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in extraction recovery can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating extraction recovery as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000360, bemo:BEMO_2000365, bemo:BEMO_2000369 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000363 a owl:Class ; rdfs:label "False Discovery Rate Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of false discovery rate control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000363" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000363" ; bemo:BEMO_3100022 370 ; bemo:BEMO_3100023 "4059adb92dbe8fea43e57c309bf3c42531450ae52d814c6f79932af37f2f97a2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses false discovery rate control using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in false discovery rate control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating false discovery rate control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000375, bemo:BEMO_2000377, bemo:BEMO_2000378 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000364 a owl:Class ; rdfs:label "Fragmentation Spectrum Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of fragmentation spectrum quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000364" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000364" ; bemo:BEMO_3100022 371 ; bemo:BEMO_3100023 "4295f539b87882bc52461f7bd190419d6afdf7864927b9a24efe1e5f65c9fcd7" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses fragmentation spectrum quality using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in fragmentation spectrum quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating fragmentation spectrum quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000367, bemo:BEMO_2000376, bemo:BEMO_2000379 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000365 a owl:Class ; rdfs:label "Internal Standard Performance"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of internal standard performance."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000365" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000365" ; bemo:BEMO_3100022 372 ; bemo:BEMO_3100023 "904dce77d19fcc637d6eae56d2d92b19b7052fd578de120e2a18bb08d00f2f54" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses internal standard performance using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in internal standard performance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating internal standard performance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000360, bemo:BEMO_2000362, bemo:BEMO_2000385 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000366 a owl:Class ; rdfs:label "Ion Suppression Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of ion suppression assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000366" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000366" ; bemo:BEMO_3100022 373 ; bemo:BEMO_3100023 "c108ebf1ca903ed7e96063f24ecaf39723dd5e925f97d641601f89fd859897b9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses ion suppression assessment using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in ion suppression assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating ion suppression assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000368, bemo:BEMO_2000372, bemo:BEMO_2000383 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000367 a owl:Class ; rdfs:label "Isotope Pattern Fidelity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of isotope pattern fidelity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000367" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000367" ; bemo:BEMO_3100022 374 ; bemo:BEMO_3100023 "beec5d62727ea3baba10451d532801205b190af60b03027284c15989d51ba1e4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses isotope pattern fidelity using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in isotope pattern fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating isotope pattern fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000364, bemo:BEMO_2000368, bemo:BEMO_2000376 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000368 a owl:Class ; rdfs:label "Mass Accuracy"@en ; iao:0000115 "The closeness of mass to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000368" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000368" ; bemo:BEMO_3100022 375 ; bemo:BEMO_3100023 "ebb0e828e6a056d20bce6788aee10b743cfcc2fc175a82fd693585711880ff73" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses mass accuracy using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in mass accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating mass accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000364, bemo:BEMO_2000367, bemo:BEMO_2000383 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000369 a owl:Class ; rdfs:label "Metabolic Feature Reproducibility"@en ; iao:0000115 "The degree to which metabolic feature reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000369" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000369" ; bemo:BEMO_3100022 376 ; bemo:BEMO_3100023 "521bf8b7c1bbe892685e95c05cc7d63a05c4e26119e9951d705ff460b3bb99d1" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses metabolic feature reproducibility using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in metabolic feature reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating metabolic feature reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000359, bemo:BEMO_2000360, bemo:BEMO_2000373 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000370 a owl:Class ; rdfs:label "Metabolite Annotation Level"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of metabolite annotation level."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000370" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000370" ; bemo:BEMO_3100022 377 ; bemo:BEMO_3100023 "883e5fdd2ff9e198b3ddcbafc3e6478eed144bbcc7f46c67f19ec93850e8ec4c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses metabolite annotation level using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in metabolite annotation level can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating metabolite annotation level as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000365, bemo:BEMO_2000371, bemo:BEMO_2000385 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000371 a owl:Class ; rdfs:label "Metabolite Identification Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to metabolite identification given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000371" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000371" ; bemo:BEMO_3100022 378 ; bemo:BEMO_3100023 "dd08774f62d4c8036bc0f7c590a94eca58c7ca0613c38dec0e386cab59cc0dbd" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses metabolite identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in metabolite identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating metabolite identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000370, bemo:BEMO_2000379, bemo:BEMO_2000385 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000372 a owl:Class ; rdfs:label "Missing-Value Burden"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of missing-value burden."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000372" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000372" ; bemo:BEMO_3100022 379 ; bemo:BEMO_3100023 "770bd2fa8c1eedf14831e8e8caca6d53a1ad4a7b7272433891be0eac41a4e30c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses missing-value burden using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in missing-value burden can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating missing-value burden as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000361, bemo:BEMO_2000366, bemo:BEMO_2000383 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000373 a owl:Class ; rdfs:label "Pathway Enrichment Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of pathway enrichment robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000373" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000373" ; bemo:BEMO_3100022 380 ; bemo:BEMO_3100023 "1a891a794290e0f5eee9ca88b64bc6b46d5840f63c8709e0e546399158fbb914" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses pathway enrichment robustness using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in pathway enrichment robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating pathway enrichment robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000359, bemo:BEMO_2000369 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000375 a owl:Class ; rdfs:label "Peptide-Spectrum Match Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of peptide-spectrum match quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000375" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000375" ; bemo:BEMO_3100022 382 ; bemo:BEMO_3100023 "69f7898b8265a7daaa45bd90d4d5387c92da6521721d3c4901a5c208a63f0169" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses peptide-spectrum match quality using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in peptide-spectrum match quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating peptide-spectrum match quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000363, bemo:BEMO_2000378, bemo:BEMO_2000380 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000376 a owl:Class ; rdfs:label "Post-Translational Modification Localization Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to post-translational modification localization given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000376" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000376" ; bemo:BEMO_3100022 383 ; bemo:BEMO_3100023 "6761ab89a934b85357a2d58a5e53503065037a8cd658104babdb5536291a3653" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses post-translational modification localization confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in post-translational modification localization confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating post-translational modification localization confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000364, bemo:BEMO_2000371, bemo:BEMO_2000379 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000378 a owl:Class ; rdfs:label "Protein Inference Reliability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protein inference reliability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000378" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000378" ; bemo:BEMO_3100022 385 ; bemo:BEMO_3100023 "601ad0978c475da6065d2502b00169f5521ae97cb0543ad15ad88f49903cb27e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses protein inference reliability using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protein inference reliability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating protein inference reliability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000375, bemo:BEMO_2000380, bemo:BEMO_2000384 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000379 a owl:Class ; rdfs:label "Proteoform Identification Confidence"@en ; iao:0000115 "The justified degree of certainty assigned to proteoform identification given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000379" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000379" ; bemo:BEMO_3100022 386 ; bemo:BEMO_3100023 "8df86e86625f432ba76b927808300a9cfa4a9b6844cae40ca0c6240f4f899eda" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses proteoform identification confidence using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in proteoform identification confidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating proteoform identification confidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000370, bemo:BEMO_2000371, bemo:BEMO_2000376 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000380 a owl:Class ; rdfs:label "Proteome Coverage"@en ; iao:0000115 "The proportion and representativeness of the relevant proteome captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000380" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000380" ; bemo:BEMO_3100022 387 ; bemo:BEMO_3100023 "5fec1390446b523e8b6072b1babcb11902375d326650ad448b800e258e0a8401" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses proteome coverage using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in proteome coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating proteome coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000378, bemo:BEMO_2000382, bemo:BEMO_2000384 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000381 a owl:Class ; rdfs:label "Quantification Accuracy"@en ; iao:0000115 "The closeness of quantification to the accepted reference or true value."