{"metric_id":"BEMO:2000079","metric_iri":"https://w3id.org/bemo/BEMO_2000079","preferred_label":"Storage Temperature Control","normalized_label":"storage_temperature_control","abbreviation":"","pillar_id":"BEMO:1000003","pillar_label":"Measurement, Assay, and Biospecimen Quality","category_id":"BEMO:1100003","category_label":"Biospecimen and Preanalytical Quality","parent_class_iri":"https://w3id.org/bemo/BEMO_1100003","ontology_namespace":"BEMO","ontology_version":"0.1.0","metric_version":"1.0.0","lifecycle_status":"Candidate","deprecated":false,"replacement_id":"","created_date":"2026-08-02","modified_date":"2026-08-02","language":"en","license_status":"Pending owner approval; CC BY 4.0 recommended for OBO compatibility.","scientific_definition":"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of storage temperature control.","what_it_measures":"Assesses storage temperature control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.","why_it_matters":"Material weakness in storage temperature control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.","measurement_criteria":"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.","methods_of_assessment":"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.","units_or_scale_source":"Metric-specific continuous, categorical, or ordinal scale","evidence_level_source":"Specimen / assay / run / laboratory / study","applicable_study_types_source":"All studies using human or animal biospecimens","related_frameworks_source":"BRISQ; ISO 15189; REMARK","closely_related_metrics_source":"Preservation Adequacy; Freeze–Thaw Burden; Transport Condition Integrity","common_misinterpretations":"Treating storage temperature control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.","limitations":"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.","scientific_importance":8,"frequency_of_use":"Established within specialty","maturity_of_metric":"Established","references_source":"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/","metric_kind":"AtomicOrCompositeNotYetCurated","output_concept":"BEMO:0000200 Metric Assessment","scale_type":"ContextDependentMixedScale","output_datatype":"xsd:anySimpleType","unit_ontology_iri":"","unit_text":"Metric-specific continuous, categorical, or ordinal scale","minimum_value":null,"maximum_value":null,"null_value":null,"directionality":"ContextDependentDirection","computation_mode":"ContextSpecificMetricComputation","computation_readiness":"OperationalDefinitionRequired","formula_status":"ContextSpecificProtocolRequired","human_readable_formula":"Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods.","machine_formula_language":"BEMO-Expression-JSON","machine_formula_expression":"{\"language\":\"BEMO-Expression-JSON\",\"operator\":\"external_protocol\",\"protocolRef\":\"REQUIRED\"}","required_inputs":"evidence_records; assessment_context; operational_definition; computation_protocol_version","optional_inputs":"weights; thresholds; reference_standard; expert_adjudication","aggregation_rule":"Not specified in source; must be defined and versioned before composite use.","normalization_method":"None by default; any normalization must be justified, versioned, and validated.","missing_data_policy":"Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material.","uncertainty_required":true,"uncertainty_method":"Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable.","confidence_interval_required":true,"threshold_policy":"Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction.","decision_thresholds":"","quality_control_requirements":"Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable.","calibration_requirement":"As applicable; mandatory for probabilistic or normalized outputs.","validation_status":"Source maturity: Established; BEMO computation profile requires independent validation.","benchmark_requirement":"A representative, versioned benchmark set is required before production use.","gold_standard_requirement":"Use an independent reference standard when one exists; document expert-adjudicated alternatives.","external_validation_required":true,"evidence_object_scope":"Specimen / assay / run / laboratory / study","study_type_applicability":"All studies using human or animal biospecimens","domain_applicability":"Biospecimen and Preanalytical Quality","required_data_sources":"Context-specific; use source references, registered studies, primary data, and authoritative biomedical resources as applicable.","computational_method_family":"metric-specific quantitative or qualitative assessment","software_implementation_status":"Specification generated; metric-specific reference implementation pending.","reference_implementation":"scripts/compute_metric.py --metric BEMO:2000079","api_endpoint_template":"/v1/metrics/BEMO:2000079/compute","json_schema_ref":"schemas/bemo-assessment.schema.json","shacl_shape_iri":"https://w3id.org/bemo/shapes/BEMO_2000079_AssessmentShape","provenance_model":"W3C