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000381" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000381" ; bemo:BEMO_3100022 388 ; bemo:BEMO_3100023 "5205abd1da59c18e5b7272ce8586c2ec2bee590ad36aa3289ce71f4aa4c17c0b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses quantification accuracy using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in quantification accuracy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating quantification accuracy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000361, bemo:BEMO_2000372, bemo:BEMO_2000382 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000382 a owl:Class ; rdfs:label "Quantification Precision"@en ; iao:0000115 "The closeness of repeated estimates or measurements and the narrowness of uncertainty around quantification."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000382" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000382" ; bemo:BEMO_3100022 389 ; bemo:BEMO_3100023 "6e5af7c1fffa7603da0abd7518a670fd09cade5fe3e47c8417886f91e6b4e07a" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses quantification precision using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in quantification precision can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating quantification precision as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000361, bemo:BEMO_2000381, bemo:BEMO_2000384 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000383 a owl:Class ; rdfs:label "Retention-Time Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of retention-time stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000383" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000383" ; bemo:BEMO_3100022 390 ; bemo:BEMO_3100023 "7ed489b83705dc957b891fd6483e7b54ca4c70547f903f7dfa9e53d0ca59fa58" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses retention-time stability using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in retention-time stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Target-decoy analysis; spectral scoring; reference standards; replicate injections; retention-time and mass-error monitoring; orthogonal confirmation."@en ; bemo:BEMO_3200006 "Treating retention-time stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000366, bemo:BEMO_2000367, bemo:BEMO_2000368 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000384 a owl:Class ; rdfs:label "Sequence Coverage"@en ; iao:0000115 "The proportion and representativeness of the relevant sequence captured by the evidence or measurement process."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000384" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000384" ; bemo:BEMO_3100022 391 ; bemo:BEMO_3100023 "f98e41911ad517a10150d0d24373bec15a553a9812e119c2e6a10081e9a89aaf" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses sequence coverage using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in sequence coverage can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating sequence coverage as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000380, bemo:BEMO_2000381, bemo:BEMO_2000382 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000385 a owl:Class ; rdfs:label "Spectral Library Match Quality"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of spectral library match quality."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000385" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100014 ; bemo:BEMO_3100001 "BEMO:2000385" ; bemo:BEMO_3100022 392 ; bemo:BEMO_3100023 "5f1fa5732761f5ddf9eae216997fca90d2ec95264368ca476160849aac179e9a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses spectral library match quality using evidence appropriate to proteomics and metabolomics, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in spectral library match quality can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating spectral library match quality as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Mass spectrometry, affinity proteomics, metabolomics, lipidomics studies"@en ; bemo:BEMO_3200010 "MIAPE; HUPO PSI; Metabolomics Standards"@en ; bemo:BEMO_3200011 "https://www.psidev.info/miape | https://www.psidev.info/ | https://www.metabolomics-msi.org/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000362, bemo:BEMO_2000365, bemo:BEMO_2000370 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000386 a owl:Class ; rdfs:label "Analytical Reproducibility"@en ; iao:0000115 "The degree to which analytical reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000386" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000386" ; bemo:BEMO_3100022 393 ; bemo:BEMO_3100023 "8e400bbae5ea25bca3af45f9c956cb2ceeb52ded61247de3b92d5364736bab99" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses analytical reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in analytical reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating analytical reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000388, bemo:BEMO_2000389, bemo:BEMO_2000393 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000387 a owl:Class ; rdfs:label "Code Availability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of code availability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000387" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000387" ; bemo:BEMO_3100022 394 ; bemo:BEMO_3100023 "196f2dc58cfb1ea70e003d9904020fcfd1f4feec7308ace2e85d573eb71d3b5e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses code availability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in code availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating code availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000390, bemo:BEMO_2000398, bemo:BEMO_2000402 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000388 a owl:Class ; rdfs:label "Computational Reproducibility"@en ; iao:0000115 "The degree to which computational reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000388" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000388" ; bemo:BEMO_3100022 395 ; bemo:BEMO_3100023 "c15f070192e578e50deb91384b3e8099e5c4b1a0c28cc84d1ac6a3163d36cd17" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses computational reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in computational reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating computational reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000386, bemo:BEMO_2000393, bemo:BEMO_2000396 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000389 a owl:Class ; rdfs:label "Conceptual Replication Success"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of conceptual replication success."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000389" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000389" ; bemo:BEMO_3100022 396 ; bemo:BEMO_3100023 "45fcdc0cd9da1d73796f886d24683b4f40ead7f7a14a06e84d39631b66a910ad" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses conceptual replication success using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in conceptual replication success can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating conceptual replication success as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000386, bemo:BEMO_2000388, bemo:BEMO_2000392 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000390 a owl:Class ; rdfs:label "Data Availability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of data availability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000390" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000390" ; bemo:BEMO_3100022 397 ; bemo:BEMO_3100023 "89d3d59a31fe591c17a3c61f83a55d18326e4b311b8033047e95bfb2a93715fa" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses data availability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in data availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating data availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000387, bemo:BEMO_2000402, bemo:BEMO_2000404 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000391 a owl:Class ; rdfs:label "Data Provenance Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of data provenance are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000391" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000391" ; bemo:BEMO_3100022 398 ; bemo:BEMO_3100023 "da25c768c2ee710f0cf6b50b686a1880c8166dd651b4f062c14e952fc1bdf622" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses data provenance completeness using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in data provenance completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating data provenance completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000398, bemo:BEMO_2000401, bemo:BEMO_2000403 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000393 a owl:Class ; rdfs:label "Experimental Reproducibility"@en ; iao:0000115 "The degree to which experimental reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000393" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000393" ; bemo:BEMO_3100022 400 ; bemo:BEMO_3100023 "6c9d1f649c85d73c0009300283cb79e817b0ca9b1d53444f1a4aa4b5a2e6d8ae" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses experimental reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in experimental reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating experimental reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000388, bemo:BEMO_2000396, bemo:BEMO_2000397 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000395 a owl:Class ; rdfs:label "Inferential Reproducibility"@en ; iao:0000115 "The degree to which inferential reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000395" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000395" ; bemo:BEMO_3100022 402 ; bemo:BEMO_3100023 "b49eb32e7bf118727039f0240b17aee8970c665e4a359a2bcecc87341188ecf1" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses inferential reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in inferential reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating inferential reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000391, bemo:BEMO_2000403, bemo:BEMO_2000405 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000396 a owl:Class ; rdfs:label "Interlaboratory Reproducibility"@en ; iao:0000115 "The degree to which interlaboratory reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000396" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000396" ; bemo:BEMO_3100022 403 ; bemo:BEMO_3100023 "0977ae8d7278730723c8d024585a95d1125aa9fe6da897fe977a079b172ddb48" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses interlaboratory reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in interlaboratory reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating interlaboratory reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000393, bemo:BEMO_2000397, bemo:BEMO_2000399 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000397 a owl:Class ; rdfs:label "Intralaboratory Repeatability"@en ; iao:0000115 "The degree to which intralaboratory repeatability yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000397" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000397" ; bemo:BEMO_3100022 404 ; bemo:BEMO_3100023 "44bfb4ae3b82bb963a97cc8f3dfed3bd610b7903405993c8f3031931f746d1ce" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses intralaboratory repeatability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in intralaboratory repeatability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating intralaboratory repeatability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000396, bemo:BEMO_2000399, bemo:BEMO_2000405 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000398 a owl:Class ; rdfs:label "Material Availability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of material availability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000398" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000398" ; bemo:BEMO_3100022 405 ; bemo:BEMO_3100023 "ad24de4b8dd0c9ae8c1a3d7d5fcdd166b9bd923967cbf8032882e26fce35feb2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses material availability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in material availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating material availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000387, bemo:BEMO_2000390, bemo:BEMO_2000401 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000399 a owl:Class ; rdfs:label "Method Reproducibility"@en ; iao:0000115 "The degree to which method reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000399" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000399" ; bemo:BEMO_3100022 406 ; bemo:BEMO_3100023 "b36c4ba0356ae6813b5bb255ebc6934635b0cbf83c44326cfea7019592803c5e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses method reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in method reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating method reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000395, bemo:BEMO_2000397, bemo:BEMO_2000405 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000400 a owl:Class ; rdfs:label "Multiverse Analysis Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of multiverse analysis robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000400" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000400" ; bemo:BEMO_3100022 407 ; bemo:BEMO_3100023 "80472d064c943a6566bee4bd605245ecac370ebde0eb5ae577d7687482d47cc8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses multiverse analysis robustness using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in multiverse analysis robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating multiverse analysis robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000404, bemo:BEMO_2000406 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Specialized / infrequent" ; bemo:BEMO_3200020 "Developing" . bemo:BEMO_2000401 a owl:Class ; rdfs:label "Protocol Reproducibility"@en ; iao:0000115 "The degree to which protocol reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000401" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000401" ; bemo:BEMO_3100022 408 ; bemo:BEMO_3100023 "caa28491bc96ceb6cd2e1c6685b9eb89f21391a6d4502473143986af13cc088b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses protocol reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protocol reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating protocol reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000387, bemo:BEMO_2000391, bemo:BEMO_2000398 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000402 a owl:Class ; rdfs:label "Random-Seed Stability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of random-seed stability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000402" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000402" ; bemo:BEMO_3100022 409 ; bemo:BEMO_3100023 "c1a5a2e956afa3ff1606fb1893282ee7b8d5d3733fbd04798630fe0746f86074" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses random-seed stability using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in random-seed stability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating random-seed stability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000390, bemo:BEMO_2000400, bemo:BEMO_2000404 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000403 a owl:Class ; rdfs:label "Reanalysis Concordance"@en ; iao:0000115 "The degree of agreement in reanalysis across measurements, studies, methods, populations, or biological levels."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000403" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000403" ; bemo:BEMO_3100022 410 ; bemo:BEMO_3100023 "07f0b47b85e307e7887d3c938a89cbcad651d37d8bfa888ea4ce710d25410a29" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses reanalysis concordance using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in reanalysis concordance can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating reanalysis concordance as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000391, bemo:BEMO_2000395, bemo:BEMO_2000401 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000404 a owl:Class ; rdfs:label "Researcher-Degrees-of-Freedom Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of researcher-degrees-of-freedom sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000404" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000404" ; bemo:BEMO_3100022 411 ; bemo:BEMO_3100023 "c196ee0e5b3c49cffc78d559a15b400e1dec74f4854200e7fbd341eef60a59c4" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses researcher-degrees-of-freedom sensitivity using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in researcher-degrees-of-freedom sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating researcher-degrees-of-freedom sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000400, bemo:BEMO_2000402, bemo:BEMO_2000406 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000405 a owl:Class ; rdfs:label "Result Reproducibility"@en ; iao:0000115 "The degree to which result reproducibility yields concordant results under the specified repeated-analysis or repeated-measurement conditions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000405" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100015 ; bemo:BEMO_3100001 "BEMO:2000405" ; bemo:BEMO_3100022 412 ; bemo:BEMO_3100023 "60121a2998efa943018d3ff7dd4130d4332ee279da0e8111b650ea175e9dacce" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses result reproducibility using evidence appropriate to reproducibility and replication, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in result reproducibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating result reproducibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All experimental, computational, clinical, and omics studies"@en ; bemo:BEMO_3200010 "PRISMA; CONSORT; MIAME; MINSEQE; MIAPE; ARRIVE 2.0"@en ; bemo:BEMO_3200011 "https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.fged.org/projects/miame | https://www.fged.org/projects/minseqe/ | https://www.psidev.info/miape | https://arriveguidelines.org/arrive-guidelines" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000395, bemo:BEMO_2000399, bemo:BEMO_2000403 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000407 a owl:Class ; rdfs:label "Code-Sharing Transparency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of code-sharing transparency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000407" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000407" ; bemo:BEMO_3100022 414 ; bemo:BEMO_3100023 "d85d4b116984de9e36c9410fc248aae4b536153c50f4651cf7e48c6b558b49eb" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses code-sharing transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in code-sharing transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating code-sharing transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000410, bemo:BEMO_2000416, bemo:BEMO_2000417 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000408 a owl:Class ; rdfs:label "Comparator Description Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of comparator description are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000408" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000408" ; bemo:BEMO_3100022 415 ; bemo:BEMO_3100023 "a4617b71362b91773383e09e14a13eab2a1f342da234aa0f9bf7cc4400a6ff10" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses comparator description completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in comparator description completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating comparator description completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000412, bemo:BEMO_2000415, bemo:BEMO_2000429 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000409 a owl:Class ; rdfs:label "Conflict-of-Interest Transparency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of conflict-of-interest transparency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000409" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000409" ; bemo:BEMO_3100022 416 ; bemo:BEMO_3100023 "e951e1891736a22e6ef317b85f2f1f3032c69473b10d7ac72b1ed8342656df25" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses conflict-of-interest transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in conflict-of-interest transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating conflict-of-interest transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000407, bemo:BEMO_2000410, bemo:BEMO_2000413 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000410 a owl:Class ; rdfs:label "Data-Sharing Transparency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of data-sharing transparency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000410" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000410" ; bemo:BEMO_3100022 417 ; bemo:BEMO_3100023 "24a8774755f1b71359ef7a35f4a7813a446670f2da0ccc38d22836e1a84f1453" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses data-sharing transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in data-sharing transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating data-sharing transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000407, bemo:BEMO_2000409, bemo:BEMO_2000416 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000411 a owl:Class ; rdfs:label "Deviations-from-Protocol Transparency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of deviations-from-protocol transparency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000411" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000411" ; bemo:BEMO_3100022 418 ; bemo:BEMO_3100023 "6d08df9b94938aa4356ba3bbe963ef6fed2e0e499e09e30936b635d55a24d3c8" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses deviations-from-protocol transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in deviations-from-protocol transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating deviations-from-protocol transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000420, bemo:BEMO_2000430 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000412 a owl:Class ; rdfs:label "Eligibility Criteria Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of eligibility criteria are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000412" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000412" ; bemo:BEMO_3100022 419 ; bemo:BEMO_3100023 "02e23f40dd856c6f19f825d6191af4cb70f9ed2e604c47f5cbd7bf406e4d2381" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses eligibility criteria completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in eligibility criteria completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating eligibility criteria completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000408, bemo:BEMO_2000422, bemo:BEMO_2000429 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000413 a owl:Class ; rdfs:label "Funding-Source Transparency"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of funding-source transparency."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000413" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000413" ; bemo:BEMO_3100022 420 ; bemo:BEMO_3100023 "35377c10ba740cabcf147ce4b6ab00e3a9c4087ca2ca810c337f7fe08223e6f9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses funding-source transparency using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in funding-source transparency can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating funding-source transparency as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000409, bemo:BEMO_2000410, bemo:BEMO_2000418 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000414 a owl:Class ; rdfs:label "Harms Reporting Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of harms reporting are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000414" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000414" ; bemo:BEMO_3100022 421 ; bemo:BEMO_3100023 "15ffc51fd66113f5e5c480a7127c592104dbff4a2e6faafcfafb509cd725ea07" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses harms reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in harms reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating harms reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000418, bemo:BEMO_2000422, bemo:BEMO_2000431 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000415 a owl:Class ; rdfs:label "Intervention Description Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of intervention description are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000415" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000415" ; bemo:BEMO_3100022 422 ; bemo:BEMO_3100023 "52ff9263e3651129913da102dae69c16126528e71dde3bf30595ca84301723b5" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses intervention description completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in intervention description completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating intervention description completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000408, bemo:BEMO_2000412, bemo:BEMO_2000421 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000416 a owl:Class ; rdfs:label "Materials-and-Reagents Reporting Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of materials-and-reagents reporting are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000416" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000416" ; bemo:BEMO_3100022 423 ; bemo:BEMO_3100023 "fc72795f141f7cb81bc8cc86190a0c7cf2a5f2f6065d3b22f9bc88dd2e13080e" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses materials-and-reagents reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in materials-and-reagents reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating materials-and-reagents reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000407, bemo:BEMO_2000417, bemo:BEMO_2000428 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000417 a owl:Class ; rdfs:label "Metadata Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of metadata are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000417" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000417" ; bemo:BEMO_3100022 424 ; bemo:BEMO_3100023 "cfce2b3ca58f108e1dc5461ad1ef2f5a84b55171c75536d306bf4e1e2b3bc58d" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses metadata completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in metadata completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating metadata completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000416, bemo:BEMO_2000424, bemo:BEMO_2000428 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000418 a owl:Class ; rdfs:label "Missing-Data Reporting Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of missing-data reporting are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000418" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000418" ; bemo:BEMO_3100022 425 ; bemo:BEMO_3100023 "810e02862dfc4630d6f7a0d7bd830ccd305d847e2d0153cfdb863b68f1c2ece8" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses missing-data reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in missing-data reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating missing-data reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000409, bemo:BEMO_2000413, bemo:BEMO_2000431 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000419 a owl:Class ; rdfs:label "Negative-Result Reporting"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of negative-result reporting."