PROV-O","source_workbook":"Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx","source_sheet":"Biomedical Evidence Metrics","source_row":86,"source_record_hash":"b39a92acfa55bd840331823c88476d9d65ca0179f68f0f37ed8d7677a63d2193","source_references":"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/","curator":"Unassigned","reviewer":"Unassigned","owner":"BEMO Project","approval_status":"Draft","governance_note":"Candidate term pending scientific, ontology-engineering, and computation-method review.","editor_note":"Source content preserved verbatim; computation metadata is a generated default and must be curated before normative use.","definition_source":"Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx row 86; see source_references","exact_synonyms":"","broad_synonyms":"","narrow_synonyms":"","related_synonyms":"","xrefs":"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/","obo_subset":"bemo_measurement_assay_and_biospecimen_quality","fair_findable":"Provisional: stable local ID assigned; public namespace registration pending.","fair_accessible":"Provisional: package is distributable; permanent public release location pending.","fair_interoperable":"Yes: OWL 2, RDF, SKOS, SHACL, JSON-LD, CSV, and OBO-style identifiers.","fair_reusable":"Provisional: rich metadata supplied; open-license owner approval pending.","confidence_in_metric_definition":"Not yet formally assessed","metric_dependency_status":"Not yet curated","dependency_notes":"Closely related metrics are represented; causal or computational dependencies require expert curation.","implementation_notes":"Exact execution requires a validated computation profile unless formula_status is GenericTemplateDefined.","test_case_status":"Generic validation template provided","example_input_ref":"examples/example_metric_input.json","example_output_ref":"examples/example_metric_output.jsonld","notes":"No source scientific statement was silently altered or replaced.","url_id":"BEMO-2000079","required_inputs_list":["evidence_records","assessment_context","operational_definition","computation_protocol_version"],"optional_inputs_list":["weights","thresholds","reference_standard","expert_adjudication"],"source_record":{"source_workbook":"Pure_Biomedical_Evidence_Research_Metrics_Part_2(3).xlsx","source_sheet":"Biomedical Evidence Metrics","source_row":"86","Category":"Biospecimen and Preanalytical Quality","Metric":"Storage Temperature Control","Scientific Definition":"A canonical biomedical evidence metric quantifying the scientific credibility, reliability, relevance, or interpretability of storage temperature control.","What It Measures":"Assesses storage temperature control using evidence appropriate to biospecimen and preanalytical quality, distinguishing random uncertainty from systematic error.","Why It Matters":"Material weakness in storage temperature control can change the direction, magnitude, certainty, or biological interpretation of the research conclusion.","Measurement Criteria":"Prespecified operational definition; appropriate comparator or reference; quantified uncertainty; independent or orthogonal corroboration; sensitivity analyses.","Typical Methods of Assessment":"Structured critical appraisal; quantitative estimation with uncertainty; prespecified thresholds; independent replication; sensitivity and subgroup analyses.","Units or Scale (if applicable)":"Metric-specific continuous, categorical, or ordinal scale","Evidence Level Where Used":"Specimen / assay / run / laboratory / study","Applicable Study Types":"All studies using human or animal biospecimens","Related Frameworks":"BRISQ; ISO 15189; REMARK","Closely Related Metrics":"Preservation Adequacy; Freeze–Thaw Burden; Transport Condition Integrity","Common Misinterpretations":"Treating storage temperature control as interchangeable with overall study quality, or interpreting a favorable value as proof that all other bias and validity domains are satisfactory.","Limitations":"Depends on context, operational definition, thresholds, data quality, and evaluator judgment; it should not be used as a stand-alone summary score without domain-level evidence.","Scientific Importance (1–10)":"8","Frequency of Use":"Established within specialty","Maturity of Metric":"Established","References or Origin":"https://www.equator-network.org/reporting-guidelines/brisq/ | https://www.iso.org/standard/76677.html | https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/"},"computation_profile":{"metric_id":"BEMO:2000079","preferred_label":"Storage Temperature Control","computation_mode":"ContextSpecificMetricComputation","computation_readiness":"OperationalDefinitionRequired","formula_status":"ContextSpecificProtocolRequired","human_readable_formula":"Apply a versioned metric-specific computation protocol consistent with the source definition, criteria, and