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000419" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000419" ; bemo:BEMO_3100022 426 ; bemo:BEMO_3100023 "f6803e55dc7d7550d62e5bed1f8773c7da7d0266b37145da5354a96ceaf769c2" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses negative-result reporting using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in negative-result reporting can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating negative-result reporting as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000411, bemo:BEMO_2000420, bemo:BEMO_2000427 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000420 a owl:Class ; rdfs:label "Null-Result Interpretability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of null-result interpretability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000420" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000420" ; bemo:BEMO_3100022 427 ; bemo:BEMO_3100023 "0e7be34e4db71c86201d878decffa3c8da8ca62a1c8481dc3779d3c4caa454b1" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses null-result interpretability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in null-result interpretability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating null-result interpretability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000411, bemo:BEMO_2000419, bemo:BEMO_2000430 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000421 a owl:Class ; rdfs:label "Outcome Definition Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of outcome definition are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000421" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000421" ; bemo:BEMO_3100022 428 ; bemo:BEMO_3100023 "129e8fff9350e8d3fb88d0a300e3816f498afcc03cf17b3f6037da094441e4fe" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses outcome definition completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in outcome definition completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating outcome definition completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000408, bemo:BEMO_2000415, bemo:BEMO_2000423 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000422 a owl:Class ; rdfs:label "Participant Flow Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of participant flow are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000422" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000422" ; bemo:BEMO_3100022 429 ; bemo:BEMO_3100023 "c3caaa14ecea68f7075a25ef235cdae89d1a9b9b86ed2b5a30dab5cb5b8bf20d" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses participant flow completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in participant flow completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating participant flow completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000414, bemo:BEMO_2000429, bemo:BEMO_2000431 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000423 a owl:Class ; rdfs:label "Prespecified Analysis Adherence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prespecified analysis adherence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000423" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000423" ; bemo:BEMO_3100022 430 ; bemo:BEMO_3100023 "fe370510831c4feb18d187a9f8348ee0b93ff3174da9ddceea906467255bbd60" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses prespecified analysis adherence using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prespecified analysis adherence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prespecified analysis adherence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000415, bemo:BEMO_2000421, bemo:BEMO_2000425 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000424 a owl:Class ; rdfs:label "Processed-Data Availability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of processed-data availability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000424" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000424" ; bemo:BEMO_3100022 431 ; bemo:BEMO_3100023 "3d4a65e6d3c66bcaca4ff40b6df33feaedf2f77c58697c32f80c96a00d211e95" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses processed-data availability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in processed-data availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating processed-data availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000419, bemo:BEMO_2000427, bemo:BEMO_2000428 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000427 a owl:Class ; rdfs:label "Quality-Control Reporting Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of quality-control reporting are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000427" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000427" ; bemo:BEMO_3100022 434 ; bemo:BEMO_3100023 "b53b586f994fd48c27b9acc1c6fff59b966085610e593ec05c03735d90e329b2" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses quality-control reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in quality-control reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating quality-control reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000419, bemo:BEMO_2000420, bemo:BEMO_2000424 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000428 a owl:Class ; rdfs:label "Raw-Data Availability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of raw-data availability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000428" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000428" ; bemo:BEMO_3100022 435 ; bemo:BEMO_3100023 "2fcf4f96e7ca202f61d3de161ead38ea506d30ac8f05b66ac8a84b27f3da645e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses raw-data availability using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in raw-data availability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating raw-data availability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000417, bemo:BEMO_2000424, bemo:BEMO_2000427 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000429 a owl:Class ; rdfs:label "Recruitment Reporting Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of recruitment reporting are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000429" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000429" ; bemo:BEMO_3100022 436 ; bemo:BEMO_3100023 "d9e587b4cd42324cc1668fb835e848ce02fea72bac0af2f37bcc6e0a40cbc327" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses recruitment reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in recruitment reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating recruitment reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000412, bemo:BEMO_2000414, bemo:BEMO_2000422 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000431 a owl:Class ; rdfs:label "Statistical Methods Reporting Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of statistical methods reporting are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000431" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100016 ; bemo:BEMO_3100001 "BEMO:2000431" ; bemo:BEMO_3100022 438 ; bemo:BEMO_3100023 "d8af14618f3e80ecff3b617a35c54caa9b3c73184f234fcea88a9ee83c7090ff" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses statistical methods reporting completeness using evidence appropriate to research transparency and reporting completeness, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in statistical methods reporting completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating statistical methods reporting completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Study report / dataset / evidence package"@en ; bemo:BEMO_3200009 "All biomedical study reports and data releases"@en ; bemo:BEMO_3200010 "EQUATOR; PRISMA; CONSORT; STROBE; STARD; TRIPOD; CARE; CHEERS"@en ; bemo:BEMO_3200011 "https://www.equator-network.org/ | https://www.prisma-statement.org/prisma-2020-checklist | https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.equator-network.org/reporting-guidelines/stard/ | https://www.tripod-statement.org/ | https://www.care-statement.org/ | https://www.equator-network.org/reporting-guidelines/cheers/" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000413, bemo:BEMO_2000414, bemo:BEMO_2000418 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Established within specialty" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000432 a owl:Class ; rdfs:label "Bayes Factor Evidence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of bayes factor evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000432" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000432" ; bemo:BEMO_3100022 439 ; bemo:BEMO_3100023 "ea8be0499c9c5441e47cac85f3e884bcc28099d593610c01dc6ad24ba5c3d0f3" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses bayes factor evidence using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in bayes factor evidence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating bayes factor evidence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000442, bemo:BEMO_2000456, bemo:BEMO_2000457 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000433 a owl:Class ; rdfs:label "Calibration of Statistical Predictions"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of calibration of statistical predictions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000433" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000433" ; bemo:BEMO_3100022 440 ; bemo:BEMO_3100023 "1d5cbda1b0dc5b30aa8339e6219d08168170bd684f74bf0679b26dd4ece9ead4" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses calibration of statistical predictions using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in calibration of statistical predictions can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating calibration of statistical predictions as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000436, bemo:BEMO_2000437, bemo:BEMO_2000446 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000434 a owl:Class ; rdfs:label "Clinical Relevance of Effect"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of clinical relevance of effect."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000434" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000434" ; bemo:BEMO_3100022 441 ; bemo:BEMO_3100023 "7e04bf59de003d9389f3d5e5a39c09dbec7b25b54fdd665e24d339ccf148fb17" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses clinical relevance of effect using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in clinical relevance of effect can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating clinical relevance of effect as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000432, bemo:BEMO_2000436, bemo:BEMO_2000442 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000435 a owl:Class ; rdfs:label "Confidence Interval Compatibility"@en ; iao:0000115 "The justified degree of certainty assigned to confidence interval compatibility given the quantity, quality, consistency, and limitations of supporting evidence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000435" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000435" ; bemo:BEMO_3100022 442 ; bemo:BEMO_3100023 "4b44e65362db0ef8f1ef0ae6eb87b631fd22642d5790f792ab6c3d6a9a693508" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses confidence interval compatibility using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in confidence interval compatibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating confidence interval compatibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000441, bemo:BEMO_2000459, bemo:BEMO_2000460 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000436 a owl:Class ; rdfs:label "Decision-Curve Net Benefit"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of decision-curve net benefit."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000436" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000436" ; bemo:BEMO_3100022 443 ; bemo:BEMO_3100023 "7e96f3c494e389efab04f0ca564863ebd840cadeaf424446d3f94ddb483ed76c" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses decision-curve net benefit using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in decision-curve net benefit can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating decision-curve net benefit as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000434, bemo:BEMO_2000437, bemo:BEMO_2000442 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000437 a owl:Class ; rdfs:label "Discrimination of Statistical Predictions"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of discrimination of statistical predictions."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000437" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000437" ; bemo:BEMO_3100022 444 ; bemo:BEMO_3100023 "cf100cd63561a5d7a167b9d561a196b9309ca048456a8705766e76a54a524fce" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses discrimination of statistical predictions using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in discrimination of statistical predictions can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating discrimination of statistical predictions as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000433, bemo:BEMO_2000434, bemo:BEMO_2000436 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000438 a owl:Class ; rdfs:label "Distributional Assumption Adequacy"@en ; iao:0000115 "The extent to which distributional assumption is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000438" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000438" ; bemo:BEMO_3100022 445 ; bemo:BEMO_3100023 "79608c041c0babc1613cca804b9e22a2fcbadbeabfda7d7b0bf2336528db7db1" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses distributional assumption adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in distributional assumption adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating distributional assumption adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000447, bemo:BEMO_2000458, bemo:BEMO_2000462 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000440 a owl:Class ; rdfs:label "Equivalence Margin Validity"@en ; iao:0000115 "The degree to which equivalence margin supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000440" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000440" ; bemo:BEMO_3100022 447 ; bemo:BEMO_3100023 "226b21fe561d36c12bfde0bcc47bb1ad6cb02760533a4b768747d6a0ab92184b" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses equivalence margin validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in equivalence margin validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating equivalence margin validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000452, bemo:BEMO_2000457 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000442 a owl:Class ; rdfs:label "Fragility Index"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of fragility index."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000442" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000442" ; bemo:BEMO_3100022 449 ; bemo:BEMO_3100023 "045c39ed086cc31d598f1fe91547a90170ea8cc0b684f22d5338144e750a0843" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses fragility index using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in fragility index can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating fragility index as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000432, bemo:BEMO_2000434, bemo:BEMO_2000456 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000443 a owl:Class ; rdfs:label "Imputation Validity"@en ; iao:0000115 "The degree to which imputation supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000443" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000443" ; bemo:BEMO_3100022 450 ; bemo:BEMO_3100023 "451bb1f13aa8cd7feb728a231f72c948355ace1a73de7f1903381352517ceaf5" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses imputation validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in imputation validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating imputation validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000444, bemo:BEMO_2000448, bemo:BEMO_2000454 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000444 a owl:Class ; rdfs:label "Influential Observation Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of influential observation sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000444" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000444" ; bemo:BEMO_3100022 451 ; bemo:BEMO_3100023 "0202d30b443e9ba2dd8ad4597c8e7b9fcc240af0f60b19db4a115b1d2866e858" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses influential observation sensitivity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in influential observation sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating influential observation sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000445, bemo:BEMO_2000453, bemo:BEMO_2000454 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000445 a owl:Class ; rdfs:label "Interaction Assessment Adequacy"@en ; iao:0000115 "The extent to which interaction assessment is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000445" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000445" ; bemo:BEMO_3100022 452 ; bemo:BEMO_3100023 "7942499ba472159741e9410722d92887d17131b3d661f12b98b8ec8f2d490791" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses interaction assessment adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in interaction assessment adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating interaction assessment adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000446, bemo:BEMO_2000453, bemo:BEMO_2000455 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000446 a owl:Class ; rdfs:label "Measurement Error Correction"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of measurement error correction."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000446" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000446" ; bemo:BEMO_3100022 453 ; bemo:BEMO_3100023 "47dddb5f2dde48130ebfa9464b01b7ed1efb5da34ac2d484caa4259055162e55" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses measurement error correction using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in measurement error correction can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating measurement error correction as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000433, bemo:BEMO_2000437, bemo:BEMO_2000455 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000447 a owl:Class ; rdfs:label "Missing-Data Mechanism Plausibility"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of missing-data mechanism plausibility."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000447" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000447" ; bemo:BEMO_3100022 454 ; bemo:BEMO_3100023 "399e0c1d410c7ca1c5cc767b5afb9291915d1ee3db3b4d7314b2092c6d4765e1" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses missing-data mechanism plausibility using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in missing-data mechanism plausibility can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating missing-data mechanism plausibility as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000443, bemo:BEMO_2000448, bemo:BEMO_2000462 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000448 a owl:Class ; rdfs:label "Missing-Data Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of missing-data sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000448" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000448" ; bemo:BEMO_3100022 455 ; bemo:BEMO_3100023 "6708217d617153345c000ff0b34cc96bd34facf9514e5d1a84b3e56623ffb545" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses missing-data sensitivity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in missing-data sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating missing-data sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000443, bemo:BEMO_2000447, bemo:BEMO_2000454 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000449 a owl:Class ; rdfs:label "Model Fit"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of model fit."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000449" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000449" ; bemo:BEMO_3100022 456 ; bemo:BEMO_3100023 "bf6f70bdb1883a9c1ba70dc7d37eb1885dd46ed70094a2b12bd2cc41e0f53bad" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses model fit using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in model fit can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating model fit as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000438, bemo:BEMO_2000450, bemo:BEMO_2000458 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000450 a owl:Class ; rdfs:label "Model Specification Adequacy"@en ; iao:0000115 "The extent to which model specification is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000450" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000450" ; bemo:BEMO_3100022 457 ; bemo:BEMO_3100023 "c5d48404d8de034fc4aa45bb9f64638b1d861e61321423aa5f11d4f63cc6783b" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses model specification adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in model specification adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating model specification adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000449, bemo:BEMO_2000451, bemo:BEMO_2000458 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000451 a owl:Class ; rdfs:label "Multiplicity Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of multiplicity control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000451" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000451" ; bemo:BEMO_3100022 458 ; bemo:BEMO_3100023 "282fd29ea793d9f6346d4b34598e7ca30406dad2a72b3f3167d354ca92803ec0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses multiplicity control using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in multiplicity control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating multiplicity control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000449, bemo:BEMO_2000450, bemo:BEMO_2000461 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000453 a owl:Class ; rdfs:label "Nonlinearity Assessment"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of nonlinearity assessment."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000453" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000453" ; bemo:BEMO_3100022 460 ; bemo:BEMO_3100023 "aec401720de6539460ff9d49f62284a772b28790802eda1b3dc7c5fc2d67af3f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses nonlinearity assessment using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in nonlinearity assessment can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating nonlinearity assessment as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000444, bemo:BEMO_2000445, bemo:BEMO_2000455 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000454 a owl:Class ; rdfs:label "Outlier Influence Robustness"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of outlier influence robustness."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000454" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000454" ; bemo:BEMO_3100022 461 ; bemo:BEMO_3100023 "3a52b33f3faa79b95100ff084b9c7ca54158523c656fcaf5c298f073960428c9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses outlier influence robustness using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in outlier influence robustness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Independent repeats; between-run/site/analyst variability; concordance of effect direction and magnitude; predefined reproducibility thresholds."