methods.","machine_formula_language":"BEMO-Expression-JSON","machine_formula_expression":{"language":"BEMO-Expression-JSON","operator":"external_protocol","protocolRef":"REQUIRED"},"required_inputs":"evidence_records; assessment_context; operational_definition; computation_protocol_version","optional_inputs":"weights; thresholds; reference_standard; expert_adjudication","output_concept":"BEMO:0000200 Metric Assessment","output_datatype":"xsd:anySimpleType","scale_type":"ContextDependentMixedScale","unit_ontology_iri":"","unit_text":"Metric-specific continuous, categorical, or ordinal scale","minimum_value":null,"maximum_value":null,"null_value":null,"directionality":"ContextDependentDirection","aggregation_rule":"Not specified in source; must be defined and versioned before composite use.","normalization_method":"None by default; any normalization must be justified, versioned, and validated.","missing_data_policy":"Must be declared before computation; report missingness; no silent imputation; perform sensitivity analysis when material.","uncertainty_required":true,"uncertainty_method":"Confidence interval, credible interval, bootstrap distribution, inter-rater reliability, or sensitivity analysis as scientifically applicable.","confidence_interval_required":true,"threshold_policy":"Prespecify, justify, version, and sensitivity-test thresholds; do not derive and evaluate on the same data without correction.","decision_thresholds":"","quality_control_requirements":"Source provenance; input validation; duplicate control; uncertainty reporting; independent or orthogonal validation where applicable.","calibration_requirement":"As applicable; mandatory for probabilistic or normalized outputs.","validation_status":"Source maturity: Established; BEMO computation profile requires independent validation.","benchmark_requirement":"A representative, versioned benchmark set is required before production use.","gold_standard_requirement":"Use an independent reference standard when one exists; document expert-adjudicated alternatives.","external_validation_required":true,"computational_method_family":"metric-specific quantitative or qualitative assessment","software_implementation_status":"Specification generated; metric-specific reference implementation pending.","reference_implementation":"scripts/compute_metric.py --metric BEMO:2000079","api_endpoint_template":"/v1/metrics/BEMO:2000079/compute","json_schema_ref":"schemas/bemo-assessment.schema.json","shacl_shape_iri":"https://w3id.org/bemo/shapes/BEMO_2000079_AssessmentShape","profile_version":"0.1.0","profile_iri":"https://w3id.org/bemo/profile/BEMO_2000079"},"relationships":[{"predicate":"closely_related_metric","source":"Source workbook: Closely Related Metrics","status":"SourceDeclared","directionality":"Directed as recorded; may be symmetric in the source","version":"0.1.0","metric_id":"BEMO:2000075","preferred_label":"Preservation Adequacy"},{"predicate":"closely_related_metric","source":"Source workbook: Closely Related Metrics","status":"SourceDeclared","directionality":"Directed as recorded; may be symmetric in the source","version":"0.1.0","metric_id":"BEMO:2000067","preferred_label":"Freeze–Thaw Burden"},{"predicate":"closely_related_metric","source":"Source workbook: Closely Related Metrics","status":"SourceDeclared","directionality":"Directed as recorded; may be symmetric in the source","version":"0.1.0","metric_id":"BEMO:2000081","preferred_label":"Transport Condition Integrity"}],"incoming_relationships":[{"predicate":"closely_related_metric","source":"Source workbook: Closely Related Metrics","status":"SourceDeclared","directionality":"Directed as recorded; may be symmetric in the source","version":"0.1.0","metric_id":"BEMO:2000066","preferred_label":"Fixation Adequacy"},{"predicate":"closely_related_metric","source":"Source workbook: Closely Related Metrics","status":"SourceDeclared","directionality":"Directed as recorded; may be symmetric in the source","version":"0.1.0","metric_id":"BEMO:2000067","preferred_label":"Freeze–Thaw Burden"},{"predicate":"closely_related_metric","source":"Source workbook: Closely Related Metrics","status":"SourceDeclared","directionality":"Directed as recorded; may be symmetric in the source","version":"0.1.0","metric_id":"BEMO:2000075","preferred_label":"Preservation Adequacy"}],"references":[{"order":1,"url":"https://www.equator-network.org/reporting-guidelines/brisq/","type":"Source framework, standard, guideline, or origin","verification_status":"Source-preserved; URL reachability not asserted by this package"},{"order":2,"url":"https://www.iso.org/standard/76677.html","type":"Source framework, standard, guideline, or origin","verification_status":"Source-preserved; URL reachability not asserted by this package"},{"order":3,"url":"https://www.equator-network.org/reporting-guidelines/reporting-recommendations-for-tumor-marker-prognostic-studies-remark/","type":"Source framework, standard, guideline, or origin","verification_status":"Source-preserved; URL reachability not asserted by this package"}]}