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating outlier influence robustness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000443, bemo:BEMO_2000444, bemo:BEMO_2000453 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000455 a owl:Class ; rdfs:label "Overadjustment Bias Risk"@en ; iao:0000115 "The probability or degree that overadjustment bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000455" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000455" ; bemo:BEMO_3100022 462 ; bemo:BEMO_3100023 "20f394b3ef37b7c0b5d8426ebcce5fe9f9ef841bbb2622101174fbb411ab7957" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses overadjustment bias risk using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in overadjustment bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating overadjustment bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000433, bemo:BEMO_2000445, bemo:BEMO_2000446 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000456 a owl:Class ; rdfs:label "Posterior Probability Strength"@en ; iao:0000115 "The magnitude and credibility of independent evidence supporting posterior probability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000456" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000456" ; bemo:BEMO_3100022 463 ; bemo:BEMO_3100023 "8a96194c8b8e65d04df266b282704e480656791b819df12c8c4924c984b02272" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses posterior probability strength using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in posterior probability strength can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating posterior probability strength as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000432, bemo:BEMO_2000440, bemo:BEMO_2000457 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000457 a owl:Class ; rdfs:label "Prior Sensitivity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of prior sensitivity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000457" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000457" ; bemo:BEMO_3100022 464 ; bemo:BEMO_3100023 "ced026349740f092de03ee4146894b4367dab3b43793f3aa048eac1fd782cbda" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses prior sensitivity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in prior sensitivity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified threshold; valid reference standard; complete 2×2 classification; confidence intervals; spectrum and prevalence assessment."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating prior sensitivity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000440, bemo:BEMO_2000452, bemo:BEMO_2000456 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000458 a owl:Class ; rdfs:label "Residual Diagnostics Adequacy"@en ; iao:0000115 "The extent to which residual diagnostics is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000458" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000458" ; bemo:BEMO_3100022 465 ; bemo:BEMO_3100023 "1193234e513641f836d7ad506af2e69fb2fcba17a604fff5710f7b53f487ad89" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses residual diagnostics adequacy using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in residual diagnostics adequacy can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating residual diagnostics adequacy as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000438, bemo:BEMO_2000449, bemo:BEMO_2000462 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000459 a owl:Class ; rdfs:label "Statistical Power"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of statistical power."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000459" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000459" ; bemo:BEMO_3100022 466 ; bemo:BEMO_3100023 "b5866270dc0b1ae7d14dc9e42f0ff6a1d28896f404d73ddeb44c5f7fdaf6b51a" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses statistical power using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in statistical power can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating statistical power as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000435, bemo:BEMO_2000460, bemo:BEMO_2000461 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000460 a owl:Class ; rdfs:label "Type I Error Control"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of type i error control."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000460" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000460" ; bemo:BEMO_3100022 467 ; bemo:BEMO_3100023 "a3eba05a4613d95dc796e3df689756346c4f78ac2fda1dcb4e8cf4b813a22638" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses type i error control using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in type i error control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating type i error control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000451, bemo:BEMO_2000459, bemo:BEMO_2000461 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000461 a owl:Class ; rdfs:label "Type II Error Risk"@en ; iao:0000115 "The probability or degree that type ii error introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000461" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000461" ; bemo:BEMO_3100022 468 ; bemo:BEMO_3100023 "de4287424d92a6f5a119531d8abefacf3d79beff40059540425ff1afc5f1021d" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses type ii error risk using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in type ii error risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating type ii error risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000450, bemo:BEMO_2000451, bemo:BEMO_2000460 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000462 a owl:Class ; rdfs:label "Variance Estimation Validity"@en ; iao:0000115 "The degree to which variance estimation supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000462" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100017 ; bemo:BEMO_3100001 "BEMO:2000462" ; bemo:BEMO_3100022 469 ; bemo:BEMO_3100023 "43a84aea1ea6cc79814a3121476a165954a222aece0c751b1ff5414b40efbe28" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses variance estimation validity using evidence appropriate to statistical validity and inference, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in variance estimation validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating variance estimation validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "All quantitative biomedical studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; TRIPOD; REMARK; ICH E9"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.tripod-statement.org/ | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/ | https://database.ich.org/sites/default/files/E9_Guideline.pdf" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000438, bemo:BEMO_2000447, bemo:BEMO_2000448 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000463 a owl:Class ; rdfs:label "Adherence Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of adherence integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000463" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000463" ; bemo:BEMO_3100022 470 ; bemo:BEMO_3100023 "9a20a1494ccbc46d7bc0acd4d260241ebc29edd15b77d8ccc525c9f0dba8e8de" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses adherence integrity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in adherence integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating adherence integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000476, bemo:BEMO_2000477, bemo:BEMO_2000479 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000465 a owl:Class ; rdfs:label "Attrition Bias Risk"@en ; iao:0000115 "The probability or degree that attrition bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000465" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000465" ; bemo:BEMO_3100022 472 ; bemo:BEMO_3100023 "0783cbbb1a7caf7ef448d6830ae564e73010beb87e2e08710ddb494b6b76ccb3" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses attrition bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in attrition bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating attrition bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000474, bemo:BEMO_2000483, bemo:BEMO_2000486 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000466 a owl:Class ; rdfs:label "Baseline Comparability"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of baseline comparability."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000466" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000466" ; bemo:BEMO_3100022 473 ; bemo:BEMO_3100023 "93fad13257c869638e96dc16ab4687d4b955a0d40d8d10736f49f12cebec65eb" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses baseline comparability using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in baseline comparability can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating baseline comparability as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000464, bemo:BEMO_2000467, bemo:BEMO_2000481 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000467 a owl:Class ; rdfs:label "Blinding Integrity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of blinding integrity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000467" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000467" ; bemo:BEMO_3100022 474 ; bemo:BEMO_3100023 "4e84b980ded4e833e93013ba317d5857e2211ad9b612e4b77eb9308cf8244573" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses blinding integrity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in blinding integrity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating blinding integrity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000466, bemo:BEMO_2000474, bemo:BEMO_2000481 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000468 a owl:Class ; rdfs:label "Carryover Effect Risk"@en ; iao:0000115 "The probability or degree that carryover effect introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000468" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000468" ; bemo:BEMO_3100022 475 ; bemo:BEMO_3100023 "6dbe1d75153c55efcce7da9af8dda3fe869c2f426eaaad651ee6f91b1670d205" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses carryover effect risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in carryover effect risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Replicate dilution series; blank and spiked samples; reference materials; method-comparison studies; predefined CLSI/ISO acceptance criteria."@en ; bemo:BEMO_3200006 "Treating carryover effect risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000469, bemo:BEMO_2000470, bemo:BEMO_2000482 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000469 a owl:Class ; rdfs:label "Cluster Recruitment Bias Risk"@en ; iao:0000115 "The probability or degree that cluster recruitment bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000469" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000469" ; bemo:BEMO_3100022 476 ; bemo:BEMO_3100023 "a9882065e899d9f8a8f701c6291666b702a9ad5b769971c1d3cb596c9e39b960" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses cluster recruitment bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in cluster recruitment bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating cluster recruitment bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000463, bemo:BEMO_2000476, bemo:BEMO_2000482 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000470 a owl:Class ; rdfs:label "Co-intervention Bias Risk"@en ; iao:0000115 "The probability or degree that co-intervention bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000470" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000470" ; bemo:BEMO_3100022 477 ; bemo:BEMO_3100023 "de36d6b209ddc70bf44fd968006b0ba61482bcc4bbe42db3c2a605301631de5e" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses co-intervention bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in co-intervention bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating co-intervention bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000468, bemo:BEMO_2000472, bemo:BEMO_2000482 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000471 a owl:Class ; rdfs:label "Comparator Validity"@en ; iao:0000115 "The degree to which comparator supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000471" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000471" ; bemo:BEMO_3100022 478 ; bemo:BEMO_3100023 "de06a641ed9f64a7c11259e9a1d1346140c2469d57bbd106c6257d947909a5a3" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses comparator validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in comparator validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating comparator validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000473, bemo:BEMO_2000479, bemo:BEMO_2000488 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000472 a owl:Class ; rdfs:label "Contamination Risk"@en ; iao:0000115 "The probability or degree that contamination introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000472" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000472" ; bemo:BEMO_3100022 479 ; bemo:BEMO_3100023 "eed78db6e72161c41f0a51c8bc55e5d20b0d6675373ef1a7bf65b4c5b0dc75c0" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses contamination risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in contamination risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating contamination risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000468, bemo:BEMO_2000470, bemo:BEMO_2000483 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000473 a owl:Class ; rdfs:label "Control Group Appropriateness"@en ; iao:0000115 "The extent to which control group is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000473" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000473" ; bemo:BEMO_3100022 480 ; bemo:BEMO_3100023 "47dcb7d2162b3c8496d326c0cd9b9dfbef0e0b4032c2c7d93f31f67139c5990f" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses control group appropriateness using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in control group appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating control group appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000471, bemo:BEMO_2000487, bemo:BEMO_2000488 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000474 a owl:Class ; rdfs:label "Detection Bias Risk"@en ; iao:0000115 "The probability or degree that detection bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000474" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000474" ; bemo:BEMO_3100022 481 ; bemo:BEMO_3100023 "98c36b49fe475eec66359fae3b2440fc1429c378e2bbe5896e082ec203855535" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses detection bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in detection bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating detection bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000465, bemo:BEMO_2000481, bemo:BEMO_2000486 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000476 a owl:Class ; rdfs:label "Early Stopping Bias Risk"@en ; iao:0000115 "The probability or degree that early stopping bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000476" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000476" ; bemo:BEMO_3100022 483 ; bemo:BEMO_3100023 "8ac86a4a6b6a886dad127939918a466b8c70bd2b6b13b03a987aab048ac4c7c3" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses early stopping bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in early stopping bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating early stopping bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000463, bemo:BEMO_2000469, bemo:BEMO_2000477 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000477 a owl:Class ; rdfs:label "Exposure Classification Validity"@en ; iao:0000115 "The degree to which exposure classification supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000477" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000477" ; bemo:BEMO_3100022 484 ; bemo:BEMO_3100023 "6d08552ad6c8b3c6d5a3c8ed35293fcfc624984197116fb158f6c3a04698789f" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses exposure classification validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in exposure classification validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating exposure classification validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000463, bemo:BEMO_2000471, bemo:BEMO_2000479 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000478 a owl:Class ; rdfs:label "Follow-up Completeness"@en ; iao:0000115 "The extent to which all scientifically necessary components of follow-up are present, documented, and evaluable."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000478" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000478" ; bemo:BEMO_3100022 485 ; bemo:BEMO_3100023 "a99fe581309ce29c4e888ffbd9a1cba6c99a6948f2a8e99e23714e0f40920b87" ; bemo:BEMO_3100024 9 ; bemo:BEMO_3200002 "Assesses follow-up completeness using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in follow-up completeness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Required elements present; traceable provenance; unambiguous definitions; accessible underlying data/materials; documented deviations."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating follow-up completeness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000475, bemo:BEMO_2000480 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000479 a owl:Class ; rdfs:label "Intervention Classification Validity"@en ; iao:0000115 "The degree to which intervention classification supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000479" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000479" ; bemo:BEMO_3100022 486 ; bemo:BEMO_3100023 "283a3544a9dd5cb1a16190c929c82c6db2608db0f4c24860780498cb89bc0ac5" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses intervention classification validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in intervention classification validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating intervention classification validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000471, bemo:BEMO_2000473, bemo:BEMO_2000477 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000480 a owl:Class ; rdfs:label "Outcome Ascertainment Validity"@en ; iao:0000115 "The degree to which outcome ascertainment supports the intended scientific interpretation without material systematic error."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000480" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000480" ; bemo:BEMO_3100022 487 ; bemo:BEMO_3100023 "654f73aad6650cd58d63f5a49ae9e034bfcb22952cbf7a018f652c070e1ba6c1" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses outcome ascertainment validity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in outcome ascertainment validity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating outcome ascertainment validity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000475, bemo:BEMO_2000478, bemo:BEMO_2000484 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000481 a owl:Class ; rdfs:label "Performance Bias Risk"@en ; iao:0000115 "The probability or degree that performance bias introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000481" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000481" ; bemo:BEMO_3100022 488 ; bemo:BEMO_3100023 "67d1ca80d7087e3cfba7c1c9f64d45d3f4094887ac27aef09ef61bfb6d49d732" ; bemo:BEMO_3100024 10 ; bemo:BEMO_3200002 "Assesses performance bias risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in performance bias risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating performance bias risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000465, bemo:BEMO_2000467, bemo:BEMO_2000474 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Mature" . bemo:BEMO_2000482 a owl:Class ; rdfs:label "Period Effect Risk"@en ; iao:0000115 "The probability or degree that period effect introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000482" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000482" ; bemo:BEMO_3100022 489 ; bemo:BEMO_3100023 "78e4475c3f570e4a3e966d2bc7b940517b5d7eaa514d888dc22a6ea5b68d38fb" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses period effect risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in period effect risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating period effect risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000468, bemo:BEMO_2000469, bemo:BEMO_2000476 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000483 a owl:Class ; rdfs:label "Protocol Deviation Risk"@en ; iao:0000115 "The probability or degree that protocol deviation introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000483" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000483" ; bemo:BEMO_3100022 490 ; bemo:BEMO_3100023 "7632dd2b67a9f407b6c186b3a54ef8714ff7082ed9c885957d4f06c0008e5f26" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses protocol deviation risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protocol deviation risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating protocol deviation risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000470, bemo:BEMO_2000472, bemo:BEMO_2000486 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000484 a owl:Class ; rdfs:label "Protocol Fidelity"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of protocol fidelity."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000484" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000484" ; bemo:BEMO_3100022 491 ; bemo:BEMO_3100023 "ae404e8a9df9a665347ede4db7ae7370bdc6c77c15da3474e23c516ad81dd25e" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses protocol fidelity using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in protocol fidelity can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating protocol fidelity as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000478, bemo:BEMO_2000480, bemo:BEMO_2000487 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000486 a owl:Class ; rdfs:label "Selective Outcome Reporting Risk"@en ; iao:0000115 "The probability or degree that selective outcome reporting introduces systematic distortion into a biomedical estimate or conclusion."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000486" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000486" ; bemo:BEMO_3100022 493 ; bemo:BEMO_3100023 "bcdaa5f06df0a5ab7941c490a740787093ffc20f433c48125d9c2e174850f7fd" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses selective outcome reporting risk using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in selective outcome reporting risk can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified signaling questions; direction and likely magnitude of distortion; domain-level and overall judgment; sensitivity to plausible bias."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating selective outcome reporting risk as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000465, bemo:BEMO_2000472, bemo:BEMO_2000483 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000487 a owl:Class ; rdfs:label "Study Design Appropriateness"@en ; iao:0000115 "The extent to which study design is sufficient and fit for the stated biomedical inference."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000487" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000487" ; bemo:BEMO_3100022 494 ; bemo:BEMO_3100023 "7f9fb8e0c1ccb555a18bd7b6b07b3173d661a6707fab17a21ee632e59503b393" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses study design appropriateness using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in study design appropriateness can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Clear intended use or estimand; accepted reference or criterion; prespecified acceptance thresholds; independent validation; performance across relevant conditions."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating study design appropriateness as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000480, bemo:BEMO_2000484, bemo:BEMO_2000488 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_2000488 a owl:Class ; rdfs:label "Temporal Precedence"@en ; iao:0000115 "A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of temporal precedence."@en ; iao:0000119 ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:2000488" ; rdfs:subClassOf [ a owl:Restriction ; owl:hasValue ; owl:onProperty bemo:BEMO_3000001 ], bemo:BEMO_1100018 ; bemo:BEMO_3100001 "BEMO:2000488" ; bemo:BEMO_3100022 495 ; bemo:BEMO_3100023 "ec85a4abfc9e480fea03dfff5177f17a293899d488f06a679715de258c8591b9" ; bemo:BEMO_3100024 8 ; bemo:BEMO_3200002 "Assesses temporal precedence using evidence appropriate to study design and internal validity, distinguishing random uncertainty from systematic error."@en ; bemo:BEMO_3200003 "Material weakness in temporal precedence can change the direction, magnitude, certainty, or biological interpretation of the research conclusion."@en ; bemo:BEMO_3200004 "Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses."@en ; bemo:BEMO_3200005 "Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses."@en ; bemo:BEMO_3200006 "Treating temporal precedence as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory."@en ; bemo:BEMO_3200007 "Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence."@en ; bemo:BEMO_3200008 "Result / experiment / study / body of evidence, as applicable"@en ; bemo:BEMO_3200009 "Randomized trials, nonrandomized intervention studies, cohort, case-control, cross-sectional studies"@en ; bemo:BEMO_3200010 "CONSORT; STROBE; RoB 2; ROBINS-I; ROBINS-E; NIH Quality Tools; JBI"@en ; bemo:BEMO_3200011 "https://www.consort-spirit.org/ | https://www.equator-network.org/reporting-guidelines/strobe/ | https://www.riskofbias.info/welcome/rob-2-0-tool | https://www.riskofbias.info/welcome/home/current-version-of-robins-i | https://www.riskofbias.info/welcome/robins-e-tool | https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools | https://jbi.global/critical-appraisal-tools" ; bemo:BEMO_3200012 ; bemo:BEMO_3200013 bemo:BEMO_2000473, bemo:BEMO_2000484, bemo:BEMO_2000487 ; bemo:BEMO_3200014 "Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx" ; bemo:BEMO_3200015 "Biomedical Evidence Metrics" ; bemo:BEMO_3200016 "Candidate" ; bemo:BEMO_3200017 "Pending owner approval; CC BY 4.0 recommended for OBO compatibility." ; bemo:BEMO_3200018 "Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use."@en ; bemo:BEMO_3200019 "Common" ; bemo:BEMO_3200020 "Established" . bemo:BEMO_4000005 a owl:NamedIndividual, bemo:BEMO_0000400 ; rdfs:label "Ratio Scale"@en ; iao:0000115 "Controlled BEMO ScaleType value: RatioScale."@en ; oboInOwl:id "BEMO:4000005" ; skos:notation "RatioScale" . bemo:BEMO_4000009 a owl:NamedIndividual, bemo:BEMO_0000401 ; rdfs:label "Quantitative Ratio Computation"@en ; iao:0000115 "Controlled BEMO ComputationMode value: QuantitativeRatioComputation."@en ; oboInOwl:id "BEMO:4000009" ; skos:notation "QuantitativeRatioComputation" . bemo:BEMO_0000400 a owl:Class ; rdfs:label "scale type"@en ; iao:0000115 "A controlled concept describing the scale used by a metric output."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000400" ; rdfs:subClassOf skos:Concept ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000401 a owl:Class ; rdfs:label "computation mode"@en ; iao:0000115 "A controlled concept describing the general computational approach used by a metric."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000401" ; rdfs:subClassOf skos:Concept ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_0000001 a owl:Class ; rdfs:label "biomedical evidence metric"@en ; iao:0000115 "An information content entity that specifies a scientifically interpretable quantity, category, rubric, or assessment construct used to evaluate biomedical evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000001" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_4000003 a owl:NamedIndividual, bemo:BEMO_0000400 ; rdfs:label "Physical Measurement Scale"@en ; iao:0000115 "Controlled BEMO ScaleType value: PhysicalMeasurementScale."@en ; oboInOwl:id "BEMO:4000003" ; skos:notation "PhysicalMeasurementScale" . bemo:BEMO_4000012 a owl:NamedIndividual, bemo:BEMO_0000401 ; rdfs:label "Validated Measurement Procedure"@en ; iao:0000115 "Controlled BEMO ComputationMode value: ValidatedMeasurementProcedure."@en ; oboInOwl:id "BEMO:4000012" ; skos:notation "ValidatedMeasurementProcedure" . bemo:BEMO_4000013 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Domain Protocol Required"@en ; iao:0000115 "Controlled BEMO ComputationReadinessStatus value: DomainProtocolRequired."@en ; oboInOwl:id "BEMO:4000013" ; skos:notation "DomainProtocolRequired" . bemo:BEMO_4000020 a owl:NamedIndividual, bemo:BEMO_0000403 ; rdfs:label "Method Specific Protocol Required"@en ; iao:0000115 "Controlled BEMO FormulaStatus value: MethodSpecificProtocolRequired."@en ; oboInOwl:id "BEMO:4000020" ; skos:notation "MethodSpecificProtocolRequired" . bemo:BEMO_0000402 a owl:Class ; rdfs:label "computation readiness status"@en ; iao:0000115 "A controlled concept describing how close a metric is to executable, validated computation."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000402" ; rdfs:subClassOf skos:Concept ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100008 a owl:Class ; rdfs:label "External Validity and Applicability metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with external validity and applicability."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100008" ; rdfs:subClassOf bemo:BEMO_1000005 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100015 a owl:Class ; rdfs:label "Reproducibility and Replication metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with reproducibility and replication."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100015" ; rdfs:subClassOf bemo:BEMO_1000004 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100007 a owl:Class ; rdfs:label "Experimental Biology and Animal Research metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with experimental biology and animal research."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100007" ; rdfs:subClassOf bemo:BEMO_1000006 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100016 a owl:Class ; rdfs:label "Research Transparency and Reporting Completeness metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with research transparency and reporting completeness."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100016" ; rdfs:subClassOf bemo:BEMO_1000004 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100003 a owl:Class ; rdfs:label "Biospecimen and Preanalytical Quality metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with biospecimen and preanalytical quality."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100003" ; rdfs:subClassOf bemo:BEMO_1000003 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100004 a owl:Class ; rdfs:label "Causal Inference metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with causal inference."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100004" ; rdfs:subClassOf bemo:BEMO_1000002 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100009 a owl:Class ; rdfs:label "Genetics and Variant Evidence metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with genetics and variant evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100009" ; rdfs:subClassOf bemo:BEMO_1000007 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100012 a owl:Class ; rdfs:label "Multi-omics and Systems Biology metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with multi-omics and systems biology."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100012" ; rdfs:subClassOf bemo:BEMO_1000007 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100018 a owl:Class ; rdfs:label "Study Design and Internal Validity metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with study design and internal validity."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100018" ; rdfs:subClassOf bemo:BEMO_1000002 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100001 a owl:Class ; rdfs:label "Biological Plausibility and Mechanism metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with biological plausibility and mechanism."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100001" ; rdfs:subClassOf bemo:BEMO_1000006 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100006 a owl:Class ; rdfs:label "Evidence Certainty and Synthesis metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with evidence certainty and synthesis."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100006" ; rdfs:subClassOf bemo:BEMO_1000001 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100014 a owl:Class ; rdfs:label "Proteomics and Metabolomics metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with proteomics and metabolomics."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100014" ; rdfs:subClassOf bemo:BEMO_1000007 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100005 a owl:Class ; rdfs:label "Diagnostic and Prognostic Evidence metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with diagnostic and prognostic evidence."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100005" ; rdfs:subClassOf bemo:BEMO_1000005 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100002 a owl:Class ; rdfs:label "Biomarker and Endpoint Validation metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with biomarker and endpoint validation."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100002" ; rdfs:subClassOf bemo:BEMO_1000005 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100010 a owl:Class ; rdfs:label "Genomics and Transcriptomics metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with genomics and transcriptomics."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100010" ; rdfs:subClassOf bemo:BEMO_1000007 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100013 a owl:Class ; rdfs:label "Pharmacology and Toxicology metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with pharmacology and toxicology."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100013" ; rdfs:subClassOf bemo:BEMO_1000008 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100017 a owl:Class ; rdfs:label "Statistical Validity and Inference metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with statistical validity and inference."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100017" ; rdfs:subClassOf bemo:BEMO_1000002 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_1100011 a owl:Class ; rdfs:label "Measurement and Assay Analytical Validity metric"@en ; iao:0000115 "Category of biomedical evidence metrics concerned with measurement and assay analytical validity."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:1100011" ; rdfs:subClassOf bemo:BEMO_1000003 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_4000006 a owl:NamedIndividual, bemo:BEMO_0000400 ; rdfs:label "Risk Scale"@en ; iao:0000115 "Controlled BEMO ScaleType value: RiskScale."@en ; oboInOwl:id "BEMO:4000006" ; skos:notation "RiskScale" . bemo:BEMO_4000010 a owl:NamedIndividual, bemo:BEMO_0000401 ; rdfs:label "Risk Assessment Computation"@en ; iao:0000115 "Controlled BEMO ComputationMode value: RiskAssessmentComputation."@en ; oboInOwl:id "BEMO:4000010" ; skos:notation "RiskAssessmentComputation" . bemo:BEMO_4000015 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Rubric Or Model Required"@en ; iao:0000115 "Controlled BEMO ComputationReadinessStatus value: RubricOrModelRequired."@en ; oboInOwl:id "BEMO:4000015" ; skos:notation "RubricOrModelRequired" . bemo:BEMO_4000022 a owl:NamedIndividual, bemo:BEMO_0000404 ; rdfs:label "Lower Is Better"@en ; iao:0000115 "Controlled BEMO Directionality value: LowerIsBetter."@en ; oboInOwl:id "BEMO:4000022" ; skos:notation "LowerIsBetter" . bemo:BEMO_4000004 a owl:NamedIndividual, bemo:BEMO_0000400 ; rdfs:label "Proportion Scale"@en ; iao:0000115 "Controlled BEMO ScaleType value: ProportionScale."@en ; oboInOwl:id "BEMO:4000004" ; skos:notation "ProportionScale" . bemo:BEMO_4000008 a owl:NamedIndividual, bemo:BEMO_0000401 ; rdfs:label "Quantitative Proportion Computation"@en ; iao:0000115 "Controlled BEMO ComputationMode value: QuantitativeProportionComputation."@en ; oboInOwl:id "BEMO:4000008" ; skos:notation "QuantitativeProportionComputation" . bemo:BEMO_4000017 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Template Computable"@en ; iao:0000115 "Controlled BEMO ComputationReadinessStatus value: TemplateComputable."@en ; oboInOwl:id "BEMO:4000017" ; skos:notation "TemplateComputable" . bemo:BEMO_4000019 a owl:NamedIndividual, bemo:BEMO_0000403 ; rdfs:label "Generic Template Defined"@en ; iao:0000115 "Controlled BEMO FormulaStatus value: GenericTemplateDefined."@en ; oboInOwl:id "BEMO:4000019" ; skos:notation "GenericTemplateDefined" . bemo:BEMO_4000002 a owl:NamedIndividual, bemo:BEMO_0000400 ; rdfs:label "Ordinal Or Normalized Score Scale"@en ; iao:0000115 "Controlled BEMO ScaleType value: OrdinalOrNormalizedScoreScale."@en ; oboInOwl:id "BEMO:4000002" ; skos:notation "OrdinalOrNormalizedScoreScale" . bemo:BEMO_4000011 a owl:NamedIndividual, bemo:BEMO_0000401 ; rdfs:label "Rule Based Rubric Computation"@en ; iao:0000115 "Controlled BEMO ComputationMode value: RuleBasedRubricComputation."@en ; oboInOwl:id "BEMO:4000011" ; skos:notation "RuleBasedRubricComputation" . bemo:BEMO_4000016 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Rubric Required"@en ; iao:0000115 "Controlled BEMO ComputationReadinessStatus value: RubricRequired."@en ; oboInOwl:id "BEMO:4000016" ; skos:notation "RubricRequired" . bemo:BEMO_4000001 a owl:NamedIndividual, bemo:BEMO_0000400 ; rdfs:label "Context Dependent Mixed Scale"@en ; iao:0000115 "Controlled BEMO ScaleType value: ContextDependentMixedScale."@en ; oboInOwl:id "BEMO:4000001" ; skos:notation "ContextDependentMixedScale" . bemo:BEMO_4000007 a owl:NamedIndividual, bemo:BEMO_0000401 ; rdfs:label "Context Specific Metric Computation"@en ; iao:0000115 "Controlled BEMO ComputationMode value: ContextSpecificMetricComputation."@en ; oboInOwl:id "BEMO:4000007" ; skos:notation "ContextSpecificMetricComputation" . bemo:BEMO_4000014 a owl:NamedIndividual, bemo:BEMO_0000402 ; rdfs:label "Operational Definition Required"@en ; iao:0000115 "Controlled BEMO ComputationReadinessStatus value: OperationalDefinitionRequired."@en ; oboInOwl:id "BEMO:4000014" ; skos:notation "OperationalDefinitionRequired" . bemo:BEMO_4000018 a owl:NamedIndividual, bemo:BEMO_0000403 ; rdfs:label "Context Specific Protocol Required"@en ; iao:0000115 "Controlled BEMO FormulaStatus value: ContextSpecificProtocolRequired."@en ; oboInOwl:id "BEMO:4000018" ; skos:notation "ContextSpecificProtocolRequired" . bemo:BEMO_4000021 a owl:NamedIndividual, bemo:BEMO_0000404 ; rdfs:label "Context Dependent Direction"@en ; iao:0000115 "Controlled BEMO Directionality value: ContextDependentDirection."@en ; oboInOwl:id "BEMO:4000021" ; skos:notation "ContextDependentDirection" . bemo:BEMO_0000100 a owl:Class ; rdfs:label "metric computation specification"@en ; iao:0000115 "An information content entity specifying inputs, outputs, formula status, uncertainty, thresholds, missing-data policy, and validation requirements for computing a metric."@en ; oboInOwl:hasOBONamespace "bemo" ; oboInOwl:id "BEMO:0000100" ; rdfs:subClassOf iao:0000030 ; bemo:BEMO_3200016 "Candidate" . bemo:BEMO_3000001 a owl:ObjectProperty ; rdfs:label "has computation profile"@en ; iao:0000115 "Connects a metric-bearing assessment or metric class restriction to its computation specification."@en ; oboInOwl:id "BEMO:3000001" .